HARMONIzation and integrative analysis of regional, national and international Cohorts on primary Sjögren’s Syndrome (pSS) towards improved stratification, treatment and health policy making

Información del proyecto

HarmonicSS

Identificador del acuerdo de subvención: 731944

DOI

10.3030/731944

Proyecto cerrado

Fecha de la firma de la CE 1 Diciembre 2016

Fecha de inicio 1 Enero 2017

Fecha de finalización 31 Diciembre 2020

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 10 193 125,00

Aportación de la UE

€ 9 998 750,00

Coordinado por

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Other (3)

Project dissemination material 2

Dissemination material (website, lay summary, social media accounts, posters) and updates

Project dissemination material

Dissemination material (website, lay summary, social media accounts, posters) and updates

Project dissemination material 3

Dissemination material (website, lay summary, social media accounts, posters) and updates

Documents, reports (13)

Formulation of common clinical practices, guidelines and rules

It includes the results of the Task 6.5

Dissemination plan and activities 2

The dissemination plan and its updates, along with the dissemination activities of the consortium

The sustainability and expandability plan

First version of the plan of the HarmonicSS consortium for sustainability beyond the project end and expandability to other domains

Data management plan

The plan for using the data to be collected in the integrative cohort, in terms of availability and access

Requirements of the HarmonicSS platform

Report of the user requirement collection process along with the detailed requirements of clinicians, researchers and health policy makers

The second version of the core services of the platform

Includes manual and prototype of all services of the WP, along with usability evaluation results and refinements based on them, integrated in the cloud platform

Results of the clinical and research pSS unmet needs

It includes the outcomes of the tasks 6.1, 6.2 and 6.3

Dissemination plan and activities

The dissemination plan and its updates, along with the dissemination activities of the consortium

The first version of the core services of the platform

Includes manual and prototype of all services of the WP

Report on geographical variations in current clinical practice and scientific evidence

It includes the outcome of Task 6.4

Report on the application of the health policy and process evaluation

In two health regions and preliminary results regarding improvements in selected indicators that demonstrate progress toward defined impact

Ethical, legal, privacy and IPR requirements for data sharing and clinical trials
The sustainability and expandability plan 2

Second version of the plan of the HarmonicSS consortium for sustainability beyond the project end and expandability to other domains

Publicaciones

Peer reviewed articles (33)

Salivary Gland Ultrasonography in Sjögren's Syndrome: A European Multicenter Reliability Exercise for the HarmonicSS Project

Autores: Alen Zabotti, Sara Zandonella Callegher, Annarita Tullio, Arso Vukicevic, Alojzija Hocevar, Vera Milic, Giacomo Cafaro, Marina Carotti, Konstantina Delli, Orazio De Lucia, Diana Ernst, Francesco Ferro, Angelica Gattamelata, Giuseppe Germanò, Ivan Giovannini, Daniel Hammenfors, Malin V. Jonsson, Sandrine Jousse-Joulin, Pierluigi Macchioni, Simone Parisi, Carlo Perricone, Martin Helmut Stradner, Ne
Publicado en: Frontiers in Medicine, Edición 7, 2020, ISSN 2296-858X
Editor: Frontiers Media S.A.
DOI: 10.3389/fmed.2020.581248

A Training Tool to support the management and diagnosis of Sjögren's syndrome

Autores: Chariklia Chatzaki, Andreas Goules, Salvatore De Vita, Alen Zabotti, Christine Delporte, Muhammad S Soyfoo, Francesca Barone, Benjamin A Fisher, Pilar Brito-Zerón, Elena Bartoloni, Clio P Mavragani, Dimitrios I Fotiadis, Athanasios G Tzioufas, Manolis Tsiknakis
Publicado en: Clinical and Experimental Rheumatology, Edición 2020 Vol.38, N°4 ,Suppl.126, 2020, ISSN 1593-098X
Editor: Clinical and Experimental Rheumatology

Update on Sjögren’s Syndrome 2018

Autores: Ourania D Argyropoulou, Athanasios G Tzioufas
Publicado en: Mediterranean Journal of Rheumatology, Edición 29/4, 2018, Página(s) 193-198, ISSN 2529-198X
Editor: Mediterranean Journal of Rheumatology
DOI: 10.31138/mjr.29.4.193

Epigenetic alterations in Sjögren’s syndrome patient saliva

Autores: P. Karagianni, A. V. Goules, A. G. Tzioufas
Publicado en: Clinical & Experimental Immunology, Edición 202/2, 2020, Página(s) 137-143, ISSN 0009-9104
Editor: Blackwell Publishing Inc.
DOI: 10.1111/cei.13492

Unraveling Human AQP5-PIP Molecular Interaction and Effect on AQP5 Salivary Glands Localization in SS Patients

Autores: Clara Chivasso, Veronika Nesverova, Michael Järvå, Anne Blanchard, Kristie L Rose, Fredrik Kryh Öberg, Zhen Wang, Maud Martin, Florent Lhotellerie, Egor Zindy, Bruna Junqueira, Karelle Leroy, Benoit Vanhollebeke, Valérie Delforge, Nargis Bolaky, Jason Perret, Muhammad Shahnawaz Soyfoo, Stefania Moscato, Chiara Baldini, François Chaumont, Letizia Mattii, Kevin L Schey, Yvonne Myal, Susanna Tö
Publicado en: Cells, Edición 10/8, 2021, Página(s) 2108, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10082108

Autophagy occurs in lymphocytes infiltrating Sjögren’s syndrome minor salivary glands and correlates with histological severity of salivary gland lesions

Autores: Serena Colafrancesco, Marta Vomero, Valentina Iannizzotto, Antonina Minniti, Cristiana Barbati, Francesca Arienzo, Linda Mastromanno, Tania Colasanti, Raffaella Izzo, Saba Nayar, Elena Pipi, Bruna Cerbelli, Carla Giordano, Francesco Ciccia, Fabrizio Conti, Guido Valesini, Francesca Barone, Roberta Priori, Cristiano Alessandri
Publicado en: Arthritis Research & Therapy, Edición 22/1, 2020, ISSN 1478-6362
Editor: BioMed Central
DOI: 10.1186/s13075-020-02317-6

Current State of Knowledge on Primary Sjögren’s Syndrome, an Autoimmune Exocrinopathy

Autores: Dorian Parisis, Clara Chivasso, Jason Perret, Muhammad Shahnawaz Soyfoo, Christine Delporte
Publicado en: Journal of Clinical Medicine, Edición 9/7, 2020, Página(s) 2299, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9072299

Insight into Salivary Gland Aquaporins

Autores: Claudia D’Agostino, Osama A. Elkashty, Clara Chivasso, Jason Perret, Simon D. Tran, Christine Delporte
Publicado en: Cells, Edición 9/6, 2020, Página(s) 1547, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells9061547

Enhancing medical data quality through data curation: a case study in primary Sjögren’s syndrome

Autores: V.C. Pezoulas1, K.D. Kourou2, F. Kalatzis3, T.P. Exarchos4, A.I. Venetsanopoulou5, E. Zampeli6, S. Gandolfo7, F.N. Skopouli8, S. De Vita9, A.G. Tzioufas10, D.I. Fotiadis11
Publicado en: Clinical and Experimental Rheumatology, 2019, ISSN 0392-856X
Editor: Pacini Editore SpA

Insight into the mammalian aquaporin interactome

Autores: Törnroth-Horsefield, S., Chivasso, C., Strandberg, H., D'Agostino, C., O'Neale, C. V., Schey, K. L., & Delporte, C.
Publicado en: International journal of molecular sciences, Edición 23,9615, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23179615

Anti-Ro52 and/or anti-Ro60 immune reactivity: autoantibody and disease associations

Autores: Evangelia Zampeli, Maria Mavrommati, Haralampos M Moutsopoulos, Fotini N Skopouli
Publicado en: Clinical and experimental Rheumatology, 2020, ISSN 0392-856X
Editor: Pacini Editore SpA

A Training Tool to support the management and diagnosis of Sjögren's syndrome

Autores: Chatzaki, Chariklia; Goules, Andreas; De Vita, Salvatore; Zabotti, Alen; Delporte, Christine; Soyfoo, Muhammad S; Barone, Francesca; Fisher, Benjamin A; Brito-Zerón, Pilar; Bartoloni, Elena; Mavragani, Clio P; Fotiadis, Dimitrios I; Tzioufas, Athanasios G; Tsiknakis, Manolis
Publicado en: Clinical and Experimental Rheumatology 38(4-126) 0174-0179, Edición 10, 2020, ISSN 0392-856X
Editor: Pacini Editore SpA
DOI: 10.5281/zenodo.4332049

Addressing the clinical unmet needs in primary Sjögren’s Syndrome through the sharing, harmonization and federated analysis of 21 European cohorts

Autores: Pezoulas, Vasileios C;Goules, Andreas;Kalatzis, Fanis;Chatzis, Luke;Kourou, Konstantina D;Venetsanopoulou, Aliki;Exarchos, Themis P;Gandolfo, Saviana;Votis, Konstantinos;Zampeli, Evi;Baurmeister, Jan;Thorsten, May;Pérez, Manuel M;Lishchuk, Iryna;Chondrogiannis, Thymios;Andronikou, Vassiliki;Varvarigou, Theodora;Filipovic, Nenad;Tsiknakis, Manolis;Baldini, Chiara;Bombardieri, Michele;Bootsma, Hend
Publicado en: Computational and Structural Biotechnology Journal, Edición Volume 20, 2022, 2022, Página(s) 471-484, ISSN 2001-0370
Editor: Elsevier
DOI: 10.1016/j.csbj.2022.01.002

Primary Sjögren’s Syndrome of Early and Late Onset: Distinct Clinical Phenotypes and Lymphoma Development

Autores: Andreas V. Goules, Ourania D. Argyropoulou, Vasileios C. Pezoulas, Loukas Chatzis, Elena Critselis, Saviana Gandolfo, Francesco Ferro, Marco Binutti, Valentina Donati, Sara Zandonella Callegher, Aliki Venetsanopoulou, Evangelia Zampeli, Maria Mavrommati, Paraskevi V. Voulgari, Themis Exarchos, Clio P. Mavragani, Chiara Baldini, Fotini N. Skopouli, Dimitrios I. Fotiadis, Salvatore De Vita, Haralamp
Publicado en: Frontiers in Immunology, Edición 11, 2020, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.594096

Fitness for purpose of routinely recorded health data to identify patients with complex diseases: The case of Sjögren's syndrome

Autores: Sytske Wiegersma, Linda E. Flinterman, Chiara Seghieri, Chiara Baldini, John Paget, Jaime Barrio Cortés, Robert A. Verheij
Publicado en: Learning Health Systems, Edición 4/4, 2020, ISSN 2379-6146
Editor: Wiley
DOI: 10.1002/lrh2.10242

Oral microbiota in autoimmune polyendocrine syndrome type 1

Autores: Øyvind Bruserud, Huma Siddiqui, Mihaela Cuida Marthinussen, Tsute Chen, Roland Jonsson, Bergithe Eikeland Oftedal, Ingar Olsen, Eystein Sverre Husebye, Anette Bøe Wolff
Publicado en: Journal of Oral Microbiology, Edición 10/1, 2018, Página(s) 1442986, ISSN 2000-2297
Editor: Co-Action Publishing
DOI: 10.1080/20002297.2018.1442986

Low miR200b-5p levels in minor salivary glands: a novel molecular marker predicting lymphoma development in patients with Sjögren’s syndrome

Autores: Efstathia K Kapsogeorgou, Aristea Papageorgiou, Athanase D Protogerou, Michael Voulgarelis, Athanasios G Tzioufas
Publicado en: Annals of the Rheumatic Diseases, 2018, Página(s) annrheumdis-2017-212639, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2017-212639

Current views on the pathogenesis of Sjögrenʼs syndrome

Autores: Elena Pontarini, Davide Lucchesi, Michele Bombardieri
Publicado en: Current Opinion in Rheumatology, Edición 30/2, 2018, Página(s) 215-221, ISSN 1040-8711
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/BOR.0000000000000473

Aberrant cell signalling in PBMCs upon IFN-α stimulation in primary Sjögren's syndrome patients associates with type I interferon signature

Autores: Richard Davies, Daniel Hammenfors, Brith Bergum, Petra Vogelsang, Sonia Gavasso, Johan G. Brun, Roland Jonsson, Silke Appel
Publicado en: European Journal of Immunology, Edición 48/7, 2018, Página(s) 1217-1227, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201747213

Patients with Primary Sjögren's Syndrome Have Alterations in Absolute Quantities of Specific Peripheral Leucocyte Populations

Autores: R. Davies, D. Hammenfors, B. Bergum, K. Jakobsen, M. Solheim, P. Vogelsang, J. G. Brun, Y. Bryceson, R. Jonsson, S. Appel
Publicado en: Scandinavian Journal of Immunology, Edición 86/6, 2017, Página(s) 491-502, ISSN 0300-9475
Editor: Blackwell Publishing Inc.
DOI: 10.1111/sji.12622

Different operators and histologic techniques in the assessment of germinal center-like structures in primary Sjögren’s syndrome minor salivary glands

Autores: Francesco Carubbi, Alessia Alunno, Paola Cipriani, Gino Coletti, Barbara Bigerna, Mirko Manetti, Paola Di Benedetto, Onelia Bistoni, Gianluca Cipolloni, Vasiliki Liakouli, Piero Ruscitti, Elena Bartoloni, Roberto Giacomelli, Roberto Gerli
Publicado en: PLOS ONE, Edición 14/1, 2019, Página(s) e0211142, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0211142

Juvenile Sjögren's Syndrome: Clinical Characteristics With Focus on Salivary Gland Ultrasonography

Autores: Daniel S. Hammenfors, Valéria Valim, Blanca E. R. G. Bica, Sandra G. Pasoto, Vibke Lilleby, Juan Carlos Nieto‐González, Clovis A. Silva, Esther Mossel, Rosa M. R. Pereira, Aline Coelho, Hendrika Bootsma, Akaluck Thatayatikom, Johan G. Brun, Malin V. Jonsson
Publicado en: Arthritis Care & Research, Edición 72/1, 2019, Página(s) 78-87, ISSN 2151-464X
Editor: John Wiley & Sons Inc.
DOI: 10.1002/acr.23839

Single Cell Based Phosphorylation Profiling Identifies Alterations in Toll-Like Receptor 7 and 9 Signaling in Patients With Primary Sjögren's Syndrome

Autores: Richard Davies, Irene Sarkar, Daniel Hammenfors, Brith Bergum, Petra Vogelsang, Silje M. Solberg, Sonia Gavasso, Johan G. Brun, Roland Jonsson, Silke Appel
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers In Immunology
DOI: 10.3389/fimmu.2019.00281

Epigenetically quantified immune cells in salivary glands of Sjögren’s syndrome patients: a novel tool that detects robust correlations of T follicular helper cells with immunopathology

Autores: Sofie L M Blokland, Fréderique M van Vliet-Moret, Maarten R Hillen, Aridaman Pandit, Roel Goldschmeding, Aike A Kruize, Gerben Bouma, André van Maurik, Sven Olek, Ulrich Hoffmueller, Joel A G van Roon, Timothy R D J Radstake
Publicado en: Rheumatology, Edición 59/2, 2019, Página(s) 335-343, ISSN 1462-0324
Editor: Oxford University Press
DOI: 10.1093/rheumatology/kez268

Additive immunosuppressive effect of leflunomide and hydroxychloroquine supports rationale for combination therapy for Sjögren’s syndrome

Autores: Eefje HM van der Heijden, Sarita AY Hartgring, Aike A Kruize, Timothy RDJ Radstake, Joel AG van Roon
Publicado en: Expert Review of Clinical Immunology, Edición 15/7, 2019, Página(s) 801-808, ISSN 1744-666X
Editor: Future Drugs Ltd.
DOI: 10.1080/1744666x.2019.1624527

Involvement of Aquaporins in the Pathogenesis, Diagnosis and Treatment of Sjögren’s Syndrome

Autores: Muhammad Soyfoo, Clara Chivasso, Jason Perret, Christine Delporte
Publicado en: International Journal of Molecular Sciences, Edición 19/11, 2018, Página(s) 3392, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19113392

Predicting Lymphoma Development by Exploiting Genetic Variants and Clinical Findings in a Machine Learning-Based Methodology With Ensemble Classifiers in a Cohort of Sjögren's Syndrome Patients

Autores: Konstantina D. Kourou, Earalampos M. Moutsopoulos, Clio Mavragani, Dimitrios I. Fotiadis, Vasileios C. Pezoulas, Eleni I. Georga, Themis Exarchos, Costas Papaloukas, Michalis Voulgarelis, Andreas Goules, Andrianos Nezos, Athanasios G. Tzioufas
Publicado en: IEEE Open Journal of Engineering in Medicine and Biology, Edición 1, 2020, Página(s) 49-56, ISSN 2644-1276
Editor: IEEE OJEMB
DOI: 10.1109/ojemb.2020.2965191

CXCL13 as biomarker for histological involvement in Sjögren’s syndrome

Autores: Serena Colafrancesco, Roberta Priori, Charlotte G Smith, Antonina Minniti, Valentina Iannizzotto, Elena Pipi, Davide Lucchesi, Elena Pontarini, Saba Nayar, Joana Campos, Francesca Arienzo, Massimo Fusconi, Bruna Cerbelli, Carla Giordano, Guido Valesini, Michele Bombardieri, Benjamin A Fisher, Francesca Barone
Publicado en: Rheumatology, Edición 59/1, 2019, Página(s) 165-170, ISSN 1462-0324
Editor: Oxford University Press
DOI: 10.1093/rheumatology/kez255

Radiomics-based assessment of Primary Sjogren's Syndrome from salivary gland ultrasonography images

Autores: Arso M. Vukicevic, Nenad Filipovic, Vera Milic, Alen Zabotti, Alojzija Hocevar, Orazio Di Lucia, Georgios Filippou, Salvatore De Vita, Alejandro F. Frangi, Athanasios Tzioufas
Publicado en: IEEE Journal of Biomedical and Health Informatics, 2018, Página(s) 1-1, ISSN 2168-2194
Editor: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/jbhi.2019.2923773

Ezrin Is a Novel Protein Partner of Aquaporin-5 in Human Salivary Glands and Shows Altered Expression and Cellular Localization in Sjögren’s Syndrome

Autores: Clara Chivasso, Carl Johan Hagströmer, Kristie L. Rose, Florent Lhotellerie, Lionel Leblanc, Zhen Wang, Stefania Moscato, Clément Chevalier, Egor Zindy, Maud Martin, Benoit Vanhollebeke, Françoise Gregoire, Nargis Bolaky, Jason Perret, Chiara Baldini, Muhammad Shahnawaz Soyfoo, Letizia Mattii, Kevin L. Schey, Susanna Törnroth-Horsefield, Christine Delporte
Publicado en: International Journal of Molecular Sciences, Edición 22/17, 2021, Página(s) 9213, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22179213

The Involvement of Innate and Adaptive Immunity in the Initiation and Perpetuation of Sjögren’s Syndrome

Autores: Clara Chivasso, Julie Sarrand, Jason Perret, Christine Delporte, Muhammad Shahnawaz Soyfoo
Publicado en: International Journal of Molecular Sciences, Edición 22/2, 2021, Página(s) 658, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020658

Current concepts on Sjögren's syndrome – classification criteria and biomarkers

Autores: Roland Jonsson, Karl A. Brokstad, Malin V. Jonsson, Nicolas Delaleu, Kathrine Skarstein
Publicado en: European Journal of Oral Sciences, Edición 126/S1, 2018, Página(s) 37-48, ISSN 0909-8836
Editor: Blackwell Publishing Inc.
DOI: 10.1111/eos.12536

TNFAIP3 F127C Coding Variation in Greek Primary Sjogren’s Syndrome Patients

Autores: Adrianos Nezos, Eliona Gkioka, Michael Koutsilieris, Michael Voulgarelis, Athanasios G. Tzioufas, Clio P. Mavragani
Publicado en: Journal of Immunology Research, Edición 2018, 2018, Página(s) 1-8, ISSN 2314-8861
Editor: Hindawi Publishing Corporation
DOI: 10.1155/2018/6923213

Conference proceedings (3)

Radiomics-based assessment of Primary Sjögren’s Syndrome from salivary gland ultrasonography

Autores: Arso Vukicevic, Vera Milic, Bojana Andjelkovic-Cirkovic, Alen Zabotti, Salvatore de Vita, Alejandro F. Frangi, Nenad Filipovic
Publicado en: 2018
Editor: 21st International conference on medical image computing & computer assisted intervention

AB0166 ENHANCING THE QUALITY OF CLINICAL DATA THROUGH DATA CURATION IN PRIMARY SJöGREN’S SYNDROME

Autores: Vasileios Pezoulas, Themis Exarchos, Aliki Venetsanopoulou, Evangelia Zampeli, Saviana Gandolfo, Salvatore De Vita, Foteini N. Skopouli, Athanasios Tzioufas, Dimitrios Fotiadis
Publicado en: Abstracts Accepted for Publication, 2019, Página(s) 1541.2-1542
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2019-eular.4139

Predicting lymphoma outcomes and risk factors in patients with primary Sjögren’s Syndrome using gradient boosting tree ensembles

Autores: Vasileios C. Pezoulas, Themis P. Exarchos, Athanasios G. Tzioufas, Salvatore De Vita, Dimitrios I. Fotiadis
Publicado en: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, Página(s) 2165-2168, ISBN 978-1-5386-1311-5
Editor: IEEE
DOI: 10.1109/embc.2019.8857557