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Understanding pathogen, livestock, environment interactions involving bluetongue virus

Resultado final

Adaptation and maintenance of spatial data website to include PALE-Blu data

D12.5: Adaptation and maintenance of spatial data website to include PALE-Blu data (all Partners). (M12)

Updated website with environment / anthropogenic data

D3.2: Updated website with environmental and anthropogenic data archive and dissemination capabilities (Partner 1, 3, 6, 7, 10, 12). (M12)

Project website

Task 12.4: Establish and maintain project website(s) with regular updates over the project lifetime with all partners contributing new material, with review of the site at every consortium meeting. (all Partners) (M1 to M36)

Archive of standardised and processed spatial data

D3.6: Archive of standardised and processed spatial data for use by WP1, WP3, & WP4 (Partner 1, 3, 6, 7, 10, 12). (M24)

Protocol for collection, shipment and onward processing of Culicoides eggs

D6.1: Protocol for collection, shipment and onward processing of Culicoides eggs (Partner 1,11,13,14,16,18). (M24)

Serotype specific qRT-PCR for novel BTV serotypes

D5.1: Serotype specific qRT-PCR for novel BTV serotypes (Partner 1, 2, 4, 5, 12, 16). (M18)

Established friction surfaces and connectivity matrices

D3.4: Established friction surfaces and connectivity matrices (Partner 1, 3, 6, 7, 10, 12). (M24)

Refined spatial epizone maps

D3.3: Refined spatial epizone maps (Partner 1, 3, 6, 7, 10, 12). (M18)

List of required environmental and landscape factors

D4.1: List of required environmental and landscape factors needed (Partner 3, 6, 7) (with WP3). (M3)

Array system for typing BTV

D5.2: Array based system for typing BTV (Partner 1, 4, 5). (M27)

DISA single BTV serotype protection

D10.5: Report on early protection against one serotype in cattle by mono-serotype DISA vaccination (Partners 9). (M24).

Reassortant strains between conventional and novel / atypical strains

D8.2: Reassortant viruses between conventional (e.g. BTV-1 or BTV-4) and novel/atypical strains (e.g. to explore the genetic basis for horizontal transmission (Partners 1, 2, 4, 5). (M18)

Assess pathogenesis / horizontal transmission of BTV strains

D8.1: An assessment of the the pathogenesis and horizontal transmission characteristics of BTV-8, BTV-26, and other ‘novel’ BTV strains in goats and sheep (Partners 2, 4, 5). (M18)

List of spatial data required

D3.1: A list of spatial data requirements from WP1, (Partners 1, 3, 4, 10). (M3)

A mouse model for horizontal transmission of BTV

D8.3: A mouse model for horizontal transmission of atypical BTV strains between mammalian hosts. (Partners 2). (M24)

Identification of BTV genes that support horizontal transmission in mammalian host.

D8.4: Identification of genome segments of the novel/atypical BTV strains/serotypes that support horizontal transmission in a mammalian host (Partners 1, 2, 4, 5). (M24)

Identification of statin doses that inhibit BTV in cell culture

D11.1: Identification of inhibitory doses of statin molecules on selected BTV strains in cell culture (Partner 2). (M24)

Protocol for successful generation of primary cell cultures from different Culicoides spp.

D6.2: Protocol for successful generation of primary cell cultures from different Culicoides spp. (Partner 1). (M27)

Culicoides host maps

D4.3: Culicoides host maps as determined by available data (Partners 3, 6, 7). (M30)

Spatial data base of vector distributions

D4.2: Spatial data base of vector distributions (Partner 3, 4, 6, 7, 12). (M12)

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Publicaciones

Evaluation of an IGM ‐specific ELISA for early detection of bluetongue virus infections in domestic ruminants sera

Autores: Emmanuel Bréard, Axel Gorlier, Cyril Viarouge, Fabien Donnet, Corinne Sailleau, Claudia Schulz, Bernd Hoffmann, Loic Comtet, Martin Beer, Stéphan Zientara, Damien Vitour
Publicado en: Transboundary and Emerging Diseases, 66/1, 2018, Page(s) 537-545, ISSN 1865-1674
Editor: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.13060

Emerging vectorial diseases: West Nile fever, Bluetongue and Schmallenberg

Autores: S Zientara 1, C Beck 1, S Lecollinet 1
Publicado en: Bulletin de l'Académie nationale de médecine, 2020, ISSN 0001-4079
Editor: Elsevier BV
DOI: 10.1016/j.banm.2020.09.041

Contrasting selective patterns across the segmented genome of bluetongue virus in a global reassortment hotspot

Autores: Maude Jacquot, Pavuluri P Rao, Sarita Yadav, Kyriaki Nomikou, Sushila Maan, Y Krishna Jyothi, Narasimha Reddy, Kalyani Putty, Divakar Hemadri, Karam P Singh, Narender Singh Maan, Nagendra R Hegde, Peter Mertens, Roman Biek
Publicado en: Virus Evolution, 5/2, 2019, ISSN 2057-1577
Editor: Oxford University Press
DOI: 10.1093/ve/vez027

Western Bluetongue virus serotype 3 in Sardinia, diagnosis and characterization.

Autores: Cappai S, Rolesu S, Loi F, Liciardi M, Leone A, Marcacci M, Teodori L, Mangone I, Sghaier S, Portanti O, Savini G, Lorusso A.
Publicado en: Transboundary and Emerging Diseases, 2019 May;66(3):1426-1431., 2019, Page(s) 1426-1431., ISSN 1865-1682
Editor: Wiley
DOI: 10.1111/tbed.13156.

Presence of bluetongue and epizootic hemorrhagic disease viruses in Egypt in 2016 and 2017

Autores: Sahar Ahmed, Mohamed Abd El-Fatah Mahmoud, Cyril Viarouge, Corinne Sailleau, Stephan Zientara, Emmanuel Breard
Publicado en: Infection, Genetics and Evolution, 73, 2019, Page(s) 221-226, ISSN 1567-1348
Editor: Elsevier BV
DOI: 10.1016/j.meegid.2019.04.033

Identifying Spanish Areas at More Risk of Monthly BTV Transmission with a Basic Reproduction Number Approach

Autores: Cecilia Aguilar-Vega, Jaime Bosch, Eduardo Fernández-Carrión, Javier Lucientes, José Manuel Sánchez-Vizcaíno
Publicado en: Viruses, 12/10, 2020, Page(s) 1158, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12101158

Mapping livestock movements in Sahelian Africa

Autores: Camille Jahel, Maxime Lenormand, Ismaila Seck, Andrea Apolloni, Ibra Toure, Coumba Faye, Baba Sall, Mbargou Lo, Cecile Squarzoni Diaw, Renaud Lancelot, Caroline Coste
Publicado en: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-65132-8

Bluetongue Virus in France: An Illustration of the European and Mediterranean Context since the 2000s

Autores: Cindy Kundlacz, Grégory Caignard, Corinne Sailleau, Cyril Viarouge, Lydie Postic, Damien Vitour, Stéphan Zientara, Emmanuel Breard
Publicado en: Viruses, 11/7, 2019, Page(s) 672, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11070672

Modeling Arboviral Infection in Mice Lacking the Interferon Alpha/Beta Receptor

Autores: Alejandro Marín-Lopez, Eva Calvo-Pinilla, Sandra Moreno, Sergio Utrilla-Trigo, Aitor Nogales, Alejandro Brun, Erol Fikrig, Javier Ortego
Publicado en: Viruses, 11/1, 2019, Page(s) 35, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11010035

A low-passage insect-cell isolate of bluetongue virus uses a macropinocytosis-like entry pathway to infect natural target cells derived from the bovine host

Autores: Lisa M. Stevens, Katy Moffat, Lyndsay Cooke, Kyriaki Nomikou, Peter P. C. Mertens, Terry Jackson, Karin E. Darpel
Publicado en: Journal of General Virology, 100/4, 2019, Page(s) 568-582, ISSN 0022-1317
Editor: Society for General Microbiology
DOI: 10.1099/jgv.0.001240

“Frozen evolution” of an RNA virus suggests accidental release as a potential cause of arbovirus re-emergence

Autores: David J. Pascall, Kyriaki Nomikou, Emmanuel Bréard, Stephan Zientara, Ana da Silva Filipe, Bernd Hoffmann, Maude Jacquot, Joshua B. Singer, Kris De Clercq, Anette Bøtner, Corinne Sailleau, Cyril Viarouge, Carrie Batten, Giantonella Puggioni, Ciriaco Ligios, Giovanni Savini, Piet A. van Rijn, Peter P. C. Mertens, Roman Biek, Massimo Palmarini
Publicado en: PLOS Biology, 18/4, 2020, Page(s) e3000673, ISSN 1545-7885
Editor: Plos
DOI: 10.1371/journal.pbio.3000673

Evidence of reduced viremia, pathogenicity and vector competence in a re-emerging European strain of bluetongue virus serotype 8 in sheep.

Autores: Flannery J, Sanz-Bernardo B, Ashby M, Brown H, Carpenter S, Cooke L, Corla A, Frost L, Gubbins S, Hicks H, Qureshi M, Rajko-Nenow P, Sanders C, Tully M, Bréard E, Sailleau C, Zientara S, Darpel K, Batten C.
Publicado en: Transboundary and Emerging Diseases, 2019, ISSN 1865-1682
Editor: Wiley
DOI: 10.1111/tbed.13131.

"""Frozen evolution"" of an RNA virus suggests accidental release as a potential cause of arbovirus re-emergence."

Autores: Pascall DJ, Nomikou K, Bréard E, Zientara S, Filipe ADS, Hoffmann B, Jacquot M, Singer JB, De Clercq K, Bøtner A, Sailleau C, Viarouge C, Batten C, Puggioni G, Ligios C, Savini G, van Rijn PA, Mertens PPC, Biek R, Palmarini M.
Publicado en: PLoS Biology, 2020, ISSN 1545-7885
Editor: Public Library of Science
DOI: 10.1371/journal.pbio.3000673

Continuous Cell Lines from the European Biting Midge Culicoides nubeculosus (Meigen, 1830)

Autores: Lesley Bell-Sakyi, Fauziah Mohd Jaafar, Baptiste Monsion, Lisa Luu, Eric Denison, Simon Carpenter, Houssam Attoui, Peter P. C. Mertens
Publicado en: Microorganisms, 8/6, 2020, Page(s) 825, ISSN 2076-2607
Editor: MDPI.AG
DOI: 10.3390/microorganisms8060825

CD8 T Cell Responses to an Immunodominant Epitope within the Nonstructural Protein NS1 Provide Wide Immunoprotection against Bluetongue Virus in IFNAR −/− Mice

Autores: Alejandro Marín-López, Eva Calvo-Pinilla, Diego Barriales, Gema Lorenzo, Alejandro Brun, Juan Anguita, Javier Ortego
Publicado en: Journal of Virology, 92/16, 2018, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/jvi.00938-18

Bluetongue Serotype 3 in Israel 2013–2018: Clinical Manifestations of the Disease and Molecular Characterization of Israeli Strains

Autores: Natalia Golender, Velizar Bumbarov, Avi Eldar, Alessio Lorusso, Gabriel Kenigswald, Joseph Seffi Varsano, Dan David, Shani Schainin, Ilan Dagoni, Iosef Gur, Alon Kaplan, Anna Gorohov, Ori Koren, Eldad Oron, Yevgeny Khinich, Ily Sclamovich, Abraham Meir, Giovanni Savini
Publicado en: Frontiers in Veterinary Science, 7, 2020, ISSN 2297-1769
Editor: Frontiers Media S.A.
DOI: 10.3389/fvets.2020.00112

Prospects of Next-Generation Vaccines for Bluetongue

Autores: Piet A. van Rijn
Publicado en: Frontiers in Veterinary Science, 6, 2019, Page(s) 407-422, ISSN 2297-1769
Editor: Frontiers Media S.A.
DOI: 10.3389/fvets.2019.00407

BTV antibody longevity in cattle five to eight years post BTV-8 vaccination

Autores: Christina Ries 1, Martin Beer 1, Bernd Hoffmann 2
Publicado en: Vaccine, 2019, ISSN 0264-410X
Editor: Elsevier BV
DOI: 10.1016/j.vaccine.2019.03.082.

Emergence of a Novel Reassortant Strain of Bluetongue Serotype 6 in Israel, 2017: Clinical Manifestations of the Disease and Molecular Characterization

Autores: Natalia Golender 1, Avi Eldar 2, Marcelo Ehrlich 3, Yevgeny Khinich 2, Gabriel Kenigswald 4, Joseph Seffi Varsano 5, Shachar Ertracht 6, Itzik Abramovitz 4, Itay Assis 4, Ily Shlamovitz 4, Eitan Tiomkin 4, Erez Yonay 7, Benny Sharir 4, Velizar Y Bumbarov 2
Publicado en: Viruses, 2019, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11070633.

Quantitative RT-PCR assays for identification and typing of the Equine encephalosis virus

Autores: Sushila Maan, Manjunatha N. Belaganahalli, Narender Singh Maan, Abraham C. Potgieter, Peter P. C. Mertens
Publicado en: Brazilian Journal of Microbiology, 50/1, 2019, Page(s) 287-296, ISSN 1517-8382
Editor: Sociedade Braslleira de Microbiologia/Brazilian Society for Microbiology
DOI: 10.1007/s42770-018-0034-1

Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference

Autores: Maude Jacquot, Kyriaki Nomikou, Massimo Palmarini, Peter Mertens, Roman Biek
Publicado en: Proceedings of the Royal Society B: Biological Sciences, 284/1864, 2017, Page(s) 20170919, ISSN 0962-8452
Editor: Royal Society of London
DOI: 10.1098/rspb.2017.0919

Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Assay for the Rapid Detection of African Horse Sickness Virus

Autores: V. L. Fowler, E. L. A. Howson, J. Flannery, M. Romito, A. Lubisi, M. Agüero, P. Mertens, C. A. Batten, H. R. Warren, J. Castillo-Olivares
Publicado en: Transboundary and Emerging Diseases, 64/5, 2017, Page(s) 1579-1588, ISSN 1865-1674
Editor: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.12549

Replication-Deficient Particles: New Insights into the Next Generation of Bluetongue Virus Vaccines

Autores: Cristina C. Celma, Meredith Stewart, Kerstin Wernike, Michael Eschbaumer, Lorenzo Gonzalez-Molleda, Emmanuel Breard, Claudia Schulz, Bernd Hoffmann, Andy Haegeman, Kris De Clercq, Stephan Zientara, Piet A. van Rijn, Martin Beer, Polly Roy
Publicado en: Journal of Virology, 91/1, 2016, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/JVI.01892-16

PPR Control in a Sahelian Setting: What Vaccination Strategy for Mauritania?

Autores: Ahmed Salem ElArbi, Yaghouba Kane, Raphaelle Metras, Pachka Hammami, Mamadou Ciss, Assane Beye, Renaud Lancelot, Adama Diallo, Andrea Apolloni
Publicado en: Frontiers in Veterinary Science, 6, 2019, ISSN 2297-1769
Editor: Frontiers Media S.A
DOI: 10.3389/fvets.2019.00242

Red deer (Cervus elaphus) Did Not Play the Role of Maintenance Host for Bluetongue Virus in France: The Burden of Proof by Long-Term Wildlife Monitoring and Culicoides Snapshots

Autores: Sophie Rossi, Thomas Balenghien, Cyril Viarouge, Eva Faure, Gina Zanella, Corinne Sailleau, Bruno Mathieu, Jean-Claude Delécolle, Camille Ninio, Claire Garros, Laëtitia Gardès, Christophe Tholoniat, Agnès Ariston, Dominique Gauthier, Stevan Mondoloni, Aurélie Barboiron, Maryline Pellerin, Philippe Gibert, Corinne Novella, Stéphane Barbier, Etienne Guillaumat, Stéphan Zientara, Damien Vitour
Publicado en: Viruses, 11/10, 2019, Page(s) 903, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11100903

The tree that hides the forest: cryptic diversity and phylogenetic relationships in the Palaearctic vector Obsoletus/Scoticus Complex (Diptera: Ceratopogonidae) at the European level

Autores: Antoine Mignotte, Claire Garros, Laetitia Gardès, Thomas Balenghien, Maxime Duhayon, Ignace Rakotoarivony, Laura Tabourin, Léa Poujol, Bruno Mathieu, Adolfo Ibañez-Justicia, Ahmet Deniz, Aleksandar Cvetkovikj, Bethan V. Purse, David W. Ramilo, Despoina Stougiou, Doreen Werner, Dubravka Pudar, Dušan Petrić, Eva Veronesi, Frans Jacobs, Helge Kampen, Isabel Pereira da Fonseca, Javier Lucientes,
Publicado en: Parasites & Vectors, 13/1, 2020, ISSN 1756-3305
Editor: BioMed Central
DOI: 10.1186/s13071-020-04114-1

The possible route of introduction of bluetongue virus serotype 3 into Sicily by windborne transportation of infected Culicoides spp.

Autores: Cecilia Aguilar‐Vega, Eduardo Fernández‐Carrión, José M. Sánchez‐Vizcaíno
Publicado en: Transboundary and Emerging Diseases, 2019, ISSN 1865-1674
Editor: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.13201

A model for the assessment of bluetongue virus serotype 1 persistence in Spain

Autores: Cecilia Aguilar-Vega, Eduardo Fernández-Carrión, Javier Lucientes, José Manuel Sánchez-Vizcaíno
Publicado en: PLOS ONE, 15/4, 2020, Page(s) e0232534, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0232534

Molecular typing of Bluetongue virus using the nCounter® analysis system platform.

Autores: Curini V, Marcacci M, Tonelli A, Di Teodoro G, Di Domenico M, D'Alterio N, Portanti O, Ancora M, Savini G, Panfili M, Camma' C, Lorusso A.
Publicado en: Journal of Virological Methods., 2019, ISSN 0166-0934
Editor: Elsevier BV
DOI: 10.1016/j.jviromet.2019.04.002.

Diversity of Transmission Outcomes Following Co-Infection of Sheep with Strains of Bluetongue Virus Serotype 1 and 8

Autores: Eva Veronesi, Karin Darpel, Simon Gubbins, Carrie Batten, Kyriaki Nomikou, Peter Mertens, Simon Carpenter
Publicado en: Microorganisms, 8/6, 2020, Page(s) 851, ISSN 2076-2607
Editor: MDPI
DOI: 10.3390/microorganisms8060851

Ecological niche modelling to estimate the distribution of Culicoides, potential vectors of bluetongue virus in Senegal

Autores: Mamadou Ciss, Biram Biteye, Assane Gueye Fall, Moussa Fall, Marie Cicille Ba Gahn, Louise Leroux & Andrea Apolloni
Publicado en: BMC Ecology, 2019, ISSN 1472-6785
Editor: BioMed Central
DOI: 10.1186/s12898-019-0261-9

Complete Coding Sequence of a Novel Bluetongue Virus Isolated from a Commercial Sheeppox Vaccine

Autores: Paulina Rajko-Nenow, Natalia Golender, Velizar Bumbarov, Hannah Brown, Lorraine Frost, Karin Darpel, Chandana Tennakoon, John Flannery, Carrie Batten
Publicado en: Microbiology Resource Announcements, 9/10, 2020, ISSN 2576-098X
Editor: American Society for Microbiology
DOI: 10.1128/mra.01539-19

Bluetongue virus outer-capsid protein VP2 expressed in Nicotiana benthamiana raises neutralising antibodies and a protective immune response in IFNAR −/− mice

Autores: Petra C. Fay, Houssam Attoui, Carrie Batten, Fauziah Mohd Jaafar, George P. Lomonossoff, Janet M. Daly, Peter P.C. Mertens
Publicado en: Vaccine: X, 2, 2019, Page(s) 100026, ISSN 2590-1362
Editor: Elsevier
DOI: 10.1016/j.jvacx.2019.100026

Evolutionary stasis of an RNA virus indicates arbovirus re-emergence triggered by accidental release

Autores: David J Pascall, View ORCID ProfileKyriaki Nomikou, Emmanuel Bréard, Stephan Zientara, Ana da Silva Filipe, View ORCID ProfileBernd Hoffmann, View ORCID ProfileMaude Jacquot, View ORCID ProfileJoshua B. Singer, View ORCID ProfileKris De Clercq, Anette Bøtner, Corinne Sailleau, Cyrille Viarouge, Carrie Batten, Giantonella Puggioni, Ciriaco Ligios, Giovanni Savini, Piet A. van Rijn, Peter PC
Publicado en: 2019
Editor: BioRxiv
DOI: 10.1101/2019.12.11.872705