Predictive models and simulations in bone regeneration: a multiscale patient-specific approach

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CuraBone web site release
CuraBone newsletters

Regular CuraBone newsletters to share the achivements and outreach of the project

Boundary and loading conditions for the mandible and maxillae
Loading conditions for the femur and tibia.
Quantification of bone formation under different scaffold microarchitectures and loading conditions
3D cell culture of human osteoblasts for assessment of bone tissue formation in-vitro
Quantitative comparison of numerical predictions with experiments measurements in-vivo
Multiscale bone regeneration algorithm and simulations for different scaffold microstructural designs.
Recreation in bioreactor of biomechanical conditions of different bone injuries estimated from musculoskeletal modelling
Definition of requirements for ESRs recruitment and training
Data Management Plan
Bone regeneration algorithm and simulations for different scaffold microstructures
Progress report
Integrative computer bone remodelling framework.
Integrative computer bone healing framework.
Integrative computer degradation algorithm.
Loading conditions for the humerus and radius.
Macroscopic bone healing, remodelling and degradation algorithms and simulations for different loading conditions.
Career Development plans & Declarations on conformity
Macroscopic bone healing and remodelling algorithms and simulations for different loading conditions and bone implants.
Assessment of scaffold degradation under different static and dynamic conditions
Mid Term report

The mid term review meeting needs to take place between month 18 and 26

Pubblicazioni

Designing Hydrogel-Based Bone-On-Chips for Personalized Medicine

Autori: Gabriele Nasello, Mar Cóndor, Ted Vaughan, Jessica Schiavi
Pubblicato in: Applied Sciences, Numero 11/10, 2021, Pagina/e 4495, ISSN 2076-3417
Editore: MDPI
DOI: 10.3390/app11104495

Mechano-driven regeneration predicts response variations in large animal model based on scaffold implantation site and individual mechano-sensitivity

Autori: Gabriele Nasello, Antoine Vautrin, Jonathan Pitocchi, Mariska Wesseling, Jan Herman Kuiper, María Ángeles Pérez, José Manuel García-Aznar
Pubblicato in: Bone, Numero 144, 2021, Pagina/e 115769, ISSN 8756-3282
Editore: Elsevier BV
DOI: 10.1016/j.bone.2020.115769

Automated muscle elongation measurement during reverse shoulder arthroplasty planning

Autori: Jonathan Pitocchi, Katrien Plessers, Roel Wirix-Speetjens, Philippe Debeer, G. Harry van Lenthe, Ilse Jonkers, Maria Angeles Pérez, Jos Vander Sloten
Pubblicato in: Journal of Shoulder and Elbow Surgery, 2020, ISSN 1058-2746
Editore: Mosby Inc.
DOI: 10.1016/j.jse.2020.07.007

Time-dependent in silico modelling of orthognathic surgery to support the design of biodegradable bone plates

Autori: Antoine Vautrin, Mariska Wesseling, Roel Wirix-Speetjens, Maria Jose Gomez-Benito
Pubblicato in: Journal of the Mechanical Behavior of Biomedical Materials, Numero 121, 2021, Pagina/e 104641, ISSN 1751-6161
Editore: Elsevier BV
DOI: 10.1016/j.jmbbm.2021.104641

Multiscale modeling of bone tissue Mechanobiology

Autori: José Manuel García-Aznar, Gabriele Nasello, Silvia Hervas-Raluy, María Ángeles Pérez, María José Gómez-Benito
Pubblicato in: Bone, 2021, Pagina/e 116032, ISSN 8756-3282
Editore: Elsevier BV
DOI: 10.1016/j.bone.2021.116032

Primary Human Osteoblasts Cultured in a 3D Microenvironment Create a Unique Representative Model of Their Differentiation Into Osteocytes

Autori: Gabriele Nasello, Pilar Alamán-Díez, Jessica Schiavi, María Ángeles Pérez, Laoise McNamara, José Manuel García-Aznar
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 8, 2020, ISSN 2296-4185
Editore: Frontiers in Bioengineering and Biotechnology
DOI: 10.3389/fbioe.2020.00336

Integration of cortical thickness data in a statistical shape model of the scapula

Autori: Jonathan Pitocchi, Roel Wirix-Speetjens, G. Harry van Lenthe, María Ángeles Pérez
Pubblicato in: Computer Methods in Biomechanics and Biomedical Engineering, Numero Volume 23, 2020, 2020, Pagina/e 1-7, ISSN 1025-5842
Editore: Taylor & Francis
DOI: 10.1080/10255842.2020.1757082

Finite Element Analysis of Custom Shoulder Implants Provides Accurate Prediction of Initial Stability

Autori: Jonathan Pitocchi, Mariska Wesseling, Gerrit Harry van Lenthe, María Angeles Pérez
Pubblicato in: Mathematics, Numero 8/7, 2020, Pagina/e 1113, ISSN 2227-7390
Editore: MPDI
DOI: 10.3390/math8071113

Measuring tightening torque and force of non-locking screws for reverse shoulder prosthesis

Autori: Jonathan Pitocchi, Roel Wirix-Speetjens, Harry Van Lenthe, Maria Angeles Perez
Pubblicato in: Orthopaedic Proceedings, Numero Vol. 102-B, No. SUPP_2, 2020, ISSN 2049-4416
Editore: Bone and Joint Publishing

Can standard implants reproduce the native kinematics of a TKA patient?

Autori: Maria Paz Quilez, Hendrik Pieter Delport, Roel Wirix-Speetjens, Mariska Wesseling, Maria Angeles Perez Anson, Ilse Jonkers, Jos Vander Sloten
Pubblicato in: EPiC Series in Health Sciences volume 3, 2019, Pagina/e 311-306
Editore: EasyChair
DOI: 10.29007/7dsg

Standard Cruciate-Retaining Total Knee Arthroplasy Implants Can Reproduce Native Kinematics

Autori: David Leandro Dejtiar, Laura Bartsoen, Mariska Wesseling, Roel Wirix-Speetjens, Jos Vander Sloten, Maria Angeles Perez
Pubblicato in: EPiC Series in Health Sciences volume 4, 2020, Pagina/e 61-56
Editore: EasyChair
DOI: 10.29007/lj2j

Automatic muscle elongation measurement during shoulder arthroplasty planning

Autori: Jonathan Pitocchi, Katrien Plessers, Mariska Wesseling, G. Harry van Lenthe, Maria Angeles Pérez
Pubblicato in: EPiC Series in Health Sciences volume 4, 2020, Pagina/e 237-233
Editore: EasyChair
DOI: 10.29007/hwz8

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