HARMONIzation and integrative analysis of regional, national and international Cohorts on primary Sjögren’s Syndrome (pSS) towards improved stratification, treatment and health policy making

Deliverables

Other (3)

Project dissemination material 2

Dissemination material (website, lay summary, social media accounts, posters) and updates

Project dissemination material

Dissemination material (website, lay summary, social media accounts, posters) and updates

Project dissemination material 3

Dissemination material (website, lay summary, social media accounts, posters) and updates

Documents, reports (13)

Formulation of common clinical practices, guidelines and rules

It includes the results of the Task 6.5

Dissemination plan and activities 2

The dissemination plan and its updates, along with the dissemination activities of the consortium

The sustainability and expandability plan

First version of the plan of the HarmonicSS consortium for sustainability beyond the project end and expandability to other domains

Data management plan

The plan for using the data to be collected in the integrative cohort, in terms of availability and access

Requirements of the HarmonicSS platform

Report of the user requirement collection process along with the detailed requirements of clinicians, researchers and health policy makers

The second version of the core services of the platform

Includes manual and prototype of all services of the WP, along with usability evaluation results and refinements based on them, integrated in the cloud platform

Results of the clinical and research pSS unmet needs

It includes the outcomes of the tasks 6.1, 6.2 and 6.3

Dissemination plan and activities

The dissemination plan and its updates, along with the dissemination activities of the consortium

The first version of the core services of the platform

Includes manual and prototype of all services of the WP

Report on geographical variations in current clinical practice and scientific evidence

It includes the outcome of Task 6.4

Report on the application of the health policy and process evaluation

In two health regions and preliminary results regarding improvements in selected indicators that demonstrate progress toward defined impact

Ethical, legal, privacy and IPR requirements for data sharing and clinical trials

Ethical, legal, privacy and IPR requirements for data sharing and clinical trials

The sustainability and expandability plan 2

Second version of the plan of the HarmonicSS consortium for sustainability beyond the project end and expandability to other domains

Publications

Peer reviewed articles (63)

Salivary Gland Ultrasonography in Sjögren's Syndrome: A European Multicenter Reliability Exercise for the HarmonicSS Project

Author(s): Alen Zabotti, Sara Zandonella Callegher, Annarita Tullio, Arso Vukicevic, Alojzija Hocevar, Vera Milic, Giacomo Cafaro, Marina Carotti, Konstantina Delli, Orazio De Lucia, Diana Ernst, Francesco Ferro, Angelica Gattamelata, Giuseppe Germanò, Ivan Giovannini, Daniel Hammenfors, Malin V. Jonsson, Sandrine Jousse-Joulin, Pierluigi Macchioni, Simone Parisi, Carlo Perricone, Martin Helmut Stradner, Ne
Published in: Frontiers in Medicine, 7, 2020, ISSN 2296-858X
Publisher: Frontiers Media S.A.
DOI: 10.3389/fmed.2020.581248

Update on Sjögren’s Syndrome 2018

Author(s): Ourania D Argyropoulou, Athanasios G Tzioufas
Published in: Mediterranean Journal of Rheumatology, 29/4, 2018, Page(s) 193-198, ISSN 2529-198X
Publisher: Mediterranean Journal of Rheumatology
DOI: 10.31138/mjr.29.4.193

Epigenetic alterations in Sjögren’s syndrome patient saliva

Author(s): P. Karagianni, A. V. Goules, A. G. Tzioufas
Published in: Clinical & Experimental Immunology, 202/2, 2020, Page(s) 137-143, ISSN 0009-9104
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cei.13492

Unraveling Human AQP5-PIP Molecular Interaction and Effect on AQP5 Salivary Glands Localization in SS Patients

Author(s): Clara Chivasso, Veronika Nesverova, Michael Järvå, Anne Blanchard, Kristie L Rose, Fredrik Kryh Öberg, Zhen Wang, Maud Martin, Florent Lhotellerie, Egor Zindy, Bruna Junqueira, Karelle Leroy, Benoit Vanhollebeke, Valérie Delforge, Nargis Bolaky, Jason Perret, Muhammad Shahnawaz Soyfoo, Stefania Moscato, Chiara Baldini, François Chaumont, Letizia Mattii, Kevin L Schey, Yvonne Myal, Susanna Tö
Published in: Cells, 10/8, 2021, Page(s) 2108, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10082108

Autophagy occurs in lymphocytes infiltrating Sjögren’s syndrome minor salivary glands and correlates with histological severity of salivary gland lesions

Author(s): Serena Colafrancesco, Marta Vomero, Valentina Iannizzotto, Antonina Minniti, Cristiana Barbati, Francesca Arienzo, Linda Mastromanno, Tania Colasanti, Raffaella Izzo, Saba Nayar, Elena Pipi, Bruna Cerbelli, Carla Giordano, Francesco Ciccia, Fabrizio Conti, Guido Valesini, Francesca Barone, Roberta Priori, Cristiano Alessandri
Published in: Arthritis Research & Therapy, 22/1, 2020, ISSN 1478-6362
Publisher: BioMed Central
DOI: 10.1186/s13075-020-02317-6

Current State of Knowledge on Primary Sjögren’s Syndrome, an Autoimmune Exocrinopathy

Author(s): Dorian Parisis, Clara Chivasso, Jason Perret, Muhammad Shahnawaz Soyfoo, Christine Delporte
Published in: Journal of Clinical Medicine, 9/7, 2020, Page(s) 2299, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9072299

Insight into Salivary Gland Aquaporins

Author(s): Claudia D’Agostino, Osama A. Elkashty, Clara Chivasso, Jason Perret, Simon D. Tran, Christine Delporte
Published in: Cells, 9/6, 2020, Page(s) 1547, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9061547

A Training Tool to support the management and diagnosis of Sjögren's syndrome

Author(s): Chatzaki, Chariklia; Goules, Andreas; De Vita, Salvatore; Zabotti, Alen; Delporte, Christine; Soyfoo, Muhammad S; Barone, Francesca; Fisher, Benjamin A; Brito-Zerón, Pilar; Bartoloni, Elena; Mavragani, Clio P; Fotiadis, Dimitrios I; Tzioufas, Athanasios G; Tsiknakis, Manolis
Published in: Clinical and Experimental Rheumatology 38(4-126) 0174-0179, 10, 2020, ISSN 0392-856X
Publisher: Pacini Editore SpA
DOI: 10.5281/zenodo.4332049

Addressing the clinical unmet needs in primary Sjögren’s Syndrome through the sharing, harmonization and federated analysis of 21 European cohorts

Author(s): Pezoulas, Vasileios C;Goules, Andreas;Kalatzis, Fanis;Chatzis, Luke;Kourou, Konstantina D;Venetsanopoulou, Aliki;Exarchos, Themis P;Gandolfo, Saviana;Votis, Konstantinos;Zampeli, Evi;Baurmeister, Jan;Thorsten, May;Pérez, Manuel M;Lishchuk, Iryna;Chondrogiannis, Thymios;Andronikou, Vassiliki;Varvarigou, Theodora;Filipovic, Nenad;Tsiknakis, Manolis;Baldini, Chiara;Bombardieri, Michele;Bootsma, Hend
Published in: Computational and Structural Biotechnology Journal, Volume 20, 2022, 2022, Page(s) 471-484, ISSN 2001-0370
Publisher: Elsevier
DOI: 10.1016/j.csbj.2022.01.002

Primary Sjögren’s Syndrome of Early and Late Onset: Distinct Clinical Phenotypes and Lymphoma Development

Author(s): Andreas V. Goules, Ourania D. Argyropoulou, Vasileios C. Pezoulas, Loukas Chatzis, Elena Critselis, Saviana Gandolfo, Francesco Ferro, Marco Binutti, Valentina Donati, Sara Zandonella Callegher, Aliki Venetsanopoulou, Evangelia Zampeli, Maria Mavrommati, Paraskevi V. Voulgari, Themis Exarchos, Clio P. Mavragani, Chiara Baldini, Fotini N. Skopouli, Dimitrios I. Fotiadis, Salvatore De Vita, Haralamp
Published in: Frontiers in Immunology, 11, 2020, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.594096

Fitness for purpose of routinely recorded health data to identify patients with complex diseases: The case of Sjögren's syndrome

Author(s): Sytske Wiegersma, Linda E. Flinterman, Chiara Seghieri, Chiara Baldini, John Paget, Jaime Barrio Cortés, Robert A. Verheij
Published in: Learning Health Systems, 4/4, 2020, ISSN 2379-6146
Publisher: Wiley
DOI: 10.1002/lrh2.10242

Oral microbiota in autoimmune polyendocrine syndrome type 1

Author(s): Øyvind Bruserud, Huma Siddiqui, Mihaela Cuida Marthinussen, Tsute Chen, Roland Jonsson, Bergithe Eikeland Oftedal, Ingar Olsen, Eystein Sverre Husebye, Anette Bøe Wolff
Published in: Journal of Oral Microbiology, 10/1, 2018, Page(s) 1442986, ISSN 2000-2297
Publisher: Co-Action Publishing
DOI: 10.1080/20002297.2018.1442986

Low miR200b-5p levels in minor salivary glands: a novel molecular marker predicting lymphoma development in patients with Sjögren’s syndrome

Author(s): Efstathia K Kapsogeorgou, Aristea Papageorgiou, Athanase D Protogerou, Michael Voulgarelis, Athanasios G Tzioufas
Published in: Annals of the Rheumatic Diseases, 2018, Page(s) annrheumdis-2017-212639, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2017-212639

The role of salivary gland histopathology in primary Sjögren’s syndrome: promises and pitfalls

Author(s): F.G.M. Kroese, E.A. Haacke, M. Bombardieri
Published in: Clinical and Experimental Rheumatology, 2018, ISSN 1593-098X
Publisher: Clinical and Experimental Rheumatology

Current views on the pathogenesis of Sjögrenʼs syndrome

Author(s): Elena Pontarini, Davide Lucchesi, Michele Bombardieri
Published in: Current Opinion in Rheumatology, 30/2, 2018, Page(s) 215-221, ISSN 1040-8711
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/BOR.0000000000000473

Aberrant cell signalling in PBMCs upon IFN-α stimulation in primary Sjögren's syndrome patients associates with type I interferon signature

Author(s): Richard Davies, Daniel Hammenfors, Brith Bergum, Petra Vogelsang, Sonia Gavasso, Johan G. Brun, Roland Jonsson, Silke Appel
Published in: European Journal of Immunology, 48/7, 2018, Page(s) 1217-1227, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201747213

Long-term follow-up in primary Sjögren’s syndrome reveals differences in clinical presentation between female and male patients

Author(s): Jorge I. Ramírez Sepúlveda, Marika Kvarnström, Per Eriksson, Thomas Mandl, Katrine Brække Norheim, Svein Joar Johnsen, Daniel Hammenfors, Malin V. Jonsson, Kathrine Skarstein, Johan G. Brun, Lars Rönnblom, Helena Forsblad-d’Elia, Sara Magnusson Bucher, Eva Baecklund, Elke Theander, Roald Omdal, Roland Jonsson, Gunnel Nordmark, Marie Wahren-Herlenius
Published in: Biology of Sex Differences, 8/1, 2017, ISSN 2042-6410
Publisher: Biology of Sex Differences
DOI: 10.1186/s13293-017-0146-6

Brief Report: Rare X Chromosome Abnormalities in Systemic Lupus Erythematosus and Sjögren's Syndrome

Author(s): Rohan Sharma, Valerie M. Harris, Joshua Cavett, Biji T. Kurien, Ke Liu, Kristi A. Koelsch, Anum Fayaaz, Kaustubh S. Chaudhari, Lida Radfar, David Lewis, Donald U. Stone, C. Erick Kaufman, Shibo Li, Barbara Segal, Daniel J. Wallace, Michael H. Weisman, Swamy Venuturupalli, Jennifer A. Kelly, Bernardo Pons-Estel, Roland Jonsson, Xianglan Lu, Jacques-Eric Gottenberg, Juan-Manuel Anaya, Deborah S. Cun
Published in: Arthritis & Rheumatology, 69/11, 2017, Page(s) 2187-2192, ISSN 2326-5191
Publisher: Arthritis and Rheumatology
DOI: 10.1002/art.40207

Expression of Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Patients with Primary Sjögren's Syndrome

Author(s): M. Karlsen, K. Jakobsen, R. Jonsson, D. Hammenfors, T. Hansen, S. Appel
Published in: Scandinavian Journal of Immunology, 85/3, 2017, Page(s) 220-226, ISSN 0300-9475
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/sji.12520

2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren's Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts

Author(s): Caroline H. Shiboski, Stephen C. Shiboski, Raphaèle Seror, Lindsey A. Criswell, Marc Labetoulle, Thomas M. Lietman, Astrid Rasmussen, Hal Scofield, Claudio Vitali, Simon J. Bowman, Xavier Mariette
Published in: Arthritis & Rheumatology, 69/1, 2017, Page(s) 35-45, ISSN 2326-5191
Publisher: 2016 American College of Rheumatology/European League Against Rheumatism
DOI: 10.1002/art.39859

Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons

Author(s): He Li, Tove Ragna Reksten, John A. Ice, Jennifer A. Kelly, Indra Adrianto, Astrid Rasmussen, Shaofeng Wang, Bo He, Kiely M. Grundahl, Stuart B. Glenn, Corinne Miceli-Richard, Simon Bowman, Sue Lester, Per Eriksson, Maija-Leena Eloranta, Johan G. Brun, Lasse G. Gøransson, Erna Harboe, Joel M. Guthridge, Kenneth M. Kaufman, Marika Kvarnström, Deborah S. Cunninghame Graham, Ketan Patel, Adam J. Adl
Published in: PLOS Genetics, 13/6, 2017, Page(s) e1006820, ISSN 1553-7404
Publisher: PLOS Genetics
DOI: 10.1371/journal.pgen.1006820

Patients with Primary Sjögren's Syndrome Have Alterations in Absolute Quantities of Specific Peripheral Leucocyte Populations

Author(s): R. Davies, D. Hammenfors, B. Bergum, K. Jakobsen, M. Solheim, P. Vogelsang, J. G. Brun, Y. Bryceson, R. Jonsson, S. Appel
Published in: Scandinavian Journal of Immunology, 86/6, 2017, Page(s) 491-502, ISSN 0300-9475
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/sji.12622

How stress contributes to autoimmunity-lessons from Sjögren's syndrome

Author(s): Fotini N. Skopouli, Stergios Katsiougiannis
Published in: FEBS Letters, 592/1, 2018, Page(s) 5-14, ISSN 0014-5793
Publisher: Elsevier BV
DOI: 10.1002/1873-3468.12933

Standardisation of labial salivary gland histopathology in clinical trials in primary Sjögren's syndrome

Author(s): Benjamin A Fisher, Roland Jonsson, Troy Daniels, Michele Bombardieri, Rachel M Brown, Peter Morgan, Stefano Bombardieri, Wan-Fai Ng, Athanasios G Tzioufas, Claudio Vitali, Pepe Shirlaw, Erlin Haacke, Sebastian Costa, Hendrika Bootsma, Valerie Devauchelle-Pensec, Timothy R Radstake, Xavier Mariette, Andrea Richards, Rebecca Stack, Simon J Bowman, Francesca Barone
Published in: Annals of the Rheumatic Diseases, 76/7, 2017, Page(s) 1161-1168, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2016-210448

H1N1 vaccination in Sjögren’s syndrome triggers polyclonal B cell activation and promotes autoantibody production

Author(s): Susanna Brauner, Lasse Folkersen, Marika Kvarnström, Sabrina Meisgen, Sven Petersen, Michaela Franzén-Malmros, Johannes Mofors, Karl A Brokstad, Lars Klareskog, Roland Jonsson, Lisa S Westerberg, Christina Trollmo, Vivianne Malmström, Aurelie Ambrosi, Vijay K Kuchroo, Gunnel Nordmark, Marie Wahren-Herlenius
Published in: Annals of the Rheumatic Diseases, 76/10, 2017, Page(s) 1755-1763, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2016-210509

Enhanced Bruton's Tyrosine Kinase Activity in Peripheral Blood B Lymphocytes From Patients With Autoimmune Disease

Author(s): Odilia B. J. Corneth, Gwenny M. P. Verstappen, Sandra M. J. Paulissen, Marjolein J. W. de Bruijn, Jasper Rip, Melanie Lukkes, Jan Piet van Hamburg, Erik Lubberts, Hendrika Bootsma, Frans G. M. Kroese, Rudi W. Hendriks
Published in: Arthritis & Rheumatology, 69/6, 2017, Page(s) 1313-1324, ISSN 2326-5191
Publisher: Arthritis Rheumatol
DOI: 10.1002/art.40059

Salivary gland ultrasound abnormalities in primary Sjögren’s syndrome: consensual US-SG core items definition and reliability

Author(s): Sandrine Jousse-Joulin, Emmanuel Nowak, Divi Cornec, Jackie Brown, Andrew Carr, Marina Carotti, Benjamin Fisher, Joel Fradin, Alojzija Hocevar, Malin V Jonsson, Nicoletta Luciano, Vera Milic, John Rout, Elke Theander, Aaltje Stel, Hendrika Bootsma, Arjan Vissink, Chiara Baldini, Alan Baer, Wan Fai Ng, Simon Bowman, Zarrin Alavi, Alain Saraux, Valérie Devauchelle-Pensec
Published in: RMD Open, 3/1, 2017, Page(s) e000364, ISSN 2056-5933
Publisher: Rheumatic and musculoskeletal diseases
DOI: 10.1136/rmdopen-2016-000364

Dysregulation of NF-kB in glandular epithelial cells results in Sjögren’s-like features

Author(s): Xiaoyan Wang, Abeer Shaalan, Silvia Liefers, Julie Coudenys, Dirk Elewaut, Gordon B. Proctor, Hendrika Bootsma, Frans G. M. Kroese, Sarah Pringle
Published in: PLOS ONE, 13/8, 2018, Page(s) e0200212, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0200212

Th17 cells in primary Sjögren's syndrome: Pathogenicity and plasticity

Author(s): Gwenny M. Verstappen, Odilia B.J. Corneth, Hendrika Bootsma, Frans G.M. Kroese
Published in: Journal of Autoimmunity, 87, 2018, Page(s) 16-25, ISSN 0896-8411
Publisher: Academic Press
DOI: 10.1016/j.jaut.2017.11.003

Acquisition of N-Glycosylation Sites in Immunoglobulin Heavy Chain Genes During Local Expansion in Parotid Salivary Glands of Primary Sjögren Patients

Author(s): Annie Visser, Marieke E. Doorenspleet, Niek de Vries, Fred K. L. Spijkervet, Arjan Vissink, Richard J. Bende, Hendrika Bootsma, Frans G. M. Kroese, Nicolaas A. Bos
Published in: Frontiers in Immunology, 9, 2018, ISSN 1664-3224
Publisher: Front Immunol
DOI: 10.3389/fimmu.2018.00491

The value of rituximab treatment in primary Sjögren's syndrome

Author(s): Gwenny M. Verstappen, Jolien F. van Nimwegen, Arjan Vissink, Frans G.M. Kroese, Hendrika Bootsma
Published in: Clinical Immunology, 182, 2017, Page(s) 62-71, ISSN 1521-6616
Publisher: Academic Press
DOI: 10.1016/j.clim.2017.05.002

FcRL4 + B-cells in salivary glands of primary Sjögren's syndrome patients

Author(s): Erlin A. Haacke, Hendrika Bootsma, Fred K.L. Spijkervet, Annie Visser, Arjan Vissink, Philip M. Kluin, Frans G.M. Kroese
Published in: Journal of Autoimmunity, 81, 2017, Page(s) 90-98, ISSN 0896-8411
Publisher: Academic Press
DOI: 10.1016/j.jaut.2017.03.012

The Diagnosis and Treatment of Sjögren’s Syndrome

Author(s): Ana-Luisa Stefanski, Christian Tomiak, Uwe Pleyer, Thomas Dietrich, Gerd Rüdiger Burmester, Thomas Dörner
Published in: Deutsches Aerzteblatt Online, 2017, ISSN 1866-0452
Publisher: Deutscher Arzte-Verlag
DOI: 10.3238/arztebl.2017.0354

Transcription profiling of peripheral B cells in antibody-positive primary Sjögren's syndrome reveals upregulated expression of CX3CR1 and a type I and type II interferon signature

Author(s): J. Imgenberg-Kreuz, J. K. Sandling, A. Björk, J. Nordlund, M. Kvarnström, M.-L. Eloranta, L. Rönnblom, M. Wahren-Herlenius, A.-C. Syvänen, G. Nordmark
Published in: Scandinavian Journal of Immunology, 87/5, 2018, Page(s) e12662, ISSN 0300-9475
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/sji.12662

Epigenetic alterations in primary Sjögren's syndrome – an overview

Author(s): Juliana Imgenberg-Kreuz, Johanna K. Sandling, Gunnel Nordmark
Published in: Clinical Immunology, 2018, ISSN 1521-6616
Publisher: Academic Press
DOI: 10.1016/j.clim.2018.04.004

Targeting B Cells and Plasma Cells in Glomerular Diseases: Translational Perspectives

Author(s): Eva Schrezenmeier, David Jayne, Thomas Dörner
Published in: Journal of the American Society of Nephrology, 2018, Page(s) ASN.2017040367, ISSN 1046-6673
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/ASN.2017040367

Postactivated B cells in systemic lupus erythematosus

Author(s): Eva Schrezenmeier, Sarah Y. Weißenberg, Ana-Luisa Stefanski, Franziska Szelinski, Annika Wiedemann, Andreia C. Lino, Thomas Dörner
Published in: Current Opinion in Rheumatology, 31/2, 2019, Page(s) 175-184, ISSN 1040-8711
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/bor.0000000000000576

Different operators and histologic techniques in the assessment of germinal center-like structures in primary Sjögren’s syndrome minor salivary glands

Author(s): Francesco Carubbi, Alessia Alunno, Paola Cipriani, Gino Coletti, Barbara Bigerna, Mirko Manetti, Paola Di Benedetto, Onelia Bistoni, Gianluca Cipolloni, Vasiliki Liakouli, Piero Ruscitti, Elena Bartoloni, Roberto Giacomelli, Roberto Gerli
Published in: PLOS ONE, 14/1, 2019, Page(s) e0211142, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0211142

Juvenile Sjögren's Syndrome: Clinical Characteristics With Focus on Salivary Gland Ultrasonography

Author(s): Daniel S. Hammenfors, Valéria Valim, Blanca E. R. G. Bica, Sandra G. Pasoto, Vibke Lilleby, Juan Carlos Nieto‐González, Clovis A. Silva, Esther Mossel, Rosa M. R. Pereira, Aline Coelho, Hendrika Bootsma, Akaluck Thatayatikom, Johan G. Brun, Malin V. Jonsson
Published in: Arthritis Care & Research, 72/1, 2019, Page(s) 78-87, ISSN 2151-464X
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/acr.23839

Cohort Harmonization and Integrative Analysis From a Biomedical Engineering Perspective

Author(s): Konstadina D. Kourou, Vasileios C. Pezoulas, Eleni I. Georga, Themis P. Exarchos, Panayiotis Tsanakas, Manolis Tsiknakis, Theodora Varvarigou, Salvatore De Vita, Athanasios Tzioufas, Dimitrios I. Fotiadis
Published in: IEEE Reviews in Biomedical Engineering, 12, 2019, Page(s) 303-318, ISSN 1937-3333
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/rbme.2018.2855055

Single Cell Based Phosphorylation Profiling Identifies Alterations in Toll-Like Receptor 7 and 9 Signaling in Patients With Primary Sjögren's Syndrome

Author(s): Richard Davies, Irene Sarkar, Daniel Hammenfors, Brith Bergum, Petra Vogelsang, Silje M. Solberg, Sonia Gavasso, Johan G. Brun, Roland Jonsson, Silke Appel
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers In Immunology
DOI: 10.3389/fimmu.2019.00281

Epigenetically quantified immune cells in salivary glands of Sjögren’s syndrome patients: a novel tool that detects robust correlations of T follicular helper cells with immunopathology

Author(s): Sofie L M Blokland, Fréderique M van Vliet-Moret, Maarten R Hillen, Aridaman Pandit, Roel Goldschmeding, Aike A Kruize, Gerben Bouma, André van Maurik, Sven Olek, Ulrich Hoffmueller, Joel A G van Roon, Timothy R D J Radstake
Published in: Rheumatology, 59/2, 2019, Page(s) 335-343, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/kez268

Additive immunosuppressive effect of leflunomide and hydroxychloroquine supports rationale for combination therapy for Sjögren’s syndrome

Author(s): Eefje HM van der Heijden, Sarita AY Hartgring, Aike A Kruize, Timothy RDJ Radstake, Joel AG van Roon
Published in: Expert Review of Clinical Immunology, 15/7, 2019, Page(s) 801-808, ISSN 1744-666X
Publisher: Future Drugs Ltd.
DOI: 10.1080/1744666x.2019.1624527

Involvement of Aquaporins in the Pathogenesis, Diagnosis and Treatment of Sjögren’s Syndrome

Author(s): Muhammad Soyfoo, Clara Chivasso, Jason Perret, Christine Delporte
Published in: International Journal of Molecular Sciences, 19/11, 2018, Page(s) 3392, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19113392

Neuro-Sjögren: Peripheral Neuropathy With Limb Weakness in Sjögren's Syndrome

Author(s): Tabea Seeliger, Nils K. Prenzler, Stefan Gingele, Benjamin Seeliger, Sonja Körner, Thea Thiele, Lena Bönig, Kurt-Wolfram Sühs, Torsten Witte, Martin Stangel, Thomas Skripuletz
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: PMC
DOI: 10.3389/fimmu.2019.01600

Sjögren-Syndrom: früher diagnostizieren, wirksam behandeln

Author(s): Torsten Witte
Published in: DMW - Deutsche Medizinische Wochenschrift, 143/24, 2018, Page(s) 1778-1782, ISSN 0012-0472
Publisher: Georg Thieme Verlag
DOI: 10.1055/a-0547-1025

Predicting Lymphoma Development by Exploiting Genetic Variants and Clinical Findings in a Machine Learning-Based Methodology With Ensemble Classifiers in a Cohort of Sjögren's Syndrome Patients

Author(s): Konstantina D. Kourou, Earalampos M. Moutsopoulos, Clio Mavragani, Dimitrios I. Fotiadis, Vasileios C. Pezoulas, Eleni I. Georga, Themis Exarchos, Costas Papaloukas, Michalis Voulgarelis, Andreas Goules, Andrianos Nezos, Athanasios G. Tzioufas
Published in: IEEE Open Journal of Engineering in Medicine and Biology, 1, 2020, Page(s) 49-56, ISSN 2644-1276
Publisher: IEEE OJEMB
DOI: 10.1109/ojemb.2020.2965191

Medical data quality assessment: On the development of an automated framework for medical data curation

Author(s): Vasileios C. Pezoulas, Konstantina D. Kourou, Fanis Kalatzis, Themis P. Exarchos, Aliki Venetsanopoulou, Evi Zampeli, Saviana Gandolfo, Fotini Skopouli, Salvatore De Vita, Athanasios G. Tzioufas, Dimitrios I. Fotiadis
Published in: Computers in Biology and Medicine, 107, 2019, Page(s) 270-283, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2019.03.001

CXCL13 as biomarker for histological involvement in Sjögren’s syndrome

Author(s): Serena Colafrancesco, Roberta Priori, Charlotte G Smith, Antonina Minniti, Valentina Iannizzotto, Elena Pipi, Davide Lucchesi, Elena Pontarini, Saba Nayar, Joana Campos, Francesca Arienzo, Massimo Fusconi, Bruna Cerbelli, Carla Giordano, Guido Valesini, Michele Bombardieri, Benjamin A Fisher, Francesca Barone
Published in: Rheumatology, 59/1, 2019, Page(s) 165-170, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/kez255

Epidemiological profile and north–south gradient driving baseline systemic involvement of primary Sjögren’s syndrome

Author(s): Pilar Brito-Zerón, Nihan Acar-Denizli, Wan-Fai Ng, Ildiko Fanny Horváth, Astrid Rasmussen, Raphaele Seror, Xiaomei Li, Chiara Baldini, Jacques-Eric Gottenberg, Debashish Danda, Luca Quartuccio, Roberta Priori, Gabriela Hernandez-Molina, Berkan Armagan, Aike A Kruize, Seung-Ki Kwok, Marika Kvarnstrom, Sonja Praprotnik, Damien Sene, Roberto Gerli, Roser Solans, Maureen Rischmueller, Thomas Mandl,
Published in: Rheumatology, 2019, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/kez578

EULAR recommendations for the management of Sjögren’s syndrome with topical and systemic therapies

Author(s): Manuel Ramos-Casals, Pilar Brito-Zerón, Stefano Bombardieri, Hendrika Bootsma, Salvatore De Vita, Thomas Dörner, Benjamin A Fisher, Jacques-Eric Gottenberg, Gabriela Hernandez-Molina, Agnes Kocher, Belchin Kostov, Aike A. Kruize, Thomas Mandl, Wan-Fai Ng, Soledad Retamozo, Raphaèle Seror, Yehuda Shoenfeld, Antoni Sisó-Almirall, Athanasios G. Tzioufas, Claudio Vitali, Simon Bowman, Xavier Marie
Published in: Annals of the Rheumatic Diseases, 79/1, 2019, Page(s) 3-18, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2019-216114

Shared and Unique Patterns of DNA Methylation in Systemic Lupus Erythematosus and Primary Sjögren's Syndrome

Author(s): Juliana Imgenberg-Kreuz, Jonas Carlsson Almlöf, Dag Leonard, Christopher Sjöwall, Ann-Christine Syvänen, Lars Rönnblom, Johanna K. Sandling, Gunnel Nordmark
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Front Immunol
DOI: 10.3389/fimmu.2019.01686

Concomitant Ro/ SSA and La/ SSB antibodies are biomarkers for the risk of venous thromboembolism and cerebral infarction in primary Sjögren's syndrome

Author(s): J. Mofors, M. Holmqvist, L. Westermark, A. Björk, M. Kvarnström, H. Forsblad‐d'Elia, S. Magnusson Bucher, P. Eriksson, E. Theander, T. Mandl, M. Wahren‐Herlenius, G. Nordmark
Published in: Journal of Internal Medicine, 286/4, 2019, Page(s) 458-468, ISSN 0954-6820
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/joim.12941

Infections increase the risk of developing Sjögren's syndrome

Author(s): J. Mofors, E. V. Arkema, A. Björk, L. Westermark, M. Kvarnström, H. Forsblad‐d'Elia, S. Magnusson Bucher, P. Eriksson, T. Mandl, G. Nordmark, M. Wahren‐Herlenius
Published in: Journal of Internal Medicine, 285/6, 2019, Page(s) 670-680, ISSN 0954-6820
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/joim.12888

Genetics and epigenetics in primary Sjögren’s syndrome

Author(s): Juliana Imgenberg-Kreuz, Astrid Rasmussen, Kathy Sivils, Gunnel Nordmark
Published in: Rheumatology, 2019, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/key330

Comparison of patients with and without pre-existing lymphoma at diagnosis of primary Sjögren’s syndrome

Author(s): L Vasaitis, G Nordmark, E Theander, C Backlin, KE Smedby, J Askling, L Rönnblom, C Sundström, E Baecklund
Published in: Scandinavian Journal of Rheumatology, 48/3, 2019, Page(s) 207-212, ISSN 0300-9742
Publisher: Taylor & Francis
DOI: 10.1080/03009742.2018.1523456

Autoimmune epithelitis (Sjögren's syndrome); the impact of metabolic status of glandular epithelial cells on auto-immunogenicity

Author(s): Stergios Katsiougiannis, Roxane Tenta, Fotini N. Skopouli
Published in: Journal of Autoimmunity, 104, 2019, Page(s) 102335, ISSN 0896-8411
Publisher: Academic Press
DOI: 10.1016/j.jaut.2019.102335

Salivary gland ultrasonography in primary Sjögren’s syndrome: opportunities and challenges

Author(s): Valerie Devauchelle-Pensec, Alen Zabotti, Guillermo Carvajal-Alegria, Nenad Filipovic, Sandrine Jousse-Joulin, Salvatore De Vita
Published in: Rheumatology, 2019, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/kez079

Radiomics-based assessment of Primary Sjogren's Syndrome from salivary gland ultrasonography images

Author(s): Arso M. Vukicevic, Nenad Filipovic, Vera Milic, Alen Zabotti, Alojzija Hocevar, Orazio Di Lucia, Georgios Filippou, Salvatore De Vita, Alejandro F. Frangi, Athanasios Tzioufas
Published in: IEEE Journal of Biomedical and Health Informatics, 2018, Page(s) 1-1, ISSN 2168-2194
Publisher: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/jbhi.2019.2923773

Ezrin Is a Novel Protein Partner of Aquaporin-5 in Human Salivary Glands and Shows Altered Expression and Cellular Localization in Sjögren’s Syndrome

Author(s): Clara Chivasso, Carl Johan Hagströmer, Kristie L. Rose, Florent Lhotellerie, Lionel Leblanc, Zhen Wang, Stefania Moscato, Clément Chevalier, Egor Zindy, Maud Martin, Benoit Vanhollebeke, Françoise Gregoire, Nargis Bolaky, Jason Perret, Chiara Baldini, Muhammad Shahnawaz Soyfoo, Letizia Mattii, Kevin L. Schey, Susanna Törnroth-Horsefield, Christine Delporte
Published in: International Journal of Molecular Sciences, 22/17, 2021, Page(s) 9213, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22179213

The Involvement of Innate and Adaptive Immunity in the Initiation and Perpetuation of Sjögren’s Syndrome

Author(s): Clara Chivasso, Julie Sarrand, Jason Perret, Christine Delporte, Muhammad Shahnawaz Soyfoo
Published in: International Journal of Molecular Sciences, 22/2, 2021, Page(s) 658, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020658

Current concepts on Sjögren's syndrome – classification criteria and biomarkers

Author(s): Roland Jonsson, Karl A. Brokstad, Malin V. Jonsson, Nicolas Delaleu, Kathrine Skarstein
Published in: European Journal of Oral Sciences, 126/S1, 2018, Page(s) 37-48, ISSN 0909-8836
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/eos.12536

TNFAIP3 F127C Coding Variation in Greek Primary Sjogren’s Syndrome Patients

Author(s): Adrianos Nezos, Eliona Gkioka, Michael Koutsilieris, Michael Voulgarelis, Athanasios G. Tzioufas, Clio P. Mavragani
Published in: Journal of Immunology Research, 2018, 2018, Page(s) 1-8, ISSN 2314-8861
Publisher: Hindawi Publishing Corporation
DOI: 10.1155/2018/6923213

Conference proceedings (8)

Development and Validation of a Questionnaire to Assess Healthcare Utilization and Access in Cohorts of Patients with Primary Sjögren’s Syndrome

Author(s): Chiara Seghieri, Chiara Baldini, Luca Quartuccio, Francesco Ferro, Saviana Gandolfo, Salvatore De Vita and Stefano Bombardieri
Published in: 2017
Publisher: 2017 ACR/ARHP Annual Meeting

Radiomics-based assessment of Primary Sjögren’s Syndrome from salivary gland ultrasonography

Author(s): Arso Vukicevic, Vera Milic, Bojana Andjelkovic-Cirkovic, Alen Zabotti, Salvatore de Vita, Alejandro F. Frangi, Nenad Filipovic
Published in: 2018
Publisher: 21st International conference on medical image computing & computer assisted intervention

AB0166 ENHANCING THE QUALITY OF CLINICAL DATA THROUGH DATA CURATION IN PRIMARY SJöGREN’S SYNDROME

Author(s): Vasileios Pezoulas, Themis Exarchos, Aliki Venetsanopoulou, Evangelia Zampeli, Saviana Gandolfo, Salvatore De Vita, Foteini N. Skopouli, Athanasios Tzioufas, Dimitrios Fotiadis
Published in: Abstracts Accepted for Publication, 2019, Page(s) 1541.2-1542
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2019-eular.4139

Predicting lymphoma outcomes and risk factors in patients with primary Sjögren’s Syndrome using gradient boosting tree ensembles

Author(s): Vasileios C. Pezoulas, Themis P. Exarchos, Athanasios G. Tzioufas, Salvatore De Vita, Dimitrios I. Fotiadis
Published in: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, Page(s) 2165-2168, ISBN 978-1-5386-1311-5
Publisher: IEEE
DOI: 10.1109/embc.2019.8857557

Towards the Establishment of a Biomedical Ontology for the Primary Sjögren’s Syndrome

Author(s): Vasileios C. Pezoulas, Themis P. Exarchos, Vassiliki Andronikou, Theodora Varvarigou, Athanasios G. Tzioufas, Salvatore De Vita, Dimitrios I. Fotiadis
Published in: 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2018, Page(s) 4089-4092, ISBN 978-1-5386-3646-6
Publisher: IEEE
DOI: 10.1109/embc.2018.8513349

Self-Service Data Preprocessing and Cohort Analysis for Medical Researchers

Author(s): Jan Burmeister, Jurgen Bernard, Thorsten May, Jorn Kohlhammer
Published in: 2019 IEEE Workshop on Visual Analytics in Healthcare (VAHC), 2019, Page(s) 17-24, ISBN 978-1-7281-2423-0
Publisher: IEEE
DOI: 10.1109/vahc47919.2019.8945040

Health Vision: An interactive web based platform for healthcare data analysis and visualisation

Author(s): Eleftheria Polychronidou, Ilias Kalamaras, Konstantinos Votis, Dimitrios Tzovaras
Published in: 2019 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB), 2019, Page(s) 1-8, ISBN 978-1-7281-1462-0
Publisher: IEEE
DOI: 10.1109/cibcb.2019.8791462

Towards visualizing primary Sjögren's Syndrome data from heterogeneous cohorts

Author(s): Eleftheria Polychronidou, Ilias Kalamaras, Kostantinos Votis, Dimitrios Tzovaras
Published in: Proceedings of the 10th Hellenic Conference on Artificial Intelligence - SETN '18, 2018, Page(s) 1-4, ISBN 9781-450364331
Publisher: ACM Press
DOI: 10.1145/3200947.3201040

Thesis dissertations (1)

Flow cytometry based analyses as a tool in biomarker discovery for patient stratification in primary Sjögren’s syndrome

Author(s): Richard Davies
Published in: 2017, ISBN 978-82-308-3108-3
Publisher: University of Bergen

Non-peer reviewed articles (1)

Sjögren syndrome genetics vary according to ancestry

Author(s): Tove Ragna Reksten, Roland Jonsson
Published in: Nature Reviews Rheumatology, 13/4, 2017, Page(s) 202-203, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/nrrheum.2017.36

Book chapters (2)

Assessment of Machine Learning Algorithms for the Purpose of Primary Sjögren’s Syndrome Grade Classification from Segmented Ultrasonography Images

Author(s): Arso Vukicevic, Alen Zabotti, Salvatore de Vita, Nenad Filipovic
Published in: Future Access Enablers for Ubiquitous and Intelligent Infrastructures, 241, 2018, Page(s) 239-245, ISBN 978-3-319-92212-6
Publisher: Springer International Publishing
DOI: 10.1007/978-3-319-92213-3_35

Utilizing Incremental Learning for the Prediction of Disease Outcomes Across Distributed Clinical Data: A Framework and a Case Study

Author(s): Vasileios C. Pezoulas, Themis P. Exarchos, Konstantina D. Kourou, Athanasios G. Tzioufas, Salvatore De Vita, Dimitrios I. Fotiadis
Published in: XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019 - Proceedings of MEDICON 2019, September 26-28, 2019, Coimbra, Portugal, 76, 2020, Page(s) 823-831, ISBN 978-3-030-31634-1
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-31635-8_98