Herpesvirus Effectors of RNA synthesis, Processing, Export and Stability

Project Information

HERPES

Grant agreement ID: 721016

DOI 10.3030/721016

Project closed

EC signature date 5 April 2017

Start date 1 May 2017

End date 30 April 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 994 375,00

EU contribution € 1 994 375,00

Coordinated by

JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Concatemeric Broccoli reduces mRNA stability and induces aggregates

Author(s): Marco R. Rink, Marisa A. P. Baptista, Felix J. Flomm, Thomas Hennig, Adam W. Whisnant, Natalia Wolf, Jürgen Seibel, Lars Dölken, Jens B. Bosse
Published in: PLoS One, Issue 16(8):e0244166, 2021, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0244166

Mechanism and consequences of herpes simplex virus 1-mediated regulation of host mRNA alternative polyadenylation

Author(s): Xiuye Wang, Liang Liu, Adam W Whisnant, Thomas Hennig, Lara Djakovic, Nabila Haque, Cindy Bach, Rozanne M Sandri-Goldin, Florian Erhard, Caroline C Friedel, Lars Dölken, Yongsheng Shi
Published in: PLoS Genetics, Issue 8;17(3):e1009263, 2021, ISSN 1553-7390
Publisher: Public Library of Science
DOI: 10.1371/journal.pgen.1009263

Selective inhibition of miRNA processing by a herpesvirus-encoded miRNA

Author(s): Thomas Hennig, Archana B. Prusty, Benedikt B. Kaufer, Adam W. Whisnant, Manivel Lodha, Antje Enders, Julius Thomas, Francesca Kasimir, Arnhild Grothey, Teresa Klein, Stefanie Herb, Christopher Jürges, Markus Sauer, Utz Fischer, Thomas Rudel, Gunter Meister, Florian Erhard, Lars Dölken & Bhupesh K. Prusty
Published in: Nature, Issue 605 (2022), 2022, Page(s) 539-544, ISSN 1476-4687
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04667-4

HSV-1-induced disruption of transcription termination resembles a cellular stress response but selectively increases chromatin accessibility downstream of genes

Author(s): Thomas Hennig, Marco Michalski, Andrzej J. Rutkowski, Lara Djakovic, Adam W. Whisnant, Marie-Sophie Friedl, Bhaskar Anand Jha, Marisa A. P. Baptista, Anne L’Hernault, Florian Erhard, Lars Dölken, Caroline C. Friedel
Published in: PLOS Pathogens, Issue 14/3, 2018, Page(s) e1006954, ISSN 1553-7374
Publisher: PLoS Pathogens
DOI: 10.1371/journal.ppat.1006954

Dissecting newly transcribed and old RNA using GRAND-SLAM

Author(s): Christopher Jürges, Lars Dölken, Florian Erhard
Published in: Bioinformatics, Issue 34/13, 2018, Page(s) i218-i226, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/bty256

Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection

Author(s): Emanuel Wyler, Jennifer Menegatti, Vedran Franke, Christine Kocks, Anastasiya Boltengagen, Thomas Hennig, Kathrin Theil, Andrzej Rutkowski, Carmelo Ferrai, Laura Baer, Lisa Kermas, Caroline Friedel, Nikolaus Rajewsky, Altuna Akalin, Lars Dölken, Friedrich Grässer, Markus Landthaler
Published in: Genome Biology, Issue 18/1, 2017, ISSN 1474-760X
Publisher: BioMed Central
DOI: 10.1186/s13059-017-1329-5

Improved Ribo-seq enables identification of cryptic translation events

Author(s): Florian Erhard, Anne Halenius, Cosima Zimmermann, Anne L'Hernault, Daniel J Kowalewski, Michael P Weekes, Stefan Stevanovic, Ralf Zimmer, Lars Dölken
Published in: Nature Methods, Issue 15/5, 2018, Page(s) 363-366, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/nmeth.4631

RNA dynamics revealed by metabolic RNA labeling and biochemical nucleoside conversions

Author(s): Marisa A P Baptista, Lars Dölken
Published in: Nature Methods, Issue 15/3, 2018, Page(s) 171-172, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/nmeth.4608

P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress

Author(s): Andrii Bugai, Alexandre J.C. Quaresma, Caroline C. Friedel, Tina Lenasi, Robert Düster, Christopher R. Sibley, Koh Fujinaga, Petra Kukanja, Thomas Hennig, Melanie Blasius, Matthias Geyer, Jernej Ule, Lars Dölken, Matjaž Barborič
Published in: Molecular Cell, Issue 74/2, 2019, Page(s) 254-267.e10, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.01.033

scSLAM-seq reveals core features of transcription dynamics in single cells

Author(s): Florian Erhard, Marisa A. P. Baptista, Tobias Krammer, Thomas Hennig, Marius Lange, Panagiota Arampatzi, Christopher S. Jürges, Fabian J. Theis, Antoine-Emmanuel Saliba, Lars Dölken
Published in: Nature, Issue 571/7765, 2019, Page(s) 419-423, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1369-y

Integrative functional genomics decodes herpes simplex virus 1

Author(s): Adam W. Whisnant, Christopher S. Jürges, Thomas Hennig, Emanuel Wyler, Bhupesh Prusty, Andrzej J. Rutkowski, Anne L’hernault, Lara Djakovic, Margarete Göbel, Kristina Döring, Jennifer Menegatti, Robin Antrobus, Nicholas J. Matheson, Florian W. H. Künzig, Guido Mastrobuoni, Chris Bielow, Stefan Kempa, Chunguang Liang, Thomas Dandekar, Ralf Zimmer, Markus Landthaler, Friedrich Grässer, Paul J
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15992-5

Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27

Author(s): Xiuye Wang, Thomas Hennig, Adam W. Whisnant, Florian Erhard, Bhupesh K. Prusty, Caroline C. Friedel, Elmira Forouzmand, William Hu, Luke Erber, Yue Chen, Rozanne M. Sandri-Goldin, Lars Dölken, Yongsheng Shi
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-14109-x

Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination

Author(s): Ashwin Narain, Pranjali Bhandare,Bikash Adhikari, Simone Backes, Martin Eilers, Lars Dölken, Andreas Schlosser, Florian Erhard, Apoorva Baluapuri, Elmar Wolf
Published in: Molecular Cell, Issue 81(15) (2021), 2021, Page(s) 3110-3127, ISSN 1097-4164
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.06.016

Other (1)

A Review of the Multipronged Attack of Herpes Simplex Virus 1 on the Host Transcriptional Machinery.

Author(s): Thomas Hennig; Lara Djakovic; Lars Dölken; Adam W. Whisnant
Published in: Viruses, Issue 13(9):1836, 2021, ISSN 1476-4687
Publisher: MDPI
DOI: 10.3390/v13091836