Blood Biomarker-based Diagnostic Tools for Early Stage Alzheimer’s Disease

Informations projet

BBDiag

N° de convention de subvention: 721281

DOI 10.3030/721281

Projet clôturé

Date de signature de la CE 12 Septembre 2016

Date de début 1 Janvier 2017

Date de fin 31 Decembre 2021

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total € 3 434 981,39

Contribution de l’UE € 3 434 981,39

Coordonné par

UNIVERSITY OF PLYMOUTH
United Kingdom

Livrables

Documents, reports (3)

Progress Report

First year progress report covering all aspects of the network.

Report on network training events & secondments

Report on network training events listed in Table 1.2b (annually, CIBERNED)

Dissemination report

Report on dissemination (URos), month 24 & 46

Other (1)

Supervisory Board of the network

Establishment of BBDiag supervisory board

Publications

Other (8)

Association of Lipidomics Signatures in Blood with Clinical Progression in Preclinical and Prodromal Alzheimer's Disease

Auteurs: Sakr F, Dyrba M, Bräuer A, Teipel S
Publié dans: Association of Lipidomics Signatures in Blood with Clinical Progression in Preclinical and Prodromal Alzheimer's Disease, 2022
Éditeur: Journal of Alzheimer's Disease
DOI: 10.3233/jad-201504

Aβ-Induced Alterations in Membrane Lipids Occur before Synaptic Loss Appears

Auteurs: Michiel Van Bulck,Nicola Brandt,Ralf A. Claus,Markus Gräler and Anja U. Bräuer
Publié dans: Aβ-Induced Alterations in Membrane Lipids Occur before Synaptic Loss Appears, 2022, ISSN 2304-2300
Éditeur: MDPI
DOI: 10.3390/ijms23042300

Graphene based electrochemical immunosensor for the ultra-sensitive label free detection of Alzheimer's beta amyloid peptides Aβ(1–42)

Auteurs: Hina Y. Abbasi; Zari Tehrani; Anitha Devadoss; Muhammad Munem Ali; Soraya Moradi-Bachiller; Diego Albani; Owen J. Guy
Publié dans: Graphene based electrochemical immunosensor for the ultra-sensitive label free detection of Alzheimer's beta amyloid peptides Aβ(1–42), 2021, ISSN 2295-2304
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0na00801j

APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: A MRS and MRI study.

Auteurs: Angela Kuhla; Claire Rühlmann; Tobias Lindner; Stefan Polei; Stefan Hadlich; Bernd J. Krause; Brigitte Vollmar; Stefan J. Teipel
Publié dans: APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: A MRS and MRI study, 2017, Page(s) 581-586
Éditeur: Elsevier
DOI: 10.1016/j.nicl.2017.06.009

Preclinical and Clinical Early Alzheimer's Disease (AD) Biomarker Discovery Using Proteins and MicroRNAs Carried by Small Extracellular Vesicles (sEVs)

Auteurs: Moradi Bachiller, Soraya
Publié dans: Preclinical and Clinical Early Alzheimer's Disease (AD) Biomarker Discovery Using Proteins and MicroRNAs Carried by Small Extracellular Vesicles (sEVs), 2021
Éditeur: OPEN UNIVERSITY
DOI: 10.21954/ou.ro.0001289b

The FAST Pump, a low-cost, easy to fabricate, SLA-3D-printed peristaltic pump for multi-channel systems in any lab

Auteurs: Alexander Jönsson, Arianna Toppi, Martin Dufva
Publié dans: The FAST Pump, a low-cost, easy to fabricate, SLA-3D-printed peristaltic pump for multi-channel systems in any lab, 2020
Éditeur: HARDWARE X
DOI: 10.1016/j.ohx.2020.e00115

Photolithographic Patterning of FluorAcryl for Biphilic Microwell-Based Digital Bioassays and Selection of Bacteria

Auteurs: Arianna Toppi; Louise L. Busk; Hongxia Hu; Asli Aybike Dogan; Alexander Jönsson; Rafael J. Taboryski; Martin Dufva
Publié dans: Photolithographic Patterning of FluorAcryl for Biphilic Microwell-Based Digital Bioassays and Selection of Bacteria, 2021, ISBN 4391443924
Éditeur: American Chemical Society
DOI: 10.1021/acsami.1c10096

A label-free biosensor based on graphene and reduced graphene oxide dual-layer for electrochemical determination of beta-amyloid biomarkers

Auteurs: Jagriti Sethi; Michiel Van Bulck; Ahmed Suhail; Mina Safarzadeh; Ana Perez-Castillo; Genhua Pan
Publié dans: A label-free biosensor based on graphene and reduced graphene oxide dual-layer for electrochemical determination of beta-amyloid biomarkers, Numéro 9, 2020, ISSN 3243-0539
Éditeur: Springer
DOI: 10.1007/s00604-020-04267-x

Peer reviewed articles (19)

Concept and Building Blocks of a Business Model: A Systematic Literature Review

Auteurs: Bin Gao, Shaofeng Liu, Genhua Pan, and Aira Patrice R. Ong
Publié dans: Concept and Building Blocks of a Business Model: A Systematic Literature Review, 2020, ISSN 2301-3567
Éditeur: JOEBM
DOI: 10.18178/joebm.2020.8.2.616

Assessing Surface Coverage of Aminophenyl Bonding Sites on Diazotised Glassy Carbon Electrodes for Optimised Electrochemical Biosensor Performance.

Auteurs: Zari Tehrani; Hina Y. Abbasi; Anitha Devadoss; Jonathan E. Evans; Owen J. Guy
Publié dans: Assessing Surface Coverage of Aminophenyl Bonding Sites on Diazotised Glassy Carbon Electrodes for Optimised Electrochemical Biosensor Performance., Numéro 1, 2021, ISSN 2079-4991
Éditeur: MDPI
DOI: 10.3390/nano11020416

A Label-Free DNA-Immunosensor Based on Aminated rGO Electrode for the Quantification of DNA Methylation

Auteurs: Safarzadeh, M.; Suhail, A.; Sethi, J.; Sattar, A.; Jenkins, D.; Pan, G.
Publié dans: A Label-Free DNA-Immunosensor Based on Aminated rGO Electrode for the Quantification of DNA Methylation, 2021, ISSN 2079-4991
Éditeur: MDPI Nanomaterials
DOI: 10.3390/nano11040985

NH2 linker for femtomolar label-free detection with reduced graphene oxide screen-printed electrodes

Auteurs: Jagriti Sethi; Ahmed Suhail; Ahmed Suhail; Mina Safarzadeh; Anas A. Sattar; Yinghui Wei; Genhua Pan
Publié dans: 'NH2 linker for femtomolar label-free detection with reduced graphene oxide screen-printed electrodes' Carbon 179,, Numéro 9, 2021, Page(s) 514-522, ISSN 0008-6223
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.carbon.2021.04.074

Development of a Label-Free Immunosensor for Clusterin Detection as an Alzheimer’s Biomarker

Auteurs: Kamrul Islam, Samar Damiati, Jagriti Sethi, Ahmed Suhail, Genhua Pan
Publié dans: Sensors, Numéro 18/1, 2018, Page(s) 308, ISSN 1424-8220
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s18010308

Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study

Auteurs: Fatemah A. Sakr, Michel J. Grothe, Enrica Cavedo, Irina Jelistratova, Marie-Odile Habert, Martin Dyrba, Gabriel Gonzalez-Escamilla, Hugo Bertin, Maxime Locatelli, Stephane Lehericy, Stefan Teipel, Bruno Dubois, Harald Hampel
Publié dans: Alzheimer's Research & Therapy, Numéro 11/1, 2019, ISSN 1758-9193
Éditeur: BioMed Central
DOI: 10.1186/s13195-019-0466-3

Ultrathin Functional Polymer Modified Graphene for Enhanced Enzymatic Electrochemical Sensing

Auteurs: Anitha Devadoss, Rhiannan Forsyth, Ryan Bigham, Hina Abbasi, Muhammad Ali, Zari Tehrani, Yufei Liu, Owen. J. Guy
Publié dans: Biosensors, Numéro 9/1, 2019, Page(s) 16, ISSN 2079-6374
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/bios9010016

CLINICAL SIGNIFICANCE OF IN-VIVO STAGING OF REGIONAL AMYLOID DEPOSITION IN SUBJECTIVE MEMORY COMPLAINERS

Auteurs: Fatemah A. Sakr, Michel J. Grothe, Enrica Cavedo, Marie-Odile Habert, Hugo Bertin, Maxime Locatelli, Stephane Lehéricy, Bruno Dubois, Stefan J. Teipel, Harald Hampel
Publié dans: Alzheimer's & Dementia, Numéro 14/7, 2018, Page(s) P1262-P1263, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1016/j.jalz.2018.06.1774

Novel Approaches for the Treatment of Alzheimer’s and Parkinson’s Disease

Auteurs: Michiel Van Bulck, Ana Sierra-Magro, Jesus Alarcon-Gil, Ana Perez-Castillo and Jose A. Morales-Garcia
Publié dans: International Journal of Molecular Sciences, Numéro 20/5, 2019, Page(s) 1044, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20030719

Systematic Analysis and Biomarker Study for Alzheimer’s Disease

Auteurs: Xinzhong Li, Haiyan Wang, Jintao Long, Genhua Pan, Taigang He, Oleg Anichtchik, Robert Belshaw, Diego Albani, Paul Edison, Elaine K Green, James Scott
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-35789-3

Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

Auteurs: Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Laura Bonanni, Raffaella Franciotti, Marco Onofrj, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Lucia Fraioli, Lucilla Parne
Publié dans: Neurobiology of Aging, Numéro 73, 2019, Page(s) 9-20, ISSN 0197-4580
Éditeur: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2018.08.010

Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer’s and Parkinson’s diseases

Auteurs: Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Laura Bonanni, Raffaella Franciotti, Marco Onofrj, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia Fraioli
Publié dans: Clinical Neurophysiology, Numéro 129/4, 2018, Page(s) 766-782, ISSN 1388-2457
Éditeur: Elsevier BV
DOI: 10.1016/j.clinph.2018.01.009

Abnormalities of Resting State Cortical EEG Rhythms in Subjects with Mild Cognitive Impairment Due to Alzheimer’s and Lewy Body Diseases

Auteurs: Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Dag Aarsland, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Laura Vacca, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia
Publié dans: Journal of Alzheimer's Disease, Numéro 62/1, 2018, Page(s) 247-268, ISSN 1387-2877
Éditeur: IOS Press
DOI: 10.3233/jad-170703

Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study

Auteurs: Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Flavio Nobili, Dario Arnaldi, Francesco Famà, Dag Aarsland, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia Fraioli, Michela Pievani, Giovanni B. Frisoni, Fabrizia
Publié dans: Neurobiology of Aging, Numéro 65, 2018, Page(s) 18-40, ISSN 0197-4580
Éditeur: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2017.12.023

Predicting and Tracking Short Term Disease Progression in Amnestic Mild Cognitive Impairment Patients with Prodromal Alzheimer’s Disease: Structural Brain Biomarkers

Auteurs: Moira Marizzoni, Clarissa Ferrari, Jorge Jovicich, Diego Albani, Claudio Babiloni, Libera Cavaliere, Mira Didic, Gianluigi Forloni, Samantha Galluzzi, Karl-Titus Hoffmann, José Luis Molinuevo, Flavio Nobili, Lucilla Parnetti, Pierre Payoux, Federica Ribaldi, Paolo Maria Rossini, Peter Schönknecht, Andrea Soricelli, Tilman Hensch, Magda Tsolaki, Pieter Jelle Visser, Jens Wiltfang, Jill C. Richard
Publié dans: Journal of Alzheimer's Disease, 2018, Page(s) 1-12, ISSN 1387-2877
Éditeur: IOS Press
DOI: 10.3233/jad-180152

Use of nonintrusive sensor-based information and communication technology for real-world evidence for clinical trials in dementia

Auteurs: Stefan Teipel, Alexandra König, Jesse Hoey, Jeff Kaye, Frank Krüger, Julie M. Robillard, Thomas Kirste, Claudio Babiloni
Publié dans: Alzheimer's & Dementia, Numéro 14/9, 2018, Page(s) 1216-1231, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1016/j.jalz.2018.05.003

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Auteurs: Harald Hampel, Nicola Toschi, Claudio Babiloni, Filippo Baldacci, Keith L. Black, Arun L.W. Bokde, René S. Bun, Francesco Cacciola, Enrica Cavedo, Patrizia A. Chiesa, Olivier Colliot, Cristina-Maria Coman, Bruno Dubois, Andrea Duggento, Stanley Durrleman, Maria-Teresa Ferretti, Nathalie George, Remy Genthon, Marie-Odile Habert, Karl Herholz, Yosef Koronyo, Maya Koronyo-Hamaoui, Foudil Lamari, Tod
Publié dans: Journal of Alzheimer's Disease, Numéro 64/s1, 2018, Page(s) S47-S105, ISSN 1387-2877
Éditeur: IOS Press
DOI: 10.3233/jad-179932

Early Detection of Alzheimer's Disease with Blood Plasma Proteins Using Support Vector Machines

Auteurs: Eke, Chima S. and Jammeh, Emmanuel and Li, Xinzhong and Carroll, Camille and Pearson, Stephen and Ifeachor, Emmanuel
Publié dans: Early Detection of Alzheimer's Disease with Blood Plasma Proteins Using Support Vector Machines, 2021, ISSN 2168-2208
Éditeur: IEEE Explore
DOI: 10.1109/jbhi.2020.2984355

In vivo staging of regional amyloid deposition predicts functional conversion in the preclinical and prodromal phases of Alzheimer's disease.

Auteurs: Teipel SJ, Dyrba M, Chiesa PA, Sakr F, Jelistratova I, Lista S, Vergallo A, Lemercier P, Cavedo E, Habert MO, Dubois B, Hampel H, Grothe MJ
Publié dans: In vivo staging of regional amyloid deposition predicts functional conversion in the preclinical and prodromal phases of Alzheimer's disease., 2020, ISSN 0197-4580
Éditeur: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2020.03.011

Conference proceedings (4)

P3-241: AN MMP-2-GENERATED FRAGMENT OF NEUROCAN IN SERUM AS A POTENTIAL BIOMARKER IN RESPONSE TO PATHOLOGICAL CHANGES IN BRAIN

Auteurs: Ourania Tzara,Ditte S. Jonesco,Morten Karsdal,Kim Henriksen
Publié dans: P3-241: AN MMP-2-GENERATED FRAGMENT OF NEUROCAN IN SERUM AS A POTENTIAL BIOMARKER IN RESPONSE TO PATHOLOGICAL CHANGES IN BRAIN, 2019, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1016/j.jalz.2019.06.3271

Identification of Optimum Panel of Blood-based Biomarkers for Alzheimer’s Disease Diagnosis Using Machine Learning

Auteurs: C. S. Eke; E. Jammeh; X. Li; C. Carroll; S. Pearson; E. Ifeachor
Publié dans: Identification of Optimum Panel of Blood-based Biomarkers for Alzheimer’s Disease Diagnosis Using Machine Learning, 2018, ISBN 978-1-5386-3646-6
Éditeur: IEEE
DOI: 10.1109/embc.2018.8513293

P4-185: NOVEL ELECTROCHEMILUMINESCENCE METHOD FOR A BLOOD-BASED BIOMARKER CANDIDATE OF TAU

Auteurs: Ourania Tzara,Ditte S. Jonesco,Morten Karsdal,Kim Henriksen
Publié dans: P4-185: NOVEL ELECTROCHEMILUMINESCENCE METHOD FOR A BLOOD-BASED BIOMARKER CANDIDATE OF TAU, 2019, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1016/j.jalz.2019.06.3847

A Robust Blood-based Signature of Cerebrospinal Fluid Aβ 42 Status

Auteurs: Eke CS, Sakr F, Jammeh E, Zhao P, Ifeachor E.
Publié dans: A Robust Blood-based Signature of Cerebrospinal Fluid Aβ 42 Status, 2020, ISSN 2694-0604
Éditeur: IEEE
DOI: 10.1109/embc44109.2020.9175158

Book chapters (2)

Classification of Healthy Subjects and Alzheimer’s Disease Patients with Dementia from Cortical Sources of Resting State EEG Rhythms: Comparing Different Approaches

Auteurs: C. Del Percio, V. Bevilacqua, A. Brunetti, R. Lizio, A. Soricelli, R. Ferri, F. Nobili, L. Gesualdo, G. Logroscino, M. De Tommaso, A. I. Triggiani, G. B. Frisoni, C. Babiloni
Publié dans: Converging Clinical and Engineering Research on Neurorehabilitation III - Proceedings of the 4th International Conference on NeuroRehabilitation (ICNR2018), October 16-20, 2018, Pisa, Italy, Numéro 21, 2019, Page(s) 977-981, ISBN 978-3-030-01844-3
Éditeur: Springer International Publishing
DOI: 10.1007/978-3-030-01845-0_196

Monitoring of Lifestyle and Cognitive Status in Seniors at Risk of Dementia: The SmartAging Program

Auteurs: Roberta Lizio, Claudio Del Percio, Jessica Janson, Attilio Guarini, Roberto Bonaduce, Viviana Armenise, Ivan Di Bari, Giuseppe Dalfino, Deni A. Procaccini, Loreto Gesualdo, Alberto Delpiano, Francesco Lombardi, Carlo Aldera, Claudio Babiloni
Publié dans: Converging Clinical and Engineering Research on Neurorehabilitation III - Proceedings of the 4th International Conference on NeuroRehabilitation (ICNR2018), October 16-20, 2018, Pisa, Italy, Numéro 21, 2019, Page(s) 888-892, ISBN 978-3-030-01844-3
Éditeur: Springer International Publishing
DOI: 10.1007/978-3-030-01845-0_178