Objective Bio-electronic microsystems hold promise for repairing the damaged central nervous system (CNS). However, this potential has not been developed because their implantation inflicts additional neural injury, and ensuing inflammation and fibrosis compromise device functionality. In Neurofibres we want to achieve a breakthrough in “Neuroregenerative Bio-electronics”, developing dual-function devices that will serve as electroactive scaffolds for CNS regeneration and neural circuit activation. We engineered electroconducting microfibres (MFs) that add negligible tissue insult while promoting guided cell migration and axonal regeneration in rodents with spinal cord injury (SCI). The MFs also meet the challenge of probe miniaturisation and biofunctionalisation for ultrasensitive recording and stimulation of neural activity. An interdisciplinary consortium composed of neuroscientists, medical specialists, researchers in biomaterials, protein engineering, physics, and electrical and mechanical engineering, together with a company specialised in fabrication of microcables and microconnectors, will join efforts to design, develop, and test the MFs and complementary technology (microfibre functionalisation, assembling, and electronic interconnection), in order to produce a biologically safe and effective bio-electronic system for the treatment of SCI. This goal will be achieved through five specific objectives: 1) To improve the electrical conductivity, strength, and chemical stability of the microfibres.2) To develop electro-responsive engineered affibodies for microfibre functionalisation.3) To develop the technology for MF interconnection and assembling into implantable systems.4) To perform comprehensive investigation of the immunological, glial, neuronal, and connective tissue responses to the implanted MFs and applied electrostimulation in rodent and swine SCI models.5) To investigate the motor and sensory effects of microfibre implantation and electrostimulation. Fields of science natural sciencesphysical scienceselectromagnetism and electronicsnatural sciencesbiological sciencesneurobiologycomputational neuroscience Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.2. - FET Proactive Topic(s) FETPROACT-01-2016 - FET Proactive: emerging themes and communities Call for proposal H2020-FETPROACT-2016-2017 See other projects for this call Sub call FETPROACT-2016 Funding Scheme RIA - Research and Innovation action Coordinator SERVICIO DE SALUD DE CASTILLA LA MANCHA Net EU contribution € 951 835,00 Address Avenida rio guadiana 4 45007 Toledo Spain See on map Region Centro (ES) Castilla-La Mancha Toledo Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 582 008,75 Participants (6) Sort alphabetically Sort by Net EU contribution Expand all Collapse all THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom Net EU contribution € 708 090,00 Address Trinity lane the old schools CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 AXON CABLE France Net EU contribution € 710 000,00 Address Route de chalons 51210 Montmirail See on map Region Grand Est Champagne-Ardenne Marne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 212 362,50 UNIVERSITA DEGLI STUDI DI TRENTO Italy Net EU contribution € 669 820,00 Address Via calepina 14 38122 Trento See on map Region Nord-Est Provincia Autonoma di Trento Trento Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 KUNGLIGA TEKNISKA HOEGSKOLAN Sweden Net EU contribution € 692 500,00 Address Brinellvagen 8 100 44 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITE D'AIX MARSEILLE France Net EU contribution € 681 875,00 Address Boulevard charles livon 58 le pharo 13284 Marseille See on map Region Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITAT DES SAARLANDES Germany Net EU contribution € 680 000,00 Address Campus 66123 Saarbrucken See on map Region Saarland Saarland Regionalverband Saarbrücken Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
