An integrated mulTidisciplinary appRoach towards a new generAtIon of aNtibiotics: Targeting function and cross-talk of bacterial Envelope proTein machineries

Deliverables

Other (2)

Industry course

Industry course

SB and SAB established

SB and SAB established

Websites, patent fillings, videos etc. (1)

Website

Website www.train2target.eu

Publications

Peer reviewed articles (6)

The lipopolysaccharide transport (Lpt) machinery: A nonconventional transporter for lipopolysaccharide assembly at the outer membrane of Gram-negative bacteria

Author(s): Paola Sperandeo, Alessandra M. Martorana, Alessandra Polissi
Published in: Journal of Biological Chemistry, Issue 292/44, 2017, Page(s) 17981-17990, ISSN 0021-9258
DOI: 10.1074/jbc.R117.802512

Copper inhibits peptidoglycan LD-transpeptidases suppressing β-lactam resistance due to bypass of penicillin-binding proteins

Author(s): Katharina Peters, Manuel Pazos, Zainab Edoo, Jean-Emmanuel Hugonnet, Alessandra M. Martorana, Alessandra Polissi, Michael S. VanNieuwenhze, Michel Arthur, Waldemar Vollmer
Published in: Proceedings of the National Academy of Sciences, Issue 115/42, 2018, Page(s) 10786-10791, ISSN 0027-8424
DOI: 10.1073/pnas.1809285115

Interaction of lipopolysaccharides at intermolecular sites of the periplasmic Lpt transport assembly

Author(s): Cedric Laguri, Paola Sperandeo, Kevin Pounot, Isabel Ayala, Alba Silipo, Catherine M. Bougault, Antonio Molinaro, Alessandra Polissi, Jean-Pierre Simorre
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/s41598-017-10136-0

Superfolder mTurquoise2 ox optimized for the bacterial periplasm allows high efficiency in vivo FRET of cell division antibiotic targets

Author(s): Nils Y. Meiresonne, Elisa Consoli, Laureen M. Y. Mertens, Anna Chertkova, Joachim Goedhart, Tanneke den Blaauwen
Published in: Molecular Microbiology, 2019, ISSN 0950-382X
DOI: 10.1111/mmi.14206

Solid State NMR Studies of Intact Lipopolysaccharide Endotoxin

Author(s): Cedric Laguri, Alba Silipo, Alessandra M. Martorana, Paul Schanda, Roberta Marchetti, Alessandra Polissi, Antonio Molinaro, Jean-Pierre Simorre
Published in: ACS Chemical Biology, Issue 13/8, 2018, Page(s) 2106-2113, ISSN 1554-8929
DOI: 10.1021/acschembio.8b00271

Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect

Author(s): Niccolò Morè, Alessandra M. Martorana, Jacob Biboy, Christian Otten, Matthias Winkle, Carlos K. Gurnani Serrano, Alejandro Montón Silva, Lisa Atkinson, Hamish Yau, Eefjan Breukink, Tanneke den Blaauwen, Waldemar Vollmer, Alessandra Polissi
Published in: mBio, Issue 10/1, 2019, ISSN 2150-7511
DOI: 10.1128/mbio.02729-18