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Biofunctionalised Electroconducting Microfibres for the Treatment of Spinal Cord Injury

Objectif

Bio-electronic microsystems hold promise for repairing the damaged central nervous system (CNS). However, this potential has not been developed because their implantation inflicts additional neural injury, and ensuing inflammation and fibrosis compromise device functionality. In Neurofibres we want to achieve a breakthrough in “Neuroregenerative Bio-electronics”, developing dual-function devices that will serve as electroactive scaffolds for CNS regeneration and neural circuit activation. We engineered electroconducting microfibres (MFs) that add negligible tissue insult while promoting guided cell migration and axonal regeneration in rodents with spinal cord injury (SCI). The MFs also meet the challenge of probe miniaturisation and biofunctionalisation for ultrasensitive recording and stimulation of neural activity. An interdisciplinary consortium composed of neuroscientists, medical specialists, researchers in biomaterials, protein engineering, physics, and electrical and mechanical engineering, together with a company specialised in fabrication of microcables and microconnectors, will join efforts to design, develop, and test the MFs and complementary technology (microfibre functionalisation, assembling, and electronic interconnection), in order to produce a biologically safe and effective bio-electronic system for the treatment of SCI. This goal will be achieved through five specific objectives:
1) To improve the electrical conductivity, strength, and chemical stability of the microfibres.
2) To develop electro-responsive engineered affibodies for microfibre functionalisation.
3) To develop the technology for MF interconnection and assembling into implantable systems.
4) To perform comprehensive investigation of the immunological, glial, neuronal, and connective tissue responses to the implanted MFs and applied electrostimulation in rodent and swine SCI models.
5) To investigate the motor and sensory effects of microfibre implantation and electrostimulation.

Appel à propositions

H2020-FETPROACT-2016-2017

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Sous appel

FETPROACT-2016

Coordinateur

SERVICIO DE SALUD DE CASTILLA LA MANCHA
Contribution nette de l'UE
€ 951 835,00
Adresse
Avenida Rio Guadiana 4
45007 Toledo
Espagne

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Région
Castilla-La Mancha Toledo
Type d’activité
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Autres sources de financement
€ 582 008,75

Participants (6)

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Contribution nette de l'UE
€ 708 090,00
Adresse
Trinity Lane The Old Schools
CB2 1TN Cambridge

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Région
East of England East Anglia Cambridgeshire CC
Type d’activité
Higher or Secondary Education Establishments
Autres sources de financement
€ 0,00
AXON CABLE
France
Contribution nette de l'UE
€ 710 000,00
Adresse
Route De Chalons
51210 Montmirail

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Région
Grand Est Champagne-Ardenne Marne
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Autres sources de financement
€ 212 362,50
UNIVERSITA DEGLI STUDI DI TRENTO
Italie
Contribution nette de l'UE
€ 669 820,00
Adresse
Via Calepina 14
38122 Trento

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Région
Nord-Est Provincia Autonoma di Trento Trento
Type d’activité
Higher or Secondary Education Establishments
Autres sources de financement
€ 0,00
KUNGLIGA TEKNISKA HOEGSKOLAN
Suède
Contribution nette de l'UE
€ 692 500,00
Adresse
Brinellvagen 8
100 44 Stockholm

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Région
Östra Sverige Stockholm Stockholms län
Type d’activité
Higher or Secondary Education Establishments
Autres sources de financement
€ 0,00
UNIVERSITE D'AIX MARSEILLE
France
Contribution nette de l'UE
€ 681 875,00
Adresse
Boulevard Charles Livon 58 Le Pharo
13284 Marseille

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Région
Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône
Type d’activité
Higher or Secondary Education Establishments
Autres sources de financement
€ 0,00
UNIVERSITAT DES SAARLANDES
Allemagne
Contribution nette de l'UE
€ 680 000,00
Adresse
Campus
66123 Saarbrucken

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Région
Saarland Saarland Regionalverband Saarbrücken
Type d’activité
Higher or Secondary Education Establishments
Autres sources de financement
€ 0,00