Descripción del proyecto
Avanzar en la investigación y el tratamiento del dolor neuropático
El dolor neuropático es un tipo de dolor crónico que surge como consecuencia de un daño o una disfunción en el sistema nervioso. Se produce cuando los propios nervios se ven afectados por lesiones o enfermedades y se asocia a una merma de la calidad de vida. En este sentido, existe una necesidad acuciante de comprender la susceptibilidad individual al dolor y la respuesta a los analgésicos a fin de mejorar el tratamiento del dolor. El equipo del proyecto PAIN-Net, financiado por el programa de acciones Marie Skłodowska-Curie, tiene como objetivo hacer frente a estos retos mediante la formación de una nueva generación de científicos expertos en dolor neuropático. El proyecto respaldará iniciativas de investigación innovadoras con empresas biotecnológicas, en las que se emplearán tecnologías de vanguardia para investigar los mecanismos del dolor neuropático y desarrollar analgésicos específicos.
Objetivo
Neuropathic pain affects 5% of the general population and 40% of patients with neurological diseases, and has a key role in the pathophysiology of cancer pain that affects up to 50% of patients in the early disease stage and 30% of survivors, causing an enormous social burden. Treatments are inadequate with less than 50% of patients achieving 50% of pain relief at best, while up to 30% of cancer pain patients experience insufficient analgesia. Signatures of individual susceptibility to pain and analgesic responsiveness are urgently needed to improve patients’ management. Such advances are expected to originate from integrated clinical, basic science and entrepreneurial research readily translating scientific findings into benefits for patients. To consolidate these aims, a new generation of scientists with wide knowledge in neuropathic pain, focused research skills and experience in the interaction with biotechnology companies is needed. The PAIN-Net programme, based on a highly innovative platform of training-through-research and strongly committed to such objectives, will support such talented and inspired early stage researchers. Their research projects, embedded in an advanced molecule-to-man pain network, will contribute to better understanding individual susceptibility to pain and analgesics responsiveness based on next generation sequencing, whole exome sequencing, epigenetics and pharmacogenomics studies, nociceptor and sodium channel functioning based on biophysics and proteomics studies, targeted analgesics based on high-throughput screening, targeted analgesic delivery based on encapsulated cell bioreactor implants, and to the development and extensive characterisation of the first knock-in mouse models of sodium channel-related neuropathic pain based on the CRISP-Cas technology. Most of all, the PAIN-Net programme will offer the unique opportunity to enhance scientific capabilities and prepare to high level academic or private applied research career.
Ámbito científico
Programa(s)
Régimen de financiación
MSCA-ITN-ETN - European Training NetworksCoordinador
20133 Milano
Italia