Biofunctionalised Electroconducting Microfibres for the Treatment of Spinal Cord Injury

Project Information

Neurofibres

Grant agreement ID: 732344

DOI 10.3030/732344

Project closed

EC signature date 27 October 2016

Start date 1 January 2017

End date 30 June 2021

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 5 888 491,25

EU contribution € 5 094 120,00

Coordinated by

SERVICIO DE SALUD DE CASTILLA LA MANCHA
Spain

Deliverables

Documents, reports (6)

Generation of new affibodies binding bFGF or N-Cadherin
First 2P-microscopy analysis of macroglial reactions to MFs.
Electrical parameters safe and effective to trigger nerve action potentials using MFs implanted in the rat spinal cord.

Electrical parameters safe and effective to trigger nerveaction potentials using MFs implanted in the rat spinal cord

2P-microscopy analysis of dynamic axonal regeneration on the MFs, visualised through an implanted glass window.

2Pmicroscopy analysis of dynamic axonal regeneration on the MFs visualised through an implanted glass window

Comparative analysis of the glial cell responses in vivo to MFs and to the different MF functionalisation schemes.

Comparative analysis of the glial cell responses in vivo to MFs and to the different MF functionalisation schemes.

Analytical and numerical models for the mechanical behaviour of the implanted MFs.

Open Research Data Pilot (1)

Data management plan

Websites, patent fillings, videos etc. (1)

Website and logo for NEUROFIBRES

Publications

Peer reviewed articles (22)

Neuropathological and Motor Impairments after Incomplete Cervical Spinal Cord Injury in Pigs

Author(s): Patricia Del Cerro, Andrés Barriga-Martín, Hugo Vara, Luis M. Romero-Muñoz, Ángel Rodríguez-De-Lope, Jorge E. Collazos-Castro
Published in: Journal of Neurotrauma, 2021, ISSN 0897-7151
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/neu.2020.7587

The Cortical Motor System in the Domestic Pig: Origin and Termination of the Corticospinal Tract and Cortico-Brainstem Projections

Author(s): Patricia del Cerro, Ángel Rodríguez-De-Lope, Jorge E. Collazos-Castro
Published in: Frontiers in Neuroanatomy, Issue 15, 2021, Page(s) 87, ISSN 1662-5129
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnana.2021.748050

YAP regulates cell mechanics by controlling focal adhesion assembly

Author(s): Giorgia Nardone, Jorge Oliver-De La Cruz, Jan Vrbsky, Cecilia Martini, Jan Pribyl, Petr Skládal, Martin Pešl, Guido Caluori, Stefania Pagliari, Fabiana Martino, Zuzana Maceckova, Marian Hajduch, Andres Sanz-Garcia, Nicola Maria Pugno, Gorazd Bernard Stokin, Giancarlo Forte
Published in: Nature Communications, Issue 8, 2017, Page(s) 15321, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms15321

Serpentine locomotion through elastic energy release

Author(s): F. Dal Corso, D. Misseroni, N. M. Pugno, A. B. Movchan, N. V. Movchan, D. Bigoni
Published in: Journal of The Royal Society Interface, Issue 14/130, 2017, Page(s) 20170055, ISSN 1742-5689
Publisher: The Royal Society
DOI: 10.1098/rsif.2017.0055

A hybrid deterministic-probabilistic approach to model the mechanical response of helically arranged hierarchical strands

Author(s): M. Fraldi, G. Perrella, M. Ciervo, F. Bosia, N.M. Pugno
Published in: Journal of the Mechanics and Physics of Solids, Issue 106, 2017, Page(s) 338-352, ISSN 0022-5096
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.jmps.2017.05.013

Hierarchical Spring-Block Model for Multiscale Friction Problems

Author(s): Gianluca Costagliola, Federico Bosia, Nicola M. Pugno
Published in: ACS Biomaterials Science & Engineering, Issue 3/11, 2017, Page(s) 2845-2852, ISSN 2373-9878
Publisher: American Chemical Society
DOI: 10.1021/acsbiomaterials.6b00709

Tuning friction with composite hierarchical surfaces

Author(s): Gianluca Costagliola, Federico Bosia, Nicola M. Pugno
Published in: Tribology International, Issue 115, 2017, Page(s) 261-267, ISSN 0301-679X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.triboint.2017.05.012

A 2-D model for friction of complex anisotropic surfaces

Author(s): Gianluca Costagliola, Federico Bosia, Nicola M. Pugno
Published in: Journal of the Mechanics and Physics of Solids, Issue 112, 2018, Page(s) 50-65, ISSN 0022-5096
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.jmps.2017.11.015

Nanomechanics of individual aerographite tetrapods

Author(s): Raimonds Meija, Stefano Signetti, Arnim Schuchardt, Kerstin Meurisch, Daria Smazna, Matthias Mecklenburg, Karl Schulte, Donats Erts, Oleg Lupan, Bodo Fiedler, Yogendra Kumar Mishra, Rainer Adelung, Nicola M. Pugno
Published in: Nature Communications, Issue 8, 2017, Page(s) 14982, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms14982

Current technical approaches to brain energy metabolism

Author(s): L. Felipe Barros, Juan P. Bolaños, Gilles Bonvento, Anne-Karine Bouzier-Sore, Angus Brown, Johannes Hirrlinger, Sergey Kasparov, Frank Kirchhoff, Anne N. Murphy, Luc Pellerin, Michael B. Robinson, Bruno Weber
Published in: Glia, 2017, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.23248

Microfluidization of Graphite and Formulation of Graphene-Based Conductive Inks

Author(s): Panagiotis G. Karagiannidis, Stephen A. Hodge, Lucia Lombardi, Flavia Tomarchio, Nicolas Decorde, Silvia Milana, Ilya Goykhman, Yang Su, Steven V. Mesite, Duncan N. Johnstone, Rowan K. Leary, Paul A. Midgley, Nicola M. Pugno, Felice Torrisi, Andrea C. Ferrari
Published in: ACS Nano, Issue 11/3, 2017, Page(s) 2742-2755, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.6b07735

The Role of the Oligodendrocyte Lineage in Acute Brain Trauma

Author(s): Anja Scheller, Xianshu Bai, Frank Kirchhoff
Published in: Neurochemical Research, Issue 42/9, 2017, Page(s) 2479-2489, ISSN 0364-3190
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11064-017-2343-4

Friction and Adhesion of Different Structural Defects of Graphene

Author(s): Manoj Tripathi, Firas Awaja, Rafael A. Bizao, Stefano Signetti, Erica Iacob, Guido Paolicelli, Sergio Valeri, Alan Dalton, Nicola Maria Pugno
Published in: ACS Applied Materials & Interfaces, Issue 10/51, 2018, Page(s) 44614-44623, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.8b10294

Grafting carbon nanotubes onto carbon fibres doubles their effective strength and the toughness of the composite

Author(s): Luca Lavagna, Daniele Massella, Maria F. Pantano, Federico Bosia, Nicola M. Pugno, Matteo Pavese
Published in: Composites Science and Technology, Issue 166, 2018, Page(s) 140-149, ISSN 0266-3538
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compscitech.2018.03.015

Nitrile butadiene rubber composites reinforced with reduced graphene oxide and carbon nanotubes show superior mechanical, electrical and icephobic properties

Author(s): L. Valentini, S. Bittolo Bon, M. Hernández, M.A. Lopez-Manchado, N.M. Pugno
Published in: Composites Science and Technology, Issue 166, 2018, Page(s) 109-114, ISSN 0266-3538
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compscitech.2018.01.050

Bionicomposites

Author(s): Nicola M. Pugno, Luca Valentini
Published in: Nanoscale, Issue 11/7, 2019, Page(s) 3102-3111, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8nr08569b

Laser-Based Texturing of Graphene to Locally Tune Electrical Potential and Surface Chemistry

Author(s): Manoj Tripathi, Alice King, Giuseppe Fratta, Manuela Meloni, Matthew Large, Jonathan P. Salvage, Nicola Maria Pugno, Alan B. Dalton
Published in: ACS Omega, Issue 3/12, 2018, Page(s) 17000-17009, ISSN 2470-1343
Publisher: American
DOI: 10.1021/acsomega.8b02815

Folding Large Graphene-on-Polymer Films Yields Laminated Composites with Enhanced Mechanical Performance

Author(s): Bin Wang, Zhancheng Li, Chunhui Wang, Stefano Signetti, Benjamin V. Cunning, Xiaozhong Wu, Yuan Huang, Yi Jiang, Haofei Shi, Seunghwa Ryu, Nicola M. Pugno, Rodney S. Ruoff
Published in: Advanced Materials, Issue 30/35, 2018, Page(s) 1707449, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201707449

The influence of substrate roughness, patterning, curvature, and compliance in peeling problems

Author(s): Lucas Brely, Federico Bosia, Nicola M Pugno
Published in: Bioinspiration & Biomimetics, Issue 13/2, 2018, Page(s) 026004, ISSN 1748-3190
Publisher: British
DOI: 10.1088/1748-3190/aaa0e5

Silkworm silk fibers vs PEEK reinforced rubber luminescent strain gauge and stretchable composites

Author(s): Luca Valentini, Silvia Bittolo Bon, Lorenzo Mussolin, Nicola M. Pugno
Published in: Composites Science and Technology, Issue 156, 2018, Page(s) 254-261, ISSN 0266-3538
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compscitech.2017.12.031

Enhanced spinal cord microstimulation using conducting polymer-coated carbon microfibers

Author(s): Hugo Vara, Jorge E. Collazos-Castro
Published in: Acta Biomaterialia, Issue 90, 2019, Page(s) 71-86, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2019.03.037

Intravital Assessment of Cells Responses to Conducting Polymer-Coated Carbon Microfibres for Bridging Spinal Cord Injury

Author(s): Bilal El Waly, Vincent Escarrat, Jimena Perez-Sanchez, Jaspreet Kaur, Florence Pelletier, Jorge Eduardo Collazos-Castro, Franck Debarbieux
Published in: Cells, Issue 10/1, 2021, Page(s) 73, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10010073

Intellectual Property Rights

Patent (1)

ROLLED HETERO-STRUCTURES AND METHOD OF MANUFACTURING ROLLED HETERO-STRUCTURES

Application/Publication number: 20 20061906
Date: 2020-04-29