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Brain-Specific, Modular and Active RNA Therapeutics


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Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle

Author(s): Mariana Conceição, Laura Forcina, Oscar P.B. Wiklander, Dhanu Gupta, Joel Z. Nordin, Besarte Vrellaku, Graham McClorey, Imre Mäger, André Gӧrgens, Per Lundin, Antonio Musarò, Matthew J.A. Wood, Samir EL Andaloussi, Thomas C. Roberts
Published in: Biomaterials, Issue 266, 2021, Page(s) 120435, ISSN 0142-9612
DOI: 10.1016/j.biomaterials.2020.120435

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

Author(s): de Jong, Olivier G.; Murphy, Daniel E.; Mäger, Imre; Willms, Eduard; Garcia-Guerra, Antonio; Gitz-Francois, Jerney J.; Lefferts, Juliet; Gupta, Dhanu; Steenbeek, Sander C.; van Rheenen, Jacco; El Andaloussi, Samir; Schiffelers, Raymond M.; Wood, Matthew J. A.; Vader, Pieter
Published in: Nature Communications, Issue 3, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-14977-8

Drug Delivery with Extracellular Vesicles: From Imagination to Innovation

Author(s): Olivier G. de Jong, Sander A. A. Kooijmans, Daniel E. Murphy, Linglei Jiang, Martijn J. W. Evers, Joost P. G. Sluijter, Pieter Vader, Raymond M. Schiffelers
Published in: Accounts of Chemical Research, Issue 52/7, 2019, Page(s) 1761-1770, ISSN 0001-4842
DOI: 10.1021/acs.accounts.9b00109

Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery

Author(s): R. Mildner, S. Hak, J. Parot, A. Hyldbakk, S.E. Borgos, D. Some, C. Johann, F. Caputo
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 163, 2021, Page(s) 252-265, ISSN 0939-6411
DOI: 10.1016/j.ejpb.2021.03.004

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

Author(s): Eduard Willms, Carlos Cabañas, Imre Mäger, Matthew J. A. Wood, Pieter Vader
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.00738

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

Author(s): Aisling J. O’Loughlin, Imre Mäger, Olivier G. de Jong, Miguel A. Varela, Raymond M. Schiffelers, Samir El Andaloussi, Matthew J.A. Wood, Pieter Vader
Published in: Molecular Therapy, Issue 25/7, 2017, Page(s) 1580-1587, ISSN 1525-0016
DOI: 10.1016/j.ymthe.2017.03.021

Nose-to-brain peptide delivery – The potential of nanotechnology

Author(s): Eleni Samaridou, Maria José Alonso
Published in: Bioorganic & Medicinal Chemistry, Issue 26/10, 2018, Page(s) 2888-2905, ISSN 0968-0896
DOI: 10.1016/j.bmc.2017.11.001

State-of-the-Art Design and Rapid-Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery

Author(s): Martijn J. W. Evers, Jayesh A. Kulkarni, Roy van der Meel, Pieter R. Cullis, Pieter Vader, Raymond M. Schiffelers
Published in: Small Methods, 2018, Page(s) 1700375, ISSN 2366-9608
DOI: 10.1002/smtd.201700375

Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome

Author(s): Helena Sork, Giulia Corso, Kaarel Krjutskov, Henrik J. Johansson, Joel Z. Nordin, Oscar P. B. Wiklander, Yi Xin Fiona Lee, Jakub Orzechowski Westholm, Janne Lehtiö, Matthew J. A. Wood, Imre Mäger, Samir EL Andaloussi
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-28485-9

Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles

Author(s): Daniel E. Murphy, Olivier G. de Jong, Martijn J. W. Evers, Maratussholikhah Nurazizah, Raymond M. Schiffelers, Pieter Vader
Published in: Nano Letters, Issue 21/4, 2021, Page(s) 1888-1895, ISSN 1530-6984
DOI: 10.1021/acs.nanolett.1c00094

Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking

Author(s): Daniel E. Murphy, Olivier G. de Jong, Maarten Brouwer, Matthew J. Wood, Grégory Lavieu, Raymond M. Schiffelers, Pieter Vader
Published in: Experimental & Molecular Medicine, Issue 51/3, 2019, ISSN 2092-6413
DOI: 10.1038/s12276-019-0223-5

Nose-to-brain delivery of enveloped RNA - cell permeating peptide nanocomplexes for the treatment of neurodegenerative diseases

Author(s): Eleni Samaridou, Hannah Walgrave, Evgenia Salta, David Moreira Álvarez, Vanessa Castro-López, Mabel Loza, Maria José Alonso
Published in: Biomaterials, Issue 230, 2020, Page(s) 119657, ISSN 0142-9612
DOI: 10.1016/j.biomaterials.2019.119657

PEG-PGA Enveloped CPP-RNA nanocomplexes (ENCPs) for the nose-to-brain RNA delivery and treatment of neurodegenerative diseases

Author(s): Eleni Samaridou Martijn Evers, Pieter Vader, Raymond Schiffelers Evgenia Salta, Hannah Walgrave, Bart De Strooper María José Alonso
Published in: 2018 Controlled Release Society (CRS) Annual Meeting, 2018