Training in Cancer Mechanisms and Therapeutics

Información del proyecto

TRACT

Identificador del acuerdo de subvención: 721906

DOI 10.3030/721906

Proyecto cerrado

Fecha de la firma de la CE 11 Agosto 2016

Fecha de inicio 1 Octubre 2016

Fecha de finalización 30 Septiembre 2020

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total € 2 877 076,80

Aportación de la UE € 2 877 076,80

Coordinado por

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

Resultado final

Documents, reports (7)

Dissemination diary, Year 3

Dissemination diary (publications, events etc.), Year 3

Dissemination diary, Year 1

Dissemination diary (publications, events etc.), year 1

Dissemination diary, Year 2

Dissemination diary (publications, events etc), Year 2

ESR training and progress Year 2

Report on ESR training and progress Year 2

Recruitment strategy

Recruitment strategy including recruitment of project manager

ESR training and progress Year 3

Report on ESR training and progress Year 3

ESR traning and progress year 1

Report on ESR training and progress, Year 1

Other (3)

PhD degree to ESRs 4-9

Awarding of PhD degree to ESRs 4-9

PhD degree to ESRs 1-3

Awarding of PhD degree to ESRs 1-3

PhD degree to ESRs 10-11

Awarding of PhD degree to ESRs 10-11

Publicaciones

Peer reviewed articles (11)

Characterizing caspase-1 involvement during esophageal disease progression

Autores: Gillian Barber, Akanksha Anand, Katarzyna Oficjalska, James J. Phelan, Aisling B. Heeran, Ewelina Flis, Niamh E. Clarke, Jenny A. Watson, Julia Strangmann, Brian Flood, Hazel O’Neill, Dermot O’Toole, Finbar MacCarthy, Narayanasamy Ravi, John V. Reynolds, Elaine W. Kay, Michael Quante, Jacintha O’Sullivan, Emma M. Creagh
Publicado en: Cancer Immunology, Immunotherapy, 2020, ISSN 0340-7004
Editor: Springer Verlag
DOI: 10.1007/s00262-020-02650-4

A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents

Autores: Stefano Federico, Tuhina Khan, Nicola Relitti, Giulia Chemi, Margherita Brindisi, Simone Brogi, Ettore Novellino, Daniela M. Zisterer, Giuseppe Campiani, Sandra Gemma, Stefania Butini
Publicado en: Tetrahedron Letters, Edición 59/51, 2018, Página(s) 4466-4470, ISSN 0040-4039
Editor: Elsevier BV
DOI: 10.1016/j.tetlet.2018.11.005

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents

Autores: Margherita Brindisi, Cristina Ulivieri, Gloria Alfano, Sandra Gemma, Francisco de Asís Balaguer, Tuhina Khan, Alessandro Grillo, Giulia Chemi, Grégory Menchon, Andrea E. Prota, Natacha Olieric, Daniel Lucena-Agell, Isabel Barasoain, J. Fernando Diaz, Angela Nebbioso, Mariarosaria Conte, Ludovica Lopresti, Stefania Magnano, Rebecca Amet, Paula Kinsella, Daniela M. Zisterer, Ola Ibrahim, Jeff O'Su
Publicado en: European Journal of Medicinal Chemistry, Edición 162, 2019, Página(s) 290-320, ISSN 0223-5234
Editor: Elsevier BV
DOI: 10.1016/j.ejmech.2018.11.004

Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis

Autores: Brian Flood, Joan Manils, Ciara Nulty, Ewelina Flis, Sinead Kenealy, Gillian Barber, Joanna Fay, Kingston H. G. Mills, Elaine W. Kay, Emma M. Creagh
Publicado en: Oncogene, 2018, ISSN 0950-9232
Editor: Nature Publishing Group
DOI: 10.1038/s41388-018-0613-5

Salivary inflammatory proteins in patients with oral potentially malignant disorders

Autores: VR Dikova, S Principe, JV Bagan
Publicado en: Journal of Clinical and Experimental Dentistry, 2019, Página(s) 0-0, ISSN 1989-5488
Editor: Medicina Oral S.L
DOI: 10.4317/jced.55917

Salivary Cytokines in patients with Head and Neck Cancer (HNC) treated with Radiotherapy

Autores: S Principe, V Dikova, J Bagan
Publicado en: Journal of Clinical and Experimental Dentistry, 2019, Página(s) 0-0, ISSN 1989-5488
Editor: Medicina Oral S.L
DOI: 10.4317/jced.56318

Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors

Autores: A. Prasanth Saraswati, Nicola Relitti, Margherita Brindisi, Sandra Gemma, Daniela Zisterer, Stefania Butini, Giuseppe Campiani
Publicado en: Drug Discovery Today, Edición 24/7, 2019, Página(s) 1370-1388, ISSN 1359-6446
Editor: Elsevier BV
DOI: 10.1016/j.drudis.2019.05.015

Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma

Autores: Richard C Turkington, Laura A Knight, Jaine K Blayney, Maria Secrier, Rosalie Douglas, Eileen E Parkes, Eilis K Sutton, Leanne Stevenson, Damian McManus, Sophia Halliday, Andrena M McCavigan, Gemma E Logan, Steven M Walker, Christopher J Steele, Juliane Perner, Jan Bornschein, Shona MacRae, Ahmad Miremadi, Eamon McCarron, Stephen McQuaid, Kenneth Arthur, Jacqueline A James, Martin M Eatock, Robert
Publicado en: Gut, Edición 68/11, 2019, Página(s) 1918-1927, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-317624

Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials

Autores: Nicola Relitti, Akella P. Saraswati, Stefano Federico, Tuhina Khan, Margherita Brindisi, Daniela Zisterer, Simone Brogi, Sandra Gemma, Stefania Butini, Giuseppe Campiani
Publicado en: Current Topics in Medicinal Chemistry, Edición 20/6, 2020, Página(s) 433-457, ISSN 1568-0266
Editor: Bentham Science Publishers
DOI: 10.2174/1568026620666200102104930

Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas

Autores: Tuhina Khan, Nicola Relitti, Margherita Brindisi, Stefania Magnano, Daniela Zisterer, Sandra Gemma, Stefania Butini, Giuseppe Campiani
Publicado en: Medicinal Research Reviews, Edición 40/3, 2020, Página(s) 1002-1060, ISSN 0198-6325
Editor: John Wiley & Sons Inc.
DOI: 10.1002/med.21646

Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation

Autores: A. Prasanth Saraswati, Nicola Relitti, Margherita Brindisi, Jeremy D. Osko, Giulia Chemi, Stefano Federico, Alessandro Grillo, Simone Brogi, Niamh H. McCabe, Richard C. Turkington, Ola Ibrahim, Jeffrey O’Sullivan, Stefania Lamponi, Magda Ghanim, Vincent P. Kelly, Daniela Zisterer, Rebecca Amet, Patricia Hannon Barroeta, Francesca Vanni, Cristina Ulivieri, Daniel Herp, Federica Sarno, Antonella D
Publicado en: ACS Medicinal Chemistry Letters, 2020, ISSN 1948-5875
Editor: American Chemical Society
DOI: 10.1021/acsmedchemlett.0c00395