Obiettivo
The aim of the research is proved to verify the existence of a causal relationship between coalworkers' pneumoconiosis and the onset of lung cancer. If this relationship is proved to exist, the relationship between exposure, smoking and lung cancer will be studied.
The population to be studied will comprise miners and ex-miners (retired miners and men who have left the coal industry for other work) from the Nord-Pas de Calais Coalfield.
The study will include male subjects who have spent at least one year working underground.
The following will be considered as cases :
all new cases of primary lung cancer diagnosed in the Nord-Pas de Calais region over a two-year period who reside in either of the two "departments" of that region and who meet the inclusion criteria described above.
For each case, a control will be selected from the population in question.
METHODS AND MEANS BY WHICH THE AIMS ARE TO BE ACHIEVED
Two types of definition of pneumoconiosis will be used : a medico-legal definition and a radiological definition. The analysis will be performed separately for each of these two definitions.
Smoking habits will be established by means of a survey using the same protocol and same interviewer, who will, as far as possible, be unaware of the subject's status (i. e. case or control) and exposure.
Traditional analysis methods for case-control studies will be used : i. e. analysis for matched cases and controls, stratification to the potentially confusing variables (in particular smoking habits), and multivariate analysis.
Argomento(i)
Data not availableInvito a presentare proposte
Data not availableMeccanismo di finanziamento
CSC - Cost-sharing contractsCoordinatore
75010 PARIS
Francia