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Innovative Strategies towards Halogenated Organic Molecules: From Reaction Design to Application in Drug Synthesis

Ziel

Halogenated arenes and heteroarenes have become essential structural motifs of the pharmaceutical industry to create novel drugs against bacterial infections and cancer, and constitute highly valuable functional units in chemistry. Current methods for the installation of carbon-halogen bonds lack efficiency, selectivity, and practicability within the complex molecular setting of drug development processes. These restrictions prevent many potential drugs from being synthesized in a time- and cost-efficient manner.
In this project, I aim to address these challenges by engineering a highly elaborated synthetic toolbox that is equipped with novel transformations of unprecedented efficiency, selectivity and practicability. I will apply these transformations to the construction of novel antibiotics against resistant strains and more efficient chemotherapeutics to combat cancer.
The first objective is to establish innovative transformations that enable for the first time an efficient access to halogenated arenes. I will accomplish this goal by developing novel ring-expansion reactions and apply them to the first synthesis of the antibiotic salimabromide in order to address the acute problem of antibiotic resistance. Within the second part of this project, I will extend this unique synthetic platform to heteroarenes and establish a groundbreaking method based on carbon-fluorine bond activation. This will represent the first broadly applicable strategy to produce novel fluorinated heteroarene based anti-cancer drugs with unparalleled precision, efficiency and selectivity. Taken together, the realization of these strategies, all of which are unprecedented, provides for the first time a solution for the limitations associated with current methods. With my expertise in synthetic chemistry, which I have gained from my achievements in natural product synthesis, and an outstanding publication record in this research field, I am confident to accomplish these ambitious goals.

Wissenschaftliches Gebiet

  • /Medizin- und Gesundheitswissenschaften/Grundlagenmedizin/Pharmakologie und Pharmazie/Arzneimittelresistenz/Antibiotikaresistenzen
  • /Naturwissenschaften/Chemiewissenschaften/anorganische Chemie/anorganischen Verbindungen

Aufforderung zur Vorschlagseinreichung

ERC-2016-STG
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

ERC-STG - Starting Grant

Gastgebende Einrichtung

UNIVERSITAET INNSBRUCK
Adresse
Innrain 52
6020 Innsbruck
Österreich
Aktivitätstyp
Higher or Secondary Education Establishments
EU-Beitrag
€ 1 425 986,80

Begünstigte (2)

UNIVERSITAET INNSBRUCK
Österreich
EU-Beitrag
€ 1 425 986,80
Adresse
Innrain 52
6020 Innsbruck
Aktivitätstyp
Higher or Secondary Education Establishments
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Beteiligung beendet

Deutschland
EU-Beitrag
€ 70 677,50
Adresse
Geschwister Scholl Platz 1
80539 Muenchen
Aktivitätstyp
Higher or Secondary Education Establishments