Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development

Project Information

LinPro

Grant agreement ID: 725780

DOI 10.3030/725780

Project closed

EC signature date 16 November 2017

Start date 1 December 2017

End date 30 November 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 996 030,00

EU contribution € 1 996 030,00

Coordinated by

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
Austria

Publications

Peer reviewed articles (21)

SymposiumThe Logic of Developing Neocortical Circuits in Health and Disease

Author(s): Hanganu-Opatz IL, Butt SJB, Hippenmeyer S, De Marco García NV, Cardin JA, Voytek B, Muotri AR
Published in: The Journal of Neuroscience, 2021, ISSN 1529-2401
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.1655-20.2020

GluD2- and Cbln1-mediated competitive interactions shape the dendritic arbors of cerebellar Purkinje cells

Author(s): Yukari H.Takeo, Andrew Shuster, LinnieJiang, Miley C.Hu, David J.Luginbuhl, Thomas Rülicke, Ximena Contreras, Simon Hippenmeyer, Mark J.Wagner, Surya Ganguli, LiqunLuo
Published in: Neuron, 2021, ISSN 1097-4199
Publisher: Science Direct
DOI: 10.1016/j.neuron.2020.11.028

A genome-wide library of MADM mice for single-cell genetic mosaic analysis

Author(s): Contreras X, Amberg N, Davaatseren A, Hansen AH, Sonntag J, Andersen L, Bernthaler T, Streicher C, Heger A-M, Johnson RL, Schwarz LA, Luo L, Rülicke T, Hippenmeyer S
Published in: Cell Reports, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109274

Clonal analysis of gliogenesis in the cerebral cortex reveals stochastic expansion of glia and cell autonomous responses to Egfr dosage

Author(s): Xuying Zhang, Christine V. Mennicke, Guanxi Xiao, Robert Beattie, Mansoor A. Haider, Simon Hippenmeyer and H. Troy Ghashghaei
Published in: Cells, 2020, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9122662

Oncogenic State and Cell Identity Combinatorially Dictate the Susceptibility of Cells within Glioma Development Hierarchy to IGF1R Targeting

Author(s): Anhao Tian, Bo Kang, Baizhou Li, Biying Qiu, Wenhong Jiang, Fangjie Shao, Qingqing Gao, Rui Liu, Chengwei Cai, Rui Jing, Wei Wang, Pengxiang Chen, Qinghui Liang, Lili Bao, Jianghong Man, Yan Wang, Yu Shi, Jin Li, Minmin Yang, Lisha Wang, Jianmin Zhang, Simon Hippenmeyer, Junming Zhu, Xiuwu Bian, Ying‐Jie Wang, Chong Liu
Published in: Advanced Science, Issue 7/21, 2020, Page(s) 2001724, ISSN 2198-3844
Publisher: Advanced Science
DOI: 10.1002/advs.202001724

Generation and isolation of single cells from mouse brain with mosaic analysis with double markers-induced uniparental chromosome disomy

Author(s): Laukoter, Susanne; Amberg, Nicole ; Pauler, Florian; Hippenmeyer, Simon
Published in: STAR Protocols, 2020, ISSN 2666-1667
Publisher: Cell Press OA
DOI: 10.1016/j.xpro.2020.100215

Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum

Author(s): Zhang T, Liu T, Mora N, Guegan J, Bertrand M, Contreras X, Hansen AH, Streicher C, Anderle M, Danda N, Tiberi L, Hippenmeyer S, Hassan BA.
Published in: Cell Reports, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109208

Tissue-wide Genetic and Cellular Landscape Shapes the Execution of Sequential PRC2 Functions in Neural Stem Cell Lineage Progression

Author(s): Amberg, N., Pauler, FM., Streicher, C. & Hippenmeyer, S.
Published in: Science Advances, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abq1263

Inducible uniparental chromosome disomy to probe genomic imprinting at single-cell level in brain and beyond

Author(s): Florian M.Pauler, Quanah J.Hudson, Susanne Laukoter, Simon Hippenmeyer
Published in: Neurochemistry International, 2021, ISSN 0197-0186
Publisher: Elsevier BV
DOI: 10.1016/j.neuint.2021.104986

A mathematical insight into cell labelling experiments for clonal analysis

Author(s): Noemi Picco, Simon Hippenmeyer, Julio Rodarte, Carmen Streicher, Zoltán Molnár, Philip K. Maini, Thomas E. Woolley
Published in: Journal of Anatomy, 2019, ISSN 0021-8782
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/joa.13001

Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex

Author(s): L. Telley, G. Agirman, J. Prados, N. Amberg, S. Fièvre, P. Oberst, G. Bartolini, I. Vitali, C. Cadilhac, S. Hippenmeyer, L. Nguyen, A. Dayer, D. Jabaudon
Published in: Science, Issue 364/6440, 2019, Page(s) eaav2522, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aav2522

Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members

Author(s): Gonzalo Ortiz-Álvarez, Marie Daclin, Asm Shihavuddin, Pauline Lansade, Aurélien Fortoul, Marion Faucourt, Solène Clavreul, Maria-Eleni Lalioti, Stavros Taraviras, Simon Hippenmeyer, Jean Livet, Alice Meunier, Auguste Genovesio, Nathalie Spassky
Published in: Neuron, Issue 102/1, 2019, Page(s) 159-172.e7, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2019.01.051

Epigenetic cues modulating the generation of cell‐type diversity in the cerebral cortex

Author(s): Nicole Amberg, Susanne Laukoter, Simon Hippenmeyer
Published in: Journal of Neurochemistry, Issue 149/1, 2019, Page(s) 12-26, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14601

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM)

Author(s): Robert Beattie, Carmen Streicher, Nicole Amberg, Giselle Cheung, Ximena Contreras, Andi H. Hansen, Simon Hippenmeyer
Published in: Journal of Visualized Experiments, Issue 159, 2020, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/61147

A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture

Author(s): Alfredo Llorca, Gabriele Ciceri, Robert Beattie, Fong Kuan Wong, Giovanni Diana, Eleni Serafeimidou-Pouliou, Marian Fernández-Otero, Carmen Streicher, Sebastian J Arnold, Martin Meyer, Simon Hippenmeyer, Miguel Maravall, Oscar Marin
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.51381

SCOPES: Sparking Curiosity Through Open-Source Platforms in Education and Science

Author(s): Robert Beattie, Simon Hippenmeyer, Florian M. Pauler
Published in: Frontiers in Education, Issue 5, 2020, ISSN 2504-284X
Publisher: Frontiers in Education
DOI: 10.3389/feduc.2020.00048

Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development

Author(s): Susanne Laukoter, Robert Beattie, Florian M. Pauler, Nicole Amberg, Keiichi I. Nakayama, Simon Hippenmeyer
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-14077-2

Cell-Type Specificity of Genomic Imprinting in Cerebral Cortex

Author(s): Susanne Laukoter, Florian M. Pauler, Robert Beattie, Nicole Amberg, Andi H. Hansen, Carmen Streicher, Thomas Penz, Christoph Bock, Simon Hippenmeyer
Published in: Neuron, Issue 107/6, 2020, Page(s) 1160-1179.e9, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.06.031

Genetic mosaic dissection of candidate genes in mice using mosaic analysis with double markers.

Author(s): Nicole Amberg; Simon Hippenmeyer
Published in: STAR Protocols, Issue 1, 2021, ISSN 2666-1667
Publisher: STAR Protocols
DOI: 10.1016/j.xpro.2021.100939

Simultaneous brain cell type and lineage determined by scRNA-seq reveals stereotyped cortical development

Author(s): Anderson, Donovan J.; Pauler, Florian; Mckenna, Aaron; Shendure, Jay; Hippenmeyer, Simon; Horwitz, Marshall S.
Published in: Cell Systems, 2021, ISSN 2405-4720
Publisher: Cell Press
DOI: 10.1016/j.cels.2022.03.006

HepaCAM controls astrocyte self-organization and coupling

Author(s): Baldwin KT, Tan CX, Strader ST, Jiang C, Savage JT, Elorza-Vidal X, Contreras X, Rülicke T, Hippenmeyer S, Estévez R, Ji R-R, Eroglu C.
Published in: Neuron, 2021, ISSN 1097-4199
Publisher: Cell Press
DOI: 10.1016/j.neuron.2021.05.025

Other (7)

Reduction of neuronal activity mediated by blood-vessel regression in the brain

Author(s): Gao, Xiaofei; Li, Jun-Liszt; Chen, Xingjun; Ci, Bo; Chen, Fei; Lu, Nannan; Shen, Bo; Zheng, Lijun; Jia, Jie-Min; Yi, Yating; Zhang, Shiwen; Shi, Ying-Chao ; Shi, Kaibin ; Propson, Nicholas E ; Huang, Yubin ; Poinsatte, Katherine ; Zhang, Zhaohuan ; Yue, Yuanlei ; Bosco, Dale B ; Lu, Ying-mei ; Yang, Shi-bing ; Adams, Ralf H. ; Lindner, Volkhard ; Huang, Fen ; Wu, Long-Jun ; Zheng, Hui ; Han, Feng
Published in: The Preprint Server for Biology, 2020
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.09.15.262782

Simultaneous Identification of Brain Cell Type and Lineage via Single Cell RNA Sequencing

Author(s): Anderson DJ, Pauler F, McKenna A, Shendure J, Hippenmeyer S, Horwitz MS
Published in: bioRxiv, 2021
Publisher: bioRxiv
DOI: 10.1101/2020.12.31.425016

Tissue-wide Genetic and Cellular Landscape Shapes the Execution of Sequential PRC2 Functions in Neural Stem Cell Lineage Progression

Author(s): Amberg N, Pauler F, Streicher C, Hippenmeyer S
Published in: bioRxiv, 2021
Publisher: bioRxiv
DOI: 10.1101/2022.04.04.487003

Heterogeneous progenitor cell behaviors underlie the assembly of neocortical cytoarchitecture

Author(s): Alfredo Llorca, Gabriele Ciceri, Robert Beattie, Fong K. Wong, Giovanni Diana, Eleni Serafeimidou, Marian Fernández-Otero, Carmen Streicher, Sebastian J. Arnold, Martin Meyer, Simon Hippenmeyer, Miguel Maravall, Oscar Marín
Published in: The Preprint Server for Biology, Issue 494088, 2018
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/494088

Generation of neuronal diversity from common progenitors via Notch signaling in the cerebellum

Author(s): Tingting Zhang, Tengyuan Liu, Natalia Mora, Justine Guegan, Mathilde Bertrand, Ximena Contreras, Andi H. Hansen, Carmen Streicher, Marica Anderle, Luca Tiberi, Simon Hippenmeyer, Bassem A. Hassan
Published in: The Preprint Server for Biology, 2020
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.03.18.997205

A Genome-wide Library of MADM Mice for Single-Cell Genetic Mosaic Analysis

Author(s): Ximena Contreras, Amarbayasgalan Davaatseren, Nicole Amberg, Andi. H. Hansen, Johanna Sonntag, Lill Andersen, Tina Bernthaler, Anna Heger, Randy Johnson, Lindsay A. Schwarz, Liqun Luo, Thomas Rülicke, Simon Hippenmeyer
Published in: The Preprint Server for Biology, 2020
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.06.05.136192

GluD2- and Cbln1-mediated Competitive Synaptogenesis Shapes the Dendritic Arbors of Cerebellar Purkinje Cells

Author(s): Yukari H. Takeo, Andrew S. Shuster, Linnie Jiang, Miley Hu, David J. Luginbuhl, Thomas Rülicke, Ximena Contreras, Simon Hippenmeyer, Mark J. Wagner, Surya Ganguli, Liqun Luo
Published in: The Preprint Server for Biology, 2020
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.06.14.151258