Individualizing statin therapy by using a systems pharmacology decision support algorithm

Publications

Functional in vitro characterization of SLCO1B1 variants and simulation of the clinical pharmacokinetic impact of impaired OATP1B1 function

Auteurs: Wilma Kiander, Noora Sjöstedt, Riikka Manninen, Liina Jaakkonen, Kati-Sisko Vellonen, Mikko Neuvonen, Mikko Niemi, Seppo Auriola, Heidi Kidron
Publié dans: European Journal of Pharmaceutical Sciences, Numéro 176, 2022, Page(s) 106246, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2022.106246

Comparative Hepatic and Intestinal Metabolism and Pharmacodynamics of Statins

Auteurs: Anne M. Filppula, Päivi Hirvensalo, Heli Parviainen, Vilma E. Ivaska, K. Ivar Lönnberg, Feng Deng, Jenni Viinamäki, Mika Kurkela, Mikko Neuvonen and Mikko Niemi
Publié dans: Drug Metabolism and Disposition, 2021, ISSN 0090-9556
Éditeur: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/dmd.121.000406

Comparative Hepatic and Intestinal Efflux Transport of Statins

Auteurs: Feng Deng, Suvi-Kukka Tuomi, Mikko Neuvonen, Päivi Hirvensalo, Sami Kulju, Christoph Wenzel, Stefan Oswald, Anne M. Filppula and Mikko Niemi
Publié dans: Drug Metabolism and Disposition, 2021, ISSN 0090-9556
Éditeur: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/dmd.121.000430

The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms

Auteurs: Rhonda M. Cooper-DeHoff,Mikko Niemi,Laura B. Ramsey,Jasmine A. Luzum,E. Katriina Tarkiainen,Robert J. Straka,Li Gong,Sony Tuteja,Russell A. Wilke,Mia Wadelius,Eric A. Larson,Dan M. Roden,Teri E. Klein,Sook Wah Yee,Ronald M. Krauss,Richard M. Turner,Latha Palaniappan,Andrea Gaedigk,Kathleen M. Giacomini,Kelly E. Caudle,Deepak Voora
Publié dans: Clinical Pharmacology & Therapeutics, 2022, ISSN 1532-6535
Éditeur: The American Society for Clinical Pharmacology and Therapeutics
DOI: 10.1002/cpt.2557

Rhabdomyolysis during concomitant ticagrelor and rosuvastatin: A breast cancer resistance protein‐mediated drug interaction?

Auteurs: Minna Lehtisalo; Wilma Kiander; Anne M. Filppula; Feng Deng; Heidi Kidron; Mari Korhonen; Johanna Sinkko; Kimmo Koivula; Mikko Niemi
Publié dans: British Journal of Clinical Pharmacology, 2023, Page(s) 2309-2315, ISSN 0306-5251
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/bcp.15684

Functional Characterization of Six <i>SLCO1B1</i> (OATP1B1) Variants Observed in Finnish Individuals with a Psychotic Disorder

Auteurs: Katja Häkkinen; Wilma Kiander; Heidi Kidron; Markku Lähteenvuo; Lea Urpa; Jonne Lintunen; Kati-Sisko Vellonen; Seppo Auriola; Minna Holm; Kaisla Lahdensuo; Olli Kampman; Erkki Isometsä; Tuula Kieseppä; Jouko Lönnqvist; Jaana Suvisaari; Jarmo Hietala; Jari Tiihonen; Aarno Palotie; Ari V. Ahola-Olli; Mikko Niemi
Publié dans: Molecular Pharmaceutics, 2023, ISSN 1543-8384
Éditeur: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.2c00715

Clinical Studies on Drug–Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls, and Interpretation

Auteurs: Aleksi Tornio; Anne M. Filppula; Mikko Niemi; Janne T. Backman
Publié dans: Clinical Pharmacology and Therapeutics, 2019, Page(s) 1345-1361, ISSN 0009-9236
Éditeur: Nature Publishing Group
DOI: 10.1002/cpt.1435

Real-world pharmacogenetics of statin intolerance: effects of SLCO1B1, ABCG2, and CYP2C9 variants

Auteurs: K. Ivar Lönnberg, Aleksi Tornio, Päivi Hirvensalo, Jenni Keskitalo, Anna-Liina Mustaniemi, Johanna I. Kiiski, Anne M. Filppula, Mikko Niemi
Publié dans: Pharmacogenetics and Genomics, 2023, ISSN 1744-6872
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/fpc.0000000000000504

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