Single cell genomic analysis and perturbations of hematopoietic progenitors: Towards a refined model of hematopoiesis

Project Information

HemTree2.0

Grant agreement ID: 724471

DOI

10.3030/724471

Project closed

EC signature date 5 April 2017

Start date 1 October 2017

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Dissecting cellular crosstalk by sequencing physically interacting cells

Author(s): Amir Giladi, Merav Cohen, Chiara Medaglia, Yael Baran, Baoguo Li, Mor Zada, Pierre Bost, Ronnie Blecher-Gonen, Tomer-Meir Salame, Johannes U. Mayer, Eyal David, Franca Ronchese, Amos Tanay & Ido Amit
Published in: Nature Biotechnology, 2020, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-020-0442-2

Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients.

Author(s): Pierre Bost; Amir Giladi; Yang Liu; Yanis Bendjelal; Gang Xu; Eyal David; Ronnie Blecher-Gonen; Merav Cohen; Chiara Medaglia; Hanjie Li; Aleksandra Deczkowska; Shuye Zhang; Benno Schwikowski; Zheng Zhang; Ido Amit
Published in: EISSN: 1097-4172, Issue 1, 2020, ISSN 1097-4172
Publisher: cell press
DOI: 10.1016/j.cell.2020.05.006

XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

Author(s): Aleksandra Deczkowska, Eyal David, Pierluigi Ramadori, Dominik Pfister, Michal Safran, Baoguo Li, Amir Giladi, Diego Adhemar Jaitin, Oren Barboy, Merav Cohen, Ido Yofe, Chamutal Gur, Shir Shlomi-Loubaton, Sandrine Henri, Yousuf Suhail, Mengjie Qiu, Shing Kam, Hila Hermon, Eylon Lahat, Gil Ben Yakov, Oranit Cohen-Ezra, Yana Davidov, Mariya Likhter, David Goitein, Susanne Roth, Achim Weber, Bernard
Published in: Nature Medicine, 2022, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-021-01344-3

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

Author(s): Diego Adhemar Jaitin, Lorenz Adlung, Christoph A. Thaiss, Assaf Weiner, Baoguo Li, Hélène Descamps, Patrick Lundgren, Camille Bleriot, Zhaoyuan Liu, Aleksandra Deczkowska, Hadas Keren-Shaul, Eyal David, Niv Zmora, Shai Meron Eldar, Nir Lubezky, Oren Shibolet, David A. Hill, Mitchell A. Lazar, Marco Colonna, Florent Ginhoux, Hagit Shapiro, Eran Elinav, Ido Amit
Published in: Cell, Issue 178/3, 2019, Page(s) 686-698.e14, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.05.054

Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer

Author(s): Katzenelenbogen Y., Sheban F., Yalin A. Yofe I., Svetlichnyy D., Jaitin D. A., Bornstein C., Moshe A., Keren-Shaul H., Cohen M., Wang S., Li B., David E., Salame T., Weiner A. & Amit I.
Published in: CELL, 2020, ISSN 1097-4172
Publisher: CELL PRESS
DOI: 10.1016/j.cell.2020.06.032

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

Author(s): Keren-Shaul H, Spinrad A, Weiner A, Matcovitch-Natan O, Dvir-Szternfeld R, Ulland TK, David E, Baruch K, Lara-Astaiso D, Toth B, Itzkovitz S, Colonna M, Schwartz M, Amit I
Published in: CELL, Issue 169(7), 2017, Page(s) 276-1290.e17, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.05.018

The interaction of CD4+ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response

Author(s): Merav Cohen, Amir Giladi, Oren Barboy, Pauline Hamon, Baoguo Li, Mor Zada, Anna Gurevich-Shapiro, Cristian Gabriel Beccaria, Eyal David, Barbara B. Maier, Mark Buckup, Iris Kamer, Aleksandra Deczkowska, Jessica Le Berichel, Jair Bar, Matteo Iannacone, Amos Tanay, Miriam Merad & Ido Amit
Published in: Nature Cancer, 2022, ISSN 2662-1347
Publisher: Nature Publishing Group
DOI: 10.1038/s43018-022-00338-5

Single-Cell Genomics: A Stepping Stone for Future Immunology Discoveries

Author(s): Amir Giladi, Ido Amit
Published in: Cell, Issue 172/1-2, 2018, Page(s) 14-21, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.11.011

Spatial reconstruction of immune niches by combining photoactivatable reporters and scRNA-seq

Author(s): Chiara Medaglia, Amir Giladi, Liat Stoler-Barak, Marco De Giovanni, Tomer Meir Salame, Adi Biram, Eyal David, Hanjie Li, Matteo Iannacone, Ziv Shulman, Ido Amit
Published in: Science, Issue 358/6370, 2017, Page(s) 1622-1626, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aao4277

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis

Author(s): Amir Giladi, Franziska Paul, Yoni Herzog, Yaniv Lubling, Assaf Weiner, Ido Yofe, Diego Jaitin, Nina Cabezas-Wallscheid, Regine Dress, Florent Ginhoux, Andreas Trumpp, Amos Tanay, Ido Amit
Published in: Nature Cell Biology, Issue 20/7, 2018, Page(s) 836-846, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-018-0121-4

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

Author(s): Chamutal Bornstein, Shir Nevo, Amir Giladi, Noam Kadouri, Marie Pouzolles, François Gerbe, Eyal David, Alice Machado, Anna Chuprin, Beáta Tóth, Ori Goldberg, Shalev Itzkovitz, Naomi Taylor, Philippe Jay, Valérie S. Zimmermann, Jakub Abramson, Ido Amit
Published in: Nature, Issue 559/7715, 2018, Page(s) 622-626, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0346-1

Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting

Author(s): Merav Cohen, Amir Giladi, Anna-Dorothea Gorki, Dikla Gelbard Solodkin, Mor Zada, Anastasiya Hladik, Andras Miklosi, Tomer-Meir Salame, Keren Bahar Halpern, Eyal David, Shalev Itzkovitz, Tibor Harkany, Sylvia Knapp, Ido Amit
Published in: Cell, Issue 175/4, 2018, Page(s) 1031-1044.e18, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.09.009

Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma

Author(s): Guy Ledergor, Assaf Weiner, Mor Zada, Shuang-Yin Wang, Yael C. Cohen, Moshe E. Gatt, Nimrod Snir, Hila Magen, Maya Koren-Michowitz, Katrin Herzog-Tzarfati, Hadas Keren-Shaul, Chamutal Bornstein, Ron Rotkopf, Ido Yofe, Eyal David, Venkata Yellapantula, Sigalit Kay, Moshe Salai, Dina Ben Yehuda, Arnon Nagler, Lev Shvidel, Avi Orr-Urtreger, Keren Bahar Halpern, Shalev Itzkovitz, Ola Landgren, Jesus S
Published in: Nature Medicine, Issue 24/12, 2018, Page(s) 1867-1876, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-018-0269-2

Single-Cell Analysis of Diverse Pathogen Responses Defines a Molecular Roadmap for Generating Antigen-Specific Immunity

Author(s): Ronnie Blecher-Gonen, Pierre Bost, Kerry L. Hilligan, Eyal David, Tomer Meir Salame, Elsa Roussel, Lisa M. Connor, Johannes U. Mayer, Keren Bahar Halpern, Beáta Tóth, Shalev Itzkovitz, Benno Schwikowski, Franca Ronchese, Ido Amit
Published in: Cell Systems, Issue 8/2, 2019, Page(s) 109-121.e6, ISSN 2405-4712
Publisher: cell press
DOI: 10.1016/j.cels.2019.01.001

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

Author(s): Hanjie Li, Anne M. van der Leun, Ido Yofe, Yaniv Lubling, Dikla Gelbard-Solodkin, Alexander C.J. van Akkooi, Marlous van den Braber, Elisa A. Rozeman, John B.A.G. Haanen, Christian U. Blank, Hugo M. Horlings, Eyal David, Yael Baran, Akhiad Bercovich, Aviezer Lifshitz, Ton N. Schumacher, Amos Tanay, Ido Amit
Published in: Cell, Issue 176/4, 2019, Page(s) 775-789.e18, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.11.043

LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma

Author(s): Chamutal Gur,1,2,14 Shuang-Yin Wang,1,14,* Fadi Sheban,1 Mor Zada,1 Baoguo Li,1 Fadi Kharouf,2 Hagit Peleg,2 Suhail Aamar,2 Adam Yalin,1 Daniel Kirschenbaum,1 Yolanda Braun-Moscovici,3 Diego Adhemar Jaitin,1 Tomer meir-salame, Efrat Hagai, Bjørt K. Kragesteen,Batia Avni,Sigal Grisariu,Chamutal Bornstein,Shir Shlomi-Loubaton,Eyal David,Rony Shreberk-Hassidim,6 Vered Molho-Pessach,6 Dalit Amar,Tome
Published in: CELL, 2022, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.03.011

Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies

Author(s): Merav Cohen, Amir Giladi, Catarina Raposo, Mor Zada, Baoguo Li, Julia Ruckh, Aleksandra Deczkowska, Boaz Mohar,Ravid Shechter, Rachel G. Lichtenstein, Ido Amit , Michal Schwartz
Published in: Life Science Alliance, 2021, ISSN 2575-1077
Publisher: Life Science Alliance LLC
DOI: 10.26508/lsa.202000907