Leistungen
Report on effects of PRRSV infection on S. suis interaction in precision cut lung slices
Report on cost of S. suis infection at the farm levelReport on cost of S suis infection at the farm level
Report on the ‘cornerstone’ species that are predicted to stabilize microbial communities in healthy pigletsReport on ‘cornerstone’ taxa that are predicted to stabilize microbial communities in healthy piglets and species that might protect piglets against S. suis and other pathogens including viruses based on co-occurrence networks
Report on the impact of PRRSV in vivo infection on S. suis co-infectionReport on the impact of PRRSV in vivo infection on S suis coinfection
Report on retrospective data on incidence of S. suis infection in humans in the partner countriesReport on estimated economic losses due to S. suis infection per country
Report on estimated economic losses due to S suis infection per country
Identification of genes required for fitness under in vivo mimicking conditions by Tn-SeqTnSeq technique applied to conditions mimicking those in vivo to identify conditionally essential genes
Report on virulence of selected mutants in porcine infection models.2 most relevant gene mutants verified in virulence in porcine infection model using data from virulence studies in vitro
Report on identified risk factors for S. suis infection of pigsReport on identified risk factors for S suis infection of pigs
Report on the effects of SIV on bacterial adherence and colonization at respiratory epithelia using PCLS and ALI cultures of airway epithelial cellsReport on precise definition of an immune status conferring colonisation resistance against S. suis
Report on precise definition of an immune status conferring colonisation resistance against S suis
Report on the precise definition of porcine immune responses to virulent and non-virulent S. suisReport on the precise definition of porcine immune responses to virulent and nonvirulent S suis
Report on the burden of (zoonotic) disease estimates in humans in the EUReport on the burden of zoonotic disease estimates in humans in the EU
Report on bacterial genes involved in S. suis/SIV interactions in epithelial cellsRReport on S. suis gene expression in blood/CSF vs artificial culture media
Report on gene expression of at least one strain of S. suis under conditions mimicking those in vivo. Information utilised in vaccine and virulence studies.
Report on the deep analysis of the microbiota composition in healthy and S. suis-diseased pigletscharacterise diversity, composition and functional capacities of microbiota and key abundant taxa associated with healthy and disease-associated microbiota communities.
Report of retrospective data on incidence of S. suis infection in pigs in the partner countriesReport on virulence of mutants
Report on the growth and virulence of 4 to 20 mutants in vitro
Report on host genes important for the innate immune response against S. suisReport on host genes important for the innate immune response against S suis
Report on the burden of disease estimates in pigs for the partner countriesReport on PRRSV /SIV on innate immunity of the lower respiratory tract
Report on PRRSV SIV on innate immunity of the lower respiratory tract
Definition of a new generation probiotic product to stabilize the microbiota, support immune system and prevent/reduce risk of S. suis disease in pigs
Definition of a new generation probiotic product comprising 1 or more commensal strains to stabilize the microbiota, support immune system and prevent/reduce risk of S. suis disease in pigs
Public Science Event 1
Presentations to the public at National Science Events or at open days or local science events for the general public
Public Science Event 31 or 2 presentations to the public at National Science Events or at open days or local science events for the general pub
Public Science Event 41 or 2 presentations to the public at National Science Events or at open days or local science events for the general public
Public Science Event 21 or 2 presentations to the public at National Science Events or at open days or local science events for the general pub
Public Science Event 51 or 2 presentations to the public at National Science Events or at open days or local science events for the general pub
Bioinformatic analyses of S. suis genome sequences in database
Molecular epidemiological analysisMolecular epidemiological analysis of S. suis for input into WP6
Collection of isolatesMultinational collection of S. suis isolates for sequencing
Characterisation of Type I and Type III phase variable systemsCharacterisation of phase variable restriction modification systems
Mutants constructed in selected candidate virulence genes in S. suis strainsMutants constructed in selected candidate virulence genes made in two virulent strains of S. suis.
Sequencing of isolate collectionGenome sequencing of around 90% S. suis isolates completed
Final workshop for stakeholdersOne year before the end of the project we will broadly advertise a Final PIGSs Workshop to present the project achievements to the most important stakeholders. The workshop will be an opportunity for politicians, decision makers, scientists and professionals to network, exchange knowledge and discuss the economic, environmental, social, and industrial impacts.
Veröffentlichungen
Autoren:
Neila-Ibáñez, Carlos; Brogaard, Louise; Pailler-García, Lola; Martínez, Jorge; Segalés, Joaquim; Segura, Mariela; Heegaard, Peter M. H.; Aragon, Virginia
Veröffentlicht in:
Neila-Ibanez , C , Brogaard , L , Pailler-Garcia , L , Martinez , J , Segales , J , Segura , M , Heegaard , P M H & Aragon , V 2021 , ' Piglet innate immune response to Streptococcus suis colonization is modulated by the virulence of the strain ' , Veterinary Research , vol. 52 , 145 . https://doi.org/10.1186/s13567-021-01013-w, Ausgabe 15, 2021, ISSN 0928-4249
Herausgeber:
BioMed Central
DOI:
10.1186/s13567-021-01013-w
Autoren:
Florencia Correa-Fiz, Carlos Neila-Ibáñez, Sergio López-Soria, Sebastian Napp, Blanca Martinez, Laia Sobrevia, Simon Tibble, Virginia Aragon, Lourdes Migura-Garcia
Veröffentlicht in:
Scientific Reports, Ausgabe 10/1, 2020, ISSN 2045-2322
Herausgeber:
Nature Publishing Group
DOI:
10.1038/s41598-020-77313-6
Autoren:
Carlos Neila-Ibáñez1,2, Jordi Casal1,2,3, Isabel Hennig-Pauka4,
Norbert Stockhofe-Zurwieden5, Marcelo Gottschalk6, Lourdes Migura-García1,2, LolaPailler-García1,2 andSebastiánNapp1,2*
Veröffentlicht in:
Frontiers in Veterinary Science, 2021, ISSN 2297-1769
Herausgeber:
Frontiers
DOI:
10.3389/fvets.2021.676002
Autoren:
Muriel Dresen; Josephine Schenk; Yenehiwot Berhanu Weldearegay; Désirée Vötsch; Wolfgang Baumgärtner; Peter Valentin-Weigand; Andreas Nerlich
Veröffentlicht in:
Microorganisms, Ausgabe 1, 2021, ISSN 2076-2607
Herausgeber:
MDPI
DOI:
10.17169/refubium-30219
Autoren:
Thomas J. Roodsant, Boas C.L. van der Putten, Sara M. Tamminga, Constance Schultsz, Kees C.H. van der Ark
Veröffentlicht in:
Virulence, 2021, Seite(n) 0-0, ISSN 2150-5594
Herausgeber:
Landes Bioscience
DOI:
10.1080/21505594.2021.1985760
Autoren:
Maria Laura Ferrando, Alex Gussak, Saskia Mentink, Marcela Fernandez Gutierrez, Peter van Baarlen, Jerry Mark Wells
Veröffentlicht in:
Pathogens, Ausgabe 10/2, 2021, Seite(n) 156, ISSN 2076-0817
Herausgeber:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/pathogens10020156
Autoren:
Jesús Arenas, Aldert Zomer, Jose Harders-Westerveen, Hester J. Bootsma, Marien I. De Jonge, Norbert Stockhofe-Zurwieden, Hilde E. Smith, Astrid De Greeff
Veröffentlicht in:
Virulence, Ausgabe 11/1, 2020, Seite(n) 446-464, ISSN 2150-5594
Herausgeber:
Landes Bioscience
DOI:
10.1080/21505594.2020.1764173
Autoren:
Boas C. L. van der Putten, Thomas J. Roodsant, Martin A. Haagmans, Constance Schultsz, Kees C. H. van der Ark
Veröffentlicht in:
Microbiology Resource Announcements, Ausgabe 9/6, 2020, ISSN 2576-098X
Herausgeber:
ASM Journals
DOI:
10.1128/mra.01439-19
Autoren:
Fandan Meng, Jie Tong, Désirée Vötsch, Ju-Yi Peng, Xuehui Cai, Maren Willenborg, Georg Herrler, Nai-Huei Wu, Peter Valentin-Weigand
Veröffentlicht in:
Infection and Immunity, Ausgabe 87/8, 2019, ISSN 0019-9567
Herausgeber:
American Society for Microbiology
DOI:
10.1128/iai.00350-19
Autoren:
Fredriksen S, Guan X, Boekhorst J, Molist F, van Baarlen P, Wells JM
Veröffentlicht in:
BMC, 2022, ISSN 1471-2180
Herausgeber:
BioMed Central
DOI:
10.1186/s12866-022-02625-8
Autoren:
Muriel Dresen; Manfred Rohde; Jesús Arenas; Astrid de Greeff; Andreas Nerlich; Andreas Nerlich; Peter Valentin-Weigand
Veröffentlicht in:
MicrobiologyOpen, 10(5), Ausgabe 17, 2021, ISSN 2045-8827
Herausgeber:
John Wiley and Sons Inc.
DOI:
10.1002/mbo3.1234
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