Brain-Specific, Modular and Active RNA Therapeutics

Deliverables

Open Data: Continuous reporting on in vitro and pre-clinical performance of RNAs and sharing of data via annotated database

Open Data Continuous reporting on in vitro and preclinical performance of RNAs and sharing of data via annotated database

B-SMART audio-visual material

-SMART audio-visual material

Public project website

Publications

Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle

Author(s): Mariana Conceição, Laura Forcina, Oscar P.B. Wiklander, Dhanu Gupta, Joel Z. Nordin, Besarte Vrellaku, Graham McClorey, Imre Mäger, André Gӧrgens, Per Lundin, Antonio Musarò, Matthew J.A. Wood, Samir EL Andaloussi, Thomas C. Roberts
Published in: Biomaterials, Issue 266, 2021, Page(s) 120435, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120435

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

Author(s): de Jong, Olivier G.; Murphy, Daniel E.; Mäger, Imre; Willms, Eduard; Garcia-Guerra, Antonio; Gitz-Francois, Jerney J.; Lefferts, Juliet; Gupta, Dhanu; Steenbeek, Sander C.; van Rheenen, Jacco; El Andaloussi, Samir; Schiffelers, Raymond M.; Wood, Matthew J. A.; Vader, Pieter
Published in: Nature Communications, Issue 3, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-14977-8

Drug Delivery with Extracellular Vesicles: From Imagination to Innovation

Author(s): Olivier G. de Jong, Sander A. A. Kooijmans, Daniel E. Murphy, Linglei Jiang, Martijn J. W. Evers, Joost P. G. Sluijter, Pieter Vader, Raymond M. Schiffelers
Published in: Accounts of Chemical Research, Issue 52/7, 2019, Page(s) 1761-1770, ISSN 0001-4842
Publisher: American Chemical Society
DOI: 10.1021/acs.accounts.9b00109

Modular lipid nanoparticle platform technology for siRNA and lipophilic prodrug delivery

Author(s): Roy van der Meel; Roy van der Meel; Roy van der Meel; Sam Chen; Josh Zaifman; Jayesh A. Kulkarni; Xu Ran Sabrina Zhang; Ying K. Tam; Marcel B. Bally; Raymond M. Schiffelers; Marco A. Ciufolini; Pieter R. Cullis; Yuen Yi C. Tam
Published in: Small, Issue 17/37, 2021, Page(s) 2103025, ISSN 1613-6829
Publisher: Wiley-VCH GmbH
DOI: 10.1002/smll.202103025

Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery

Author(s): R. Mildner, S. Hak, J. Parot, A. Hyldbakk, S.E. Borgos, D. Some, C. Johann, F. Caputo
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 163, 2021, Page(s) 252-265, ISSN 0939-6411
Publisher: Elsevier BV
DOI: 10.1016/j.ejpb.2021.03.004

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

Author(s): Eduard Willms, Carlos Cabañas, Imre Mäger, Matthew J. A. Wood, Pieter Vader
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: tbd
DOI: 10.3389/fimmu.2018.00738

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

Author(s): Aisling J. O’Loughlin, Imre Mäger, Olivier G. de Jong, Miguel A. Varela, Raymond M. Schiffelers, Samir El Andaloussi, Matthew J.A. Wood, Pieter Vader
Published in: Molecular Therapy, Issue 25/7, 2017, Page(s) 1580-1587, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2017.03.021

Nose-to-brain peptide delivery – The potential of nanotechnology

Author(s): Eleni Samaridou, Maria José Alonso
Published in: Bioorganic & Medicinal Chemistry, Issue 26/10, 2018, Page(s) 2888-2905, ISSN 0968-0896
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2017.11.001

State-of-the-Art Design and Rapid-Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery

Author(s): Martijn J. W. Evers, Jayesh A. Kulkarni, Roy van der Meel, Pieter R. Cullis, Pieter Vader, Raymond M. Schiffelers
Published in: Small Methods, 2018, Page(s) 1700375, ISSN 2366-9608
Publisher: Wiley
DOI: 10.1002/smtd.201700375

Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome

Author(s): Helena Sork, Giulia Corso, Kaarel Krjutskov, Henrik J. Johansson, Joel Z. Nordin, Oscar P. B. Wiklander, Yi Xin Fiona Lee, Jakub Orzechowski Westholm, Janne Lehtiö, Matthew J. A. Wood, Imre Mäger, Samir EL Andaloussi
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-28485-9

Profiling of Extracellular Small RNAs Highlights a Strong Bias towards Non-Vesicular Secretion

Author(s): Helena Sork; Mariana Conceicao; Giulia Corso; Joel Nordin; Yi Xin Fiona Lee; Kaarel Krjutskov; Jakub Orzechowski Westholm; Pieter Vader; Marie Pauwels; Roosmarijn E. Vandenbroucke; Matthew JA Wood; Samir EL Andaloussi; Imre Mäger
Published in: Cells, Issue 10(6), 2021, Page(s) 1543, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10061543

Delivery of oligonucleotide‐based therapeutics: challenges and opportunities

Author(s): Hammond, S.M.; Aartsma-Rus, A.; Alves, S.; Borgos, S.E.; Buijsen, R.A.M.; Collin, R.W.J.; Covello, G.; Denti, M.A.; Desviat, L.R.; Echevarría, L.; Foged, C.; Gaina, G.; Garanto, A.; Garanto, A.; Goyenvalle, A.T.; Guzowska, M.; Holodnuka, I.; Jones, D.R.; Krause, S.; Lehto, T.; Montolio, M.; Van Roon-Mom, W.; Arechavala-Gomeza, V.
Published in: EMBO Molecular Medicine, Issue 13(4):e13243, 2021, ISSN 1757-4684
Publisher: EMBO Press
DOI: 10.15252/emmm.202013243

Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles

Author(s): Daniel E. Murphy, Olivier G. de Jong, Martijn J. W. Evers, Maratussholikhah Nurazizah, Raymond M. Schiffelers, Pieter Vader
Published in: Nano Letters, Issue 21/4, 2021, Page(s) 1888-1895, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.1c00094

challenges and perspectives

Author(s): Hannah Walgrave; Hannah Walgrave; Lujia Zhou; Bart De Strooper; Bart De Strooper; Bart De Strooper; Evgenia Salta
Published in: Molecular Neurodegeneration, 16(1). BioMed Central, Issue 1, 2021, ISSN 1750-1326
Publisher: BioMed Central
DOI: 10.1186/s13024-021-00496-7

Using nanotechnology to deliver biomolecules from nose to brain — peptides, proteins, monoclonal antibodies and RNA

Author(s): Mireya L Borrajo, María José Alonso
Published in: Drug delivery and translational research, Issue 12, 862–880, 2021, ISSN 2190-393X
Publisher: Springer Pub. Co.,
DOI: 10.1007/s13346-021-01086-2

Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking

Author(s): Daniel E. Murphy, Olivier G. de Jong, Maarten Brouwer, Matthew J. Wood, Grégory Lavieu, Raymond M. Schiffelers, Pieter Vader
Published in: Experimental & Molecular Medicine, Issue 51/3, 2019, ISSN 2092-6413
Publisher: Springer Nature
DOI: 10.1038/s12276-019-0223-5

Nose-to-brain delivery of enveloped RNA - cell permeating peptide nanocomplexes for the treatment of neurodegenerative diseases

Author(s): Eleni Samaridou, Hannah Walgrave, Evgenia Salta, David Moreira Álvarez, Vanessa Castro-López, Mabel Loza, Maria José Alonso
Published in: Biomaterials, Issue 230, 2020, Page(s) 119657, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2019.119657

PEG-PGA Enveloped CPP-RNA nanocomplexes (ENCPs) for the nose-to-brain RNA delivery and treatment of neurodegenerative diseases

Author(s): Eleni Samaridou Martijn Evers, Pieter Vader, Raymond Schiffelers Evgenia Salta, Hannah Walgrave, Bart De Strooper María José Alonso
Published in: 2018 Controlled Release Society (CRS) Annual Meeting, 2018
Publisher: tbd

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