CORDIS - Forschungsergebnisse der EU
CORDIS

Blood Biomarker-based Diagnostic Tools for Early Stage Alzheimer’s Disease

Leistungen

Progress Report

First year progress report covering all aspects of the network.

Report on network training events & secondments

Report on network training events listed in Table 1.2b (annually, CIBERNED)

Dissemination report

Report on dissemination (URos), month 24 & 46

Supervisory Board of the network

Establishment of BBDiag supervisory board

Veröffentlichungen

Association of Lipidomics Signatures in Blood with Clinical Progression in Preclinical and Prodromal Alzheimer's Disease

Autoren: Sakr F, Dyrba M, Bräuer A, Teipel S
Veröffentlicht in: Association of Lipidomics Signatures in Blood with Clinical Progression in Preclinical and Prodromal Alzheimer's Disease, 2022
Herausgeber: Journal of Alzheimer's Disease
DOI: 10.3233/jad-201504

Aβ-Induced Alterations in Membrane Lipids Occur before Synaptic Loss Appears

Autoren: Michiel Van Bulck,Nicola Brandt,Ralf A. Claus,Markus Gräler and Anja U. Bräuer
Veröffentlicht in: Aβ-Induced Alterations in Membrane Lipids Occur before Synaptic Loss Appears, 2022, ISSN 2304-2300
Herausgeber: MDPI
DOI: 10.3390/ijms23042300

Graphene based electrochemical immunosensor for the ultra-sensitive label free detection of Alzheimer's beta amyloid peptides Aβ(1–42)

Autoren: Hina Y. Abbasi; Zari Tehrani; Anitha Devadoss; Muhammad Munem Ali; Soraya Moradi-Bachiller; Diego Albani; Owen J. Guy
Veröffentlicht in: Graphene based electrochemical immunosensor for the ultra-sensitive label free detection of Alzheimer's beta amyloid peptides Aβ(1–42), 2021, ISSN 2295-2304
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/d0na00801j

APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: A MRS and MRI study.

Autoren: Angela Kuhla; Claire Rühlmann; Tobias Lindner; Stefan Polei; Stefan Hadlich; Bernd J. Krause; Brigitte Vollmar; Stefan J. Teipel
Veröffentlicht in: APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: A MRS and MRI study, 2017, Seite(n) 581-586
Herausgeber: Elsevier
DOI: 10.1016/j.nicl.2017.06.009

Preclinical and Clinical Early Alzheimer's Disease (AD) Biomarker Discovery Using Proteins and MicroRNAs Carried by Small Extracellular Vesicles (sEVs)

Autoren: Moradi Bachiller, Soraya
Veröffentlicht in: Preclinical and Clinical Early Alzheimer's Disease (AD) Biomarker Discovery Using Proteins and MicroRNAs Carried by Small Extracellular Vesicles (sEVs), 2021
Herausgeber: OPEN UNIVERSITY
DOI: 10.21954/ou.ro.0001289b

The FAST Pump, a low-cost, easy to fabricate, SLA-3D-printed peristaltic pump for multi-channel systems in any lab

Autoren: Alexander Jönsson, Arianna Toppi, Martin Dufva
Veröffentlicht in: The FAST Pump, a low-cost, easy to fabricate, SLA-3D-printed peristaltic pump for multi-channel systems in any lab, 2020
Herausgeber: HARDWARE X
DOI: 10.1016/j.ohx.2020.e00115

Photolithographic Patterning of FluorAcryl for Biphilic Microwell-Based Digital Bioassays and Selection of Bacteria

Autoren: Arianna Toppi; Louise L. Busk; Hongxia Hu; Asli Aybike Dogan; Alexander Jönsson; Rafael J. Taboryski; Martin Dufva
Veröffentlicht in: Photolithographic Patterning of FluorAcryl for Biphilic Microwell-Based Digital Bioassays and Selection of Bacteria, 2021, ISBN 4391443924
Herausgeber: American Chemical Society
DOI: 10.1021/acsami.1c10096

A label-free biosensor based on graphene and reduced graphene oxide dual-layer for electrochemical determination of beta-amyloid biomarkers

Autoren: Jagriti Sethi; Michiel Van Bulck; Ahmed Suhail; Mina Safarzadeh; Ana Perez-Castillo; Genhua Pan
Veröffentlicht in: A label-free biosensor based on graphene and reduced graphene oxide dual-layer for electrochemical determination of beta-amyloid biomarkers, Ausgabe 9, 2020, ISSN 3243-0539
Herausgeber: Springer
DOI: 10.1007/s00604-020-04267-x

Concept and Building Blocks of a Business Model: A Systematic Literature Review

Autoren: Bin Gao, Shaofeng Liu, Genhua Pan, and Aira Patrice R. Ong
Veröffentlicht in: Concept and Building Blocks of a Business Model: A Systematic Literature Review, 2020, ISSN 2301-3567
Herausgeber: JOEBM
DOI: 10.18178/joebm.2020.8.2.616

Assessing Surface Coverage of Aminophenyl Bonding Sites on Diazotised Glassy Carbon Electrodes for Optimised Electrochemical Biosensor Performance.

Autoren: Zari Tehrani; Hina Y. Abbasi; Anitha Devadoss; Jonathan E. Evans; Owen J. Guy
Veröffentlicht in: Assessing Surface Coverage of Aminophenyl Bonding Sites on Diazotised Glassy Carbon Electrodes for Optimised Electrochemical Biosensor Performance., Ausgabe 1, 2021, ISSN 2079-4991
Herausgeber: MDPI
DOI: 10.3390/nano11020416

A Label-Free DNA-Immunosensor Based on Aminated rGO Electrode for the Quantification of DNA Methylation

Autoren: Safarzadeh, M.; Suhail, A.; Sethi, J.; Sattar, A.; Jenkins, D.; Pan, G.
Veröffentlicht in: A Label-Free DNA-Immunosensor Based on Aminated rGO Electrode for the Quantification of DNA Methylation, 2021, ISSN 2079-4991
Herausgeber: MDPI Nanomaterials
DOI: 10.3390/nano11040985

NH2 linker for femtomolar label-free detection with reduced graphene oxide screen-printed electrodes

Autoren: Jagriti Sethi; Ahmed Suhail; Ahmed Suhail; Mina Safarzadeh; Anas A. Sattar; Yinghui Wei; Genhua Pan
Veröffentlicht in: 'NH2 linker for femtomolar label-free detection with reduced graphene oxide screen-printed electrodes' Carbon 179,, Ausgabe 9, 2021, Seite(n) 514-522, ISSN 0008-6223
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.carbon.2021.04.074

Development of a Label-Free Immunosensor for Clusterin Detection as an Alzheimer’s Biomarker

Autoren: Kamrul Islam, Samar Damiati, Jagriti Sethi, Ahmed Suhail, Genhua Pan
Veröffentlicht in: Sensors, Ausgabe 18/1, 2018, Seite(n) 308, ISSN 1424-8220
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s18010308

Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study

Autoren: Fatemah A. Sakr, Michel J. Grothe, Enrica Cavedo, Irina Jelistratova, Marie-Odile Habert, Martin Dyrba, Gabriel Gonzalez-Escamilla, Hugo Bertin, Maxime Locatelli, Stephane Lehericy, Stefan Teipel, Bruno Dubois, Harald Hampel
Veröffentlicht in: Alzheimer's Research & Therapy, Ausgabe 11/1, 2019, ISSN 1758-9193
Herausgeber: BioMed Central
DOI: 10.1186/s13195-019-0466-3

Ultrathin Functional Polymer Modified Graphene for Enhanced Enzymatic Electrochemical Sensing

Autoren: Anitha Devadoss, Rhiannan Forsyth, Ryan Bigham, Hina Abbasi, Muhammad Ali, Zari Tehrani, Yufei Liu, Owen. J. Guy
Veröffentlicht in: Biosensors, Ausgabe 9/1, 2019, Seite(n) 16, ISSN 2079-6374
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/bios9010016

CLINICAL SIGNIFICANCE OF IN-VIVO STAGING OF REGIONAL AMYLOID DEPOSITION IN SUBJECTIVE MEMORY COMPLAINERS

Autoren: Fatemah A. Sakr, Michel J. Grothe, Enrica Cavedo, Marie-Odile Habert, Hugo Bertin, Maxime Locatelli, Stephane Lehéricy, Bruno Dubois, Stefan J. Teipel, Harald Hampel
Veröffentlicht in: Alzheimer's & Dementia, Ausgabe 14/7, 2018, Seite(n) P1262-P1263, ISSN 1552-5260
Herausgeber: Elsevier BV
DOI: 10.1016/j.jalz.2018.06.1774

Novel Approaches for the Treatment of Alzheimer’s and Parkinson’s Disease

Autoren: Michiel Van Bulck, Ana Sierra-Magro, Jesus Alarcon-Gil, Ana Perez-Castillo and Jose A. Morales-Garcia
Veröffentlicht in: International Journal of Molecular Sciences, Ausgabe 20/5, 2019, Seite(n) 1044, ISSN 1422-0067
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20030719

Systematic Analysis and Biomarker Study for Alzheimer’s Disease

Autoren: Xinzhong Li, Haiyan Wang, Jintao Long, Genhua Pan, Taigang He, Oleg Anichtchik, Robert Belshaw, Diego Albani, Paul Edison, Elaine K Green, James Scott
Veröffentlicht in: Scientific Reports, Ausgabe 8/1, 2018, ISSN 2045-2322
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41598-018-35789-3

Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

Autoren: Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Laura Bonanni, Raffaella Franciotti, Marco Onofrj, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Lucia Fraioli, Lucilla Parne
Veröffentlicht in: Neurobiology of Aging, Ausgabe 73, 2019, Seite(n) 9-20, ISSN 0197-4580
Herausgeber: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2018.08.010

Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer’s and Parkinson’s diseases

Autoren: Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Laura Bonanni, Raffaella Franciotti, Marco Onofrj, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia Fraioli
Veröffentlicht in: Clinical Neurophysiology, Ausgabe 129/4, 2018, Seite(n) 766-782, ISSN 1388-2457
Herausgeber: Elsevier BV
DOI: 10.1016/j.clinph.2018.01.009

Abnormalities of Resting State Cortical EEG Rhythms in Subjects with Mild Cognitive Impairment Due to Alzheimer’s and Lewy Body Diseases

Autoren: Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Dag Aarsland, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Laura Vacca, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia
Veröffentlicht in: Journal of Alzheimer's Disease, Ausgabe 62/1, 2018, Seite(n) 247-268, ISSN 1387-2877
Herausgeber: IOS Press
DOI: 10.3233/jad-170703

Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study

Autoren: Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Flavio Nobili, Dario Arnaldi, Francesco Famà, Dag Aarsland, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia Fraioli, Michela Pievani, Giovanni B. Frisoni, Fabrizia
Veröffentlicht in: Neurobiology of Aging, Ausgabe 65, 2018, Seite(n) 18-40, ISSN 0197-4580
Herausgeber: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2017.12.023

Predicting and Tracking Short Term Disease Progression in Amnestic Mild Cognitive Impairment Patients with Prodromal Alzheimer’s Disease: Structural Brain Biomarkers

Autoren: Moira Marizzoni, Clarissa Ferrari, Jorge Jovicich, Diego Albani, Claudio Babiloni, Libera Cavaliere, Mira Didic, Gianluigi Forloni, Samantha Galluzzi, Karl-Titus Hoffmann, José Luis Molinuevo, Flavio Nobili, Lucilla Parnetti, Pierre Payoux, Federica Ribaldi, Paolo Maria Rossini, Peter Schönknecht, Andrea Soricelli, Tilman Hensch, Magda Tsolaki, Pieter Jelle Visser, Jens Wiltfang, Jill C. Richard
Veröffentlicht in: Journal of Alzheimer's Disease, 2018, Seite(n) 1-12, ISSN 1387-2877
Herausgeber: IOS Press
DOI: 10.3233/jad-180152

Use of nonintrusive sensor-based information and communication technology for real-world evidence for clinical trials in dementia

Autoren: Stefan Teipel, Alexandra König, Jesse Hoey, Jeff Kaye, Frank Krüger, Julie M. Robillard, Thomas Kirste, Claudio Babiloni
Veröffentlicht in: Alzheimer's & Dementia, Ausgabe 14/9, 2018, Seite(n) 1216-1231, ISSN 1552-5260
Herausgeber: Elsevier BV
DOI: 10.1016/j.jalz.2018.05.003

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Autoren: Harald Hampel, Nicola Toschi, Claudio Babiloni, Filippo Baldacci, Keith L. Black, Arun L.W. Bokde, René S. Bun, Francesco Cacciola, Enrica Cavedo, Patrizia A. Chiesa, Olivier Colliot, Cristina-Maria Coman, Bruno Dubois, Andrea Duggento, Stanley Durrleman, Maria-Teresa Ferretti, Nathalie George, Remy Genthon, Marie-Odile Habert, Karl Herholz, Yosef Koronyo, Maya Koronyo-Hamaoui, Foudil Lamari, Tod
Veröffentlicht in: Journal of Alzheimer's Disease, Ausgabe 64/s1, 2018, Seite(n) S47-S105, ISSN 1387-2877
Herausgeber: IOS Press
DOI: 10.3233/jad-179932

Early Detection of Alzheimer's Disease with Blood Plasma Proteins Using Support Vector Machines

Autoren: Eke, Chima S. and Jammeh, Emmanuel and Li, Xinzhong and Carroll, Camille and Pearson, Stephen and Ifeachor, Emmanuel
Veröffentlicht in: Early Detection of Alzheimer's Disease with Blood Plasma Proteins Using Support Vector Machines, 2021, ISSN 2168-2208
Herausgeber: IEEE Explore
DOI: 10.1109/jbhi.2020.2984355

In vivo staging of regional amyloid deposition predicts functional conversion in the preclinical and prodromal phases of Alzheimer's disease.

Autoren: Teipel SJ, Dyrba M, Chiesa PA, Sakr F, Jelistratova I, Lista S, Vergallo A, Lemercier P, Cavedo E, Habert MO, Dubois B, Hampel H, Grothe MJ
Veröffentlicht in: In vivo staging of regional amyloid deposition predicts functional conversion in the preclinical and prodromal phases of Alzheimer's disease., 2020, ISSN 0197-4580
Herausgeber: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2020.03.011

P3-241: AN MMP-2-GENERATED FRAGMENT OF NEUROCAN IN SERUM AS A POTENTIAL BIOMARKER IN RESPONSE TO PATHOLOGICAL CHANGES IN BRAIN

Autoren: Ourania Tzara,Ditte S. Jonesco,Morten Karsdal,Kim Henriksen
Veröffentlicht in: P3-241: AN MMP-2-GENERATED FRAGMENT OF NEUROCAN IN SERUM AS A POTENTIAL BIOMARKER IN RESPONSE TO PATHOLOGICAL CHANGES IN BRAIN, 2019, ISSN 1552-5260
Herausgeber: Elsevier BV
DOI: 10.1016/j.jalz.2019.06.3271

Identification of Optimum Panel of Blood-based Biomarkers for Alzheimer’s Disease Diagnosis Using Machine Learning

Autoren: C. S. Eke; E. Jammeh; X. Li; C. Carroll; S. Pearson; E. Ifeachor
Veröffentlicht in: Identification of Optimum Panel of Blood-based Biomarkers for Alzheimer’s Disease Diagnosis Using Machine Learning, 2018, ISBN 978-1-5386-3646-6
Herausgeber: IEEE
DOI: 10.1109/embc.2018.8513293

P4-185: NOVEL ELECTROCHEMILUMINESCENCE METHOD FOR A BLOOD-BASED BIOMARKER CANDIDATE OF TAU

Autoren: Ourania Tzara,Ditte S. Jonesco,Morten Karsdal,Kim Henriksen
Veröffentlicht in: P4-185: NOVEL ELECTROCHEMILUMINESCENCE METHOD FOR A BLOOD-BASED BIOMARKER CANDIDATE OF TAU, 2019, ISSN 1552-5260
Herausgeber: Elsevier BV
DOI: 10.1016/j.jalz.2019.06.3847

A Robust Blood-based Signature of Cerebrospinal Fluid Aβ 42 Status

Autoren: Eke CS, Sakr F, Jammeh E, Zhao P, Ifeachor E.
Veröffentlicht in: A Robust Blood-based Signature of Cerebrospinal Fluid Aβ 42 Status, 2020, ISSN 2694-0604
Herausgeber: IEEE
DOI: 10.1109/embc44109.2020.9175158

Classification of Healthy Subjects and Alzheimer’s Disease Patients with Dementia from Cortical Sources of Resting State EEG Rhythms: Comparing Different Approaches

Autoren: C. Del Percio, V. Bevilacqua, A. Brunetti, R. Lizio, A. Soricelli, R. Ferri, F. Nobili, L. Gesualdo, G. Logroscino, M. De Tommaso, A. I. Triggiani, G. B. Frisoni, C. Babiloni
Veröffentlicht in: Converging Clinical and Engineering Research on Neurorehabilitation III - Proceedings of the 4th International Conference on NeuroRehabilitation (ICNR2018), October 16-20, 2018, Pisa, Italy, Ausgabe 21, 2019, Seite(n) 977-981, ISBN 978-3-030-01844-3
Herausgeber: Springer International Publishing
DOI: 10.1007/978-3-030-01845-0_196

Monitoring of Lifestyle and Cognitive Status in Seniors at Risk of Dementia: The SmartAging Program

Autoren: Roberta Lizio, Claudio Del Percio, Jessica Janson, Attilio Guarini, Roberto Bonaduce, Viviana Armenise, Ivan Di Bari, Giuseppe Dalfino, Deni A. Procaccini, Loreto Gesualdo, Alberto Delpiano, Francesco Lombardi, Carlo Aldera, Claudio Babiloni
Veröffentlicht in: Converging Clinical and Engineering Research on Neurorehabilitation III - Proceedings of the 4th International Conference on NeuroRehabilitation (ICNR2018), October 16-20, 2018, Pisa, Italy, Ausgabe 21, 2019, Seite(n) 888-892, ISBN 978-3-030-01844-3
Herausgeber: Springer International Publishing
DOI: 10.1007/978-3-030-01845-0_178

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