Objective Bone injuries represent a high cost for the European health system, requiring corrective surgery to fix the bones. Traditionally, their treatment relies on classical orthopaedic techniques but, nowadays, it is possible to design and fabricate custom-made implants. Thanks to the current advance in image-based technologies, the reconstruction of models that are exact copies of patient specific bones is possible. Thus, this methodology is appropriate for preoperative surgical planning, but currently lacks of a predictive capacity. It presents a low impact for quantitatively determine the effectiveness of different treatments on bone regeneration and, consequently, the patient recovery. CURABONE aims to bridge this gap, integrating and extending numerical simulation technologies based on image analysis to achieve a predictive methodology, to optimize patient-specific treatment of bone injuries and rehabilitation therapies. Therefore, CURABONE will focus on the establishment of a currently non-existent, but essential multi-validation platform at different scale levels for the creation of bone models. At organ level, patient-specific loads will be quantified from image-based analysis and musculoskeletal rigid-body modelling. At implant level, Finite Element analyses (FEA) of bone and implant/scaffold will be evaluated. At cell level, in-vitro experiments will be developed under controlled microenvironmental conditions in bioreactors to estimate the cell response under different mechanical conditions. All this information obtained from validation at different scales will be integrated in a computational model with a predictive capacity. Hence, CURABONE will not only develop patient-specific musculoskeletal modelling based on FEA and bone adaptive algorithms, but will also bring a step-forward to validate these models at different scales together with supervision of different orthopaedic hospitals expert on bone injuries. Fields of science engineering and technologymedical engineeringmedical and health sciencesclinical medicinesurgeryengineering and technologymechanical engineeringapplied mechanicsmedical and health sciencesclinical medicineorthopaedicsmedical and health sciencesmedical biotechnologyimplants Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers Topic(s) MSCA-ITN-2016 - Innovative Training Networks Call for proposal H2020-MSCA-ITN-2016 See other projects for this call Funding Scheme MSCA-ITN-EID - European Industrial Doctorates Coordinator UNIVERSIDAD DE ZARAGOZA Net EU contribution € 495 745,92 Address CALLE PEDRO CERBUNA 12 50009 Zaragoza Spain See on map Region Noreste Aragón Zaragoza Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 495 745,92 Participants (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all MATERIALISE NV Belgium Net EU contribution € 751 680,00 Address TECHNOLOGIELAAN 15 3001 Heverlee See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 751 680,00 Partners (7) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. ANYBODY TECHNOLOGY AS Denmark Net EU contribution € 0,00 Address NIELS JERNES VEJ 10 9220 Aalborg See on map Region Danmark Nordjylland Nordjylland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. TA INSTRUMENTS United States Net EU contribution € 0,00 Address New Castle See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. KATHOLIEKE UNIVERSITEIT LEUVEN Belgium Net EU contribution € 0,00 Address OUDE MARKT 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. AALBORG UNIVERSITET Denmark Net EU contribution € 0,00 Address FREDRIK BAJERS VEJ 7K 9220 Aalborg See on map Region Danmark Nordjylland Nordjylland Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. RJAH ORTHOPAEDIC HOSPITAL United Kingdom Net EU contribution € 0,00 Address Oswestry See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. LOZANO BLESA HOSPITAL Spain Net EU contribution € 0,00 Address Zaragoza See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. MAZ HOSPITAL Spain Net EU contribution € 0,00 Address Zaragoza See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data
