Exploitation of Glycosylation Signatures for Precision Medicine

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The sweet spot for biologics: recent advances in characterization of biotherapeutic glycoproteins

Autori: O'Flaherty, R (O'Flaherty, Roisin) [1]; Trbojevic-Akmacic, I (Trbojevic-Akmacic, Irena) [2]; Greville, G (Greville, Gordon) [1]; Rudd, PM (Rudd, Pauline M.) [1]; Lauc, G (Lauc, Gordan) [2], [3]
Pubblicato in: EXPERT REVIEW OF PROTEOMICS, 2017, ISSN 1478-9450
Editore: Future Drugs Ltd.
DOI: 10.1080/14789450.2018.1404907

Profiling the proteoforms of urinary prostate-specific antigen by capillary electrophoresis – mass spectrometry

Autori: Alan B. Moran, Elena Domínguez-Vega, Jan Nouta, Tamas Pongracz, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer
Pubblicato in: Journal of Proteomics, Numero 238, 2021, Pagina/e 104148, ISSN 1874-3919
Editore: Elsevier BV
DOI: 10.1016/j.jprot.2021.104148

Large-Scale Analysis of Apolipoprotein CIII Glycosylation by Ultrahigh Resolution Mass Spectrometry.

Autori: Daniel Demus; Daniel Demus; Annemieke Naber; Viktoria Dotz; Bas C. Jansen; Bas C. Jansen; Marco R. Bladergroen; Jan Nouta; Eric J. G. Sijbrands; Mandy Van Hoek; Simone Nicolardi; Manfred Wuhrer
Pubblicato in: Frontiers in Chemistry, Vol 9 (2021), Numero 1, 2021, ISSN 2296-2646
Editore: Frontiers Media S.A.
DOI: 10.3389/fchem.2021.678883

Immunoglobulin G N-Glycans as Potential Postgenomic Biomarkers for Hypertension in the Kazakh Population

Autori: Qing Gao, Mamatyusupu Dolikun, Jerko Štambuk, Hao Wang, Feifei Zhao, Nizam Yiliham, Youxin Wang, Irena Trbojević-Akmačić, Jie Zhang, Honghong Fang, Yang Sun, Hongli Peng, Zhongyao Zhao, Di Liu, Jiaonan Liu, Qihuan Li, Qi Sun, Lijuan Wu, Gordan Lauc, Wei Wang, and Manshu Song
Pubblicato in: OMICS: A Journal of Integrative Biology, 2017, ISSN 1536-2310
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/omi.2017.0044

MS-Based Allotype-Specific Analysis of Polyclonal IgG-Fc N-Glycosylation

Autori: Thomas Sénard, Andrea F. G. Gargano, David Falck, Steven W. de Taeye, Theo Rispens, Gestur Vidarsson, Manfred Wuhrer, Govert W. Somsen, Elena Domínguez-Vega
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2020.02049

The association between subclass-specific IgG Fc N-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations

Autori: JN Liu, M Dolikun, J Štambuk, I Trbojević-Akmačić, J Zhang, H Wang, DQ Zheng, XY Zhang, HL Peng, ZY Zhao, D Liu, Y Sun, Q Sun, QH Li, JX Zhang, M Sun, WJ Cao, A Momčilović, G. Razdorov, LJ Wu, A Russell, YX Wang, MS Song, G Lauc & W Wang
Pubblicato in: JOURNAL OF HUMAN HYPERTENSION, 2018, ISSN 0950-9240
Editore: Nature Publishing Group
DOI: 10.1038/s41371-018-0071-0

Fucosidases from the human gut symbiont Ruminococcus gnavus

Autori: Haiyang Wu, Osmond Rebello, Emmanuelle H. Crost, C. David Owen, Samuel Walpole, Chloe Bennati-Granier, Didier Ndeh, Serena Monaco, Thomas Hicks, Anna Colvile, Paulina A. Urbanowicz, Martin A. Walsh, Jesus Angulo, Daniel I. R. Spencer, Nathalie Juge
Pubblicato in: Cellular and Molecular Life Sciences, 2020, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-020-03514-x

Profiling and genetic control of the murine immunoglobulin G glycome

Autori: Jasminka Krištić, Olga O. Zaytseva, Ramesh Ram, Quang Nguyen, Mislav Novokmet, Frano Vučković, Marija Vilaj, Irena Trbojević-Akmačić, Marija Pezer, Kathleen M. Davern, Grant Morahan & Gordan Lauc
Pubblicato in: NATURE CHEMICAL BIOLOGY, 2018, ISSN 1552-4450
Editore: Nature Publishing Group
DOI: 10.1038/s41589-018-0034-3

Metformin and statin use associate with plasma protein N -glycosylation in people with type 2 diabetes

Autori: Sunny S Singh, Annemieke Naber, Viktoria Dotz, Emma Schoep, Elham Memarian, Roderick C Slieker, Petra J M Elders, Gerda Vreeker, Simone Nicolardi, Manfred Wuhrer, Eric J G Sijbrands, Aloysius G Lieverse, Leen M 't Hart, Mandy van Hoek
Pubblicato in: BMJ Open Diabetes Research & Care, Numero 8/1, 2020, Pagina/e e001230, ISSN 2052-4897
Editore: BMJ Open Diabetes Research & Care
DOI: 10.1136/bmjdrc-2020-001230

Glycosylation of IgG Associates with Hypertension and Type 2 Diabetes Mellitus Comorbidity in the Chinese Muslim Ethnic Minorities and the Han Chinese

Autori: Xiaoni Meng, Manshu Song, Marija Vilaj, Jerko Štambuk, Mamatyusupu Dolikun, Jie Zhang, Di Liu, Hao Wang, Xiaoyu Zhang, Jinxia Zhang, Weijie Cao, Ana Momčilović, Irena Trbojević-Akmačić, Xingang Li, Deqiang Zheng, Lijuan Wu, Xiuhua Guo, Youxin Wang, Gordan Lauc, and Wei Wang
Pubblicato in: JOURNAL OF PERSONALIZED MEDICINE, 2021, ISSN 2075-4426
Editore: MDPI
DOI: 10.3390/jpm11070614

Plasma protein N-glycosylation is associated with cardiovascular disease, nephropathy, and retinopathy in type 2 diabetes

Autori: Elham Memarian, Leen M 't Hart, Roderick C Slieker, Roosmarijn F L Lemmers, Amber A van der Heijden, Femke Rutters, Giel Nijpels, Emma Schoep, Aloysius G Lieverse, Eric J G Sijbrands, Manfred Wuhrer, Mandy van Hoek, Viktoria Dotz
Pubblicato in: BMJ OPEN DIABETES RESEARCH & CARE, 2021, ISSN 2052-4897
Editore: BMJ PUBLISHING GROUP
DOI: 10.1136/bmjdrc-2021-002345

A novel glycosidase plate-based assay for the quantification of galactosylation and sialylation on human IgG

Autori: Osmond D. Rebello, Richard A. Gardner, Paulina A. Urbanowicz, David N. Bolam, Lucy I. Crouch, David Falck & Daniel I. R. Spencer
Pubblicato in: Glycoconjugate Journal, 2020, ISSN 0282-0080
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10719-020-09953-9

Complex N-glycan breakdown by gut Bacteroides involves an extensive enzymatic apparatus encoded by multiple co-regulated genetic loci

Autori: Justina Briliūtė, Paulina A. Urbanowicz, Ana S. Luis, Arnaud Baslé, Neil Paterson, Osmond Rebello, Jenifer Hendel, Didier A. Ndeh, Elisabeth C. Lowe, Eric C. Martens, Daniel I. R. Spencer, David N. Bolam, Lucy I. Crouch
Pubblicato in: Nature Microbiology, Numero 4/9, 2019, Pagina/e 1571-1581, ISSN 2058-5276
Editore: Nature
DOI: 10.1038/s41564-019-0466-x

Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases

Autori: Mirna Šimurina, Noortje de Haan, Frano Vučković, Nicholas A Kennedy, Jerko Štambuk David Falck, Irena Trbojević-Akmačić, Florent Clerc, Genadij Razdorov, Anna Khon, Anna Latiano, Renata D'Incà, Silvio Danese, Stephan Targan, Carol Landers, Marla Dubinsky, Inflammatory Bowel Disease Biomarkers Consortium; Dermot P B McGovern, Vito Annese, Manfred Wuhrer, Gordan Lauc
Pubblicato in: GASTROENTEROLOGY, 2018, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.01.002

Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans

Autori: Russell, Alyce C.; Kepka, Agnieszka; Trbojević-Akmačić, Irena; Ugrina, Ivo; Song, Manshu; Hui, Jennie; Hunter, Michael; Laws, Simon M.; Lauc, Gordan; Wang, Wei
Pubblicato in: Immunobiology, Numero 1, 2019, ISSN 0171-2985
Editore: Elsevier BV
DOI: 10.1016/j.imbio.2018.10.002

N-glycome of the Lysosomal Glycocalyx is Altered in Niemann-Pick Type C Disease (NPC) Model Cells

Autori: Marko Kosicek, Ivan Gudelj, Anita Horvatic, Tanja Jovic, Frano Vuckovic, Gordan Lauc, Silva Hecimovic
Pubblicato in: Molecular & Cellular Proteomics, Numero 17/4, 2018, Pagina/e 631-642, ISSN 1535-9476
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra117.000129

Site-specific glycosylation mapping of Fc gamma receptor IIIb from neutrophils of individual healthy donors

Autori: Iwona Wojcik, Thomas Sénard, Erik de Graaf, George Janssen, Arnoud de Ru, Yassene Mohammed, Peter A. van Veelen, Gestur Vidarsson, Manfred Wuhrer, David Falck
Pubblicato in: Analytical Chemistry, 2020, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.0c02342

Software-Assisted Data Processing Workflow for Intact Glycoprotein Mass Spectrometry

Autori: Alan B. Moran; Elena Domínguez-Vega; Manfred Wuhrer; Guinevere S. M. Lageveen-Kammeijer
Pubblicato in: J. Proteome REs, Numero 3, 2023, ISSN 1535-3893
Editore: American Chemical Society
DOI: 10.1021/acs.jproteome.2c00762

A functional spleen contributes to afucosylated IgG in humans

Autori: Iwona Wojcik; David E. Schmidt; Lisa A. de Neef; Minke A. E. Rab; Bob Meek; Okke de Weerdt; Manfred Wuhrer; C. Ellen van der Schoot; Jaap J. Zwaginga; Masja de Haas; David Falck; Gestur Vidarsson
Pubblicato in: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021), Numero 1, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-03196-w

Serum sialylation changes in cancer

Autori: Zejian Zhang, Manfred Wuhrer, Stephanie Holst
Pubblicato in: Glycoconjugate Journal, Numero 35/2, 2018, Pagina/e 139-160, ISSN 0282-0080
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10719-018-9820-0

Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation

Autori: Xia Shen, Lucija Klarić, Sodbo Sharapov, Massimo Mangino, Zheng Ning, Di Wu, Irena Trbojević-Akmačić, Maja Pučić-Baković, Igor Rudan, Ozren Polašek, Caroline Hayward, Timothy D. Spector, James F. Wilson, Gordan Lauc, Yurii S. Aulchenko
Pubblicato in: Nature Communications, Numero 8/1, 2017, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-00453-3

Glycosylation Profile of Immunoglobulin G Is Cross-Sectionally Associated With Cardiovascular Disease Risk Score and Subclinical Atherosclerosis in Two Independent Cohorts

Autori: Cristina Menni, Ivan Gudelj, Erin Macdonald-Dunlop, Massimo Mangino, Jonas Zierer, Erim Bešić, Peter K. Joshi, Irena Trbojević-Akmačić, Phil J. Chowienczyk, Tim D. Spector, James F. Wilson, Gordan Lauc, Ana M. Valdes
Pubblicato in: Circulation Research, Numero 122/11, 2018, Pagina/e 1555-1564, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.117.312174

Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up

Autori: Ivan Gudelj, Perttu P. Salo, Irena Trbojević-Akmačić, Malena Albers, Dragan Primorac, Markus Perola, Gordan Lauc
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numero 1864/6, 2018, Pagina/e 2034-2039, ISSN 0925-4439
Editore: Elsevier BV
DOI: 10.1016/j.bbadis.2018.03.018

High throughput profiling of whole plasma N-glycans in type II diabetes mellitus patients and healthy individuals: A perspective from a Ghanaian population

Autori: Eric Adua, Elham Memarian, Alyce Russell, Irena Trbojević-Akmačić, Ivan Gudelj, Julija Jurić, Peter Roberts, Gordan Lauc, Wei Wang
Pubblicato in: Archives of Biochemistry and Biophysics, Numero 661, 2019, Pagina/e 10-21, ISSN 0003-9861
Editore: Academic Press
DOI: 10.1016/j.abb.2018.10.015

Altered N‐glycosylation profiles as potential biomarkers and drug targets in diabetes

Autori: Najda Rudman, Olga Gornik, Gordan Lauc
Pubblicato in: FEBS Letters, Numero 593/13, 2019, Pagina/e 1598-1615, ISSN 0014-5793
Editore: Elsevier BV
DOI: 10.1002/1873-3468.13495

Utilization of N-glycosylation profiles as risk stratification biomarkers for suboptimal health status and metabolic syndrome in a Ghanaian population

Autori: Eric Adua, Elham Memarian, Alyce Russell, Irena Trbojević-Akmačić, Ivan Gudelj, Julija Jurić, Peter Roberts, Gordan Lauc, Wei Wang
Pubblicato in: Biomarkers in Medicine, Numero 13/15, 2019, Pagina/e 1273-1287, ISSN 1752-0363
Editore: Future Medicine Ltd.
DOI: 10.2217/bmm-2019-0005

Decreased Complexity of Serum N-glycan Structures Associates with Successful Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection

Autori: Tanya M. Monaghan, Maja Pučić-Baković, Frano Vučković, Christine Lee, Dina Kao, Iwona Wójcik, Filip Kliček, Christos Polytarchou, Brandi Roach, Tom Louie, Peter Kim, Brandi Roach, Christos Polytarchou, Marcin Frankowski, Gordan Lauc
Pubblicato in: Gastroenterology, Numero 157/6, 2019, Pagina/e 1676-1678.e3, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.08.034

Plasma N -Glycans as Emerging Biomarkers of Cardiometabolic Risk: A Prospective Investigation in the EPIC-Potsdam Cohort Study

Autori: Clemens Wittenbecher, Tamara Štambuk, Olga Kuxhaus, Najda Rudman, Frano Vučković, Jerko Štambuk, Catarina Schiborn, Dario Rahelić, Stefan Dietrich, Olga Gornik, Markus Perola, Heiner Boeing, Matthias B. Schulze, Gordan Lauc
Pubblicato in: Diabetes Care, 2020, Pagina/e dc191507, ISSN 0149-5992
Editore: American Diabetes Association
DOI: 10.2337/dc19-1507

Glycomics for Type 2 Diabetes Biomarker Discovery: Promise of Immunoglobulin G Subclass-Specific Fragment Crystallizable N-glycosylation in the Uyghur Population

Autori: Jiaonan Liu, Mamatyusupu Dolikun, Jerko Štambuk, Irena Trbojević-Akmačić, Jie Zhang, Jinxia Zhang, Hao Wang, Xiaoni Meng, Genadij Razdorov, Desmond Menon, Deqiang Zheng, Lijuan Wu, Youxin Wang, Manshu Song, Gordan Lauc, Wei Wang
Pubblicato in: OMICS: A Journal of Integrative Biology, Numero 23/12, 2019, Pagina/e 640-648, ISSN 1557-8100
Editore: Mary Ann Liebert, Inc.
DOI: 10.1089/omi.2019.0052

A Matrix-Assisted Laser Desorption/Ionization—Mass Spectrometry Assay for the Relative Quantitation of Antennary Fucosylated N-Glycans in Human Plasma

Autori: Osmond D. Rebello, Simone Nicolardi, Guinevere S. M. Lageveen-Kammeijer, Jan Nouta, Richard A. Gardner, Wilma E. Mesker, Rob A. E. M. Tollenaar, Daniel I. R. Spencer, Manfred Wuhrer, David Falck
Pubblicato in: Frontiers in Chemistry, Numero 8, 2020, Pagina/e 138, ISSN 2296-2646
Editore: Frontiers Media SA
DOI: 10.3389/fchem.2020.00138

Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases

Autori: Tiphaine C. Martin, Mirna Šimurina, Marta Ząbczyńska, Marina Martinic Kavur, Magdalena Rydlewska, Marija Pezer, Kamila Kozłowska, Andrea Burri, Marija Vilaj, Renata Turek-Jabrocka, Milena Krnjajić-Tadijanović, Małgorzata Trofimiuk-Müldner, Ivo Ugrina, Anna Lityńska, Alicja Hubalewska-Dydejczyk, Irena Trbojevic-Akmacic, Ee Mun Lim, John P. Walsh, Ewa Pocheć, Tim D. Spector, Scott G. Wilso
Pubblicato in: Molecular & Cellular Proteomics, Numero 19/5, 2020, Pagina/e 774-792, ISSN 1535-9476
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra119.001860

Interlaboratory evaluation of plasma N-glycan antennary fucosylation as a clinical biomarker for HNF1A-MODY using liquid chromatography methods

Autori: Daniel Demus; Bas C. Jansen; Richard A. Gardner; Paulina A. Urbanowicz; Haiyang Wu; Tamara Štambuk; Agata Juszczak; Edita Pape Medvidović; Nathalie Juge; Olga Gornik; Katharine R. Owen; Daniel I. R. Spencer
Pubblicato in: Glycoconjugate Journal, Numero 1, 2021, ISSN 0282-0080
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10719-021-09992-w

Glycosylation of human plasma lipoproteins reveals a high level of diversity, which directly impacts their functional properties.

Autori: Vasily N. Sukhorukov; Ivan Gudelj; Maja Pučić-Baković; Emile Zakiev; Alexander N. Orekhov; Anatol Kontush; Anatol Kontush; Gordan Lauc
Pubblicato in: "Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, Elsevier, 2019, 1864 (5), pp.643-653. ⟨10.1016/j.bbalip.2019.01.005⟩", Numero 1, 2019, ISSN 1388-1981
Editore: Elsevier BV
DOI: 10.1016/j.bbalip.2019.01.005

Serum protein N-glycosylation changes in multiple myeloma

Autori: Zejian Zhanga, Marita Westhrin, Albert Bondt, Manfred Wuhrer, Therese Standal, Stephanie Holst
Pubblicato in: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2019, ISSN 0304-4165
Editore: Elsevier BV
DOI: 10.1016/j.bbagen.2019.03.001

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity.

Autori: Mads Delbo Larsen; Erik L. de Graaf; Myrthe E. Sonneveld; H. Rosina Plomp; Jan Nouta; Willianne Hoepel; Hung-Jen Chen; Federica Linty; Remco Visser; Maximilian Brinkhaus; Tonci Sustic; Steven W. de Taeye; Arthur E. H. Bentlage; Suvi Toivonen; Carolien A. M. Koeleman; Susanna Sainio; Neeltje A. Kootstra; Philip J. M. Brouwer; Chiara Elisabeth Geyer; Ninotska I. L. Derksen; Gertjan Wolbink; Menno P.
Pubblicato in: Science, Numero 1, 2020, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abc8378

Why Not Use the Immunoglobulin G N-Glycans as Predictor Variables in Disease Biomarker–Phenotype Association Studies? A Multivariate Analysis

Autori: Alyce C. Russell, Agnieszka Kepka, Irena Trbojević-Akmačić, Ivo Ugrina, Manshu Song, Jennie Hui, Michael Hunter, Simon M. Laws, Gordan Lauc, and Wei Wang
Pubblicato in: OMICS: A Journal of Integrative Biology, 2019, ISSN 1536-2310
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/omi.2019.0155

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