Investigating fibROmuscular dysplasia and spontaneous coronary Artery dissection using genetic and functionaL genomics to decipher the origIN of two female specific cardiovascular Diseases

Informazioni relative al progetto

ROSALIND

ID dell’accordo di sovvenzione: 716628

DOI

10.3030/716628

Progetto chiuso

Data della firma CE 22 Febbraio 2017

Data di avvio 1 Marzo 2017

Data di completamento 28 Febbraio 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 500 000,00

Contributo UE

€ 1 500 000,00

Coordinato da

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (13)

Recent Advances on the Genetics of Spontaneous Coronary Artery Dissection

Autori: Amrani-Midoun A, Adlam D, Bouatia-Naji N
Pubblicato in: Circulation Genom Precis Med, 2021, ISSN 2574-8300
Editore: Lippincott Williams & Wilkins
DOI: 10.1161/circgen.121.003393

Genomic, Transcriptomic, and Proteomic Depiction of Induced Pluripotent Stem Cells-Derived Smooth Muscle Cells As Emerging Cellular Models for Arterial Diseases

Autori: Liu L, Jouve C, Henry J, Berrandou TE, Hulot JS, Georges A, Bouatia-Naji N
Pubblicato in: Hypertension, 2023, ISSN 0194-911X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.122.19733

Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation

Autori: Adlam D, Berrandou TE, Georges A, Nelson CP, Giannoulatou E, Henry J, Ma L, Blencowe M, Turley TN, Yang ML, Chopade S, Finan C, Braund PS, Sadeg-Sayoud I, Iismaa SE, Kosel ML, Zhou X, Hamby SE, Cheng J, Liu L, Tarr I, Muller DWM, d'Escamard V, King A, Brunham LR, Baranowska-Clarke AA, Debette S, Amouyel P, Olin JW, Patil S, Hesselson SE, Junday K, Kanoni S, Aragam KG, Butterworth AS, Tweet MS, Gul
Pubblicato in: Nature Genetics, 2023, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-023-01410-1

Genetic Study of PHACTR1 and Fibromuscular Dysplasia, Meta-Analysis and Effects on Clinical Features of Patients

Autori: Ewa Warchol-Celinska, Takiy Berrandou, Aleksander Prejbisz, Adrien Georges, Delia Dupré, Magdalena Januszewicz, Elzbieta Florczak, Katarzyna Jozwik-Plebanek, Piotr Dobrowolski, Witold Smigielski, Wojciech Drygas, Jacek Kadziela, Adam Witkowski, Marek Kabat, Malgorzata Szczerbo-Trojanowska, Marco Pappaccogli, Alexandre Persu, Xavier Jeunemaitre, Andrzej Januszewicz, Nabila Bouatia-Naji
Pubblicato in: Hypertension, Numero 76/1, 2020, ISSN 0194-911X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.120.14793

Rare loss-of-function mutations of PTGIR are enriched in fibromuscular dysplasia

Autori: Adrien Georges, Juliette Albuisson, Takiy Berrandou, Délia Dupré, Aurélien Lorthioir, Valentina D’Escamard, Antonio F Di Narzo, Daniella Kadian-Dodov, Jeffrey W Olin, Ewa Warchol-Celinska, Aleksander Prejbisz, Andrzej Januszewicz, Patrick Bruneval, Anna A Baranowska, Tom R Webb, Stephen E Hamby, Nilesh J Samani, David Adlam, Natalia Fendrikova-Mahlay, Stanley Hazen, Yu Wang, Min-Lee Yang, Kri
Pubblicato in: Cardiovascular Research, Numero 117/4, 2020, Pagina/e 1154-1165, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvaa161

Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci

Autori: Sergiy Kyryachenko, Adrien Georges, Mengyao Yu, Takiy Barrandou, Lilong Guo, Patrick Bruneval, Tony Rubio, Judith Gronwald, Hassina Baraki, Ingo Kutschka, Kedar K. Aras, Igor R. Efimov, Russel A. Norris, Niels Voigt and Nabila Bouatia-Naji
Pubblicato in: Circulation Research, 2021, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.317581

Spontaneous coronary artery dissections and fibromuscular dysplasia: Current insights on pathophysiology, sex and gender

Autori: Angela H.E.M. Maas, Nabila Bouatia-Naji, Alexandre Persu, David Adlam
Pubblicato in: International Journal of Cardiology, Numero 286, 2019, Pagina/e 220-225, ISSN 0167-5273
Editore: Elsevier BV
DOI: 10.1016/j.ijcard.2018.11.023

Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection

Autori: David Adlam, Timothy M. Olson, Nicolas Combaret, Jason C. Kovacic, Siiri E. Iismaa, Abtehale Al-Hussaini, Megan M. O'Byrne, Sara Bouajila, Adrien Georges, Ketan Mishra, Peter S. Braund, Valentina d’Escamard, Siying Huang, Marios Margaritis, Christopher P. Nelson, Mariza de Andrade, Daniella Kadian-Dodov, Catherine A. Welch, Stephani Mazurkiewicz, Xavier Jeunemaitre, Claire Mei Yi Wong, Eleni Gia
Pubblicato in: Journal of the American College of Cardiology, Numero 73/1, 2019, Pagina/e 58-66, ISSN 0735-1097
Editore: Elsevier BV
DOI: 10.1016/j.jacc.2018.09.085

A Plasma Proteogenomic Signature for Fibromuscular Dysplasia

Autori: Jeffrey W Olin, Antonio F Di Narzo, Valentina d’Escamard, Daniella Kadian-Dodov, Haoxiang Cheng, Adrien Georges, Annette King, Allison Thomas, Temo Barwari, Katherine C Michelis, Rihab Bouchareb, Emir Bander, Anelechi Anyanwu, Paul Stelzer, Farzan Filsoufi, Sander Florman, Mete Civelek, Stephanie Debette, Xavier Jeunemaitre, Johan LM Björkegren, Manuel Mayr, Nabila Bouatia-Naji, Ke Hao, Jason C
Pubblicato in: Cardiovascular Research, 2019, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvz219

Fibromuscular Dysplasia and Its Neurologic Manifestations

Autori: Emmanuel Touzé, Andrew M. Southerland, Marion Boulanger, Paul-Emile Labeyrie, Michel Azizi, Nabila Bouatia-Naji, Stéphanie Debette, Heather L. Gornik, Shazam M. Hussain, Xavier Jeunemaitre, Julien Joux, Adam Kirton, Claire Le Hello, Jennifer J. Majersik, J. Mocco, Alexandre Persu, Aditya Sharma, Bradford B. Worrall, Jeffrey W. Olin, Pierre-François Plouin
Pubblicato in: JAMA Neurology, Numero 76/2, 2019, Pagina/e 217, ISSN 2168-6149
Editore: American Medical Association
DOI: 10.1001/jamaneurol.2018.2848

National French registry of spontaneous coronary artery dissections: prevalence of fibromuscular dysplasia and genetic analyses

Autori: Nicolas Combaret, Edouard Gerbaud, François Dérimay, Geraud Souteyrand, Lucie Cassagnes, Sara Bouajila, Takiy Berrandou, Gregoire Rangé, Nicolas Meneveau, Brahim Harbaoui, Benoit Lattuca, Nabila Bouatia-Naji, Pascal Motreff
Pubblicato in: EuroIntervention, Numero 17/6, 2021, Pagina/e 508-515, ISSN 1774-024X
Editore: Europa Ed
DOI: 10.4244/eij-d-20-01046

Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases

Autori: Adrien Georges, Min-Lee Yang, Takiy-Eddine Berrandou, Mark K. Bakker, Ozan Dikilitas, Soto Romuald Kiando, Lijiang Ma, Benjamin A. Satterfield, Sebanti Sengupta, Mengyao Yu, Jean-François Deleuze, Delia Dupré, Kristina L. Hunker, Sergiy Kyryachenko, Lu Liu, Ines Sayoud-Sadeg, Laurence Amar, Chad M. Brummett, Dawn M. Coleman, Valentina d’Escamard, Peter de Leeuw, Natalia Fendrikova-Mahlay, Dani
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-26174-2

Spontaneous Coronary Artery Dissection

Autori: Keren J. Carss, Anna A. Baranowska, Javier Armisen, Tom R. Webb, Stephen E. Hamby, Diluka Premawardhana, Abtehale Al-Hussaini, Alice Wood, Quanli Wang, Sri V. V. Deevi, Dimitrios Vitsios, Samuel H. Lewis, Deevia Kotecha, Nabila Bouatia-Naji, Stephanie Hesselson, Siiri E. Iismaa, Ingrid Tarr, Lucy McGrath-Cadell, David W. Muller, Sally L. Dunwoodie, Diane Fatkin, Robert M. Graham, Eleni Giannoulato
Pubblicato in: Circulation: Genomic and Precision Medicine, Numero 13/6, 2020, ISSN 2574-8300
Editore: Wolters Kluwer Health, Inc
DOI: 10.1161/circgen.120.003030

Non-peer reviewed articles (2)

La génétique établit le lien entre plusieurs maladies cardiovasculaires affectant préférentiellement les femmes

Autori: Adrien Georges, Nabila Bouatia-Naji
Pubblicato in: médecine/sciences, Numero 35/8-9, 2019, Pagina/e 605-607, ISSN 0767-0974
Editore: Editions E D K
DOI: 10.1051/medsci/2019119

The complex genetic basis of fibromuscular dysplasia, a systemic arteriopathy associated with multiple forms of cardiovascular disease.

Autori: Georges A, Bouatia-Naji N
Pubblicato in: Clin Sci, 2022, ISSN 0143-5221
Editore: Portland Press, Ltd.
DOI: 10.1042/cs20210990