EurOPDX Distributed Infrastructure for Research on patient-derived cancer Xenografts

Resultado final

Outline of the information recorded in a “PDX Passport”

This Deliverable relates to Task 2.2.1. All PDX models biobanked for the performance of WP3 and WP4 will be accompanied by a PDX Passport. This information sheet will summarise all relevant information on health status (WP2), as well as ethics (WP5) and minimal information on the model defined under WP1. An outline of the Passport will be drafted at the consensus meeting in M1-M2 and further optimised along the first 6 months of the project. This report will therefore outline the information agreed to be recorded in the PDX Passport.

Summary of the outcome of the two ethics workshops

This deliverable is related to Task 52 and will describe the discussions and outcome of the two ethics workshops organised at M18 and M36 of the project on the side of our GA meetings

Flyer describing the EurOPDX Infrastructure and available resources and services

This deliverable relates to Task 7.1.4. A flyer will be designed to include crucial information about the project, the partners involved, the services provided. Its content will remain general, in order to remain valid during the whole project duration, and provide all useful links to allow users to follow our activities through the website, Data Portal, and our Twitter account and LinkedIn group. The flyer will be available at M20, and its design and content described in this deliverable.

Publicaciones

The EurOPDX Data Portal: an open platform for patient-derived cancer xenograft data sharing and visualization

Autores: Zdenka Dudová; Nathalie Conte; Jeremy Mason; Dalibor Stuchlík; Radim Peša; Csaba Halmagyi; Zinaida Perova; Abayomi Mosaku; Ross Thorne; Alex Follette; Ľuboslav Pivarč; Radim Šašinka; Muhammad Usman; Steven Neuhauser; Dale A. Begley; Debra M. Krupke; Massimiliano Frassà; Alessandro Fiori; Riccardo Corsi; Luca Vezzadini; Claudio Isella; Andrea Bertotti; Carol Bult; Helen Parkinson; Enzo Medi
Publicado en: BMC Genomics, Edición 14712164, 2022, ISSN 1471-2164
Editor: BioMed Central
DOI: 10.1186/s12864-022-08367-1

Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models

Autores: Alice C O'Farrell 1 , Monika A Jarzabek 1 , Andreas U Lindner 2 , Steven Carberry 2 , Emer Conroy 3 , Ian S Miller 1 , Kate Connor 1 , Liam Shiels 1 , Eugenia R Zanella 4 5 , Federico Lucantoni 2 , Adam Lafferty 1 , Kieron White 1 , Mariangela Meyer Meyer Villamandos 2 , Patrick Dicker 6 , William M Gallagher 3 , Simon A Keek 7 , Sebastian Sanduleanu 7 , Philippe Lambin 7 8 ,
Publicado en: Cancers, Edición 2020, 2020, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12102978

Implementing subtype-specific pre-clinical models of breast cancer to study pre-treatment aspirin effects.

Autores: Ian S. Miller; Sonja Khan; Liam P. Shiels; Sudipto Das; Alice C. O' Farrell; Kate Connor; Adam Lafferty; Bruce Moran; Claudio Isella; Paul Loadman; Emer Conroy; Susan Cohrs; Roger Schibli; Robert S. Kerbel; William M. Gallagher; Elisabetta Marangoni; Kathleen Bennett; Darran P. O' Connor; Róisín M. Dwyer; Annette T. Byrne
Publicado en: Cancer Medicine, 2022, ISSN 2045-7634
Editor: John Wiley and Sons Ltd
DOI: 10.1002/cam4.4756

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Autores: Xing Yi Woo, Jessica Giordano, Anuj Srivastava, Zi-Ming Zhao, Michael W. Lloyd, Roebi de Bruijn, Yun-Suhk Suh, Rajesh Patidar, Li Chen, Sandra Scherer, Matthew H. Bailey, Chieh-Hsiang Yang, Emilio Cortes-Sanchez, Yuanxin Xi, Jing Wang, Jayamanna Wickramasinghe, Andrew V. Kossenkov, Vito W. Rebecca, Hua Sun, R. Jay Mashl, Sherri R. Davies, Ryan Jeon, Christian Frech, Jelena Randjelovic, Jacqueline
Publicado en: Nature Genetics, Edición 53/1, 2021, Página(s) 86-99, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-020-00750-6

EGFR Blockade Reverts Resistance to KRAS G12C Inhibition in Colorectal Cancer

Autores: Vito Amodio, Rona Yaeger, Pamela Arcella, Carlotta Cancelliere, Simona Lamba, Annalisa Lorenzato, Sabrina Arena, Monica Montone, Benedetta Mussolin, Yu Bian, Adele Whaley, Marika Pinnelli, Yonina R. Murciano-Goroff, Efsevia Vakiani, Nicola Valeri, Wei-Li Liao, Anuja Bhalkikar, Sheeno Thyparambil, Hui-Yong Zhao, Elisa de Stanchina, Silvia Marsoni, Salvatore Siena, Andrea Bertotti, Livio Trusolino,
Publicado en: Cancer Discovery, Edición 10/8, 2020, Página(s) 1129-1139, ISSN 2159-8274
Editor: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0187

Semalytics: a semantic analytics platform for the exploration of distributed and heterogeneous cancer data in translational research

Autores: Andrea Mignone, Alberto Grand, Alessandro Fiori, Enzo Medico, Andrea Bertotti
Publicado en: Database, Edición 2019, 2019, ISSN 1758-0463
Editor: Oxford University Press
DOI: 10.1093/database/baz080

A comprehensive PDX gastric cancer collection captures cancer cell intrinsic transcriptional MSI traits.

Autores: Simona Corso, Claudio Isella, Sara E Bellomo, Maria Apicella, Stefania Durando, Cristina Migliore, Stefano Ughetto, Laura D'Errico, Silvia Menegon, Daniel Moya-Rull, Marilisa Cargnelutti, Tania Capeloa, Daniela Conticelli, Jessica Giordano, Tiziana Venesio, Antonella Balsamo, Caterina Marchiò, Maurizio Degiuli, Rossella Reddavid, Uberto Fumagalli Romario, Stefano de Pascale, Giovanni Sgroi, Emanu
Publicado en: Cancer Research, 2019, Página(s) canres.1166.2019, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-19-1166

Patient-derived xenografts (PDXs) as model systems for human cancer

Autores: Federica Invrea, Roberta Rovito, Erica Torchiaro, Consalvo Petti, Claudio Isella, Enzo Medico
Publicado en: Current Opinion in Biotechnology, Edición 63, 2020, Página(s) 151-156, ISSN 0958-1669
Editor: Elsevier BV
DOI: 10.1016/j.copbio.2020.01.003

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

Autores: Rachel Eyre, Denis G. Alférez, Angélica Santiago-Gómez, Kath Spence, James C. McConnell, Claire Hart, Bruno M. Simões, Diane Lefley, Claudia Tulotta, Joanna Storer, Austin Gurney, Noel Clarke, Mick Brown, Sacha J. Howell, Andrew H. Sims, Gillian Farnie, Penelope D. Ottewell, Robert B. Clarke
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-12807-0

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype

Autores: Barbara Lupo, Francesco Sassi, Marika Pinnelli, Francesco Galimi, Eugenia R. Zanella, Valentina Vurchio, Giorgia Migliardi, Paolo Armando Gagliardi, Alberto Puliafito, Daria Manganaro, Paolo Luraghi, Michael Kragh, Mikkel W. Pedersen, Ivan D. Horak, Carla Boccaccio, Enzo Medico, Luca Primo, Daniel Nichol, Inmaculada Spiteri, Timon Heide, Alexandra Vatsiou, Trevor A. Graham, Elena Élez, Guillem Ar
Publicado en: Science Translational Medicine, Edición 12/555, 2020, Página(s) eaax8313, ISSN 1946-6234
Editor: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aax8313

One tool to find them all: a case of data integration and querying in a distributed LIMS platform

Autores: Alberto Grand, Emanuele Geda, Andrea Mignone, Andrea Bertotti, Alessandro Fiori
Publicado en: Database, Edición 2019, 2019, ISSN 1758-0463
Editor: Oxford University Press
DOI: 10.1093/database/baz004

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

Autores: Diane Lefley, Faith Howard, Fawaz Arshad, Steven Bradbury, Hannah Brown, Claudia Tulotta, Rachel Eyre, Denis Alférez, J. Mark Wilkinson, Ingunn Holen, Robert B. Clarke, Penelope Ottewell
Publicado en: Breast Cancer Research, Edición 21/1, 2019, ISSN 1465-542X
Editor: Springer Nature
DOI: 10.1186/s13058-019-1220-2

Melanoma models for the next generation of therapies

Autores: E. Elizabeth Patton, Kristen L. Mueller, David J. Adams, Niroshana Anandasabapathy, Andrew E. Aplin, Corine Bertolotto, Marcus Bosenberg, Craig J. Ceol, Ping Chi, Meenhard Herlyn, Sheri L. Holmen, Florian A. Karreth, Charles K. Kaufman, Shaheen Khan, Sebastian Kobold, Eleonora Leucci, Carmit Levy, David B. Lombard, Amanda W. Lund, Kerrie L. Marie, Jean-Christophe Marine, Richard Marais, Martin McM
Publicado en: Cancer Cell, 2021, ISSN 1535-6108
Editor: Cell Press
DOI: 10.1016/j.ccell.2021.01.011

EurOPDX IT tools to support cancer research with patient-derived xenograft models

Autores: Enzo Medico, Emilie Vinolo
Publicado en: Webinar, 2020
Editor: EMBL-EBI
DOI: 10.6019/tol.europdxtools-w.2020.00001.1

EurOPDX Data Portal: a repository of patient-derived xenograft models

Autores: Enzo Medico, Emilie Vinolo
Publicado en: Webinar, 2019
Editor: EMBL-EBI
DOI: 10.6019/tol.europdx-w.2019.00001.1

The EurOPDX EDIReX project: Towards a European research infrastructure on patient-derived cancer models

Autores: E. Medico, M.Bentires-Alj, A. V. Biankin, A. Bruna, A. T. Byrne, C. Caldas, R. B. Clarke, G. Coukos, O. Elemento, M. Hidalgo, G. Inghirami, S. de Jong, J. Jonkers, A. Krenek, E. Leucci, G. M. Maelandsmo, M. Th. Mayrhofer, T. F. Meehan, S. P. Niclou, P. G. Pelicci, A. Piris-Gimenez, L. Price, S. Roman-Roman, L. Trusolino, L. Vezzadini, A. Villanueva, E. Vinolo.
Publicado en: AACR Annual Meeting 2018 Online Proceedings, 2018
Editor: American Association for Cancer Research

The EurOPDX EDIReX project: towards a European Research Infrastructure on patient-derived cancer models

Autores: E. Vinolo1, J.P. Morris1, A. Bruna2, A.T. Byrne3, R.B. Clarke4, S. de Jong5, J. Jonkers6, A. Krenek7, G.M. Maelandsmo8, M.T. Mayrhofer9, T.F. Meehan10, P.G. Pelicci11, A. Piris-Gimenez12, L. Price13, L. Rizzotto14, S. Roman-Roman15, F. Sarno16, L. Vezzadini17, A. Villanueva18, E. Medico19. 1Seeding Science SPRL, Limelette, Belgium; 2Cancer Research UK Cambridge Institute, Cambridge Cancer Centre
Publicado en: European Journal of Cancer, Edición Volume 103S1, November 2018, 2018, Página(s) 118, ISSN 0959-8049
Editor: Elsevier

Patient-derived 3D tumor cultures for compound screening and pre-clinical drug development

Autores: Sander Basten, Bram Herpers, Kuan Yan, Julia Schueler, Leo S. Price
Publicado en: AACR Annual Meeting 2019 Online Proceedings, 2019
Editor: American Association for Cancer Research

Resultado final

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