Training in Cancer Mechanisms and Therapeutics

Informations projet

TRACT

N° de convention de subvention: 721906

DOI 10.3030/721906

Projet clôturé

Date de signature de la CE 11 Août 2016

Date de début 1 Octobre 2016

Date de fin 30 Septembre 2020

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total € 2 877 076,80

Contribution de l’UE € 2 877 076,80

Coordonné par

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

Livrables

Documents, reports (7)

Dissemination diary, Year 3

Dissemination diary (publications, events etc.), Year 3

Dissemination diary, Year 1

Dissemination diary (publications, events etc.), year 1

Dissemination diary, Year 2

Dissemination diary (publications, events etc), Year 2

ESR training and progress Year 2

Report on ESR training and progress Year 2

Recruitment strategy

Recruitment strategy including recruitment of project manager

ESR training and progress Year 3

Report on ESR training and progress Year 3

ESR traning and progress year 1

Report on ESR training and progress, Year 1

Other (3)

PhD degree to ESRs 4-9

Awarding of PhD degree to ESRs 4-9

PhD degree to ESRs 1-3

Awarding of PhD degree to ESRs 1-3

PhD degree to ESRs 10-11

Awarding of PhD degree to ESRs 10-11

Publications

Peer reviewed articles (11)

Characterizing caspase-1 involvement during esophageal disease progression

Auteurs: Gillian Barber, Akanksha Anand, Katarzyna Oficjalska, James J. Phelan, Aisling B. Heeran, Ewelina Flis, Niamh E. Clarke, Jenny A. Watson, Julia Strangmann, Brian Flood, Hazel O’Neill, Dermot O’Toole, Finbar MacCarthy, Narayanasamy Ravi, John V. Reynolds, Elaine W. Kay, Michael Quante, Jacintha O’Sullivan, Emma M. Creagh
Publié dans: Cancer Immunology, Immunotherapy, 2020, ISSN 0340-7004
Éditeur: Springer Verlag
DOI: 10.1007/s00262-020-02650-4

A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents

Auteurs: Stefano Federico, Tuhina Khan, Nicola Relitti, Giulia Chemi, Margherita Brindisi, Simone Brogi, Ettore Novellino, Daniela M. Zisterer, Giuseppe Campiani, Sandra Gemma, Stefania Butini
Publié dans: Tetrahedron Letters, Numéro 59/51, 2018, Page(s) 4466-4470, ISSN 0040-4039
Éditeur: Elsevier BV
DOI: 10.1016/j.tetlet.2018.11.005

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents

Auteurs: Margherita Brindisi, Cristina Ulivieri, Gloria Alfano, Sandra Gemma, Francisco de Asís Balaguer, Tuhina Khan, Alessandro Grillo, Giulia Chemi, Grégory Menchon, Andrea E. Prota, Natacha Olieric, Daniel Lucena-Agell, Isabel Barasoain, J. Fernando Diaz, Angela Nebbioso, Mariarosaria Conte, Ludovica Lopresti, Stefania Magnano, Rebecca Amet, Paula Kinsella, Daniela M. Zisterer, Ola Ibrahim, Jeff O'Su
Publié dans: European Journal of Medicinal Chemistry, Numéro 162, 2019, Page(s) 290-320, ISSN 0223-5234
Éditeur: Elsevier BV
DOI: 10.1016/j.ejmech.2018.11.004

Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis

Auteurs: Brian Flood, Joan Manils, Ciara Nulty, Ewelina Flis, Sinead Kenealy, Gillian Barber, Joanna Fay, Kingston H. G. Mills, Elaine W. Kay, Emma M. Creagh
Publié dans: Oncogene, 2018, ISSN 0950-9232
Éditeur: Nature Publishing Group
DOI: 10.1038/s41388-018-0613-5

Salivary inflammatory proteins in patients with oral potentially malignant disorders

Auteurs: VR Dikova, S Principe, JV Bagan
Publié dans: Journal of Clinical and Experimental Dentistry, 2019, Page(s) 0-0, ISSN 1989-5488
Éditeur: Medicina Oral S.L
DOI: 10.4317/jced.55917

Salivary Cytokines in patients with Head and Neck Cancer (HNC) treated with Radiotherapy

Auteurs: S Principe, V Dikova, J Bagan
Publié dans: Journal of Clinical and Experimental Dentistry, 2019, Page(s) 0-0, ISSN 1989-5488
Éditeur: Medicina Oral S.L
DOI: 10.4317/jced.56318

Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors

Auteurs: A. Prasanth Saraswati, Nicola Relitti, Margherita Brindisi, Sandra Gemma, Daniela Zisterer, Stefania Butini, Giuseppe Campiani
Publié dans: Drug Discovery Today, Numéro 24/7, 2019, Page(s) 1370-1388, ISSN 1359-6446
Éditeur: Elsevier BV
DOI: 10.1016/j.drudis.2019.05.015

Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma

Auteurs: Richard C Turkington, Laura A Knight, Jaine K Blayney, Maria Secrier, Rosalie Douglas, Eileen E Parkes, Eilis K Sutton, Leanne Stevenson, Damian McManus, Sophia Halliday, Andrena M McCavigan, Gemma E Logan, Steven M Walker, Christopher J Steele, Juliane Perner, Jan Bornschein, Shona MacRae, Ahmad Miremadi, Eamon McCarron, Stephen McQuaid, Kenneth Arthur, Jacqueline A James, Martin M Eatock, Robert
Publié dans: Gut, Numéro 68/11, 2019, Page(s) 1918-1927, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-317624

Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials

Auteurs: Nicola Relitti, Akella P. Saraswati, Stefano Federico, Tuhina Khan, Margherita Brindisi, Daniela Zisterer, Simone Brogi, Sandra Gemma, Stefania Butini, Giuseppe Campiani
Publié dans: Current Topics in Medicinal Chemistry, Numéro 20/6, 2020, Page(s) 433-457, ISSN 1568-0266
Éditeur: Bentham Science Publishers
DOI: 10.2174/1568026620666200102104930

Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas

Auteurs: Tuhina Khan, Nicola Relitti, Margherita Brindisi, Stefania Magnano, Daniela Zisterer, Sandra Gemma, Stefania Butini, Giuseppe Campiani
Publié dans: Medicinal Research Reviews, Numéro 40/3, 2020, Page(s) 1002-1060, ISSN 0198-6325
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/med.21646

Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation

Auteurs: A. Prasanth Saraswati, Nicola Relitti, Margherita Brindisi, Jeremy D. Osko, Giulia Chemi, Stefano Federico, Alessandro Grillo, Simone Brogi, Niamh H. McCabe, Richard C. Turkington, Ola Ibrahim, Jeffrey O’Sullivan, Stefania Lamponi, Magda Ghanim, Vincent P. Kelly, Daniela Zisterer, Rebecca Amet, Patricia Hannon Barroeta, Francesca Vanni, Cristina Ulivieri, Daniel Herp, Federica Sarno, Antonella D
Publié dans: ACS Medicinal Chemistry Letters, 2020, ISSN 1948-5875
Éditeur: American Chemical Society
DOI: 10.1021/acsmedchemlett.0c00395