Predictive models and simulations in bone regeneration: a multiscale patient-specific approach

Project Information

CuraBone

Grant agreement ID: 722535

DOI 10.3030/722535

Project closed

EC signature date 15 July 2016

Start date 1 April 2017

End date 31 March 2021

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 1 247 425,92

EU contribution € 1 247 425,92

Coordinated by

UNIVERSIDAD DE ZARAGOZA
Spain

Deliverables

Websites, patent fillings, videos etc. (2)

CuraBone web site release
CuraBone newsletters

Regular CuraBone newsletters to share the achivements and outreach of the project

Documents, reports (20)

Boundary and loading conditions for the mandible and maxillae
Loading conditions for the femur and tibia.
Quantification of bone formation under different scaffold microarchitectures and loading conditions
3D cell culture of human osteoblasts for assessment of bone tissue formation in-vitro
Quantitative comparison of numerical predictions with experiments measurements in-vivo
Multiscale bone regeneration algorithm and simulations for different scaffold microstructural designs.
Recreation in bioreactor of biomechanical conditions of different bone injuries estimated from musculoskeletal modelling
Definition of requirements for ESRs recruitment and training
Data Management Plan
Bone regeneration algorithm and simulations for different scaffold microstructures
Progress report
Integrative computer bone remodelling framework.
Integrative computer bone healing framework.
Integrative computer degradation algorithm.
Loading conditions for the humerus and radius.
Macroscopic bone healing, remodelling and degradation algorithms and simulations for different loading conditions.
Career Development plans & Declarations on conformity
Macroscopic bone healing and remodelling algorithms and simulations for different loading conditions and bone implants.
Assessment of scaffold degradation under different static and dynamic conditions
Mid Term report

The mid term review meeting needs to take place between month 18 and 26

Publications

Peer reviewed articles (8)

Designing Hydrogel-Based Bone-On-Chips for Personalized Medicine

Author(s): Gabriele Nasello, Mar Cóndor, Ted Vaughan, Jessica Schiavi
Published in: Applied Sciences, Issue 11/10, 2021, Page(s) 4495, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app11104495

Mechano-driven regeneration predicts response variations in large animal model based on scaffold implantation site and individual mechano-sensitivity

Author(s): Gabriele Nasello, Antoine Vautrin, Jonathan Pitocchi, Mariska Wesseling, Jan Herman Kuiper, María Ángeles Pérez, José Manuel García-Aznar
Published in: Bone, Issue 144, 2021, Page(s) 115769, ISSN 8756-3282
Publisher: Elsevier BV
DOI: 10.1016/j.bone.2020.115769

Automated muscle elongation measurement during reverse shoulder arthroplasty planning

Author(s): Jonathan Pitocchi, Katrien Plessers, Roel Wirix-Speetjens, Philippe Debeer, G. Harry van Lenthe, Ilse Jonkers, Maria Angeles Pérez, Jos Vander Sloten
Published in: Journal of Shoulder and Elbow Surgery, 2020, ISSN 1058-2746
Publisher: Mosby Inc.
DOI: 10.1016/j.jse.2020.07.007

Time-dependent in silico modelling of orthognathic surgery to support the design of biodegradable bone plates

Author(s): Antoine Vautrin, Mariska Wesseling, Roel Wirix-Speetjens, Maria Jose Gomez-Benito
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 121, 2021, Page(s) 104641, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2021.104641

Multiscale modeling of bone tissue Mechanobiology

Author(s): José Manuel García-Aznar, Gabriele Nasello, Silvia Hervas-Raluy, María Ángeles Pérez, María José Gómez-Benito
Published in: Bone, 2021, Page(s) 116032, ISSN 8756-3282
Publisher: Elsevier BV
DOI: 10.1016/j.bone.2021.116032

Primary Human Osteoblasts Cultured in a 3D Microenvironment Create a Unique Representative Model of Their Differentiation Into Osteocytes

Author(s): Gabriele Nasello, Pilar Alamán-Díez, Jessica Schiavi, María Ángeles Pérez, Laoise McNamara, José Manuel García-Aznar
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers in Bioengineering and Biotechnology
DOI: 10.3389/fbioe.2020.00336

Integration of cortical thickness data in a statistical shape model of the scapula

Author(s): Jonathan Pitocchi, Roel Wirix-Speetjens, G. Harry van Lenthe, María Ángeles Pérez
Published in: Computer Methods in Biomechanics and Biomedical Engineering, Issue Volume 23, 2020, 2020, Page(s) 1-7, ISSN 1025-5842
Publisher: Taylor & Francis
DOI: 10.1080/10255842.2020.1757082

Finite Element Analysis of Custom Shoulder Implants Provides Accurate Prediction of Initial Stability

Author(s): Jonathan Pitocchi, Mariska Wesseling, Gerrit Harry van Lenthe, María Angeles Pérez
Published in: Mathematics, Issue 8/7, 2020, Page(s) 1113, ISSN 2227-7390
Publisher: MPDI
DOI: 10.3390/math8071113

Conference proceedings (4)

Measuring tightening torque and force of non-locking screws for reverse shoulder prosthesis

Author(s): Jonathan Pitocchi, Roel Wirix-Speetjens, Harry Van Lenthe, Maria Angeles Perez
Published in: Orthopaedic Proceedings, Issue Vol. 102-B, No. SUPP_2, 2020, ISSN 2049-4416
Publisher: Bone and Joint Publishing

Can standard implants reproduce the native kinematics of a TKA patient?

Author(s): Maria Paz Quilez, Hendrik Pieter Delport, Roel Wirix-Speetjens, Mariska Wesseling, Maria Angeles Perez Anson, Ilse Jonkers, Jos Vander Sloten
Published in: EPiC Series in Health Sciences volume 3, 2019, Page(s) 311-306
Publisher: EasyChair
DOI: 10.29007/7dsg

Standard Cruciate-Retaining Total Knee Arthroplasy Implants Can Reproduce Native Kinematics

Author(s): David Leandro Dejtiar, Laura Bartsoen, Mariska Wesseling, Roel Wirix-Speetjens, Jos Vander Sloten, Maria Angeles Perez
Published in: EPiC Series in Health Sciences volume 4, 2020, Page(s) 61-56
Publisher: EasyChair
DOI: 10.29007/lj2j

Automatic muscle elongation measurement during shoulder arthroplasty planning

Author(s): Jonathan Pitocchi, Katrien Plessers, Mariska Wesseling, G. Harry van Lenthe, Maria Angeles Pérez
Published in: EPiC Series in Health Sciences volume 4, 2020, Page(s) 237-233
Publisher: EasyChair
DOI: 10.29007/hwz8