Training in Cancer Mechanisms and Therapeutics

Project Information

TRACT

Grant agreement ID: 721906

DOI 10.3030/721906

Project closed

EC signature date 11 August 2016

Start date 1 October 2016

End date 30 September 2020

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 2 877 076,80

EU contribution € 2 877 076,80

Coordinated by

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

Deliverables

Documents, reports (7)

Dissemination diary, Year 3

Dissemination diary (publications, events etc.), Year 3

Dissemination diary, Year 1

Dissemination diary (publications, events etc.), year 1

Dissemination diary, Year 2

Dissemination diary (publications, events etc), Year 2

ESR training and progress Year 2

Report on ESR training and progress Year 2

Recruitment strategy

Recruitment strategy including recruitment of project manager

ESR training and progress Year 3

Report on ESR training and progress Year 3

ESR traning and progress year 1

Report on ESR training and progress, Year 1

Other (3)

PhD degree to ESRs 4-9

Awarding of PhD degree to ESRs 4-9

PhD degree to ESRs 1-3

Awarding of PhD degree to ESRs 1-3

PhD degree to ESRs 10-11

Awarding of PhD degree to ESRs 10-11

Publications

Peer reviewed articles (11)

Characterizing caspase-1 involvement during esophageal disease progression

Author(s): Gillian Barber, Akanksha Anand, Katarzyna Oficjalska, James J. Phelan, Aisling B. Heeran, Ewelina Flis, Niamh E. Clarke, Jenny A. Watson, Julia Strangmann, Brian Flood, Hazel O’Neill, Dermot O’Toole, Finbar MacCarthy, Narayanasamy Ravi, John V. Reynolds, Elaine W. Kay, Michael Quante, Jacintha O’Sullivan, Emma M. Creagh
Published in: Cancer Immunology, Immunotherapy, 2020, ISSN 0340-7004
Publisher: Springer Verlag
DOI: 10.1007/s00262-020-02650-4

A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents

Author(s): Stefano Federico, Tuhina Khan, Nicola Relitti, Giulia Chemi, Margherita Brindisi, Simone Brogi, Ettore Novellino, Daniela M. Zisterer, Giuseppe Campiani, Sandra Gemma, Stefania Butini
Published in: Tetrahedron Letters, Issue 59/51, 2018, Page(s) 4466-4470, ISSN 0040-4039
Publisher: Elsevier BV
DOI: 10.1016/j.tetlet.2018.11.005

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents

Author(s): Margherita Brindisi, Cristina Ulivieri, Gloria Alfano, Sandra Gemma, Francisco de Asís Balaguer, Tuhina Khan, Alessandro Grillo, Giulia Chemi, Grégory Menchon, Andrea E. Prota, Natacha Olieric, Daniel Lucena-Agell, Isabel Barasoain, J. Fernando Diaz, Angela Nebbioso, Mariarosaria Conte, Ludovica Lopresti, Stefania Magnano, Rebecca Amet, Paula Kinsella, Daniela M. Zisterer, Ola Ibrahim, Jeff O'Su
Published in: European Journal of Medicinal Chemistry, Issue 162, 2019, Page(s) 290-320, ISSN 0223-5234
Publisher: Elsevier BV
DOI: 10.1016/j.ejmech.2018.11.004

Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis

Author(s): Brian Flood, Joan Manils, Ciara Nulty, Ewelina Flis, Sinead Kenealy, Gillian Barber, Joanna Fay, Kingston H. G. Mills, Elaine W. Kay, Emma M. Creagh
Published in: Oncogene, 2018, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-018-0613-5

Salivary inflammatory proteins in patients with oral potentially malignant disorders

Author(s): VR Dikova, S Principe, JV Bagan
Published in: Journal of Clinical and Experimental Dentistry, 2019, Page(s) 0-0, ISSN 1989-5488
Publisher: Medicina Oral S.L
DOI: 10.4317/jced.55917

Salivary Cytokines in patients with Head and Neck Cancer (HNC) treated with Radiotherapy

Author(s): S Principe, V Dikova, J Bagan
Published in: Journal of Clinical and Experimental Dentistry, 2019, Page(s) 0-0, ISSN 1989-5488
Publisher: Medicina Oral S.L
DOI: 10.4317/jced.56318

Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors

Author(s): A. Prasanth Saraswati, Nicola Relitti, Margherita Brindisi, Sandra Gemma, Daniela Zisterer, Stefania Butini, Giuseppe Campiani
Published in: Drug Discovery Today, Issue 24/7, 2019, Page(s) 1370-1388, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.1016/j.drudis.2019.05.015

Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma

Author(s): Richard C Turkington, Laura A Knight, Jaine K Blayney, Maria Secrier, Rosalie Douglas, Eileen E Parkes, Eilis K Sutton, Leanne Stevenson, Damian McManus, Sophia Halliday, Andrena M McCavigan, Gemma E Logan, Steven M Walker, Christopher J Steele, Juliane Perner, Jan Bornschein, Shona MacRae, Ahmad Miremadi, Eamon McCarron, Stephen McQuaid, Kenneth Arthur, Jacqueline A James, Martin M Eatock, Robert
Published in: Gut, Issue 68/11, 2019, Page(s) 1918-1927, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-317624

Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials

Author(s): Nicola Relitti, Akella P. Saraswati, Stefano Federico, Tuhina Khan, Margherita Brindisi, Daniela Zisterer, Simone Brogi, Sandra Gemma, Stefania Butini, Giuseppe Campiani
Published in: Current Topics in Medicinal Chemistry, Issue 20/6, 2020, Page(s) 433-457, ISSN 1568-0266
Publisher: Bentham Science Publishers
DOI: 10.2174/1568026620666200102104930

Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas

Author(s): Tuhina Khan, Nicola Relitti, Margherita Brindisi, Stefania Magnano, Daniela Zisterer, Sandra Gemma, Stefania Butini, Giuseppe Campiani
Published in: Medicinal Research Reviews, Issue 40/3, 2020, Page(s) 1002-1060, ISSN 0198-6325
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/med.21646

Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation

Author(s): A. Prasanth Saraswati, Nicola Relitti, Margherita Brindisi, Jeremy D. Osko, Giulia Chemi, Stefano Federico, Alessandro Grillo, Simone Brogi, Niamh H. McCabe, Richard C. Turkington, Ola Ibrahim, Jeffrey O’Sullivan, Stefania Lamponi, Magda Ghanim, Vincent P. Kelly, Daniela Zisterer, Rebecca Amet, Patricia Hannon Barroeta, Francesca Vanni, Cristina Ulivieri, Daniel Herp, Federica Sarno, Antonella D
Published in: ACS Medicinal Chemistry Letters, 2020, ISSN 1948-5875
Publisher: American Chemical Society
DOI: 10.1021/acsmedchemlett.0c00395