Exploitation of Glycosylation Signatures for Precision Medicine

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The sweet spot for biologics: recent advances in characterization of biotherapeutic glycoproteins

Autores: O'Flaherty, R (O'Flaherty, Roisin) [1]; Trbojevic-Akmacic, I (Trbojevic-Akmacic, Irena) [2]; Greville, G (Greville, Gordon) [1]; Rudd, PM (Rudd, Pauline M.) [1]; Lauc, G (Lauc, Gordan) [2], [3]
Publicado en: EXPERT REVIEW OF PROTEOMICS, 2017, ISSN 1478-9450
Editor: Future Drugs Ltd.
DOI: 10.1080/14789450.2018.1404907

Profiling the proteoforms of urinary prostate-specific antigen by capillary electrophoresis – mass spectrometry

Autores: Alan B. Moran, Elena Domínguez-Vega, Jan Nouta, Tamas Pongracz, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer
Publicado en: Journal of Proteomics, Edición 238, 2021, Página(s) 104148, ISSN 1874-3919
Editor: Elsevier BV
DOI: 10.1016/j.jprot.2021.104148

Large-Scale Analysis of Apolipoprotein CIII Glycosylation by Ultrahigh Resolution Mass Spectrometry.

Autores: Daniel Demus; Daniel Demus; Annemieke Naber; Viktoria Dotz; Bas C. Jansen; Bas C. Jansen; Marco R. Bladergroen; Jan Nouta; Eric J. G. Sijbrands; Mandy Van Hoek; Simone Nicolardi; Manfred Wuhrer
Publicado en: Frontiers in Chemistry, Vol 9 (2021), Edición 1, 2021, ISSN 2296-2646
Editor: Frontiers Media S.A.
DOI: 10.3389/fchem.2021.678883

Immunoglobulin G N-Glycans as Potential Postgenomic Biomarkers for Hypertension in the Kazakh Population

Autores: Qing Gao, Mamatyusupu Dolikun, Jerko Štambuk, Hao Wang, Feifei Zhao, Nizam Yiliham, Youxin Wang, Irena Trbojević-Akmačić, Jie Zhang, Honghong Fang, Yang Sun, Hongli Peng, Zhongyao Zhao, Di Liu, Jiaonan Liu, Qihuan Li, Qi Sun, Lijuan Wu, Gordan Lauc, Wei Wang, and Manshu Song
Publicado en: OMICS: A Journal of Integrative Biology, 2017, ISSN 1536-2310
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/omi.2017.0044

MS-Based Allotype-Specific Analysis of Polyclonal IgG-Fc N-Glycosylation

Autores: Thomas Sénard, Andrea F. G. Gargano, David Falck, Steven W. de Taeye, Theo Rispens, Gestur Vidarsson, Manfred Wuhrer, Govert W. Somsen, Elena Domínguez-Vega
Publicado en: Frontiers in Immunology, Edición 11, 2020, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2020.02049

The association between subclass-specific IgG Fc N-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations

Autores: JN Liu, M Dolikun, J Štambuk, I Trbojević-Akmačić, J Zhang, H Wang, DQ Zheng, XY Zhang, HL Peng, ZY Zhao, D Liu, Y Sun, Q Sun, QH Li, JX Zhang, M Sun, WJ Cao, A Momčilović, G. Razdorov, LJ Wu, A Russell, YX Wang, MS Song, G Lauc & W Wang
Publicado en: JOURNAL OF HUMAN HYPERTENSION, 2018, ISSN 0950-9240
Editor: Nature Publishing Group
DOI: 10.1038/s41371-018-0071-0

Fucosidases from the human gut symbiont Ruminococcus gnavus

Autores: Haiyang Wu, Osmond Rebello, Emmanuelle H. Crost, C. David Owen, Samuel Walpole, Chloe Bennati-Granier, Didier Ndeh, Serena Monaco, Thomas Hicks, Anna Colvile, Paulina A. Urbanowicz, Martin A. Walsh, Jesus Angulo, Daniel I. R. Spencer, Nathalie Juge
Publicado en: Cellular and Molecular Life Sciences, 2020, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-020-03514-x

Profiling and genetic control of the murine immunoglobulin G glycome

Autores: Jasminka Krištić, Olga O. Zaytseva, Ramesh Ram, Quang Nguyen, Mislav Novokmet, Frano Vučković, Marija Vilaj, Irena Trbojević-Akmačić, Marija Pezer, Kathleen M. Davern, Grant Morahan & Gordan Lauc
Publicado en: NATURE CHEMICAL BIOLOGY, 2018, ISSN 1552-4450
Editor: Nature Publishing Group
DOI: 10.1038/s41589-018-0034-3

Metformin and statin use associate with plasma protein N -glycosylation in people with type 2 diabetes

Autores: Sunny S Singh, Annemieke Naber, Viktoria Dotz, Emma Schoep, Elham Memarian, Roderick C Slieker, Petra J M Elders, Gerda Vreeker, Simone Nicolardi, Manfred Wuhrer, Eric J G Sijbrands, Aloysius G Lieverse, Leen M 't Hart, Mandy van Hoek
Publicado en: BMJ Open Diabetes Research & Care, Edición 8/1, 2020, Página(s) e001230, ISSN 2052-4897
Editor: BMJ Open Diabetes Research & Care
DOI: 10.1136/bmjdrc-2020-001230

Glycosylation of IgG Associates with Hypertension and Type 2 Diabetes Mellitus Comorbidity in the Chinese Muslim Ethnic Minorities and the Han Chinese

Autores: Xiaoni Meng, Manshu Song, Marija Vilaj, Jerko Štambuk, Mamatyusupu Dolikun, Jie Zhang, Di Liu, Hao Wang, Xiaoyu Zhang, Jinxia Zhang, Weijie Cao, Ana Momčilović, Irena Trbojević-Akmačić, Xingang Li, Deqiang Zheng, Lijuan Wu, Xiuhua Guo, Youxin Wang, Gordan Lauc, and Wei Wang
Publicado en: JOURNAL OF PERSONALIZED MEDICINE, 2021, ISSN 2075-4426
Editor: MDPI
DOI: 10.3390/jpm11070614

Plasma protein N-glycosylation is associated with cardiovascular disease, nephropathy, and retinopathy in type 2 diabetes

Autores: Elham Memarian, Leen M 't Hart, Roderick C Slieker, Roosmarijn F L Lemmers, Amber A van der Heijden, Femke Rutters, Giel Nijpels, Emma Schoep, Aloysius G Lieverse, Eric J G Sijbrands, Manfred Wuhrer, Mandy van Hoek, Viktoria Dotz
Publicado en: BMJ OPEN DIABETES RESEARCH & CARE, 2021, ISSN 2052-4897
Editor: BMJ PUBLISHING GROUP
DOI: 10.1136/bmjdrc-2021-002345

A novel glycosidase plate-based assay for the quantification of galactosylation and sialylation on human IgG

Autores: Osmond D. Rebello, Richard A. Gardner, Paulina A. Urbanowicz, David N. Bolam, Lucy I. Crouch, David Falck & Daniel I. R. Spencer
Publicado en: Glycoconjugate Journal, 2020, ISSN 0282-0080
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10719-020-09953-9

Complex N-glycan breakdown by gut Bacteroides involves an extensive enzymatic apparatus encoded by multiple co-regulated genetic loci

Autores: Justina Briliūtė, Paulina A. Urbanowicz, Ana S. Luis, Arnaud Baslé, Neil Paterson, Osmond Rebello, Jenifer Hendel, Didier A. Ndeh, Elisabeth C. Lowe, Eric C. Martens, Daniel I. R. Spencer, David N. Bolam, Lucy I. Crouch
Publicado en: Nature Microbiology, Edición 4/9, 2019, Página(s) 1571-1581, ISSN 2058-5276
Editor: Nature
DOI: 10.1038/s41564-019-0466-x

Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases

Autores: Mirna Šimurina, Noortje de Haan, Frano Vučković, Nicholas A Kennedy, Jerko Štambuk David Falck, Irena Trbojević-Akmačić, Florent Clerc, Genadij Razdorov, Anna Khon, Anna Latiano, Renata D'Incà, Silvio Danese, Stephan Targan, Carol Landers, Marla Dubinsky, Inflammatory Bowel Disease Biomarkers Consortium; Dermot P B McGovern, Vito Annese, Manfred Wuhrer, Gordan Lauc
Publicado en: GASTROENTEROLOGY, 2018, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.01.002

Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans

Autores: Russell, Alyce C.; Kepka, Agnieszka; Trbojević-Akmačić, Irena; Ugrina, Ivo; Song, Manshu; Hui, Jennie; Hunter, Michael; Laws, Simon M.; Lauc, Gordan; Wang, Wei
Publicado en: Immunobiology, Edición 1, 2019, ISSN 0171-2985
Editor: Elsevier BV
DOI: 10.1016/j.imbio.2018.10.002

N-glycome of the Lysosomal Glycocalyx is Altered in Niemann-Pick Type C Disease (NPC) Model Cells

Autores: Marko Kosicek, Ivan Gudelj, Anita Horvatic, Tanja Jovic, Frano Vuckovic, Gordan Lauc, Silva Hecimovic
Publicado en: Molecular & Cellular Proteomics, Edición 17/4, 2018, Página(s) 631-642, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra117.000129

Site-specific glycosylation mapping of Fc gamma receptor IIIb from neutrophils of individual healthy donors

Autores: Iwona Wojcik, Thomas Sénard, Erik de Graaf, George Janssen, Arnoud de Ru, Yassene Mohammed, Peter A. van Veelen, Gestur Vidarsson, Manfred Wuhrer, David Falck
Publicado en: Analytical Chemistry, 2020, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.0c02342

Software-Assisted Data Processing Workflow for Intact Glycoprotein Mass Spectrometry

Autores: Alan B. Moran; Elena Domínguez-Vega; Manfred Wuhrer; Guinevere S. M. Lageveen-Kammeijer
Publicado en: J. Proteome REs, Edición 3, 2023, ISSN 1535-3893
Editor: American Chemical Society
DOI: 10.1021/acs.jproteome.2c00762

A functional spleen contributes to afucosylated IgG in humans

Autores: Iwona Wojcik; David E. Schmidt; Lisa A. de Neef; Minke A. E. Rab; Bob Meek; Okke de Weerdt; Manfred Wuhrer; C. Ellen van der Schoot; Jaap J. Zwaginga; Masja de Haas; David Falck; Gestur Vidarsson
Publicado en: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021), Edición 1, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-03196-w

Serum sialylation changes in cancer

Autores: Zejian Zhang, Manfred Wuhrer, Stephanie Holst
Publicado en: Glycoconjugate Journal, Edición 35/2, 2018, Página(s) 139-160, ISSN 0282-0080
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10719-018-9820-0

Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation

Autores: Xia Shen, Lucija Klarić, Sodbo Sharapov, Massimo Mangino, Zheng Ning, Di Wu, Irena Trbojević-Akmačić, Maja Pučić-Baković, Igor Rudan, Ozren Polašek, Caroline Hayward, Timothy D. Spector, James F. Wilson, Gordan Lauc, Yurii S. Aulchenko
Publicado en: Nature Communications, Edición 8/1, 2017, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-00453-3

Glycosylation Profile of Immunoglobulin G Is Cross-Sectionally Associated With Cardiovascular Disease Risk Score and Subclinical Atherosclerosis in Two Independent Cohorts

Autores: Cristina Menni, Ivan Gudelj, Erin Macdonald-Dunlop, Massimo Mangino, Jonas Zierer, Erim Bešić, Peter K. Joshi, Irena Trbojević-Akmačić, Phil J. Chowienczyk, Tim D. Spector, James F. Wilson, Gordan Lauc, Ana M. Valdes
Publicado en: Circulation Research, Edición 122/11, 2018, Página(s) 1555-1564, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.117.312174

Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up

Autores: Ivan Gudelj, Perttu P. Salo, Irena Trbojević-Akmačić, Malena Albers, Dragan Primorac, Markus Perola, Gordan Lauc
Publicado en: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Edición 1864/6, 2018, Página(s) 2034-2039, ISSN 0925-4439
Editor: Elsevier BV
DOI: 10.1016/j.bbadis.2018.03.018

High throughput profiling of whole plasma N-glycans in type II diabetes mellitus patients and healthy individuals: A perspective from a Ghanaian population

Autores: Eric Adua, Elham Memarian, Alyce Russell, Irena Trbojević-Akmačić, Ivan Gudelj, Julija Jurić, Peter Roberts, Gordan Lauc, Wei Wang
Publicado en: Archives of Biochemistry and Biophysics, Edición 661, 2019, Página(s) 10-21, ISSN 0003-9861
Editor: Academic Press
DOI: 10.1016/j.abb.2018.10.015

Altered N‐glycosylation profiles as potential biomarkers and drug targets in diabetes

Autores: Najda Rudman, Olga Gornik, Gordan Lauc
Publicado en: FEBS Letters, Edición 593/13, 2019, Página(s) 1598-1615, ISSN 0014-5793
Editor: Elsevier BV
DOI: 10.1002/1873-3468.13495

Utilization of N-glycosylation profiles as risk stratification biomarkers for suboptimal health status and metabolic syndrome in a Ghanaian population

Autores: Eric Adua, Elham Memarian, Alyce Russell, Irena Trbojević-Akmačić, Ivan Gudelj, Julija Jurić, Peter Roberts, Gordan Lauc, Wei Wang
Publicado en: Biomarkers in Medicine, Edición 13/15, 2019, Página(s) 1273-1287, ISSN 1752-0363
Editor: Future Medicine Ltd.
DOI: 10.2217/bmm-2019-0005

Decreased Complexity of Serum N-glycan Structures Associates with Successful Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection

Autores: Tanya M. Monaghan, Maja Pučić-Baković, Frano Vučković, Christine Lee, Dina Kao, Iwona Wójcik, Filip Kliček, Christos Polytarchou, Brandi Roach, Tom Louie, Peter Kim, Brandi Roach, Christos Polytarchou, Marcin Frankowski, Gordan Lauc
Publicado en: Gastroenterology, Edición 157/6, 2019, Página(s) 1676-1678.e3, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.08.034

Plasma N -Glycans as Emerging Biomarkers of Cardiometabolic Risk: A Prospective Investigation in the EPIC-Potsdam Cohort Study

Autores: Clemens Wittenbecher, Tamara Štambuk, Olga Kuxhaus, Najda Rudman, Frano Vučković, Jerko Štambuk, Catarina Schiborn, Dario Rahelić, Stefan Dietrich, Olga Gornik, Markus Perola, Heiner Boeing, Matthias B. Schulze, Gordan Lauc
Publicado en: Diabetes Care, 2020, Página(s) dc191507, ISSN 0149-5992
Editor: American Diabetes Association
DOI: 10.2337/dc19-1507

Glycomics for Type 2 Diabetes Biomarker Discovery: Promise of Immunoglobulin G Subclass-Specific Fragment Crystallizable N-glycosylation in the Uyghur Population

Autores: Jiaonan Liu, Mamatyusupu Dolikun, Jerko Štambuk, Irena Trbojević-Akmačić, Jie Zhang, Jinxia Zhang, Hao Wang, Xiaoni Meng, Genadij Razdorov, Desmond Menon, Deqiang Zheng, Lijuan Wu, Youxin Wang, Manshu Song, Gordan Lauc, Wei Wang
Publicado en: OMICS: A Journal of Integrative Biology, Edición 23/12, 2019, Página(s) 640-648, ISSN 1557-8100
Editor: Mary Ann Liebert, Inc.
DOI: 10.1089/omi.2019.0052

A Matrix-Assisted Laser Desorption/Ionization—Mass Spectrometry Assay for the Relative Quantitation of Antennary Fucosylated N-Glycans in Human Plasma

Autores: Osmond D. Rebello, Simone Nicolardi, Guinevere S. M. Lageveen-Kammeijer, Jan Nouta, Richard A. Gardner, Wilma E. Mesker, Rob A. E. M. Tollenaar, Daniel I. R. Spencer, Manfred Wuhrer, David Falck
Publicado en: Frontiers in Chemistry, Edición 8, 2020, Página(s) 138, ISSN 2296-2646
Editor: Frontiers Media SA
DOI: 10.3389/fchem.2020.00138

Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases

Autores: Tiphaine C. Martin, Mirna Šimurina, Marta Ząbczyńska, Marina Martinic Kavur, Magdalena Rydlewska, Marija Pezer, Kamila Kozłowska, Andrea Burri, Marija Vilaj, Renata Turek-Jabrocka, Milena Krnjajić-Tadijanović, Małgorzata Trofimiuk-Müldner, Ivo Ugrina, Anna Lityńska, Alicja Hubalewska-Dydejczyk, Irena Trbojevic-Akmacic, Ee Mun Lim, John P. Walsh, Ewa Pocheć, Tim D. Spector, Scott G. Wilso
Publicado en: Molecular & Cellular Proteomics, Edición 19/5, 2020, Página(s) 774-792, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra119.001860

Interlaboratory evaluation of plasma N-glycan antennary fucosylation as a clinical biomarker for HNF1A-MODY using liquid chromatography methods

Autores: Daniel Demus; Bas C. Jansen; Richard A. Gardner; Paulina A. Urbanowicz; Haiyang Wu; Tamara Štambuk; Agata Juszczak; Edita Pape Medvidović; Nathalie Juge; Olga Gornik; Katharine R. Owen; Daniel I. R. Spencer
Publicado en: Glycoconjugate Journal, Edición 1, 2021, ISSN 0282-0080
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10719-021-09992-w

Glycosylation of human plasma lipoproteins reveals a high level of diversity, which directly impacts their functional properties.

Autores: Vasily N. Sukhorukov; Ivan Gudelj; Maja Pučić-Baković; Emile Zakiev; Alexander N. Orekhov; Anatol Kontush; Anatol Kontush; Gordan Lauc
Publicado en: "Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, Elsevier, 2019, 1864 (5), pp.643-653. ⟨10.1016/j.bbalip.2019.01.005⟩", Edición 1, 2019, ISSN 1388-1981
Editor: Elsevier BV
DOI: 10.1016/j.bbalip.2019.01.005

Serum protein N-glycosylation changes in multiple myeloma

Autores: Zejian Zhanga, Marita Westhrin, Albert Bondt, Manfred Wuhrer, Therese Standal, Stephanie Holst
Publicado en: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2019, ISSN 0304-4165
Editor: Elsevier BV
DOI: 10.1016/j.bbagen.2019.03.001

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity.

Autores: Mads Delbo Larsen; Erik L. de Graaf; Myrthe E. Sonneveld; H. Rosina Plomp; Jan Nouta; Willianne Hoepel; Hung-Jen Chen; Federica Linty; Remco Visser; Maximilian Brinkhaus; Tonci Sustic; Steven W. de Taeye; Arthur E. H. Bentlage; Suvi Toivonen; Carolien A. M. Koeleman; Susanna Sainio; Neeltje A. Kootstra; Philip J. M. Brouwer; Chiara Elisabeth Geyer; Ninotska I. L. Derksen; Gertjan Wolbink; Menno P.
Publicado en: Science, Edición 1, 2020, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abc8378

Why Not Use the Immunoglobulin G N-Glycans as Predictor Variables in Disease Biomarker–Phenotype Association Studies? A Multivariate Analysis

Autores: Alyce C. Russell, Agnieszka Kepka, Irena Trbojević-Akmačić, Ivo Ugrina, Manshu Song, Jennie Hui, Michael Hunter, Simon M. Laws, Gordan Lauc, and Wei Wang
Publicado en: OMICS: A Journal of Integrative Biology, 2019, ISSN 1536-2310
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/omi.2019.0155

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