Deliverables Documents, reports (1) Scientific publications Min. 45 publications in peer-reviewed journals Other (2) Industry course SB and SAB established Websites, patent fillings, videos etc. (2) Website Website www.train2target.eu Science Slams Publications Peer reviewed articles (27) Effective approaches to discover new microbial metabolites in a large strain library. Author(s): Mitja M Zdouc, Marianna Iorio, Kristiina Vind, Matteo Simone, Stefania Serina, Cristina Brunati, Paolo Monciardini, Arianna Tocchetti, Guadalupe S Zarazúa, Max Crüsemann, Sonia I Maffioli, Margherita Sosio, Stefano Donadio Published in: Journal of Industrial Microbiology and Biotechnology, 2021, ISSN 1476-5535 Publisher: Springer-Nature DOI: 10.1093/jimb/kuab017 The active repertoire of Escherichia coli peptidoglycan amidases varies with physiochemical environment Author(s): Mueller, Elizabeth A; Iken, Abbygail G; Öztürk, Mehmet; Winkle, Matthias; Schmitz, Mirko; Vollmer, Waldemar; Di Ventura, Barbara; Levin, Petra Anne Published in: Molecular Microbiology, 2021, ISSN 0950-382X Publisher: Blackwell Publishing Inc. DOI: 10.1111/mmi.14711 Carbohydrate-based adjuvants Author(s): Pilar Garcia-Vello, Immacolata Speciale, Fabrizio Chiodo, Antonio Molinaro, Cristina De Castro Published in: Drug Discovery Today: Technologies, Issue 35-36, 2020, Page(s) 57-68, ISSN 1740-6749 Publisher: Elsevier BV DOI: 10.1016/j.ddtec.2020.09.005 A biaryl-linked tripeptide from Planomonospora reveals a widespread class of minimal RiPP gene clusters Author(s): Mitja M. Zdouc, Mohammad M. Alanjary, Guadalupe S. Zarazúa, Sonia I. Maffioli, Max Crüsemann, Marnix H. Medema, Stefano Donadio, Margherita Sosio Published in: Cell Chemical Biology, 2020, ISSN 2451-9456 Publisher: Cell Chemical Biology DOI: 10.1016/j.chembiol.2020.11.009 "Detection of in vivo Protein Interactions in All Bacterial Components by Förster Resonance Energy Transfer with the Superfolder mTurquoise2 ox-mNeongreen FRET Pair" Author(s): Nils Meiresonne, Elisa Consoli, Laureen Mertens, Tanneke den Blaauwen Published in: BIO-PROTOCOL, Issue 9/23, 2019, ISSN 2331-8325 Publisher: Bio-protocol DOI: 10.21769/bioprotoc.3448 Lipoproteins in Gram-negative bacteria: new insights into their biogenesis, subcellular targeting and functional roles Author(s): Jessica El Rayes, Raquel Rodríguez-Alonso, Jean-François Collet Published in: Current Opinion in Microbiology, Issue 61, 2021, Page(s) 25-34, ISSN 1369-5274 Publisher: Elsevier BV DOI: 10.1016/j.mib.2021.02.003 Structural features and immunological perception of the cell surface glycans of Lactobacillus plantarum: a novel rhamnose-rich polysaccharide and teichoic acids Author(s): Pilar Garcia-Vello, Garima Sharma, Immacolata Speciale, Antonio Molinaro, Sin-Hyeog Im, Cristina De Castro Published in: Carbohydrate Polymers, Issue 233, 2020, Page(s) 115857, ISSN 0144-8617 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.carbpol.2020.115857 The Lpt ABC transporter for lipopolysaccharide export to the cell surface Author(s): Paola Sperandeo, Alessandra M. Martorana, Alessandra Polissi Published in: Research in Microbiology, Issue 170/8, 2019, Page(s) 366-373, ISSN 0923-2508 Publisher: Elsevier BV DOI: 10.1016/j.resmic.2019.07.005 Planomonospora : A Metabolomics Perspective on an Underexplored Actinobacteria Genus Author(s): Mitja M. Zdouc, Marianna Iorio, Sonia I. Maffioli, Max Crüsemann, Stefano Donadio, Margherita Sosio Published in: Journal of Natural Products, Issue 84/2, 2021, Page(s) 204-219, ISSN 0163-3864 Publisher: American Chemical Society DOI: 10.1021/acs.jnatprod.0c00807 In vitro activity of rifabutin against 293 contemporary carbapenem-resistant Acinetobacter baumannii clinical isolates and characterization of rifabutin mode of action and resistance mechanisms Author(s): Vincent Trebosc, Birgit Schellhorn, Julian Schill, Valentina Lucchini, Jacqueline Bühler, Marilyne Bourotte, Jonathan J Butcher, Marc Gitzinger, Sergio Lociuro, Christian Kemmer, Glenn E Dale Published in: Journal of Antimicrobial Chemotherapy, Issue 75/12, 2020, Page(s) 3552-3562, ISSN 0305-7453 Publisher: Oxford University Press DOI: 10.1093/jac/dkaa370 The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes Author(s): Robert M. Cleverley, Zoe J. Rutter, Jeanine Rismondo, Federico Corona, Ho-Ching Tiffany Tsui, Fuad A. Alatawi, Richard A. Daniel, Sven Halbedel, Orietta Massidda, Malcolm E. Winkler, Richard J. Lewis Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-018-08056-2 Thanatin Impairs Lipopolysaccharide Transport Complex Assembly by Targeting LptC–LptA Interaction and Decreasing LptA Stability Author(s): Elisabete C. C. M. Moura, Tiago Baeta, Alessandra Romanelli, Cedric Laguri, Alessandra M. Martorana, Emanuela Erba, Jean-Pierre Simorre, Paola Sperandeo, Alessandra Polissi Published in: Frontiers in Microbiology, Issue 11, 2020, ISSN 1664-302X Publisher: Frontiers Media DOI: 10.3389/fmicb.2020.00909 ActS activates peptidoglycan amidases during outer membrane stress in Escherichia coli Author(s): Carlos K. Gurnani Serrano, Matthias Winkle, Alessandra M. Martorana, Jacob Biboy, Niccolo Morè, Patrick Moynihan, Manuel Banzhaf, Waldemar Vollmer, Alessandra Polissi Published in: Molecular Microbiology, 2021, ISSN 0950-382X Publisher: Blackwell Publishing Inc. DOI: 10.1111/mmi.14712 The lipopolysaccharide transport (Lpt) machinery: A nonconventional transporter for lipopolysaccharide assembly at the outer membrane of Gram-negative bacteria Author(s): Paola Sperandeo, Alessandra M. Martorana, Alessandra Polissi Published in: Journal of Biological Chemistry, Issue 292/44, 2017, Page(s) 17981-17990, ISSN 0021-9258 Publisher: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1074/jbc.R117.802512 Copper inhibits peptidoglycan LD-transpeptidases suppressing β-lactam resistance due to bypass of penicillin-binding proteins Author(s): Katharina Peters, Manuel Pazos, Zainab Edoo, Jean-Emmanuel Hugonnet, Alessandra M. Martorana, Alessandra Polissi, Michael S. VanNieuwenhze, Michel Arthur, Waldemar Vollmer Published in: Proceedings of the National Academy of Sciences, Issue 115/42, 2018, Page(s) 10786-10791, ISSN 0027-8424 Publisher: National Academy of Sciences DOI: 10.1073/pnas.1809285115 Interaction of lipopolysaccharides at intermolecular sites of the periplasmic Lpt transport assembly Author(s): Cedric Laguri, Paola Sperandeo, Kevin Pounot, Isabel Ayala, Alba Silipo, Catherine M. Bougault, Antonio Molinaro, Alessandra Polissi, Jean-Pierre Simorre Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-017-10136-0 Superfolder mTurquoise2 ox optimized for the bacterial periplasm allows high efficiency in vivo FRET of cell division antibiotic targets Author(s): Nils Y. Meiresonne, Elisa Consoli, Laureen M. Y. Mertens, Anna Chertkova, Joachim Goedhart, Tanneke den Blaauwen Published in: Molecular Microbiology, 2019, ISSN 0950-382X Publisher: Blackwell Publishing Inc. DOI: 10.1111/mmi.14206 Solid State NMR Studies of Intact Lipopolysaccharide Endotoxin Author(s): Cedric Laguri, Alba Silipo, Alessandra M. Martorana, Paul Schanda, Roberta Marchetti, Alessandra Polissi, Antonio Molinaro, Jean-Pierre Simorre Published in: ACS Chemical Biology, Issue 13/8, 2018, Page(s) 2106-2113, ISSN 1554-8929 Publisher: American Chemical Society DOI: 10.1021/acschembio.8b00271 Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect Author(s): Niccolò Morè, Alessandra M. Martorana, Jacob Biboy, Christian Otten, Matthias Winkle, Carlos K. Gurnani Serrano, Alejandro Montón Silva, Lisa Atkinson, Hamish Yau, Eefjan Breukink, Tanneke den Blaauwen, Waldemar Vollmer, Alessandra Polissi Published in: mBio, Issue 10/1, 2019, ISSN 2150-7511 Publisher: American Society for Microbiology DOI: 10.1128/mbio.02729-18 Structural insight into the formation of lipoprotein-β-barrel complexes Author(s): Raquel Rodríguez-Alonso, Juliette Létoquart, Van Son Nguyen, Gwennaelle Louis, Antonio N. Calabrese, Bogdan I. Iorga, Sheena E. Radford, Seung-Hyun Cho, Han Remaut, Jean-François Collet Published in: Nature Chemical Biology, Issue 16/9, 2020, Page(s) 1019-1025, ISSN 1552-4450 Publisher: Nature Publishing Group DOI: 10.1038/s41589-020-0575-0 Structure of the O‐Antigen and the Lipid A from the Lipopolysaccharide of Fusobacterium nucleatum ATCC 51191 Author(s): Pilar Garcia‐Vello, Flaviana Di Lorenzo, Dimitra Lamprinaki, Anna Notaro, Immacolata Speciale, Antonio Molinaro, Nathalie Juge, Cristina De Castro Published in: ChemBioChem, Issue 22/7, 2021, Page(s) 1252-1260, ISSN 1439-4227 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/cbic.202000751 The Escherichia coli Outer Membrane β-Barrel Assembly Machinery (BAM) Anchors the Peptidoglycan Layer by Spanning It with All Subunits Author(s): Elisa Consoli, Jean-François Collet, Tanneke den Blaauwen Published in: International Journal of Molecular Sciences, Issue 22/4, 2021, Page(s) 1853, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms22041853 Blocks in the pseudouridimycin pathway unlock hidden metabolites in the Streptomyces producer strain Author(s): Marianna Iorio, Sahar Davatgarbenam, Stefania Serina, Paolo Criscenzo, Mitja M. Zdouc, Matteo Simone, Sonia I. Maffioli, Richard H. Ebright, Stefano Donadio, Margherita Sosio Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-021-84833-2 Dissecting Colistin Resistance Mechanisms in Extensively Drug-Resistant Acinetobacter baumannii Clinical Isolates Author(s): Vincent Trebosc, Sarah Gartenmann, Marcus Tötzl, Valentina Lucchini, Birgit Schellhorn, Michel Pieren, Sergio Lociuro, Marc Gitzinger, Marcel Tigges, Dirk Bumann, Christian Kemmer Published in: mBio, Issue 10/4, 2019, ISSN 2150-7511 Publisher: American Society for Microbiology DOI: 10.1128/mbio.01083-19 MreC and MreD balance the interaction between the elongasome proteins PBP2 and RodA Author(s): Xiaolong Liu, Jacob Biboy, Elisa Consoli, Waldemar Vollmer, Tanneke den Blaauwen Published in: Plos Genetics, Issue 16(12), 2020, Page(s) e1009276, ISSN 1553-7390 Publisher: Public Library of Science DOI: 10.1371/journal.pgen.1009276 Fat Matters for Bugs: How Lipids and Lipid Modifications Make the Difference in Bacterial Life Author(s): Paola Sperandeo, Alessandra Polissi, Emma De Fabiani Published in: European Journal of Lipid Science and Technology, Issue 121/10, 2019, Page(s) 1900204, ISSN 1438-7697 Publisher: Wiley - V C H Verlag GmbbH & Co. DOI: 10.1002/ejlt.201900204 Mutation and Suppressor Analysis of the Essential Lipopolysaccharide Transport Protein LptA Reveals Strategies To Overcome Severe Outer Membrane Permeability Defects in Escherichia coli Author(s): Federica A. Falchi, Elisa A. Maccagni, Simone Puccio, Clelia Peano, Cristina De Castro, Angelo Palmigiano, Domenico Garozzo, Alessandra M. Martorana, Alessandra Polissi, Gianni Dehò, Paola Sperandeo Published in: Journal of Bacteriology, Issue 200/2, 2018, ISSN 0021-9193 Publisher: American Society for Microbiology DOI: 10.1128/jb.00487-17 Other (3) Structure-function analyses of dual-BON domain protein DolP identifies phospholipid binding as a new mechanism for protein localisation Author(s): J. A. Bryant, F. C. Morris, T. J. Knowles, R. Maderbocus, E. Heinz, G. Boelter, D. Alodaini, A. Colyer, P. J. Wotherspoon, K. A. Staunton, M. Jeeves, D. F. Browning, Y. R. Sevastsyanovich, T. J. Wells, A. E. Rossiter, V. N. Bavro, P. Sridhar, D. G. Ward, Z-S. Chong, C. Icke, A. Teo, S-S. Chng, View ORCID ProfileD. I. Roper, T. Lithgow, A. F. Cunningham, M. Banzhaf, M. Overduin, I. R. Henderson Published in: BioRxiv, 2020 Publisher: BioRxiv DOI: 10.1101/2020.08.10.244616 Disorder is a critical component of lipoprotein sorting in Gram-negative bacteria Author(s): Jessica El Rayes, Joanna Szewczyk, Michael Deghelt, André Matagne, Bogdan I. Iorga, Seung-Hyun Cho, Jean-François Collet Published in: BioRxiv, 2021 Publisher: BioRxiv DOI: 10.1101/2021.01.05.425367 Metabolomic investigation of the pseudouridimycin producer, a prolific streptomycete Author(s): Iorio, M., Davatgarbenam, S., Serina, S., Criscenzo, P., Zdouc, M.M., Simone, M., Maffioli, S.I., Ebright, R.H., Donadio, S. and Sosio, M. Published in: BioRxiv, Issue 5. November 2020, 2020 Publisher: BioRxiv DOI: 10.1101/2020.11.05.369249 Thesis and dissertations (1) Antibiotic drug development Author(s): Matias, C. S. S., Sommer, M. O. A., Ingmer, H., Weber, T., Polissi, A., & Olsen, J. E. Published in: 2020 Publisher: Technical University of Denmark Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available