Individualizing statin therapy by using a systems pharmacology decision support algorithm

Publicaciones

Functional in vitro characterization of SLCO1B1 variants and simulation of the clinical pharmacokinetic impact of impaired OATP1B1 function

Autores: Wilma Kiander, Noora Sjöstedt, Riikka Manninen, Liina Jaakkonen, Kati-Sisko Vellonen, Mikko Neuvonen, Mikko Niemi, Seppo Auriola, Heidi Kidron
Publicado en: European Journal of Pharmaceutical Sciences, Edición 176, 2022, Página(s) 106246, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2022.106246

Comparative Hepatic and Intestinal Metabolism and Pharmacodynamics of Statins

Autores: Anne M. Filppula, Päivi Hirvensalo, Heli Parviainen, Vilma E. Ivaska, K. Ivar Lönnberg, Feng Deng, Jenni Viinamäki, Mika Kurkela, Mikko Neuvonen and Mikko Niemi
Publicado en: Drug Metabolism and Disposition, 2021, ISSN 0090-9556
Editor: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/dmd.121.000406

Comparative Hepatic and Intestinal Efflux Transport of Statins

Autores: Feng Deng, Suvi-Kukka Tuomi, Mikko Neuvonen, Päivi Hirvensalo, Sami Kulju, Christoph Wenzel, Stefan Oswald, Anne M. Filppula and Mikko Niemi
Publicado en: Drug Metabolism and Disposition, 2021, ISSN 0090-9556
Editor: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/dmd.121.000430

The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms

Autores: Rhonda M. Cooper-DeHoff,Mikko Niemi,Laura B. Ramsey,Jasmine A. Luzum,E. Katriina Tarkiainen,Robert J. Straka,Li Gong,Sony Tuteja,Russell A. Wilke,Mia Wadelius,Eric A. Larson,Dan M. Roden,Teri E. Klein,Sook Wah Yee,Ronald M. Krauss,Richard M. Turner,Latha Palaniappan,Andrea Gaedigk,Kathleen M. Giacomini,Kelly E. Caudle,Deepak Voora
Publicado en: Clinical Pharmacology & Therapeutics, 2022, ISSN 1532-6535
Editor: The American Society for Clinical Pharmacology and Therapeutics
DOI: 10.1002/cpt.2557

Rhabdomyolysis during concomitant ticagrelor and rosuvastatin: A breast cancer resistance protein‐mediated drug interaction?

Autores: Minna Lehtisalo; Wilma Kiander; Anne M. Filppula; Feng Deng; Heidi Kidron; Mari Korhonen; Johanna Sinkko; Kimmo Koivula; Mikko Niemi
Publicado en: British Journal of Clinical Pharmacology, 2023, Página(s) 2309-2315, ISSN 0306-5251
Editor: Blackwell Publishing Inc.
DOI: 10.1111/bcp.15684

Functional Characterization of Six <i>SLCO1B1</i> (OATP1B1) Variants Observed in Finnish Individuals with a Psychotic Disorder

Autores: Katja Häkkinen; Wilma Kiander; Heidi Kidron; Markku Lähteenvuo; Lea Urpa; Jonne Lintunen; Kati-Sisko Vellonen; Seppo Auriola; Minna Holm; Kaisla Lahdensuo; Olli Kampman; Erkki Isometsä; Tuula Kieseppä; Jouko Lönnqvist; Jaana Suvisaari; Jarmo Hietala; Jari Tiihonen; Aarno Palotie; Ari V. Ahola-Olli; Mikko Niemi
Publicado en: Molecular Pharmaceutics, 2023, ISSN 1543-8384
Editor: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.2c00715

Clinical Studies on Drug–Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls, and Interpretation

Autores: Aleksi Tornio; Anne M. Filppula; Mikko Niemi; Janne T. Backman
Publicado en: Clinical Pharmacology and Therapeutics, 2019, Página(s) 1345-1361, ISSN 0009-9236
Editor: Nature Publishing Group
DOI: 10.1002/cpt.1435

Real-world pharmacogenetics of statin intolerance: effects of SLCO1B1, ABCG2, and CYP2C9 variants

Autores: K. Ivar Lönnberg, Aleksi Tornio, Päivi Hirvensalo, Jenni Keskitalo, Anna-Liina Mustaniemi, Johanna I. Kiiski, Anne M. Filppula, Mikko Niemi
Publicado en: Pharmacogenetics and Genomics, 2023, ISSN 1744-6872
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/fpc.0000000000000504

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