TRANSlating the role of Mitochondria in Tumorigenesis

Información del proyecto

TRANSMIT

Identificador del acuerdo de subvención: 722605

DOI

10.3030/722605

Proyecto cerrado

Fecha de la firma de la CE 16 Agosto 2016

Fecha de inicio 1 Enero 2017

Fecha de finalización 30 Junio 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 2 851 761,40

Aportación de la UE

€ 2 851 761,40

Coordinado por

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (13)

Progress report

Progress Report will be delivered at M13.

Joint Press Conference

Joint Press Conference This deliverable will be delivered by UNIBO and KI

Course on “European Public Funding Schemes for R&D and Innovation and Technology Transfer”.
Course in Cancer Metabolism

Course in Cancer Metabolism Lead Beneficiaries : CEUB and UNIBO

Representative of Trainees Elections
Course in Social Entrepreneurship and Managerial Skills
Summer School in Metabolomics
Project dissemination activities

Project dissemination activities Deliverables due at M12-24-36-48

Course in Science Communication
Dissemination activities in high schools

Dissemination activities in high school Lead beneficiaries : UNIBO and FUV

ESRs participation in Dynamo Camp Open Day

ESRs participation in Dynamo Camp Open Day Lead beneficiaries: UNIBO and DYNAMO ACADEMY

Project Website
Recruitment procedure accomplished and list of ESRs appointed

Publicaciones

Peer reviewed articles (23)

Mitochondria Participate in Chemoresistance to Cisplatin in Human Ovarian Cancer Cells

Autores: Luca X. Zampieri, Debora Grasso, Caroline Bouzin, Davide Brusa, Rodrigue Rossignol, Pierre Sonveaux
Publicado en: Molecular Cancer Research, Edición 18/9, 2020, Página(s) 1379-1391, ISSN 1541-7786
Editor: American Association for Cancer Research
DOI: 10.1158/1541-7786.mcr-19-1145

Role of coenzymes in cancer metabolism

Autores: Maheshwor Thapa, Guido Dallmann
Publicado en: Seminars in Cell & Developmental Biology, Edición 98, 2020, Página(s) 44-53, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2019.05.027

Metabolic and non-metabolic pathways that control cancer resistance to anthracyclines

Autores: Tânia Capelôa, Zohra Benyahia, Luca X. Zampieri, Marine C.N.M. Blackman, Pierre Sonveaux
Publicado en: Seminars in Cell & Developmental Biology, Edición 98, 2020, Página(s) 181-191, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2019.05.006

Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses

Autores: Ivana Kurelac, Luisa Iommarini, Renaud Vatrinet, Laura Benedetta Amato, Monica De Luise, Giulia Leone, Giulia Girolimetti, Nikkitha Umesh Ganesh, Victoria Louise Bridgeman, Luigi Ombrato, Marta Columbaro, Moira Ragazzi, Lara Gibellini, Manuela Sollazzo, Rene Gunther Feichtinger, Silvia Vidali, Maurizio Baldassarre, Sarah Foriel, Michele Vidone, Andrea Cossarizza, Daniela Grifoni, Barbara Kofler, I
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-08839-1

A Humanized Bone Niche Model Reveals Bone Tissue Preservation Upon Targeting Mitochondrial Complex I in Pseudo-Orthotopic Osteosarcoma

Autores: Ivana Kurelac, Ander Abarrategi, Moira Ragazzi, Luisa Iommarini, Nikkitha Umesh Ganesh, Thomas Snoeks, Dominique Bonnet, Anna Maria Porcelli, Ilaria Malanchi, Giuseppe Gasparre
Publicado en: Journal of Clinical Medicine, Edición 8/12, 2019, Página(s) 2184, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm8122184

Pro- and antitumor effects of mitochondrial reactive oxygen species

Autores: Valéry L. Payen, Luca X. Zampieri, Paolo E. Porporato, Pierre Sonveaux
Publicado en: Cancer and Metastasis Reviews, Edición 38/1-2, 2019, Página(s) 189-203, ISSN 0167-7659
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10555-019-09789-2

In Vitro and In Vivo Characterization of MCT1 Inhibitor AZD3965 Confirms Preclinical Safety Compatible with Breast Cancer Treatment

Autores: Zohra Benyahia, Marine C. N. M. Blackman, Loïc Hamelin, Luca X. Zampieri, Tania Capeloa, Marie L. Bedin, Thibaut Vazeille, Olivier Schakman, Pierre Sonveaux
Publicado en: Cancers, Edición 13/3, 2021, Página(s) 569, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030569

Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells

Autores: Ana Carolina B. Sant’Anna-Silva, Juan A. Perez-Valencia, Marco Sciacovelli, Claude Lalou, Saharnaz Sarlak, Laura Tronci, Efterpi Nikitopoulou, Andras T. Meszaros, Christian Frezza, Rodrigue Rossignol, Erich Gnaiger, Helmut Klocker
Publicado en: Cancers, Edición 13/7, 2021, Página(s) 1727, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13071727

Metabolic Drivers in Hereditary Cancer Syndromes

Autores: Marco Sciacovelli, Christina Schmidt, Eamonn R. Maher, Christian Frezza
Publicado en: Annual Review of Cancer Biology, Edición 4/1, 2020, Página(s) 77-97, ISSN 2472-3428
Editor: Annual Rewiew of Cancer Biology
DOI: 10.1146/annurev-cancerbio-030419-033612

The multifaceted contribution of α-ketoglutarate to tumor progression: An opportunity to exploit?

Autores: Houda Abla, Manuela Sollazzo, Giuseppe Gasparre, Luisa Iommarini, Anna Maria Porcelli
Publicado en: Seminars in Cell & Developmental Biology, Edición 98, 2020, Página(s) 26-33, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2019.05.031

Fumarate hydratase in cancer: A multifaceted tumour suppressor

Autores: Christina Schmidt, Marco Sciacovelli, Christian Frezza
Publicado en: Seminars in Cell & Developmental Biology, Edición 98, 2020, Página(s) 15-25, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2019.05.002

Ketogenic diet in the treatment of cancer – Where do we stand?

Autores: Daniela D. Weber, Sepideh Aminzadeh-Gohari, Julia Tulipan, Luca Catalano, René G. Feichtinger, Barbara Kofler
Publicado en: Molecular Metabolism, Edición 33, 2020, Página(s) 102-121, ISSN 2212-8778
Editor: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.06.026

The Oncojanus Paradigm of Respiratory Complex I

Autores: Giulia Leone, Houda Abla, Giuseppe Gasparre, Anna Porcelli, Luisa Iommarini
Publicado en: Genes, Edición 9/5, 2018, Página(s) 243, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes9050243

The multifaceted effects of metformin on tumor microenvironment

Autores: Ivana Kurelac, Nikkitha Umesh Ganesh, Maria Iorio, Anna Maria Porcelli, Giuseppe Gasparre
Publicado en: Seminars in Cell & Developmental Biology, Edición 98, 2020, Página(s) 90-97, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2019.05.010

Mitochondria in cancer

Autores: Debora Grasso, Luca X. Zampieri, Tânia Capelôa, Justine A. Van de Velde, Pierre Sonveaux
Publicado en: Cell Stress, Edición 4/6, 2020, Página(s) 114-146, ISSN 2523-0204
Editor: Shared Science Publishers OG
DOI: 10.15698/cst2020.06.221

Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer

Autores: José M. Matés, Floriana J. Di Paola, José A. Campos-Sandoval, Sybille Mazurek, Javier Márquez
Publicado en: Seminars in Cell & Developmental Biology, Edición 98, 2020, Página(s) 34-43, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2019.05.012

Mitochondrial Transfer in Cancer: A Comprehensive Review

Autores: Luca X. Zampieri, Catarina Silva-Almeida, Justin D. Rondeau, Pierre Sonveaux
Publicado en: International Journal of Molecular Sciences, Edición 22/6, 2021, Página(s) 3245, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22063245

Targeting Mitochondria in Melanoma

Autores: Sepideh Aminzadeh-Gohari, Daniela D. Weber, Luca Catalano, René G. Feichtinger, Barbara Kofler, Roland Lang
Publicado en: Biomolecules, Edición 10/10, 2020, Página(s) 1395, ISSN 2218-273X
Editor: MDPI AG
DOI: 10.3390/biom10101395

Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells

Autores: Debora Grasso, Hyllana C. D. Medeiros, Luca X. Zampieri, Vanesa Bol, Pierre Danhier, Marike W. van Gisbergen, Caroline Bouzin, Davide Brusa, Vincent Grégoire, Hubert Smeets, Alphons P. M. Stassen, Ludwig J. Dubois, Philippe Lambin, Marie Dutreix, Pierre Sonveaux
Publicado en: Frontiers in Pharmacology, Edición 11, 2020, Página(s) 1-16, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.00263

From old to new — Repurposing drugs to target mitochondrial energy metabolism in cancer

Autores: Sepideh Aminzadeh-Gohari, Daniela D. Weber, Silvia Vidali, Luca Catalano, Barbara Kofler, René G. Feichtinger
Publicado en: Seminars in Cell & Developmental Biology, Edición 98, 2020, Página(s) 211-223, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2019.05.025

A Shifty Target: Tumor-Initiating Cells and Their Metabolism

Autores: Bezuidenhout, Shoshan
Publicado en: International Journal of Molecular Sciences, Edición 20/21, 2019, Página(s) 5370, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20215370

NDUFS3 depletion permits complex I maturation and reveals TMEM126A/OPA7 as an assembly factor binding the ND4-module intermediate

Autores: Luigi D’Angelo, Elisa Astro, Monica De Luise, Ivana Kurelac, Nikkitha Umesh-Ganesh, Shujing Ding, Ian M. Fearnley, Giuseppe Gasparre, Massimo Zeviani, Anna Maria Porcelli, Erika Fernandez-Vizarra, Luisa Iommarini
Publicado en: Cell Reports, Edición 35/3, 2021, Página(s) 109002, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.109002

Targeted Metabolomics Identifies Plasma Biomarkers in Mice with Metabolically Heterogeneous Melanoma Xenografts

Autores: Daniela D. Weber, Maheshwor Thapa, Sepideh Aminzadeh-Gohari, Anna-Sophia Redtenbacher, Luca Catalano, René G. Feichtinger, Peter Koelblinger, Guido Dallmann, Michael Emberger, Barbara Kofler, Roland Lang
Publicado en: Cancers, Edición 13/3, 2021, Página(s) 434, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030434