Objective
Train2Target is a multidisciplinary European Training Network built to address the challenge of the discovery of alternative antimicrobials. Innovative strategies to deliver a next generation of drugs are urgently needed. The alarming threats and spread of multi-drug resistant bacteria is currently leaving clinicians with very limited options to combat infections especially those from Gram-negative pathogens.
The Train 2Target research programme focuses on the assembly of the well-known bacterial cell envelope from a new perspective. Indeed it aims to inhibit novel targets in envelope biogenesis by altering the function and misbalancing the coordination of envelope assembly machines, which build and assemble the Gram-negative bacterial envelope. A wide variety of chemical classes and compounds sources will be screened using innovative biochemical, biophysical and genetic assays to identify valuable hit scaffolds to be optimized into druggable leads.
The high quality and credibility of our consortium is ensured by a strong interdisciplinary academia-industry partnership to encompass different complementary expertise ranging from microbiology, bacterial genetics, biochemistry, cell imaging, structural biology, biophysics and chemical synthesis. Our 9 academic groups are all renowned leaders in the cell envelope biogenesis field, whereas the complementary 5 SMEs and 3 Industry partners are specialised in drug discovery and development of novel anti-infective drugs. This unique combination of scientific excellence and industrial know-how in drug discovery covers the entire process from the design to the implementation of innovative antibacterial strategies and lead identification.
Train2Target also represents a unique research platform to train 15 Early Stage Researchers and equip them with the necessary scientific and transferable skills that will make them highly competitive for both top European research institutions and the pharma/biotech job market.
Fields of science
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- natural sciencesbiological sciencesmicrobiologybacteriology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistance
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance
Programme(s)
Funding Scheme
MSCA-ITN-ETN - European Training NetworksCoordinator
20122 Milano
Italy
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Participants (10)
75794 Paris
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NE1 7RU Newcastle Upon Tyne
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1348 Louvain La Neuve
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1012WX Amsterdam
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B15 2TT Birmingham
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80138 Napoli
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42117 Wuppertal
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2900 Hellerup
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
4057 Basel
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
20147 Saronno Va
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partners (6)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
8008 Zurich
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
31670 Labege
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
4058 Basel
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
2800 Kongens Lyngby
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
4051 Basel
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
75014 Paris
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