HARMONIzation and integrative analysis of regional, national and international Cohorts on primary Sjögren’s Syndrome (pSS) towards improved stratification, treatment and health policy making

Risultati finali

Project dissemination material 2

Dissemination material (website, lay summary, social media accounts, posters) and updates

Project dissemination material

Dissemination material (website, lay summary, social media accounts, posters) and updates

Project dissemination material 3

Dissemination material (website, lay summary, social media accounts, posters) and updates

Formulation of common clinical practices, guidelines and rules

It includes the results of the Task 6.5

Dissemination plan and activities 2

The dissemination plan and its updates, along with the dissemination activities of the consortium

The sustainability and expandability plan

First version of the plan of the HarmonicSS consortium for sustainability beyond the project end and expandability to other domains

Data management plan

The plan for using the data to be collected in the integrative cohort, in terms of availability and access

Requirements of the HarmonicSS platform

Report of the user requirement collection process along with the detailed requirements of clinicians, researchers and health policy makers

The second version of the core services of the platform

Includes manual and prototype of all services of the WP, along with usability evaluation results and refinements based on them, integrated in the cloud platform

Results of the clinical and research pSS unmet needs

It includes the outcomes of the tasks 6.1, 6.2 and 6.3

Dissemination plan and activities

The dissemination plan and its updates, along with the dissemination activities of the consortium

The first version of the core services of the platform

Includes manual and prototype of all services of the WP

Report on geographical variations in current clinical practice and scientific evidence

It includes the outcome of Task 6.4

Report on the application of the health policy and process evaluation

In two health regions and preliminary results regarding improvements in selected indicators that demonstrate progress toward defined impact

Ethical, legal, privacy and IPR requirements for data sharing and clinical trials
The sustainability and expandability plan 2

Second version of the plan of the HarmonicSS consortium for sustainability beyond the project end and expandability to other domains

Pubblicazioni

Salivary Gland Ultrasonography in Sjögren's Syndrome: A European Multicenter Reliability Exercise for the HarmonicSS Project

Autori: Alen Zabotti, Sara Zandonella Callegher, Annarita Tullio, Arso Vukicevic, Alojzija Hocevar, Vera Milic, Giacomo Cafaro, Marina Carotti, Konstantina Delli, Orazio De Lucia, Diana Ernst, Francesco Ferro, Angelica Gattamelata, Giuseppe Germanò, Ivan Giovannini, Daniel Hammenfors, Malin V. Jonsson, Sandrine Jousse-Joulin, Pierluigi Macchioni, Simone Parisi, Carlo Perricone, Martin Helmut Stradner, Ne
Pubblicato in: Frontiers in Medicine, Numero 7, 2020, ISSN 2296-858X
Editore: Frontiers Media S.A.
DOI: 10.3389/fmed.2020.581248

A Training Tool to support the management and diagnosis of Sjögren's syndrome

Autori: Chariklia Chatzaki, Andreas Goules, Salvatore De Vita, Alen Zabotti, Christine Delporte, Muhammad S Soyfoo, Francesca Barone, Benjamin A Fisher, Pilar Brito-Zerón, Elena Bartoloni, Clio P Mavragani, Dimitrios I Fotiadis, Athanasios G Tzioufas, Manolis Tsiknakis
Pubblicato in: Clinical and Experimental Rheumatology, Numero 2020 Vol.38, N°4 ,Suppl.126, 2020, ISSN 1593-098X
Editore: Clinical and Experimental Rheumatology

Update on Sjögren’s Syndrome 2018

Autori: Ourania D Argyropoulou, Athanasios G Tzioufas
Pubblicato in: Mediterranean Journal of Rheumatology, Numero 29/4, 2018, Pagina/e 193-198, ISSN 2529-198X
Editore: Mediterranean Journal of Rheumatology
DOI: 10.31138/mjr.29.4.193

Epigenetic alterations in Sjögren’s syndrome patient saliva

Autori: P. Karagianni, A. V. Goules, A. G. Tzioufas
Pubblicato in: Clinical & Experimental Immunology, Numero 202/2, 2020, Pagina/e 137-143, ISSN 0009-9104
Editore: Blackwell Publishing Inc.
DOI: 10.1111/cei.13492

Unraveling Human AQP5-PIP Molecular Interaction and Effect on AQP5 Salivary Glands Localization in SS Patients

Autori: Clara Chivasso, Veronika Nesverova, Michael Järvå, Anne Blanchard, Kristie L Rose, Fredrik Kryh Öberg, Zhen Wang, Maud Martin, Florent Lhotellerie, Egor Zindy, Bruna Junqueira, Karelle Leroy, Benoit Vanhollebeke, Valérie Delforge, Nargis Bolaky, Jason Perret, Muhammad Shahnawaz Soyfoo, Stefania Moscato, Chiara Baldini, François Chaumont, Letizia Mattii, Kevin L Schey, Yvonne Myal, Susanna Tö
Pubblicato in: Cells, Numero 10/8, 2021, Pagina/e 2108, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10082108

Autophagy occurs in lymphocytes infiltrating Sjögren’s syndrome minor salivary glands and correlates with histological severity of salivary gland lesions

Autori: Serena Colafrancesco, Marta Vomero, Valentina Iannizzotto, Antonina Minniti, Cristiana Barbati, Francesca Arienzo, Linda Mastromanno, Tania Colasanti, Raffaella Izzo, Saba Nayar, Elena Pipi, Bruna Cerbelli, Carla Giordano, Francesco Ciccia, Fabrizio Conti, Guido Valesini, Francesca Barone, Roberta Priori, Cristiano Alessandri
Pubblicato in: Arthritis Research & Therapy, Numero 22/1, 2020, ISSN 1478-6362
Editore: BioMed Central
DOI: 10.1186/s13075-020-02317-6

Current State of Knowledge on Primary Sjögren’s Syndrome, an Autoimmune Exocrinopathy

Autori: Dorian Parisis, Clara Chivasso, Jason Perret, Muhammad Shahnawaz Soyfoo, Christine Delporte
Pubblicato in: Journal of Clinical Medicine, Numero 9/7, 2020, Pagina/e 2299, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9072299

Insight into Salivary Gland Aquaporins

Autori: Claudia D’Agostino, Osama A. Elkashty, Clara Chivasso, Jason Perret, Simon D. Tran, Christine Delporte
Pubblicato in: Cells, Numero 9/6, 2020, Pagina/e 1547, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells9061547

Enhancing medical data quality through data curation: a case study in primary Sjögren’s syndrome

Autori: V.C. Pezoulas1, K.D. Kourou2, F. Kalatzis3, T.P. Exarchos4, A.I. Venetsanopoulou5, E. Zampeli6, S. Gandolfo7, F.N. Skopouli8, S. De Vita9, A.G. Tzioufas10, D.I. Fotiadis11
Pubblicato in: Clinical and Experimental Rheumatology, 2019, ISSN 0392-856X
Editore: Pacini Editore SpA

Insight into the mammalian aquaporin interactome

Autori: Törnroth-Horsefield, S., Chivasso, C., Strandberg, H., D'Agostino, C., O'Neale, C. V., Schey, K. L., & Delporte, C.
Pubblicato in: International journal of molecular sciences, Numero 23,9615, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23179615

Anti-Ro52 and/or anti-Ro60 immune reactivity: autoantibody and disease associations

Autori: Evangelia Zampeli, Maria Mavrommati, Haralampos M Moutsopoulos, Fotini N Skopouli
Pubblicato in: Clinical and experimental Rheumatology, 2020, ISSN 0392-856X
Editore: Pacini Editore SpA

A Training Tool to support the management and diagnosis of Sjögren's syndrome

Autori: Chatzaki, Chariklia; Goules, Andreas; De Vita, Salvatore; Zabotti, Alen; Delporte, Christine; Soyfoo, Muhammad S; Barone, Francesca; Fisher, Benjamin A; Brito-Zerón, Pilar; Bartoloni, Elena; Mavragani, Clio P; Fotiadis, Dimitrios I; Tzioufas, Athanasios G; Tsiknakis, Manolis
Pubblicato in: Clinical and Experimental Rheumatology 38(4-126) 0174-0179, Numero 10, 2020, ISSN 0392-856X
Editore: Pacini Editore SpA
DOI: 10.5281/zenodo.4332049

Addressing the clinical unmet needs in primary Sjögren’s Syndrome through the sharing, harmonization and federated analysis of 21 European cohorts

Autori: Pezoulas, Vasileios C;Goules, Andreas;Kalatzis, Fanis;Chatzis, Luke;Kourou, Konstantina D;Venetsanopoulou, Aliki;Exarchos, Themis P;Gandolfo, Saviana;Votis, Konstantinos;Zampeli, Evi;Baurmeister, Jan;Thorsten, May;Pérez, Manuel M;Lishchuk, Iryna;Chondrogiannis, Thymios;Andronikou, Vassiliki;Varvarigou, Theodora;Filipovic, Nenad;Tsiknakis, Manolis;Baldini, Chiara;Bombardieri, Michele;Bootsma, Hend
Pubblicato in: Computational and Structural Biotechnology Journal, Numero Volume 20, 2022, 2022, Pagina/e 471-484, ISSN 2001-0370
Editore: Elsevier
DOI: 10.1016/j.csbj.2022.01.002

Primary Sjögren’s Syndrome of Early and Late Onset: Distinct Clinical Phenotypes and Lymphoma Development

Autori: Andreas V. Goules, Ourania D. Argyropoulou, Vasileios C. Pezoulas, Loukas Chatzis, Elena Critselis, Saviana Gandolfo, Francesco Ferro, Marco Binutti, Valentina Donati, Sara Zandonella Callegher, Aliki Venetsanopoulou, Evangelia Zampeli, Maria Mavrommati, Paraskevi V. Voulgari, Themis Exarchos, Clio P. Mavragani, Chiara Baldini, Fotini N. Skopouli, Dimitrios I. Fotiadis, Salvatore De Vita, Haralamp
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.594096

Fitness for purpose of routinely recorded health data to identify patients with complex diseases: The case of Sjögren's syndrome

Autori: Sytske Wiegersma, Linda E. Flinterman, Chiara Seghieri, Chiara Baldini, John Paget, Jaime Barrio Cortés, Robert A. Verheij
Pubblicato in: Learning Health Systems, Numero 4/4, 2020, ISSN 2379-6146
Editore: Wiley
DOI: 10.1002/lrh2.10242

Oral microbiota in autoimmune polyendocrine syndrome type 1

Autori: Øyvind Bruserud, Huma Siddiqui, Mihaela Cuida Marthinussen, Tsute Chen, Roland Jonsson, Bergithe Eikeland Oftedal, Ingar Olsen, Eystein Sverre Husebye, Anette Bøe Wolff
Pubblicato in: Journal of Oral Microbiology, Numero 10/1, 2018, Pagina/e 1442986, ISSN 2000-2297
Editore: Co-Action Publishing
DOI: 10.1080/20002297.2018.1442986

Low miR200b-5p levels in minor salivary glands: a novel molecular marker predicting lymphoma development in patients with Sjögren’s syndrome

Autori: Efstathia K Kapsogeorgou, Aristea Papageorgiou, Athanase D Protogerou, Michael Voulgarelis, Athanasios G Tzioufas
Pubblicato in: Annals of the Rheumatic Diseases, 2018, Pagina/e annrheumdis-2017-212639, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2017-212639

Current views on the pathogenesis of Sjögrenʼs syndrome

Autori: Elena Pontarini, Davide Lucchesi, Michele Bombardieri
Pubblicato in: Current Opinion in Rheumatology, Numero 30/2, 2018, Pagina/e 215-221, ISSN 1040-8711
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/BOR.0000000000000473

Aberrant cell signalling in PBMCs upon IFN-α stimulation in primary Sjögren's syndrome patients associates with type I interferon signature

Autori: Richard Davies, Daniel Hammenfors, Brith Bergum, Petra Vogelsang, Sonia Gavasso, Johan G. Brun, Roland Jonsson, Silke Appel
Pubblicato in: European Journal of Immunology, Numero 48/7, 2018, Pagina/e 1217-1227, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201747213

Patients with Primary Sjögren's Syndrome Have Alterations in Absolute Quantities of Specific Peripheral Leucocyte Populations

Autori: R. Davies, D. Hammenfors, B. Bergum, K. Jakobsen, M. Solheim, P. Vogelsang, J. G. Brun, Y. Bryceson, R. Jonsson, S. Appel
Pubblicato in: Scandinavian Journal of Immunology, Numero 86/6, 2017, Pagina/e 491-502, ISSN 0300-9475
Editore: Blackwell Publishing Inc.
DOI: 10.1111/sji.12622

Different operators and histologic techniques in the assessment of germinal center-like structures in primary Sjögren’s syndrome minor salivary glands

Autori: Francesco Carubbi, Alessia Alunno, Paola Cipriani, Gino Coletti, Barbara Bigerna, Mirko Manetti, Paola Di Benedetto, Onelia Bistoni, Gianluca Cipolloni, Vasiliki Liakouli, Piero Ruscitti, Elena Bartoloni, Roberto Giacomelli, Roberto Gerli
Pubblicato in: PLOS ONE, Numero 14/1, 2019, Pagina/e e0211142, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0211142

Juvenile Sjögren's Syndrome: Clinical Characteristics With Focus on Salivary Gland Ultrasonography

Autori: Daniel S. Hammenfors, Valéria Valim, Blanca E. R. G. Bica, Sandra G. Pasoto, Vibke Lilleby, Juan Carlos Nieto‐González, Clovis A. Silva, Esther Mossel, Rosa M. R. Pereira, Aline Coelho, Hendrika Bootsma, Akaluck Thatayatikom, Johan G. Brun, Malin V. Jonsson
Pubblicato in: Arthritis Care & Research, Numero 72/1, 2019, Pagina/e 78-87, ISSN 2151-464X
Editore: John Wiley & Sons Inc.
DOI: 10.1002/acr.23839

Single Cell Based Phosphorylation Profiling Identifies Alterations in Toll-Like Receptor 7 and 9 Signaling in Patients With Primary Sjögren's Syndrome

Autori: Richard Davies, Irene Sarkar, Daniel Hammenfors, Brith Bergum, Petra Vogelsang, Silje M. Solberg, Sonia Gavasso, Johan G. Brun, Roland Jonsson, Silke Appel
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: Frontiers In Immunology
DOI: 10.3389/fimmu.2019.00281

Epigenetically quantified immune cells in salivary glands of Sjögren’s syndrome patients: a novel tool that detects robust correlations of T follicular helper cells with immunopathology

Autori: Sofie L M Blokland, Fréderique M van Vliet-Moret, Maarten R Hillen, Aridaman Pandit, Roel Goldschmeding, Aike A Kruize, Gerben Bouma, André van Maurik, Sven Olek, Ulrich Hoffmueller, Joel A G van Roon, Timothy R D J Radstake
Pubblicato in: Rheumatology, Numero 59/2, 2019, Pagina/e 335-343, ISSN 1462-0324
Editore: Oxford University Press
DOI: 10.1093/rheumatology/kez268

Additive immunosuppressive effect of leflunomide and hydroxychloroquine supports rationale for combination therapy for Sjögren’s syndrome

Autori: Eefje HM van der Heijden, Sarita AY Hartgring, Aike A Kruize, Timothy RDJ Radstake, Joel AG van Roon
Pubblicato in: Expert Review of Clinical Immunology, Numero 15/7, 2019, Pagina/e 801-808, ISSN 1744-666X
Editore: Future Drugs Ltd.
DOI: 10.1080/1744666x.2019.1624527

Involvement of Aquaporins in the Pathogenesis, Diagnosis and Treatment of Sjögren’s Syndrome

Autori: Muhammad Soyfoo, Clara Chivasso, Jason Perret, Christine Delporte
Pubblicato in: International Journal of Molecular Sciences, Numero 19/11, 2018, Pagina/e 3392, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19113392

Predicting Lymphoma Development by Exploiting Genetic Variants and Clinical Findings in a Machine Learning-Based Methodology With Ensemble Classifiers in a Cohort of Sjögren's Syndrome Patients

Autori: Konstantina D. Kourou, Earalampos M. Moutsopoulos, Clio Mavragani, Dimitrios I. Fotiadis, Vasileios C. Pezoulas, Eleni I. Georga, Themis Exarchos, Costas Papaloukas, Michalis Voulgarelis, Andreas Goules, Andrianos Nezos, Athanasios G. Tzioufas
Pubblicato in: IEEE Open Journal of Engineering in Medicine and Biology, Numero 1, 2020, Pagina/e 49-56, ISSN 2644-1276
Editore: IEEE OJEMB
DOI: 10.1109/ojemb.2020.2965191

CXCL13 as biomarker for histological involvement in Sjögren’s syndrome

Autori: Serena Colafrancesco, Roberta Priori, Charlotte G Smith, Antonina Minniti, Valentina Iannizzotto, Elena Pipi, Davide Lucchesi, Elena Pontarini, Saba Nayar, Joana Campos, Francesca Arienzo, Massimo Fusconi, Bruna Cerbelli, Carla Giordano, Guido Valesini, Michele Bombardieri, Benjamin A Fisher, Francesca Barone
Pubblicato in: Rheumatology, Numero 59/1, 2019, Pagina/e 165-170, ISSN 1462-0324
Editore: Oxford University Press
DOI: 10.1093/rheumatology/kez255

Radiomics-based assessment of Primary Sjogren's Syndrome from salivary gland ultrasonography images

Autori: Arso M. Vukicevic, Nenad Filipovic, Vera Milic, Alen Zabotti, Alojzija Hocevar, Orazio Di Lucia, Georgios Filippou, Salvatore De Vita, Alejandro F. Frangi, Athanasios Tzioufas
Pubblicato in: IEEE Journal of Biomedical and Health Informatics, 2018, Pagina/e 1-1, ISSN 2168-2194
Editore: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/jbhi.2019.2923773

Ezrin Is a Novel Protein Partner of Aquaporin-5 in Human Salivary Glands and Shows Altered Expression and Cellular Localization in Sjögren’s Syndrome

Autori: Clara Chivasso, Carl Johan Hagströmer, Kristie L. Rose, Florent Lhotellerie, Lionel Leblanc, Zhen Wang, Stefania Moscato, Clément Chevalier, Egor Zindy, Maud Martin, Benoit Vanhollebeke, Françoise Gregoire, Nargis Bolaky, Jason Perret, Chiara Baldini, Muhammad Shahnawaz Soyfoo, Letizia Mattii, Kevin L. Schey, Susanna Törnroth-Horsefield, Christine Delporte
Pubblicato in: International Journal of Molecular Sciences, Numero 22/17, 2021, Pagina/e 9213, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22179213

The Involvement of Innate and Adaptive Immunity in the Initiation and Perpetuation of Sjögren’s Syndrome

Autori: Clara Chivasso, Julie Sarrand, Jason Perret, Christine Delporte, Muhammad Shahnawaz Soyfoo
Pubblicato in: International Journal of Molecular Sciences, Numero 22/2, 2021, Pagina/e 658, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020658

Current concepts on Sjögren's syndrome – classification criteria and biomarkers

Autori: Roland Jonsson, Karl A. Brokstad, Malin V. Jonsson, Nicolas Delaleu, Kathrine Skarstein
Pubblicato in: European Journal of Oral Sciences, Numero 126/S1, 2018, Pagina/e 37-48, ISSN 0909-8836
Editore: Blackwell Publishing Inc.
DOI: 10.1111/eos.12536

TNFAIP3 F127C Coding Variation in Greek Primary Sjogren’s Syndrome Patients

Autori: Adrianos Nezos, Eliona Gkioka, Michael Koutsilieris, Michael Voulgarelis, Athanasios G. Tzioufas, Clio P. Mavragani
Pubblicato in: Journal of Immunology Research, Numero 2018, 2018, Pagina/e 1-8, ISSN 2314-8861
Editore: Hindawi Publishing Corporation
DOI: 10.1155/2018/6923213

Radiomics-based assessment of Primary Sjögren’s Syndrome from salivary gland ultrasonography

Autori: Arso Vukicevic, Vera Milic, Bojana Andjelkovic-Cirkovic, Alen Zabotti, Salvatore de Vita, Alejandro F. Frangi, Nenad Filipovic
Pubblicato in: 2018
Editore: 21st International conference on medical image computing & computer assisted intervention

AB0166 ENHANCING THE QUALITY OF CLINICAL DATA THROUGH DATA CURATION IN PRIMARY SJöGREN’S SYNDROME

Autori: Vasileios Pezoulas, Themis Exarchos, Aliki Venetsanopoulou, Evangelia Zampeli, Saviana Gandolfo, Salvatore De Vita, Foteini N. Skopouli, Athanasios Tzioufas, Dimitrios Fotiadis
Pubblicato in: Abstracts Accepted for Publication, 2019, Pagina/e 1541.2-1542
Editore: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2019-eular.4139

Predicting lymphoma outcomes and risk factors in patients with primary Sjögren’s Syndrome using gradient boosting tree ensembles

Autori: Vasileios C. Pezoulas, Themis P. Exarchos, Athanasios G. Tzioufas, Salvatore De Vita, Dimitrios I. Fotiadis
Pubblicato in: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, Pagina/e 2165-2168, ISBN 978-1-5386-1311-5
Editore: IEEE
DOI: 10.1109/embc.2019.8857557

Risultati finali

Pubblicazioni

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