EurOPDX Distributed Infrastructure for Research on patient-derived cancer Xenografts

Leistungen

Outline of the information recorded in a “PDX Passport”

This Deliverable relates to Task 2.2.1. All PDX models biobanked for the performance of WP3 and WP4 will be accompanied by a PDX Passport. This information sheet will summarise all relevant information on health status (WP2), as well as ethics (WP5) and minimal information on the model defined under WP1. An outline of the Passport will be drafted at the consensus meeting in M1-M2 and further optimised along the first 6 months of the project. This report will therefore outline the information agreed to be recorded in the PDX Passport.

Summary of the outcome of the two ethics workshops

This deliverable is related to Task 52 and will describe the discussions and outcome of the two ethics workshops organised at M18 and M36 of the project on the side of our GA meetings

Flyer describing the EurOPDX Infrastructure and available resources and services

This deliverable relates to Task 7.1.4. A flyer will be designed to include crucial information about the project, the partners involved, the services provided. Its content will remain general, in order to remain valid during the whole project duration, and provide all useful links to allow users to follow our activities through the website, Data Portal, and our Twitter account and LinkedIn group. The flyer will be available at M20, and its design and content described in this deliverable.

Veröffentlichungen

The EurOPDX Data Portal: an open platform for patient-derived cancer xenograft data sharing and visualization

Autoren: Zdenka Dudová; Nathalie Conte; Jeremy Mason; Dalibor Stuchlík; Radim Peša; Csaba Halmagyi; Zinaida Perova; Abayomi Mosaku; Ross Thorne; Alex Follette; Ľuboslav Pivarč; Radim Šašinka; Muhammad Usman; Steven Neuhauser; Dale A. Begley; Debra M. Krupke; Massimiliano Frassà; Alessandro Fiori; Riccardo Corsi; Luca Vezzadini; Claudio Isella; Andrea Bertotti; Carol Bult; Helen Parkinson; Enzo Medi
Veröffentlicht in: BMC Genomics, Ausgabe 14712164, 2022, ISSN 1471-2164
Herausgeber: BioMed Central
DOI: 10.1186/s12864-022-08367-1

Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models

Autoren: Alice C O'Farrell 1 , Monika A Jarzabek 1 , Andreas U Lindner 2 , Steven Carberry 2 , Emer Conroy 3 , Ian S Miller 1 , Kate Connor 1 , Liam Shiels 1 , Eugenia R Zanella 4 5 , Federico Lucantoni 2 , Adam Lafferty 1 , Kieron White 1 , Mariangela Meyer Meyer Villamandos 2 , Patrick Dicker 6 , William M Gallagher 3 , Simon A Keek 7 , Sebastian Sanduleanu 7 , Philippe Lambin 7 8 ,
Veröffentlicht in: Cancers, Ausgabe 2020, 2020, ISSN 2072-6694
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12102978

Implementing subtype-specific pre-clinical models of breast cancer to study pre-treatment aspirin effects.

Autoren: Ian S. Miller; Sonja Khan; Liam P. Shiels; Sudipto Das; Alice C. O' Farrell; Kate Connor; Adam Lafferty; Bruce Moran; Claudio Isella; Paul Loadman; Emer Conroy; Susan Cohrs; Roger Schibli; Robert S. Kerbel; William M. Gallagher; Elisabetta Marangoni; Kathleen Bennett; Darran P. O' Connor; Róisín M. Dwyer; Annette T. Byrne
Veröffentlicht in: Cancer Medicine, 2022, ISSN 2045-7634
Herausgeber: John Wiley and Sons Ltd
DOI: 10.1002/cam4.4756

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Autoren: Xing Yi Woo, Jessica Giordano, Anuj Srivastava, Zi-Ming Zhao, Michael W. Lloyd, Roebi de Bruijn, Yun-Suhk Suh, Rajesh Patidar, Li Chen, Sandra Scherer, Matthew H. Bailey, Chieh-Hsiang Yang, Emilio Cortes-Sanchez, Yuanxin Xi, Jing Wang, Jayamanna Wickramasinghe, Andrew V. Kossenkov, Vito W. Rebecca, Hua Sun, R. Jay Mashl, Sherri R. Davies, Ryan Jeon, Christian Frech, Jelena Randjelovic, Jacqueline
Veröffentlicht in: Nature Genetics, Ausgabe 53/1, 2021, Seite(n) 86-99, ISSN 1061-4036
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41588-020-00750-6

EGFR Blockade Reverts Resistance to KRAS G12C Inhibition in Colorectal Cancer

Autoren: Vito Amodio, Rona Yaeger, Pamela Arcella, Carlotta Cancelliere, Simona Lamba, Annalisa Lorenzato, Sabrina Arena, Monica Montone, Benedetta Mussolin, Yu Bian, Adele Whaley, Marika Pinnelli, Yonina R. Murciano-Goroff, Efsevia Vakiani, Nicola Valeri, Wei-Li Liao, Anuja Bhalkikar, Sheeno Thyparambil, Hui-Yong Zhao, Elisa de Stanchina, Silvia Marsoni, Salvatore Siena, Andrea Bertotti, Livio Trusolino,
Veröffentlicht in: Cancer Discovery, Ausgabe 10/8, 2020, Seite(n) 1129-1139, ISSN 2159-8274
Herausgeber: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0187

Semalytics: a semantic analytics platform for the exploration of distributed and heterogeneous cancer data in translational research

Autoren: Andrea Mignone, Alberto Grand, Alessandro Fiori, Enzo Medico, Andrea Bertotti
Veröffentlicht in: Database, Ausgabe 2019, 2019, ISSN 1758-0463
Herausgeber: Oxford University Press
DOI: 10.1093/database/baz080

A comprehensive PDX gastric cancer collection captures cancer cell intrinsic transcriptional MSI traits.

Autoren: Simona Corso, Claudio Isella, Sara E Bellomo, Maria Apicella, Stefania Durando, Cristina Migliore, Stefano Ughetto, Laura D'Errico, Silvia Menegon, Daniel Moya-Rull, Marilisa Cargnelutti, Tania Capeloa, Daniela Conticelli, Jessica Giordano, Tiziana Venesio, Antonella Balsamo, Caterina Marchiò, Maurizio Degiuli, Rossella Reddavid, Uberto Fumagalli Romario, Stefano de Pascale, Giovanni Sgroi, Emanu
Veröffentlicht in: Cancer Research, 2019, Seite(n) canres.1166.2019, ISSN 0008-5472
Herausgeber: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-19-1166

Patient-derived xenografts (PDXs) as model systems for human cancer

Autoren: Federica Invrea, Roberta Rovito, Erica Torchiaro, Consalvo Petti, Claudio Isella, Enzo Medico
Veröffentlicht in: Current Opinion in Biotechnology, Ausgabe 63, 2020, Seite(n) 151-156, ISSN 0958-1669
Herausgeber: Elsevier BV
DOI: 10.1016/j.copbio.2020.01.003

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

Autoren: Rachel Eyre, Denis G. Alférez, Angélica Santiago-Gómez, Kath Spence, James C. McConnell, Claire Hart, Bruno M. Simões, Diane Lefley, Claudia Tulotta, Joanna Storer, Austin Gurney, Noel Clarke, Mick Brown, Sacha J. Howell, Andrew H. Sims, Gillian Farnie, Penelope D. Ottewell, Robert B. Clarke
Veröffentlicht in: Nature Communications, Ausgabe 10/1, 2019, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-019-12807-0

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype

Autoren: Barbara Lupo, Francesco Sassi, Marika Pinnelli, Francesco Galimi, Eugenia R. Zanella, Valentina Vurchio, Giorgia Migliardi, Paolo Armando Gagliardi, Alberto Puliafito, Daria Manganaro, Paolo Luraghi, Michael Kragh, Mikkel W. Pedersen, Ivan D. Horak, Carla Boccaccio, Enzo Medico, Luca Primo, Daniel Nichol, Inmaculada Spiteri, Timon Heide, Alexandra Vatsiou, Trevor A. Graham, Elena Élez, Guillem Ar
Veröffentlicht in: Science Translational Medicine, Ausgabe 12/555, 2020, Seite(n) eaax8313, ISSN 1946-6234
Herausgeber: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aax8313

One tool to find them all: a case of data integration and querying in a distributed LIMS platform

Autoren: Alberto Grand, Emanuele Geda, Andrea Mignone, Andrea Bertotti, Alessandro Fiori
Veröffentlicht in: Database, Ausgabe 2019, 2019, ISSN 1758-0463
Herausgeber: Oxford University Press
DOI: 10.1093/database/baz004

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

Autoren: Diane Lefley, Faith Howard, Fawaz Arshad, Steven Bradbury, Hannah Brown, Claudia Tulotta, Rachel Eyre, Denis Alférez, J. Mark Wilkinson, Ingunn Holen, Robert B. Clarke, Penelope Ottewell
Veröffentlicht in: Breast Cancer Research, Ausgabe 21/1, 2019, ISSN 1465-542X
Herausgeber: Springer Nature
DOI: 10.1186/s13058-019-1220-2

Melanoma models for the next generation of therapies

Autoren: E. Elizabeth Patton, Kristen L. Mueller, David J. Adams, Niroshana Anandasabapathy, Andrew E. Aplin, Corine Bertolotto, Marcus Bosenberg, Craig J. Ceol, Ping Chi, Meenhard Herlyn, Sheri L. Holmen, Florian A. Karreth, Charles K. Kaufman, Shaheen Khan, Sebastian Kobold, Eleonora Leucci, Carmit Levy, David B. Lombard, Amanda W. Lund, Kerrie L. Marie, Jean-Christophe Marine, Richard Marais, Martin McM
Veröffentlicht in: Cancer Cell, 2021, ISSN 1535-6108
Herausgeber: Cell Press
DOI: 10.1016/j.ccell.2021.01.011

EurOPDX IT tools to support cancer research with patient-derived xenograft models

Autoren: Enzo Medico, Emilie Vinolo
Veröffentlicht in: Webinar, 2020
Herausgeber: EMBL-EBI
DOI: 10.6019/tol.europdxtools-w.2020.00001.1

EurOPDX Data Portal: a repository of patient-derived xenograft models

Autoren: Enzo Medico, Emilie Vinolo
Veröffentlicht in: Webinar, 2019
Herausgeber: EMBL-EBI
DOI: 10.6019/tol.europdx-w.2019.00001.1

The EurOPDX EDIReX project: Towards a European research infrastructure on patient-derived cancer models

Autoren: E. Medico, M.Bentires-Alj, A. V. Biankin, A. Bruna, A. T. Byrne, C. Caldas, R. B. Clarke, G. Coukos, O. Elemento, M. Hidalgo, G. Inghirami, S. de Jong, J. Jonkers, A. Krenek, E. Leucci, G. M. Maelandsmo, M. Th. Mayrhofer, T. F. Meehan, S. P. Niclou, P. G. Pelicci, A. Piris-Gimenez, L. Price, S. Roman-Roman, L. Trusolino, L. Vezzadini, A. Villanueva, E. Vinolo.
Veröffentlicht in: AACR Annual Meeting 2018 Online Proceedings, 2018
Herausgeber: American Association for Cancer Research

The EurOPDX EDIReX project: towards a European Research Infrastructure on patient-derived cancer models

Autoren: E. Vinolo1, J.P. Morris1, A. Bruna2, A.T. Byrne3, R.B. Clarke4, S. de Jong5, J. Jonkers6, A. Krenek7, G.M. Maelandsmo8, M.T. Mayrhofer9, T.F. Meehan10, P.G. Pelicci11, A. Piris-Gimenez12, L. Price13, L. Rizzotto14, S. Roman-Roman15, F. Sarno16, L. Vezzadini17, A. Villanueva18, E. Medico19. 1Seeding Science SPRL, Limelette, Belgium; 2Cancer Research UK Cambridge Institute, Cambridge Cancer Centre
Veröffentlicht in: European Journal of Cancer, Ausgabe Volume 103S1, November 2018, 2018, Seite(n) 118, ISSN 0959-8049
Herausgeber: Elsevier

Patient-derived 3D tumor cultures for compound screening and pre-clinical drug development

Autoren: Sander Basten, Bram Herpers, Kuan Yan, Julia Schueler, Leo S. Price
Veröffentlicht in: AACR Annual Meeting 2019 Online Proceedings, 2019
Herausgeber: American Association for Cancer Research

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