Blood Biomarker-based Diagnostic Tools for Early Stage Alzheimer’s Disease

Project Information

BBDiag

Grant agreement ID: 721281

DOI 10.3030/721281

Project closed

EC signature date 12 September 2016

Start date 1 January 2017

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 434 981,39

EU contribution € 3 434 981,39

Coordinated by

UNIVERSITY OF PLYMOUTH
United Kingdom

Deliverables

Documents, reports (3)

Progress Report

First year progress report covering all aspects of the network.

Report on network training events & secondments

Report on network training events listed in Table 1.2b (annually, CIBERNED)

Dissemination report

Report on dissemination (URos), month 24 & 46

Other (1)

Supervisory Board of the network

Establishment of BBDiag supervisory board

Publications

Other (8)

Association of Lipidomics Signatures in Blood with Clinical Progression in Preclinical and Prodromal Alzheimer's Disease

Author(s): Sakr F, Dyrba M, Bräuer A, Teipel S
Published in: Association of Lipidomics Signatures in Blood with Clinical Progression in Preclinical and Prodromal Alzheimer's Disease, 2022
Publisher: Journal of Alzheimer's Disease
DOI: 10.3233/jad-201504

Aβ-Induced Alterations in Membrane Lipids Occur before Synaptic Loss Appears

Author(s): Michiel Van Bulck,Nicola Brandt,Ralf A. Claus,Markus Gräler and Anja U. Bräuer
Published in: Aβ-Induced Alterations in Membrane Lipids Occur before Synaptic Loss Appears, 2022, ISSN 2304-2300
Publisher: MDPI
DOI: 10.3390/ijms23042300

Graphene based electrochemical immunosensor for the ultra-sensitive label free detection of Alzheimer's beta amyloid peptides Aβ(1–42)

Author(s): Hina Y. Abbasi; Zari Tehrani; Anitha Devadoss; Muhammad Munem Ali; Soraya Moradi-Bachiller; Diego Albani; Owen J. Guy
Published in: Graphene based electrochemical immunosensor for the ultra-sensitive label free detection of Alzheimer's beta amyloid peptides Aβ(1–42), 2021, ISSN 2295-2304
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0na00801j

APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: A MRS and MRI study.

Author(s): Angela Kuhla; Claire Rühlmann; Tobias Lindner; Stefan Polei; Stefan Hadlich; Bernd J. Krause; Brigitte Vollmar; Stefan J. Teipel
Published in: APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: A MRS and MRI study, 2017, Page(s) 581-586
Publisher: Elsevier
DOI: 10.1016/j.nicl.2017.06.009

Preclinical and Clinical Early Alzheimer's Disease (AD) Biomarker Discovery Using Proteins and MicroRNAs Carried by Small Extracellular Vesicles (sEVs)

Author(s): Moradi Bachiller, Soraya
Published in: Preclinical and Clinical Early Alzheimer's Disease (AD) Biomarker Discovery Using Proteins and MicroRNAs Carried by Small Extracellular Vesicles (sEVs), 2021
Publisher: OPEN UNIVERSITY
DOI: 10.21954/ou.ro.0001289b

The FAST Pump, a low-cost, easy to fabricate, SLA-3D-printed peristaltic pump for multi-channel systems in any lab

Author(s): Alexander Jönsson, Arianna Toppi, Martin Dufva
Published in: The FAST Pump, a low-cost, easy to fabricate, SLA-3D-printed peristaltic pump for multi-channel systems in any lab, 2020
Publisher: HARDWARE X
DOI: 10.1016/j.ohx.2020.e00115

Photolithographic Patterning of FluorAcryl for Biphilic Microwell-Based Digital Bioassays and Selection of Bacteria

Author(s): Arianna Toppi; Louise L. Busk; Hongxia Hu; Asli Aybike Dogan; Alexander Jönsson; Rafael J. Taboryski; Martin Dufva
Published in: Photolithographic Patterning of FluorAcryl for Biphilic Microwell-Based Digital Bioassays and Selection of Bacteria, 2021, ISBN 4391443924
Publisher: American Chemical Society
DOI: 10.1021/acsami.1c10096

A label-free biosensor based on graphene and reduced graphene oxide dual-layer for electrochemical determination of beta-amyloid biomarkers

Author(s): Jagriti Sethi; Michiel Van Bulck; Ahmed Suhail; Mina Safarzadeh; Ana Perez-Castillo; Genhua Pan
Published in: A label-free biosensor based on graphene and reduced graphene oxide dual-layer for electrochemical determination of beta-amyloid biomarkers, Issue 9, 2020, ISSN 3243-0539
Publisher: Springer
DOI: 10.1007/s00604-020-04267-x

Peer reviewed articles (19)

Concept and Building Blocks of a Business Model: A Systematic Literature Review

Author(s): Bin Gao, Shaofeng Liu, Genhua Pan, and Aira Patrice R. Ong
Published in: Concept and Building Blocks of a Business Model: A Systematic Literature Review, 2020, ISSN 2301-3567
Publisher: JOEBM
DOI: 10.18178/joebm.2020.8.2.616

Assessing Surface Coverage of Aminophenyl Bonding Sites on Diazotised Glassy Carbon Electrodes for Optimised Electrochemical Biosensor Performance.

Author(s): Zari Tehrani; Hina Y. Abbasi; Anitha Devadoss; Jonathan E. Evans; Owen J. Guy
Published in: Assessing Surface Coverage of Aminophenyl Bonding Sites on Diazotised Glassy Carbon Electrodes for Optimised Electrochemical Biosensor Performance., Issue 1, 2021, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano11020416

A Label-Free DNA-Immunosensor Based on Aminated rGO Electrode for the Quantification of DNA Methylation

Author(s): Safarzadeh, M.; Suhail, A.; Sethi, J.; Sattar, A.; Jenkins, D.; Pan, G.
Published in: A Label-Free DNA-Immunosensor Based on Aminated rGO Electrode for the Quantification of DNA Methylation, 2021, ISSN 2079-4991
Publisher: MDPI Nanomaterials
DOI: 10.3390/nano11040985

NH2 linker for femtomolar label-free detection with reduced graphene oxide screen-printed electrodes

Author(s): Jagriti Sethi; Ahmed Suhail; Ahmed Suhail; Mina Safarzadeh; Anas A. Sattar; Yinghui Wei; Genhua Pan
Published in: 'NH2 linker for femtomolar label-free detection with reduced graphene oxide screen-printed electrodes' Carbon 179,, Issue 9, 2021, Page(s) 514-522, ISSN 0008-6223
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbon.2021.04.074

Development of a Label-Free Immunosensor for Clusterin Detection as an Alzheimer’s Biomarker

Author(s): Kamrul Islam, Samar Damiati, Jagriti Sethi, Ahmed Suhail, Genhua Pan
Published in: Sensors, Issue 18/1, 2018, Page(s) 308, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s18010308

Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study

Author(s): Fatemah A. Sakr, Michel J. Grothe, Enrica Cavedo, Irina Jelistratova, Marie-Odile Habert, Martin Dyrba, Gabriel Gonzalez-Escamilla, Hugo Bertin, Maxime Locatelli, Stephane Lehericy, Stefan Teipel, Bruno Dubois, Harald Hampel
Published in: Alzheimer's Research & Therapy, Issue 11/1, 2019, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-019-0466-3

Ultrathin Functional Polymer Modified Graphene for Enhanced Enzymatic Electrochemical Sensing

Author(s): Anitha Devadoss, Rhiannan Forsyth, Ryan Bigham, Hina Abbasi, Muhammad Ali, Zari Tehrani, Yufei Liu, Owen. J. Guy
Published in: Biosensors, Issue 9/1, 2019, Page(s) 16, ISSN 2079-6374
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/bios9010016

CLINICAL SIGNIFICANCE OF IN-VIVO STAGING OF REGIONAL AMYLOID DEPOSITION IN SUBJECTIVE MEMORY COMPLAINERS

Author(s): Fatemah A. Sakr, Michel J. Grothe, Enrica Cavedo, Marie-Odile Habert, Hugo Bertin, Maxime Locatelli, Stephane Lehéricy, Bruno Dubois, Stefan J. Teipel, Harald Hampel
Published in: Alzheimer's & Dementia, Issue 14/7, 2018, Page(s) P1262-P1263, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1016/j.jalz.2018.06.1774

Novel Approaches for the Treatment of Alzheimer’s and Parkinson’s Disease

Author(s): Michiel Van Bulck, Ana Sierra-Magro, Jesus Alarcon-Gil, Ana Perez-Castillo and Jose A. Morales-Garcia
Published in: International Journal of Molecular Sciences, Issue 20/5, 2019, Page(s) 1044, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20030719

Systematic Analysis and Biomarker Study for Alzheimer’s Disease

Author(s): Xinzhong Li, Haiyan Wang, Jintao Long, Genhua Pan, Taigang He, Oleg Anichtchik, Robert Belshaw, Diego Albani, Paul Edison, Elaine K Green, James Scott
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-35789-3

Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

Author(s): Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Laura Bonanni, Raffaella Franciotti, Marco Onofrj, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Lucia Fraioli, Lucilla Parne
Published in: Neurobiology of Aging, Issue 73, 2019, Page(s) 9-20, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2018.08.010

Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer’s and Parkinson’s diseases

Author(s): Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Laura Bonanni, Raffaella Franciotti, Marco Onofrj, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia Fraioli
Published in: Clinical Neurophysiology, Issue 129/4, 2018, Page(s) 766-782, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2018.01.009

Abnormalities of Resting State Cortical EEG Rhythms in Subjects with Mild Cognitive Impairment Due to Alzheimer’s and Lewy Body Diseases

Author(s): Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Dag Aarsland, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Laura Vacca, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia
Published in: Journal of Alzheimer's Disease, Issue 62/1, 2018, Page(s) 247-268, ISSN 1387-2877
Publisher: IOS Press
DOI: 10.3233/jad-170703

Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study

Author(s): Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Flavio Nobili, Dario Arnaldi, Francesco Famà, Dag Aarsland, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia Fraioli, Michela Pievani, Giovanni B. Frisoni, Fabrizia
Published in: Neurobiology of Aging, Issue 65, 2018, Page(s) 18-40, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2017.12.023

Predicting and Tracking Short Term Disease Progression in Amnestic Mild Cognitive Impairment Patients with Prodromal Alzheimer’s Disease: Structural Brain Biomarkers

Author(s): Moira Marizzoni, Clarissa Ferrari, Jorge Jovicich, Diego Albani, Claudio Babiloni, Libera Cavaliere, Mira Didic, Gianluigi Forloni, Samantha Galluzzi, Karl-Titus Hoffmann, José Luis Molinuevo, Flavio Nobili, Lucilla Parnetti, Pierre Payoux, Federica Ribaldi, Paolo Maria Rossini, Peter Schönknecht, Andrea Soricelli, Tilman Hensch, Magda Tsolaki, Pieter Jelle Visser, Jens Wiltfang, Jill C. Richard
Published in: Journal of Alzheimer's Disease, 2018, Page(s) 1-12, ISSN 1387-2877
Publisher: IOS Press
DOI: 10.3233/jad-180152

Use of nonintrusive sensor-based information and communication technology for real-world evidence for clinical trials in dementia

Author(s): Stefan Teipel, Alexandra König, Jesse Hoey, Jeff Kaye, Frank Krüger, Julie M. Robillard, Thomas Kirste, Claudio Babiloni
Published in: Alzheimer's & Dementia, Issue 14/9, 2018, Page(s) 1216-1231, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1016/j.jalz.2018.05.003

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Author(s): Harald Hampel, Nicola Toschi, Claudio Babiloni, Filippo Baldacci, Keith L. Black, Arun L.W. Bokde, René S. Bun, Francesco Cacciola, Enrica Cavedo, Patrizia A. Chiesa, Olivier Colliot, Cristina-Maria Coman, Bruno Dubois, Andrea Duggento, Stanley Durrleman, Maria-Teresa Ferretti, Nathalie George, Remy Genthon, Marie-Odile Habert, Karl Herholz, Yosef Koronyo, Maya Koronyo-Hamaoui, Foudil Lamari, Tod
Published in: Journal of Alzheimer's Disease, Issue 64/s1, 2018, Page(s) S47-S105, ISSN 1387-2877
Publisher: IOS Press
DOI: 10.3233/jad-179932

Early Detection of Alzheimer's Disease with Blood Plasma Proteins Using Support Vector Machines

Author(s): Eke, Chima S. and Jammeh, Emmanuel and Li, Xinzhong and Carroll, Camille and Pearson, Stephen and Ifeachor, Emmanuel
Published in: Early Detection of Alzheimer's Disease with Blood Plasma Proteins Using Support Vector Machines, 2021, ISSN 2168-2208
Publisher: IEEE Explore
DOI: 10.1109/jbhi.2020.2984355

In vivo staging of regional amyloid deposition predicts functional conversion in the preclinical and prodromal phases of Alzheimer's disease.

Author(s): Teipel SJ, Dyrba M, Chiesa PA, Sakr F, Jelistratova I, Lista S, Vergallo A, Lemercier P, Cavedo E, Habert MO, Dubois B, Hampel H, Grothe MJ
Published in: In vivo staging of regional amyloid deposition predicts functional conversion in the preclinical and prodromal phases of Alzheimer's disease., 2020, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2020.03.011

Conference proceedings (4)

P3-241: AN MMP-2-GENERATED FRAGMENT OF NEUROCAN IN SERUM AS A POTENTIAL BIOMARKER IN RESPONSE TO PATHOLOGICAL CHANGES IN BRAIN

Author(s): Ourania Tzara,Ditte S. Jonesco,Morten Karsdal,Kim Henriksen
Published in: P3-241: AN MMP-2-GENERATED FRAGMENT OF NEUROCAN IN SERUM AS A POTENTIAL BIOMARKER IN RESPONSE TO PATHOLOGICAL CHANGES IN BRAIN, 2019, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1016/j.jalz.2019.06.3271

Identification of Optimum Panel of Blood-based Biomarkers for Alzheimer’s Disease Diagnosis Using Machine Learning

Author(s): C. S. Eke; E. Jammeh; X. Li; C. Carroll; S. Pearson; E. Ifeachor
Published in: Identification of Optimum Panel of Blood-based Biomarkers for Alzheimer’s Disease Diagnosis Using Machine Learning, 2018, ISBN 978-1-5386-3646-6
Publisher: IEEE
DOI: 10.1109/embc.2018.8513293

P4-185: NOVEL ELECTROCHEMILUMINESCENCE METHOD FOR A BLOOD-BASED BIOMARKER CANDIDATE OF TAU

Author(s): Ourania Tzara,Ditte S. Jonesco,Morten Karsdal,Kim Henriksen
Published in: P4-185: NOVEL ELECTROCHEMILUMINESCENCE METHOD FOR A BLOOD-BASED BIOMARKER CANDIDATE OF TAU, 2019, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1016/j.jalz.2019.06.3847

A Robust Blood-based Signature of Cerebrospinal Fluid Aβ 42 Status

Author(s): Eke CS, Sakr F, Jammeh E, Zhao P, Ifeachor E.
Published in: A Robust Blood-based Signature of Cerebrospinal Fluid Aβ 42 Status, 2020, ISSN 2694-0604
Publisher: IEEE
DOI: 10.1109/embc44109.2020.9175158

Book chapters (2)

Classification of Healthy Subjects and Alzheimer’s Disease Patients with Dementia from Cortical Sources of Resting State EEG Rhythms: Comparing Different Approaches

Author(s): C. Del Percio, V. Bevilacqua, A. Brunetti, R. Lizio, A. Soricelli, R. Ferri, F. Nobili, L. Gesualdo, G. Logroscino, M. De Tommaso, A. I. Triggiani, G. B. Frisoni, C. Babiloni
Published in: Converging Clinical and Engineering Research on Neurorehabilitation III - Proceedings of the 4th International Conference on NeuroRehabilitation (ICNR2018), October 16-20, 2018, Pisa, Italy, Issue 21, 2019, Page(s) 977-981, ISBN 978-3-030-01844-3
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-01845-0_196

Monitoring of Lifestyle and Cognitive Status in Seniors at Risk of Dementia: The SmartAging Program

Author(s): Roberta Lizio, Claudio Del Percio, Jessica Janson, Attilio Guarini, Roberto Bonaduce, Viviana Armenise, Ivan Di Bari, Giuseppe Dalfino, Deni A. Procaccini, Loreto Gesualdo, Alberto Delpiano, Francesco Lombardi, Carlo Aldera, Claudio Babiloni
Published in: Converging Clinical and Engineering Research on Neurorehabilitation III - Proceedings of the 4th International Conference on NeuroRehabilitation (ICNR2018), October 16-20, 2018, Pisa, Italy, Issue 21, 2019, Page(s) 888-892, ISBN 978-3-030-01844-3
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-01845-0_178