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An integrated mulTidisciplinary appRoach towards a new generAtIon of aNtibiotics: Targeting function and cross-talk of bacterial Envelope proTein machineries

Deliverables

Scientific publications

Min. 45 publications in peer-reviewed journals

Industry course

Industry course

SB and SAB established

SB and SAB established

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Publications

Carbohydrate-based adjuvants

Author(s): Pilar Garcia-Vello, Immacolata Speciale, Fabrizio Chiodo, Antonio Molinaro, Cristina De Castro
Published in: Drug Discovery Today: Technologies, Issue 35-36, 2020, Page(s) 57-68, ISSN 1740-6749
DOI: 10.1016/j.ddtec.2020.09.005

A biaryl-linked tripeptide from Planomonospora reveals a widespread class of minimal RiPP gene clusters

Author(s): Mitja M. Zdouc, Mohammad M. Alanjary, Guadalupe S. Zarazúa, Sonia I. Maffioli, Max Crüsemann, Marnix H. Medema, Stefano Donadio, Margherita Sosio
Published in: Cell Chemical Biology, 2020, ISSN 2451-9456
DOI: 10.1016/j.chembiol.2020.11.009

"Detection of in vivo Protein Interactions in All Bacterial Components by Förster Resonance Energy Transfer with the Superfolder mTurquoise2 ox-mNeongreen FRET Pair"

Author(s): Nils Meiresonne, Elisa Consoli, Laureen Mertens, Tanneke den Blaauwen
Published in: BIO-PROTOCOL, Issue 9/23, 2019, ISSN 2331-8325
DOI: 10.21769/bioprotoc.3448

Structural features and immunological perception of the cell surface glycans of Lactobacillus plantarum: a novel rhamnose-rich polysaccharide and teichoic acids

Author(s): Pilar Garcia-Vello, Garima Sharma, Immacolata Speciale, Antonio Molinaro, Sin-Hyeog Im, Cristina De Castro
Published in: Carbohydrate Polymers, Issue 233, 2020, Page(s) 115857, ISSN 0144-8617
DOI: 10.1016/j.carbpol.2020.115857

The Lpt ABC transporter for lipopolysaccharide export to the cell surface

Author(s): Paola Sperandeo, Alessandra M. Martorana, Alessandra Polissi
Published in: Research in Microbiology, Issue 170/8, 2019, Page(s) 366-373, ISSN 0923-2508
DOI: 10.1016/j.resmic.2019.07.005

Planomonospora : A Metabolomics Perspective on an Underexplored Actinobacteria Genus

Author(s): Mitja M. Zdouc, Marianna Iorio, Sonia I. Maffioli, Max Crüsemann, Stefano Donadio, Margherita Sosio
Published in: Journal of Natural Products, Issue 84/2, 2021, Page(s) 204-219, ISSN 0163-3864
DOI: 10.1021/acs.jnatprod.0c00807

In vitro activity of rifabutin against 293 contemporary carbapenem-resistant Acinetobacter baumannii clinical isolates and characterization of rifabutin mode of action and resistance mechanisms

Author(s): Vincent Trebosc, Birgit Schellhorn, Julian Schill, Valentina Lucchini, Jacqueline Bühler, Marilyne Bourotte, Jonathan J Butcher, Marc Gitzinger, Sergio Lociuro, Christian Kemmer, Glenn E Dale
Published in: Journal of Antimicrobial Chemotherapy, Issue 75/12, 2020, Page(s) 3552-3562, ISSN 0305-7453
DOI: 10.1093/jac/dkaa370

The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes

Author(s): Robert M. Cleverley, Zoe J. Rutter, Jeanine Rismondo, Federico Corona, Ho-Ching Tiffany Tsui, Fuad A. Alatawi, Richard A. Daniel, Sven Halbedel, Orietta Massidda, Malcolm E. Winkler, Richard J. Lewis
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-018-08056-2

Thanatin Impairs Lipopolysaccharide Transport Complex Assembly by Targeting LptC–LptA Interaction and Decreasing LptA Stability

Author(s): Elisabete C. C. M. Moura, Tiago Baeta, Alessandra Romanelli, Cedric Laguri, Alessandra M. Martorana, Emanuela Erba, Jean-Pierre Simorre, Paola Sperandeo, Alessandra Polissi
Published in: Frontiers in Microbiology, Issue 11, 2020, ISSN 1664-302X
DOI: 10.3389/fmicb.2020.00909

The lipopolysaccharide transport (Lpt) machinery: A nonconventional transporter for lipopolysaccharide assembly at the outer membrane of Gram-negative bacteria

Author(s): Paola Sperandeo, Alessandra M. Martorana, Alessandra Polissi
Published in: Journal of Biological Chemistry, Issue 292/44, 2017, Page(s) 17981-17990, ISSN 0021-9258
DOI: 10.1074/jbc.R117.802512

Copper inhibits peptidoglycan LD-transpeptidases suppressing β-lactam resistance due to bypass of penicillin-binding proteins

Author(s): Katharina Peters, Manuel Pazos, Zainab Edoo, Jean-Emmanuel Hugonnet, Alessandra M. Martorana, Alessandra Polissi, Michael S. VanNieuwenhze, Michel Arthur, Waldemar Vollmer
Published in: Proceedings of the National Academy of Sciences, Issue 115/42, 2018, Page(s) 10786-10791, ISSN 0027-8424
DOI: 10.1073/pnas.1809285115

Interaction of lipopolysaccharides at intermolecular sites of the periplasmic Lpt transport assembly

Author(s): Cedric Laguri, Paola Sperandeo, Kevin Pounot, Isabel Ayala, Alba Silipo, Catherine M. Bougault, Antonio Molinaro, Alessandra Polissi, Jean-Pierre Simorre
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/s41598-017-10136-0

Superfolder mTurquoise2 ox optimized for the bacterial periplasm allows high efficiency in vivo FRET of cell division antibiotic targets

Author(s): Nils Y. Meiresonne, Elisa Consoli, Laureen M. Y. Mertens, Anna Chertkova, Joachim Goedhart, Tanneke den Blaauwen
Published in: Molecular Microbiology, 2019, ISSN 0950-382X
DOI: 10.1111/mmi.14206

Solid State NMR Studies of Intact Lipopolysaccharide Endotoxin

Author(s): Cedric Laguri, Alba Silipo, Alessandra M. Martorana, Paul Schanda, Roberta Marchetti, Alessandra Polissi, Antonio Molinaro, Jean-Pierre Simorre
Published in: ACS Chemical Biology, Issue 13/8, 2018, Page(s) 2106-2113, ISSN 1554-8929
DOI: 10.1021/acschembio.8b00271

Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect

Author(s): Niccolò Morè, Alessandra M. Martorana, Jacob Biboy, Christian Otten, Matthias Winkle, Carlos K. Gurnani Serrano, Alejandro Montón Silva, Lisa Atkinson, Hamish Yau, Eefjan Breukink, Tanneke den Blaauwen, Waldemar Vollmer, Alessandra Polissi
Published in: mBio, Issue 10/1, 2019, ISSN 2150-7511
DOI: 10.1128/mbio.02729-18

Structural insight into the formation of lipoprotein-β-barrel complexes

Author(s): Raquel Rodríguez-Alonso, Juliette Létoquart, Van Son Nguyen, Gwennaelle Louis, Antonio N. Calabrese, Bogdan I. Iorga, Sheena E. Radford, Seung-Hyun Cho, Han Remaut, Jean-François Collet
Published in: Nature Chemical Biology, Issue 16/9, 2020, Page(s) 1019-1025, ISSN 1552-4450
DOI: 10.1038/s41589-020-0575-0

The Escherichia coli Outer Membrane β-Barrel Assembly Machinery (BAM) Anchors the Peptidoglycan Layer by Spanning It with All Subunits

Author(s): Elisa Consoli, Jean-François Collet, Tanneke den Blaauwen
Published in: International Journal of Molecular Sciences, Issue 22/4, 2021, Page(s) 1853, ISSN 1422-0067
DOI: 10.3390/ijms22041853

Dissecting Colistin Resistance Mechanisms in Extensively Drug-Resistant Acinetobacter baumannii Clinical Isolates

Author(s): Vincent Trebosc, Sarah Gartenmann, Marcus Tötzl, Valentina Lucchini, Birgit Schellhorn, Michel Pieren, Sergio Lociuro, Marc Gitzinger, Marcel Tigges, Dirk Bumann, Christian Kemmer
Published in: mBio, Issue 10/4, 2019, ISSN 2150-7511
DOI: 10.1128/mbio.01083-19

Fat Matters for Bugs: How Lipids and Lipid Modifications Make the Difference in Bacterial Life

Author(s): Paola Sperandeo, Alessandra Polissi, Emma De Fabiani
Published in: European Journal of Lipid Science and Technology, Issue 121/10, 2019, Page(s) 1900204, ISSN 1438-7697
DOI: 10.1002/ejlt.201900204

Antibiotic drug development

Author(s): Matias, C. S. S., Sommer, M. O. A., Ingmer, H., Weber, T., Polissi, A., & Olsen, J. E.
Published in: 2020