Brain-Specific, Modular and Active RNA Therapeutics

Risultati finali

Open Data: Continuous reporting on in vitro and pre-clinical performance of RNAs and sharing of data via annotated database

Open Data Continuous reporting on in vitro and preclinical performance of RNAs and sharing of data via annotated database

B-SMART audio-visual material

-SMART audio-visual material

Public project website

Pubblicazioni

Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle

Autori: Mariana Conceição, Laura Forcina, Oscar P.B. Wiklander, Dhanu Gupta, Joel Z. Nordin, Besarte Vrellaku, Graham McClorey, Imre Mäger, André Gӧrgens, Per Lundin, Antonio Musarò, Matthew J.A. Wood, Samir EL Andaloussi, Thomas C. Roberts
Pubblicato in: Biomaterials, Numero 266, 2021, Pagina/e 120435, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120435

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

Autori: de Jong, Olivier G.; Murphy, Daniel E.; Mäger, Imre; Willms, Eduard; Garcia-Guerra, Antonio; Gitz-Francois, Jerney J.; Lefferts, Juliet; Gupta, Dhanu; Steenbeek, Sander C.; van Rheenen, Jacco; El Andaloussi, Samir; Schiffelers, Raymond M.; Wood, Matthew J. A.; Vader, Pieter
Pubblicato in: Nature Communications, Numero 3, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-14977-8

Drug Delivery with Extracellular Vesicles: From Imagination to Innovation

Autori: Olivier G. de Jong, Sander A. A. Kooijmans, Daniel E. Murphy, Linglei Jiang, Martijn J. W. Evers, Joost P. G. Sluijter, Pieter Vader, Raymond M. Schiffelers
Pubblicato in: Accounts of Chemical Research, Numero 52/7, 2019, Pagina/e 1761-1770, ISSN 0001-4842
Editore: American Chemical Society
DOI: 10.1021/acs.accounts.9b00109

Modular lipid nanoparticle platform technology for siRNA and lipophilic prodrug delivery

Autori: Roy van der Meel; Roy van der Meel; Roy van der Meel; Sam Chen; Josh Zaifman; Jayesh A. Kulkarni; Xu Ran Sabrina Zhang; Ying K. Tam; Marcel B. Bally; Raymond M. Schiffelers; Marco A. Ciufolini; Pieter R. Cullis; Yuen Yi C. Tam
Pubblicato in: Small, Numero 17/37, 2021, Pagina/e 2103025, ISSN 1613-6829
Editore: Wiley-VCH GmbH
DOI: 10.1002/smll.202103025

Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery

Autori: R. Mildner, S. Hak, J. Parot, A. Hyldbakk, S.E. Borgos, D. Some, C. Johann, F. Caputo
Pubblicato in: European Journal of Pharmaceutics and Biopharmaceutics, Numero 163, 2021, Pagina/e 252-265, ISSN 0939-6411
Editore: Elsevier BV
DOI: 10.1016/j.ejpb.2021.03.004

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

Autori: Eduard Willms, Carlos Cabañas, Imre Mäger, Matthew J. A. Wood, Pieter Vader
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: tbd
DOI: 10.3389/fimmu.2018.00738

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

Autori: Aisling J. O’Loughlin, Imre Mäger, Olivier G. de Jong, Miguel A. Varela, Raymond M. Schiffelers, Samir El Andaloussi, Matthew J.A. Wood, Pieter Vader
Pubblicato in: Molecular Therapy, Numero 25/7, 2017, Pagina/e 1580-1587, ISSN 1525-0016
Editore: Nature Publishing Group
DOI: 10.1016/j.ymthe.2017.03.021

Nose-to-brain peptide delivery – The potential of nanotechnology

Autori: Eleni Samaridou, Maria José Alonso
Pubblicato in: Bioorganic & Medicinal Chemistry, Numero 26/10, 2018, Pagina/e 2888-2905, ISSN 0968-0896
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2017.11.001

State-of-the-Art Design and Rapid-Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery

Autori: Martijn J. W. Evers, Jayesh A. Kulkarni, Roy van der Meel, Pieter R. Cullis, Pieter Vader, Raymond M. Schiffelers
Pubblicato in: Small Methods, 2018, Pagina/e 1700375, ISSN 2366-9608
Editore: Wiley
DOI: 10.1002/smtd.201700375

Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome

Autori: Helena Sork, Giulia Corso, Kaarel Krjutskov, Henrik J. Johansson, Joel Z. Nordin, Oscar P. B. Wiklander, Yi Xin Fiona Lee, Jakub Orzechowski Westholm, Janne Lehtiö, Matthew J. A. Wood, Imre Mäger, Samir EL Andaloussi
Pubblicato in: Scientific Reports, Numero 8/1, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-28485-9

Profiling of Extracellular Small RNAs Highlights a Strong Bias towards Non-Vesicular Secretion

Autori: Helena Sork; Mariana Conceicao; Giulia Corso; Joel Nordin; Yi Xin Fiona Lee; Kaarel Krjutskov; Jakub Orzechowski Westholm; Pieter Vader; Marie Pauwels; Roosmarijn E. Vandenbroucke; Matthew JA Wood; Samir EL Andaloussi; Imre Mäger
Pubblicato in: Cells, Numero 10(6), 2021, Pagina/e 1543, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10061543

Delivery of oligonucleotide‐based therapeutics: challenges and opportunities

Autori: Hammond, S.M.; Aartsma-Rus, A.; Alves, S.; Borgos, S.E.; Buijsen, R.A.M.; Collin, R.W.J.; Covello, G.; Denti, M.A.; Desviat, L.R.; Echevarría, L.; Foged, C.; Gaina, G.; Garanto, A.; Garanto, A.; Goyenvalle, A.T.; Guzowska, M.; Holodnuka, I.; Jones, D.R.; Krause, S.; Lehto, T.; Montolio, M.; Van Roon-Mom, W.; Arechavala-Gomeza, V.
Pubblicato in: EMBO Molecular Medicine, Numero 13(4):e13243, 2021, ISSN 1757-4684
Editore: EMBO Press
DOI: 10.15252/emmm.202013243

Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles

Autori: Daniel E. Murphy, Olivier G. de Jong, Martijn J. W. Evers, Maratussholikhah Nurazizah, Raymond M. Schiffelers, Pieter Vader
Pubblicato in: Nano Letters, Numero 21/4, 2021, Pagina/e 1888-1895, ISSN 1530-6984
Editore: American Chemical Society
DOI: 10.1021/acs.nanolett.1c00094

challenges and perspectives

Autori: Hannah Walgrave; Hannah Walgrave; Lujia Zhou; Bart De Strooper; Bart De Strooper; Bart De Strooper; Evgenia Salta
Pubblicato in: Molecular Neurodegeneration, 16(1). BioMed Central, Numero 1, 2021, ISSN 1750-1326
Editore: BioMed Central
DOI: 10.1186/s13024-021-00496-7

Using nanotechnology to deliver biomolecules from nose to brain — peptides, proteins, monoclonal antibodies and RNA

Autori: Mireya L Borrajo, María José Alonso
Pubblicato in: Drug delivery and translational research, Numero 12, 862–880, 2021, ISSN 2190-393X
Editore: Springer Pub. Co.,
DOI: 10.1007/s13346-021-01086-2

Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking

Autori: Daniel E. Murphy, Olivier G. de Jong, Maarten Brouwer, Matthew J. Wood, Grégory Lavieu, Raymond M. Schiffelers, Pieter Vader
Pubblicato in: Experimental & Molecular Medicine, Numero 51/3, 2019, ISSN 2092-6413
Editore: Springer Nature
DOI: 10.1038/s12276-019-0223-5

Nose-to-brain delivery of enveloped RNA - cell permeating peptide nanocomplexes for the treatment of neurodegenerative diseases

Autori: Eleni Samaridou, Hannah Walgrave, Evgenia Salta, David Moreira Álvarez, Vanessa Castro-López, Mabel Loza, Maria José Alonso
Pubblicato in: Biomaterials, Numero 230, 2020, Pagina/e 119657, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2019.119657

PEG-PGA Enveloped CPP-RNA nanocomplexes (ENCPs) for the nose-to-brain RNA delivery and treatment of neurodegenerative diseases

Autori: Eleni Samaridou Martijn Evers, Pieter Vader, Raymond Schiffelers Evgenia Salta, Hannah Walgrave, Bart De Strooper María José Alonso
Pubblicato in: 2018 Controlled Release Society (CRS) Annual Meeting, 2018
Editore: tbd

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