TRANSlating the role of Mitochondria in Tumorigenesis

Risultati finali

Progress Report will be delivered at M13.

Joint Press Conference This deliverable will be delivered by UNIBO and KI

Course on “European Public Funding Schemes for R&D and Innovation and Technology Transfer”.
Course in Cancer Metabolism

Course in Cancer Metabolism Lead Beneficiaries : CEUB and UNIBO

Representative of Trainees Elections
Course in Social Entrepreneurship and Managerial Skills
Summer School in Metabolomics
Project dissemination activities

Project dissemination activities Deliverables due at M12-24-36-48

Course in Science Communication
Dissemination activities in high schools

Dissemination activities in high school Lead beneficiaries : UNIBO and FUV

ESRs participation in Dynamo Camp Open Day

ESRs participation in Dynamo Camp Open Day Lead beneficiaries: UNIBO and DYNAMO ACADEMY

Project Website
Recruitment procedure accomplished and list of ESRs appointed

Pubblicazioni

Mitochondria Participate in Chemoresistance to Cisplatin in Human Ovarian Cancer Cells

Autori: Luca X. Zampieri, Debora Grasso, Caroline Bouzin, Davide Brusa, Rodrigue Rossignol, Pierre Sonveaux
Pubblicato in: Molecular Cancer Research, Numero 18/9, 2020, Pagina/e 1379-1391, ISSN 1541-7786
Editore: American Association for Cancer Research
DOI: 10.1158/1541-7786.mcr-19-1145

Role of coenzymes in cancer metabolism

Autori: Maheshwor Thapa, Guido Dallmann
Pubblicato in: Seminars in Cell & Developmental Biology, Numero 98, 2020, Pagina/e 44-53, ISSN 1084-9521
Editore: Academic Press
DOI: 10.1016/j.semcdb.2019.05.027

Metabolic and non-metabolic pathways that control cancer resistance to anthracyclines

Autori: Tânia Capelôa, Zohra Benyahia, Luca X. Zampieri, Marine C.N.M. Blackman, Pierre Sonveaux
Pubblicato in: Seminars in Cell & Developmental Biology, Numero 98, 2020, Pagina/e 181-191, ISSN 1084-9521
Editore: Academic Press
DOI: 10.1016/j.semcdb.2019.05.006

Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses

Autori: Ivana Kurelac, Luisa Iommarini, Renaud Vatrinet, Laura Benedetta Amato, Monica De Luise, Giulia Leone, Giulia Girolimetti, Nikkitha Umesh Ganesh, Victoria Louise Bridgeman, Luigi Ombrato, Marta Columbaro, Moira Ragazzi, Lara Gibellini, Manuela Sollazzo, Rene Gunther Feichtinger, Silvia Vidali, Maurizio Baldassarre, Sarah Foriel, Michele Vidone, Andrea Cossarizza, Daniela Grifoni, Barbara Kofler, I
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-08839-1

A Humanized Bone Niche Model Reveals Bone Tissue Preservation Upon Targeting Mitochondrial Complex I in Pseudo-Orthotopic Osteosarcoma

Autori: Ivana Kurelac, Ander Abarrategi, Moira Ragazzi, Luisa Iommarini, Nikkitha Umesh Ganesh, Thomas Snoeks, Dominique Bonnet, Anna Maria Porcelli, Ilaria Malanchi, Giuseppe Gasparre
Pubblicato in: Journal of Clinical Medicine, Numero 8/12, 2019, Pagina/e 2184, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm8122184

Pro- and antitumor effects of mitochondrial reactive oxygen species

Autori: Valéry L. Payen, Luca X. Zampieri, Paolo E. Porporato, Pierre Sonveaux
Pubblicato in: Cancer and Metastasis Reviews, Numero 38/1-2, 2019, Pagina/e 189-203, ISSN 0167-7659
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10555-019-09789-2

In Vitro and In Vivo Characterization of MCT1 Inhibitor AZD3965 Confirms Preclinical Safety Compatible with Breast Cancer Treatment

Autori: Zohra Benyahia, Marine C. N. M. Blackman, Loïc Hamelin, Luca X. Zampieri, Tania Capeloa, Marie L. Bedin, Thibaut Vazeille, Olivier Schakman, Pierre Sonveaux
Pubblicato in: Cancers, Numero 13/3, 2021, Pagina/e 569, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030569

Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells

Autori: Ana Carolina B. Sant’Anna-Silva, Juan A. Perez-Valencia, Marco Sciacovelli, Claude Lalou, Saharnaz Sarlak, Laura Tronci, Efterpi Nikitopoulou, Andras T. Meszaros, Christian Frezza, Rodrigue Rossignol, Erich Gnaiger, Helmut Klocker
Pubblicato in: Cancers, Numero 13/7, 2021, Pagina/e 1727, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13071727

Metabolic Drivers in Hereditary Cancer Syndromes

Autori: Marco Sciacovelli, Christina Schmidt, Eamonn R. Maher, Christian Frezza
Pubblicato in: Annual Review of Cancer Biology, Numero 4/1, 2020, Pagina/e 77-97, ISSN 2472-3428
Editore: Annual Rewiew of Cancer Biology
DOI: 10.1146/annurev-cancerbio-030419-033612

The multifaceted contribution of α-ketoglutarate to tumor progression: An opportunity to exploit?

Autori: Houda Abla, Manuela Sollazzo, Giuseppe Gasparre, Luisa Iommarini, Anna Maria Porcelli
Pubblicato in: Seminars in Cell & Developmental Biology, Numero 98, 2020, Pagina/e 26-33, ISSN 1084-9521
Editore: Academic Press
DOI: 10.1016/j.semcdb.2019.05.031

Fumarate hydratase in cancer: A multifaceted tumour suppressor

Autori: Christina Schmidt, Marco Sciacovelli, Christian Frezza
Pubblicato in: Seminars in Cell & Developmental Biology, Numero 98, 2020, Pagina/e 15-25, ISSN 1084-9521
Editore: Academic Press
DOI: 10.1016/j.semcdb.2019.05.002

Ketogenic diet in the treatment of cancer – Where do we stand?

Autori: Daniela D. Weber, Sepideh Aminzadeh-Gohari, Julia Tulipan, Luca Catalano, René G. Feichtinger, Barbara Kofler
Pubblicato in: Molecular Metabolism, Numero 33, 2020, Pagina/e 102-121, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.06.026

The Oncojanus Paradigm of Respiratory Complex I

Autori: Giulia Leone, Houda Abla, Giuseppe Gasparre, Anna Porcelli, Luisa Iommarini
Pubblicato in: Genes, Numero 9/5, 2018, Pagina/e 243, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes9050243

The multifaceted effects of metformin on tumor microenvironment

Autori: Ivana Kurelac, Nikkitha Umesh Ganesh, Maria Iorio, Anna Maria Porcelli, Giuseppe Gasparre
Pubblicato in: Seminars in Cell & Developmental Biology, Numero 98, 2020, Pagina/e 90-97, ISSN 1084-9521
Editore: Academic Press
DOI: 10.1016/j.semcdb.2019.05.010

Mitochondria in cancer

Autori: Debora Grasso, Luca X. Zampieri, Tânia Capelôa, Justine A. Van de Velde, Pierre Sonveaux
Pubblicato in: Cell Stress, Numero 4/6, 2020, Pagina/e 114-146, ISSN 2523-0204
Editore: Shared Science Publishers OG
DOI: 10.15698/cst2020.06.221

Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer

Autori: José M. Matés, Floriana J. Di Paola, José A. Campos-Sandoval, Sybille Mazurek, Javier Márquez
Pubblicato in: Seminars in Cell & Developmental Biology, Numero 98, 2020, Pagina/e 34-43, ISSN 1084-9521
Editore: Academic Press
DOI: 10.1016/j.semcdb.2019.05.012

Mitochondrial Transfer in Cancer: A Comprehensive Review

Autori: Luca X. Zampieri, Catarina Silva-Almeida, Justin D. Rondeau, Pierre Sonveaux
Pubblicato in: International Journal of Molecular Sciences, Numero 22/6, 2021, Pagina/e 3245, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22063245

Targeting Mitochondria in Melanoma

Autori: Sepideh Aminzadeh-Gohari, Daniela D. Weber, Luca Catalano, René G. Feichtinger, Barbara Kofler, Roland Lang
Pubblicato in: Biomolecules, Numero 10/10, 2020, Pagina/e 1395, ISSN 2218-273X
Editore: MDPI AG
DOI: 10.3390/biom10101395

Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells

Autori: Debora Grasso, Hyllana C. D. Medeiros, Luca X. Zampieri, Vanesa Bol, Pierre Danhier, Marike W. van Gisbergen, Caroline Bouzin, Davide Brusa, Vincent Grégoire, Hubert Smeets, Alphons P. M. Stassen, Ludwig J. Dubois, Philippe Lambin, Marie Dutreix, Pierre Sonveaux
Pubblicato in: Frontiers in Pharmacology, Numero 11, 2020, Pagina/e 1-16, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.00263

From old to new — Repurposing drugs to target mitochondrial energy metabolism in cancer

Autori: Sepideh Aminzadeh-Gohari, Daniela D. Weber, Silvia Vidali, Luca Catalano, Barbara Kofler, René G. Feichtinger
Pubblicato in: Seminars in Cell & Developmental Biology, Numero 98, 2020, Pagina/e 211-223, ISSN 1084-9521
Editore: Academic Press
DOI: 10.1016/j.semcdb.2019.05.025

A Shifty Target: Tumor-Initiating Cells and Their Metabolism

Autori: Bezuidenhout, Shoshan
Pubblicato in: International Journal of Molecular Sciences, Numero 20/21, 2019, Pagina/e 5370, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20215370

NDUFS3 depletion permits complex I maturation and reveals TMEM126A/OPA7 as an assembly factor binding the ND4-module intermediate

Autori: Luigi D’Angelo, Elisa Astro, Monica De Luise, Ivana Kurelac, Nikkitha Umesh-Ganesh, Shujing Ding, Ian M. Fearnley, Giuseppe Gasparre, Massimo Zeviani, Anna Maria Porcelli, Erika Fernandez-Vizarra, Luisa Iommarini
Pubblicato in: Cell Reports, Numero 35/3, 2021, Pagina/e 109002, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.109002

Targeted Metabolomics Identifies Plasma Biomarkers in Mice with Metabolically Heterogeneous Melanoma Xenografts

Autori: Daniela D. Weber, Maheshwor Thapa, Sepideh Aminzadeh-Gohari, Anna-Sophia Redtenbacher, Luca Catalano, René G. Feichtinger, Peter Koelblinger, Guido Dallmann, Michael Emberger, Barbara Kofler, Roland Lang
Pubblicato in: Cancers, Numero 13/3, 2021, Pagina/e 434, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030434

Risultati finali

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