Magnetic Solid Lipid Nanoparticles as a Multifunctional Platform against Glioblastoma Multiforme

Información del proyecto

SLaMM

Identificador del acuerdo de subvención: 709613

DOI

10.3030/709613

Proyecto cerrado

Fecha de la firma de la CE 19 Diciembre 2016

Fecha de inicio 1 Marzo 2017

Fecha de finalización 31 Diciembre 2022

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 499 997,42

Aportación de la UE

€ 1 499 997,42

Coordinado por

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (23)

Porous Optically Transparent Cellulose Acetate Scaffolds for Biomimetic Blood-Brain Barrierin vitro Models

Autores: Attilio Marino, Micol Baronio, Umberto Buratti, Elisa Mele, Gianni Ciofani
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 9, 2021, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/fbioe.2021.630063

Ultrasound-responsive nutlin-loaded nanoparticles for combined chemotherapy and piezoelectric treatment of glioblastoma cells.

Autores: Carlotta Pucci; Attilio Marino; Özlem Şen; Daniele De Pasquale; Martina Bartolucci; Nerea Iturrioz-Rodríguez; Nicoletta di Leo; Giuseppe de Vito; Doriana Debellis; Andrea Petretto; Gianni Ciofani
Publicado en: Acta Biomaterialia, Edición 139, 2022, Página(s) 218-236, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2021.04.005

Combining confocal microscopy, dSTORM, and mass spectroscopy to unveil the evolution of the protein corona associated with nanostructured lipid carriers during blood-brain barrier crossing

Autores: Matteo Battaglini, Natalia Feiner, Christos Tapeinos, Daniele De Pasquale, Carlotta Pucci, Attilio Marino, Martina Bartolucci, Andrea Petretto, Lorenzo Albertazzi, Gianni Ciofani
Publicado en: Nanoscale, Edición 20403364, 2022, Página(s) 13292-13307, ISSN 2040-3364
Editor: Royal Society of Chemistry
DOI: 10.1039/d2nr00484d

Drug-loaded lipid magnetic nanoparticles for combined local hyperthermia and chemotherapy against glioblastoma multiforme

Autores: Beola Lilianne, Iturrioz-Rodríguez Nera, Pucci Carlotta, Bertorelli Rosalia, Ciofani Gianni
Publicado en: ACS Nano, Edición 17(18), 2023, Página(s) 18441-18455, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.3c06085

Nanotechnology‐Based Strategies to Evaluate and Counteract Cancer Metastasis and Neoangiogenesis

Autores: Özlem Şen, Melis Emanet, Gianni Ciofani
Publicado en: Advanced Healthcare Materials, Edición 10/10, 2021, Página(s) 2002163, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202002163

Modulation of anti-angiogenic activity using ultrasound-activated nutlin-loaded piezoelectric nanovectors

Autores: Ozlem Sen, Attilio Marino, Carlotta Pucci, Gianni Ciofani
Publicado en: Materials Today Bio, Edición 13, 2022, Página(s) 100196, ISSN 2590-0064
Editor: Elsevier
DOI: 10.1016/j.mtbio.2021.100196

Magnetic Nanotransducers in Biomedicine

Autores: Agostina Grillone, Gianni Ciofani
Publicado en: Chemistry - A European Journal, Edición 23/64, 2017, Página(s) 16109-16114, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201703660

Smart Materials Meet Multifunctional Biomedical Devices: Current and Prospective Implications for Nanomedicine

Autores: Giada Graziana Genchi, Attilio Marino, Christos Tapeinos, Gianni Ciofani
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 5, 2017, Página(s) 8, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/fbioe.2017.00080

Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases

Autores: Christos Tapeinos, Matteo Battaglini, Gianni Ciofani
Publicado en: Journal of Controlled Release, Edición 264, 2017, Página(s) 306-332, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2017.08.033

A 3D Real-Scale, Biomimetic, and Biohybrid Model of the Blood-Brain Barrier Fabricated through Two-Photon Lithography

Autores: Attilio Marino, Omar Tricinci, Matteo Battaglini, Carlo Filippeschi, Virgilio Mattoli, Edoardo Sinibaldi, Gianni Ciofani
Publicado en: Small, Edición 14/6, 2018, Página(s) 1702959, ISSN 1613-6810
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201702959

Stimuli-responsive lipid-based magnetic nanovectors increase apoptosis in glioblastoma cells through synergic intracellular hyperthermia and chemotherapy

Autores: Christos Tapeinos, Attilio Marino, Matteo Battaglini, Simone Migliorin, Rosaria Brescia, Alice Scarpellini, César De Julián Fernández, Mirko Prato, Filippo Drago, Gianni Ciofani
Publicado en: Nanoscale, Edición 11/1, 2019, Página(s) 72-88, ISSN 2040-3364
Editor: Royal Society of Chemistry
DOI: 10.1039/C8NR05520C

Piezoelectric barium titanate nanostimulators for the treatment of glioblastoma multiforme

Autores: Attilio Marino, Enrico Almici, Simone Migliorin, Christos Tapeinos, Matteo Battaglini, Valentina Cappello, Marco Marchetti, Giuseppe de Vito, Riccardo Cicchi, Francesco Saverio Pavone, Gianni Ciofani
Publicado en: Journal of Colloid and Interface Science, Edición 538, 2019, Página(s) 449-461, ISSN 0021-9797
Editor: Academic Press
DOI: 10.1016/j.jcis.2018.12.014

Nutlin-loaded magnetic solid lipid nanoparticles for targeted glioblastoma treatment

Autores: Agostina Grillone, Matteo Battaglini, Stefania Moscato, Letizia Mattii, César de Julián Fernández, Alice Scarpellini, Mario Giorgi, Edoardo Sinibaldi, Gianni Ciofani
Publicado en: Nanomedicine, Edición 14/6, 2019, Página(s) 727-752, ISSN 1743-5889
Editor: Future Medicine Ltd.
DOI: 10.2217/nnm-2018-0436

Nanostructured carriers as innovative tools for cancer diagnosis and therapy

Autores: Chiara Martinelli, Carlotta Pucci, Gianni Ciofani
Publicado en: APL Bioengineering, Edición 3/1, 2019, Página(s) 011502, ISSN 2473-2877
Editor: AIP
DOI: 10.1063/1.5079943

Cell Membrane‐Coated Magnetic Nanocubes with a Homotypic Targeting Ability Increase Intracellular Temperature due to ROS Scavenging and Act as a Versatile Theranostic System for Glioblastoma Multiforme

Autores: Christos Tapeinos, Francesca Tomatis, Matteo Battaglini, Aitor Larrañaga, Attilio Marino, Iker Aguirrezabal Telleria, Makis Angelakeris, Doriana Debellis, Filippo Drago, Francesca Brero, Paolo Arosio, Alessandro Lascialfari, Andrea Petretto, Edoardo Sinibaldi, Gianni Ciofani
Publicado en: Advanced Healthcare Materials, Edición 8(18), 2019, Página(s) 1900612, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201900612

Innovative approaches for cancer treatment: current perspectives and new challenges

Autores: Carlotta Pucci, Chiara Martinelli, Gianni Ciofani
Publicado en: ecancermedicalscience, Edición 13, 2019, Página(s) 961, ISSN 1754-6605
Editor: eCancer Global Foundation
DOI: 10.3332/ecancer.2019.961

Multifunctional temozolomide-loaded lipid superparamagnetic nanovectors: dual targeting and disintegration of glioblastoma spheroids by synergic chemotherapy and hyperthermia treatment

Autores: Attilio Marino, Alice Camponovo, Andrea Degl'Innocenti, Martina Bartolucci, Christos Tapeinos, Chiara Martinelli, Daniele De Pasquale, Francesca Santoro, Valentina Mollo, Satoshi Arai, Madoka Suzuki, Yoshie Harada, Andrea Petretto, Gianni Ciofani
Publicado en: Nanoscale, Edición 11/44, 2019, Página(s) 21227-21248, ISSN 2040-3364
Editor: Royal Society of Chemistry
DOI: 10.1039/c9nr07976a

Genetic Hallmarks and Heterogeneity of Glioblastoma in the Single‐Cell Omics Era

Autores: Andrea Degl'Innocenti, Nicoletta di Leo, Gianni Ciofani
Publicado en: Advanced Therapeutics, Edición 3/1, 2019, Página(s) 1900152, ISSN 2366-3987
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adtp.201900152

What does the future hold for chemotherapy with the use of lipid-based nanocarriers?

Autores: Carlotta Pucci, Chiara Martinelli, Gianni Ciofani
Publicado en: Future Oncology, Edición 16/5, 2020, Página(s) 81-84, ISSN 1479-6694
Editor: Future Medicine Ltd.
DOI: 10.2217/fon-2019-0767

Editorial: Advanced Theranostic Nanomedicine in Oncology

Autores: Christos Tapeinos, Attilio Marino, Gianni Ciofani
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 8, 2020, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/fbioe.2020.00142

Homotypic targeting and drug delivery in glioblastoma cells through cell membrane-coated boron nitride nanotubes

Autores: Daniele De Pasquale, Attilio Marino, Christos Tapeinos, Carlotta Pucci, Silvia Rocchiccioli, Elena Michelucci, Francesco Finamore, Liam McDonnell, Alice Scarpellini, Simone Lauciello, Mirko Prato, Aitor Larrañaga, Filippo Drago, Gianni Ciofani
Publicado en: Materials & Design, Edición 192, 2020, Página(s) 108742, ISSN 0264-1275
Editor: Elsevier BV
DOI: 10.1016/j.matdes.2020.108742

Hybrid Magnetic Nanovectors Promote Selective Glioblastoma Cell Death through a Combined Effect of Lysosomal Membrane Permeabilization and Chemotherapy

Autores: Carlotta Pucci, Daniele De Pasquale, Attilio Marino, Chiara Martinelli, Simone Lauciello, Gianni Ciofani
Publicado en: ACS Applied Materials & Interfaces, Edición 12/26, 2020, Página(s) 29037-29055, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.0c05556

Lipid‐Based Nanocarriers for The Treatment of Glioblastoma

Autores: Nerea Iturrioz-Rodríguez, Rosalia Bertorelli, Gianni Ciofani
Publicado en: Advanced NanoBiomed Research, Edición 1/2, 2021, Página(s) 2000054, ISSN 2699-9307
Editor: John Wiley and Sons Ltd
DOI: 10.1002/anbr.202000054

Derechos de propiedad intelectual

Patent (1)

CELL CO-CULTURE SYSTEM AND METHOD

Número de solicitud/publicación: 20 796929
Fecha: 2020-10-06
Solicitante(s): FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA