Objective Colorectal cancer represents around one tenth of all cancers worldwide. Early and accurate diagnosis and precise intervention can increase cure rate up to 90%. Improved diagnostic techniques with enough sensitivity and specificity are required to allow in situ assessment, safe characterization and resection of lesions during clinical practice interventions.The multidisciplinary PICCOLO team proposes a new compact, hybrid and multimodal photonics endoscope based on Optical Coherence Tomography (OCT) and Multi-Photon Tomography (MPT) combined with novel red-flag fluorescence technology for in vivo diagnosis and clinical decision support. By combining the outstanding structural information from OCT with the precise functional information from MPT, this innovative endoscope will provide gastroenterologists immediate and detailed in situ identification of colorectal neoplastic lesions and facilitate accurate and reliable in vivo diagnostics, with additional, grading capabilities for colon cancer as well as in-situ lesion infiltration and margin assessment. With the development of compact instrumentation, the cost of the components and thus the system will be significantly reduced. Human representative animal models will be used to generate imaging biomarkers that allow automated detection, assessment and grading of disease. The developed system will be tested in operating room conditions.The consortium comprises the whole value chain including pre-clinical and clinical partners, technology providers, photonics SMEs and endoscopy market leader company. The project will permit these companies to enhance their competitiveness and leadership in the diagnostics sector as well as exploiting new market opportunities. The new endoscope will significantly impact clinical practice allowing in vivo optical biopsy assessment via the automatic analysis of images allowing accurate and efficient characterisation of colorectal lesions. Fields of science natural sciencescomputer and information sciencessoftwarenatural sciencescomputer and information sciencesdatabaseshumanitieslanguages and literatureliterature studiesliterary genresessaysmedical and health sciencesclinical medicineoncologycolorectal cancernatural sciencesphysical sciencesopticslaser physics Programme(s) H2020-EU.2.1.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT) Main Programme Topic(s) ICT-29-2016 - Photonics KET 2016 Call for proposal H2020-ICT-2016-2017 See other projects for this call Sub call H2020-ICT-2016-1 Funding Scheme RIA - Research and Innovation action Coordinator FUNDACION TECNALIA RESEARCH & INNOVATION Net EU contribution € 683 500,00 Address Parque cientifico y tecnologico de gipuzkoa, paseo mikeletegi 2 20009 Donostia-san sebastian (gipuzkoa) Spain See on map Region Noreste País Vasco Gipuzkoa Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 683 500,00 Participants (10) Sort alphabetically Sort by Net EU contribution Expand all Collapse all KARL STORZ SE & CO. KG Germany Net EU contribution € 492 500,00 Address Dr.-karl-storz-strasse 34 78532 Tuttlingen See on map Region Baden-Württemberg Freiburg Tuttlingen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 492 500,00 L4T-LIGHT4TECH SRL Italy Net EU contribution € 501 250,00 Address Via della cernaia 5 50129 Firenze See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (IT) Toscana Firenze Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 501 250,00 UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Ireland Net EU contribution € 305 667,50 Address Western road T12 YN60 Cork See on map Region Ireland Southern South-East Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 481 337,50 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. MUNSTER TECHNOLOGICAL UNIVERSITY Ireland Net EU contribution € 175 670,00 Address Rossa avenue bishopstown T12 P928 Cork See on map Region Ireland Southern South-East Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 175 670,00 M-SQUARED LASERS LIMITED United Kingdom Net EU contribution € 358 750,00 Address Venture building 1 kelvin campus maryhill road west of scotland science park G20 0SP Glasgow See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Scotland West Central Scotland Glasgow City Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 358 750,00 LABORATORIO EUROPEO DI SPETTROSCOPIE NON LINEARI Italy Net EU contribution € 361 500,00 Address Via nello carrara 1 50019 Sesto-fiorentino (fi) See on map Region Centro (IT) Toscana Firenze Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 361 500,00 FUNDACION CENTRO DE CIRUGIA DE MINIMA INVASION JESUS USON Spain Net EU contribution € 440 450,00 Address Carretera nacional 521 km 41 8 10071 Caceres See on map Region Centro (ES) Extremadura Cáceres Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 440 450,00 IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom Net EU contribution € 358 242,50 Address South kensington campus exhibition road SW7 2AZ London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 358 242,50 FUNDACION VASCA DE INNOVACION E INVESTIGACION SANITARIAS Spain Net EU contribution € 247 962,50 Address Ronda de azkue,1 48902 Barakaldo See on map Region Noreste País Vasco Bizkaia Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 320 125,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. Servicio Vasco de Salud Osakidetza Spain Net EU contribution € 72 162,50 Address Alava 45 01006 Vitoria-gasteiz See on map Region Noreste País Vasco Araba/Álava Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 72 162,50