Brain-Specific, Modular and Active RNA Therapeutics

Rezultaty

Open Data: Continuous reporting on in vitro and pre-clinical performance of RNAs and sharing of data via annotated database

Open Data Continuous reporting on in vitro and preclinical performance of RNAs and sharing of data via annotated database

B-SMART audio-visual material

-SMART audio-visual material

Public project website

Publikacje

Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle

Autorzy: Mariana Conceição, Laura Forcina, Oscar P.B. Wiklander, Dhanu Gupta, Joel Z. Nordin, Besarte Vrellaku, Graham McClorey, Imre Mäger, André Gӧrgens, Per Lundin, Antonio Musarò, Matthew J.A. Wood, Samir EL Andaloussi, Thomas C. Roberts
Opublikowane w: Biomaterials, Numer 266, 2021, Strona(/y) 120435, ISSN 0142-9612
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120435

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

Autorzy: de Jong, Olivier G.; Murphy, Daniel E.; Mäger, Imre; Willms, Eduard; Garcia-Guerra, Antonio; Gitz-Francois, Jerney J.; Lefferts, Juliet; Gupta, Dhanu; Steenbeek, Sander C.; van Rheenen, Jacco; El Andaloussi, Samir; Schiffelers, Raymond M.; Wood, Matthew J. A.; Vader, Pieter
Opublikowane w: Nature Communications, Numer 3, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-14977-8

Drug Delivery with Extracellular Vesicles: From Imagination to Innovation

Autorzy: Olivier G. de Jong, Sander A. A. Kooijmans, Daniel E. Murphy, Linglei Jiang, Martijn J. W. Evers, Joost P. G. Sluijter, Pieter Vader, Raymond M. Schiffelers
Opublikowane w: Accounts of Chemical Research, Numer 52/7, 2019, Strona(/y) 1761-1770, ISSN 0001-4842
Wydawca: American Chemical Society
DOI: 10.1021/acs.accounts.9b00109

Modular lipid nanoparticle platform technology for siRNA and lipophilic prodrug delivery

Autorzy: Roy van der Meel; Roy van der Meel; Roy van der Meel; Sam Chen; Josh Zaifman; Jayesh A. Kulkarni; Xu Ran Sabrina Zhang; Ying K. Tam; Marcel B. Bally; Raymond M. Schiffelers; Marco A. Ciufolini; Pieter R. Cullis; Yuen Yi C. Tam
Opublikowane w: Small, Numer 17/37, 2021, Strona(/y) 2103025, ISSN 1613-6829
Wydawca: Wiley-VCH GmbH
DOI: 10.1002/smll.202103025

Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery

Autorzy: R. Mildner, S. Hak, J. Parot, A. Hyldbakk, S.E. Borgos, D. Some, C. Johann, F. Caputo
Opublikowane w: European Journal of Pharmaceutics and Biopharmaceutics, Numer 163, 2021, Strona(/y) 252-265, ISSN 0939-6411
Wydawca: Elsevier BV
DOI: 10.1016/j.ejpb.2021.03.004

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

Autorzy: Eduard Willms, Carlos Cabañas, Imre Mäger, Matthew J. A. Wood, Pieter Vader
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: tbd
DOI: 10.3389/fimmu.2018.00738

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

Autorzy: Aisling J. O’Loughlin, Imre Mäger, Olivier G. de Jong, Miguel A. Varela, Raymond M. Schiffelers, Samir El Andaloussi, Matthew J.A. Wood, Pieter Vader
Opublikowane w: Molecular Therapy, Numer 25/7, 2017, Strona(/y) 1580-1587, ISSN 1525-0016
Wydawca: Nature Publishing Group
DOI: 10.1016/j.ymthe.2017.03.021

Nose-to-brain peptide delivery – The potential of nanotechnology

Autorzy: Eleni Samaridou, Maria José Alonso
Opublikowane w: Bioorganic & Medicinal Chemistry, Numer 26/10, 2018, Strona(/y) 2888-2905, ISSN 0968-0896
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2017.11.001

State-of-the-Art Design and Rapid-Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery

Autorzy: Martijn J. W. Evers, Jayesh A. Kulkarni, Roy van der Meel, Pieter R. Cullis, Pieter Vader, Raymond M. Schiffelers
Opublikowane w: Small Methods, 2018, Strona(/y) 1700375, ISSN 2366-9608
Wydawca: Wiley
DOI: 10.1002/smtd.201700375

Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome

Autorzy: Helena Sork, Giulia Corso, Kaarel Krjutskov, Henrik J. Johansson, Joel Z. Nordin, Oscar P. B. Wiklander, Yi Xin Fiona Lee, Jakub Orzechowski Westholm, Janne Lehtiö, Matthew J. A. Wood, Imre Mäger, Samir EL Andaloussi
Opublikowane w: Scientific Reports, Numer 8/1, 2018, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-018-28485-9

Profiling of Extracellular Small RNAs Highlights a Strong Bias towards Non-Vesicular Secretion

Autorzy: Helena Sork; Mariana Conceicao; Giulia Corso; Joel Nordin; Yi Xin Fiona Lee; Kaarel Krjutskov; Jakub Orzechowski Westholm; Pieter Vader; Marie Pauwels; Roosmarijn E. Vandenbroucke; Matthew JA Wood; Samir EL Andaloussi; Imre Mäger
Opublikowane w: Cells, Numer 10(6), 2021, Strona(/y) 1543, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells10061543

Delivery of oligonucleotide‐based therapeutics: challenges and opportunities

Autorzy: Hammond, S.M.; Aartsma-Rus, A.; Alves, S.; Borgos, S.E.; Buijsen, R.A.M.; Collin, R.W.J.; Covello, G.; Denti, M.A.; Desviat, L.R.; Echevarría, L.; Foged, C.; Gaina, G.; Garanto, A.; Garanto, A.; Goyenvalle, A.T.; Guzowska, M.; Holodnuka, I.; Jones, D.R.; Krause, S.; Lehto, T.; Montolio, M.; Van Roon-Mom, W.; Arechavala-Gomeza, V.
Opublikowane w: EMBO Molecular Medicine, Numer 13(4):e13243, 2021, ISSN 1757-4684
Wydawca: EMBO Press
DOI: 10.15252/emmm.202013243

Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles

Autorzy: Daniel E. Murphy, Olivier G. de Jong, Martijn J. W. Evers, Maratussholikhah Nurazizah, Raymond M. Schiffelers, Pieter Vader
Opublikowane w: Nano Letters, Numer 21/4, 2021, Strona(/y) 1888-1895, ISSN 1530-6984
Wydawca: American Chemical Society
DOI: 10.1021/acs.nanolett.1c00094

challenges and perspectives

Autorzy: Hannah Walgrave; Hannah Walgrave; Lujia Zhou; Bart De Strooper; Bart De Strooper; Bart De Strooper; Evgenia Salta
Opublikowane w: Molecular Neurodegeneration, 16(1). BioMed Central, Numer 1, 2021, ISSN 1750-1326
Wydawca: BioMed Central
DOI: 10.1186/s13024-021-00496-7

Using nanotechnology to deliver biomolecules from nose to brain — peptides, proteins, monoclonal antibodies and RNA

Autorzy: Mireya L Borrajo, María José Alonso
Opublikowane w: Drug delivery and translational research, Numer 12, 862–880, 2021, ISSN 2190-393X
Wydawca: Springer Pub. Co.,
DOI: 10.1007/s13346-021-01086-2

Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking

Autorzy: Daniel E. Murphy, Olivier G. de Jong, Maarten Brouwer, Matthew J. Wood, Grégory Lavieu, Raymond M. Schiffelers, Pieter Vader
Opublikowane w: Experimental & Molecular Medicine, Numer 51/3, 2019, ISSN 2092-6413
Wydawca: Springer Nature
DOI: 10.1038/s12276-019-0223-5

Nose-to-brain delivery of enveloped RNA - cell permeating peptide nanocomplexes for the treatment of neurodegenerative diseases

Autorzy: Eleni Samaridou, Hannah Walgrave, Evgenia Salta, David Moreira Álvarez, Vanessa Castro-López, Mabel Loza, Maria José Alonso
Opublikowane w: Biomaterials, Numer 230, 2020, Strona(/y) 119657, ISSN 0142-9612
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2019.119657

PEG-PGA Enveloped CPP-RNA nanocomplexes (ENCPs) for the nose-to-brain RNA delivery and treatment of neurodegenerative diseases

Autorzy: Eleni Samaridou Martijn Evers, Pieter Vader, Raymond Schiffelers Evgenia Salta, Hannah Walgrave, Bart De Strooper María José Alonso
Opublikowane w: 2018 Controlled Release Society (CRS) Annual Meeting, 2018
Wydawca: tbd

Rezultaty

Publikacje

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