Brain-Specific, Modular and Active RNA Therapeutics

Resultado final

Open Data: Continuous reporting on in vitro and pre-clinical performance of RNAs and sharing of data via annotated database

Open Data Continuous reporting on in vitro and preclinical performance of RNAs and sharing of data via annotated database

B-SMART audio-visual material

-SMART audio-visual material

Public project website

Publicaciones

Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle

Autores: Mariana Conceição, Laura Forcina, Oscar P.B. Wiklander, Dhanu Gupta, Joel Z. Nordin, Besarte Vrellaku, Graham McClorey, Imre Mäger, André Gӧrgens, Per Lundin, Antonio Musarò, Matthew J.A. Wood, Samir EL Andaloussi, Thomas C. Roberts
Publicado en: Biomaterials, Edición 266, 2021, Página(s) 120435, ISSN 0142-9612
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120435

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

Autores: de Jong, Olivier G.; Murphy, Daniel E.; Mäger, Imre; Willms, Eduard; Garcia-Guerra, Antonio; Gitz-Francois, Jerney J.; Lefferts, Juliet; Gupta, Dhanu; Steenbeek, Sander C.; van Rheenen, Jacco; El Andaloussi, Samir; Schiffelers, Raymond M.; Wood, Matthew J. A.; Vader, Pieter
Publicado en: Nature Communications, Edición 3, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-14977-8

Drug Delivery with Extracellular Vesicles: From Imagination to Innovation

Autores: Olivier G. de Jong, Sander A. A. Kooijmans, Daniel E. Murphy, Linglei Jiang, Martijn J. W. Evers, Joost P. G. Sluijter, Pieter Vader, Raymond M. Schiffelers
Publicado en: Accounts of Chemical Research, Edición 52/7, 2019, Página(s) 1761-1770, ISSN 0001-4842
Editor: American Chemical Society
DOI: 10.1021/acs.accounts.9b00109

Modular lipid nanoparticle platform technology for siRNA and lipophilic prodrug delivery

Autores: Roy van der Meel; Roy van der Meel; Roy van der Meel; Sam Chen; Josh Zaifman; Jayesh A. Kulkarni; Xu Ran Sabrina Zhang; Ying K. Tam; Marcel B. Bally; Raymond M. Schiffelers; Marco A. Ciufolini; Pieter R. Cullis; Yuen Yi C. Tam
Publicado en: Small, Edición 17/37, 2021, Página(s) 2103025, ISSN 1613-6829
Editor: Wiley-VCH GmbH
DOI: 10.1002/smll.202103025

Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery

Autores: R. Mildner, S. Hak, J. Parot, A. Hyldbakk, S.E. Borgos, D. Some, C. Johann, F. Caputo
Publicado en: European Journal of Pharmaceutics and Biopharmaceutics, Edición 163, 2021, Página(s) 252-265, ISSN 0939-6411
Editor: Elsevier BV
DOI: 10.1016/j.ejpb.2021.03.004

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

Autores: Eduard Willms, Carlos Cabañas, Imre Mäger, Matthew J. A. Wood, Pieter Vader
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: tbd
DOI: 10.3389/fimmu.2018.00738

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

Autores: Aisling J. O’Loughlin, Imre Mäger, Olivier G. de Jong, Miguel A. Varela, Raymond M. Schiffelers, Samir El Andaloussi, Matthew J.A. Wood, Pieter Vader
Publicado en: Molecular Therapy, Edición 25/7, 2017, Página(s) 1580-1587, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.ymthe.2017.03.021

Nose-to-brain peptide delivery – The potential of nanotechnology

Autores: Eleni Samaridou, Maria José Alonso
Publicado en: Bioorganic & Medicinal Chemistry, Edición 26/10, 2018, Página(s) 2888-2905, ISSN 0968-0896
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2017.11.001

State-of-the-Art Design and Rapid-Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery

Autores: Martijn J. W. Evers, Jayesh A. Kulkarni, Roy van der Meel, Pieter R. Cullis, Pieter Vader, Raymond M. Schiffelers
Publicado en: Small Methods, 2018, Página(s) 1700375, ISSN 2366-9608
Editor: Wiley
DOI: 10.1002/smtd.201700375

Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome

Autores: Helena Sork, Giulia Corso, Kaarel Krjutskov, Henrik J. Johansson, Joel Z. Nordin, Oscar P. B. Wiklander, Yi Xin Fiona Lee, Jakub Orzechowski Westholm, Janne Lehtiö, Matthew J. A. Wood, Imre Mäger, Samir EL Andaloussi
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-28485-9

Profiling of Extracellular Small RNAs Highlights a Strong Bias towards Non-Vesicular Secretion

Autores: Helena Sork; Mariana Conceicao; Giulia Corso; Joel Nordin; Yi Xin Fiona Lee; Kaarel Krjutskov; Jakub Orzechowski Westholm; Pieter Vader; Marie Pauwels; Roosmarijn E. Vandenbroucke; Matthew JA Wood; Samir EL Andaloussi; Imre Mäger
Publicado en: Cells, Edición 10(6), 2021, Página(s) 1543, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10061543

Delivery of oligonucleotide‐based therapeutics: challenges and opportunities

Autores: Hammond, S.M.; Aartsma-Rus, A.; Alves, S.; Borgos, S.E.; Buijsen, R.A.M.; Collin, R.W.J.; Covello, G.; Denti, M.A.; Desviat, L.R.; Echevarría, L.; Foged, C.; Gaina, G.; Garanto, A.; Garanto, A.; Goyenvalle, A.T.; Guzowska, M.; Holodnuka, I.; Jones, D.R.; Krause, S.; Lehto, T.; Montolio, M.; Van Roon-Mom, W.; Arechavala-Gomeza, V.
Publicado en: EMBO Molecular Medicine, Edición 13(4):e13243, 2021, ISSN 1757-4684
Editor: EMBO Press
DOI: 10.15252/emmm.202013243

Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles

Autores: Daniel E. Murphy, Olivier G. de Jong, Martijn J. W. Evers, Maratussholikhah Nurazizah, Raymond M. Schiffelers, Pieter Vader
Publicado en: Nano Letters, Edición 21/4, 2021, Página(s) 1888-1895, ISSN 1530-6984
Editor: American Chemical Society
DOI: 10.1021/acs.nanolett.1c00094

challenges and perspectives

Autores: Hannah Walgrave; Hannah Walgrave; Lujia Zhou; Bart De Strooper; Bart De Strooper; Bart De Strooper; Evgenia Salta
Publicado en: Molecular Neurodegeneration, 16(1). BioMed Central, Edición 1, 2021, ISSN 1750-1326
Editor: BioMed Central
DOI: 10.1186/s13024-021-00496-7

Using nanotechnology to deliver biomolecules from nose to brain — peptides, proteins, monoclonal antibodies and RNA

Autores: Mireya L Borrajo, María José Alonso
Publicado en: Drug delivery and translational research, Edición 12, 862–880, 2021, ISSN 2190-393X
Editor: Springer Pub. Co.,
DOI: 10.1007/s13346-021-01086-2

Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking

Autores: Daniel E. Murphy, Olivier G. de Jong, Maarten Brouwer, Matthew J. Wood, Grégory Lavieu, Raymond M. Schiffelers, Pieter Vader
Publicado en: Experimental & Molecular Medicine, Edición 51/3, 2019, ISSN 2092-6413
Editor: Springer Nature
DOI: 10.1038/s12276-019-0223-5

Nose-to-brain delivery of enveloped RNA - cell permeating peptide nanocomplexes for the treatment of neurodegenerative diseases

Autores: Eleni Samaridou, Hannah Walgrave, Evgenia Salta, David Moreira Álvarez, Vanessa Castro-López, Mabel Loza, Maria José Alonso
Publicado en: Biomaterials, Edición 230, 2020, Página(s) 119657, ISSN 0142-9612
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2019.119657

PEG-PGA Enveloped CPP-RNA nanocomplexes (ENCPs) for the nose-to-brain RNA delivery and treatment of neurodegenerative diseases

Autores: Eleni Samaridou Martijn Evers, Pieter Vader, Raymond Schiffelers Evgenia Salta, Hannah Walgrave, Bart De Strooper María José Alonso
Publicado en: 2018 Controlled Release Society (CRS) Annual Meeting, 2018
Editor: tbd

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