Novel Mechanism of Behavioural Change

Informations projet

ChangeBehavNeuro

N° de convention de subvention: 715016

DOI

10.3030/715016

Projet clôturé

Date de signature de la CE 15 Decembre 2016

Date de début 1 Janvier 2017

Date de fin 31 Decembre 2022

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total

€ 1 500 000,00

Contribution de l’UE

€ 1 500 000,00

Coordonné par

TEL AVIV UNIVERSITY
Israel

Periodic Reporting for period 4 - ChangeBehavNeuro (Novel Mechanism of Behavioural Change)

Période du rapport: 2021-07-01 au 2022-12-31

Résumé du contexte et des objectifs généraux du projet

Understanding how values of different options that lead to choice are represented in the brain is a basic scientific question with far reaching implications. The far-reaching goal of this project was to study the mechanism, by which low-level sensory, perceptual and motor neural processes underlie value representation and change in the human brain even in the absence of external reinforcement. Multiple disorders can benefit from behavioural change such as addictions, mental and food disorders. Current methods of behavioural change rely on self-control or external reinforcement. Here, we explored the behavioral boundaries and neural basis of a novel mechanism of behavioral change that does not rely on external feedback or self-control. We studied the behavioral and neural differences between reinforced and non-reinforced change and how memory is related to value-based decision-making. We showed how low-level features influence the neural representation of value. We tested the interaction with the known striatal representation of reinforced behavioural change, which has been the main focus of research thus far. Finally, the project culminated in an opinion paper of a novel non-reinforced pathway in the brain that will influence development of future interventions for mental disorders and addictions.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

We investigated the generalizability and boundaries of the novel non-reinforced behavioral change effect and reveled that this novel mechanism of behavioral change relies on changes in visual sensory mechanisms. We further developed a new behavioural task to change behavior with reinforcement as well study the neural basis of reinforced habits in humans.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

We have published 9 manuscrips. We expect additional 1-2 papers to be published in the coming years.

Potential novel neural pathway for Nonreinforced preference change