Biofunctionalised Electroconducting Microfibres for the Treatment of Spinal Cord Injury

Informazioni relative al progetto

Neurofibres

ID dell’accordo di sovvenzione: 732344

DOI 10.3030/732344

Progetto chiuso

Data della firma CE 27 Ottobre 2016

Data di avvio 1 Gennaio 2017

Data di completamento 30 Giugno 2021

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale € 5 888 491,25

Contributo UE € 5 094 120,00

Coordinato da

SERVICIO DE SALUD DE CASTILLA LA MANCHA
Spain

Risultati finali

Documents, reports (6)

Generation of new affibodies binding bFGF or N-Cadherin
First 2P-microscopy analysis of macroglial reactions to MFs.
Electrical parameters safe and effective to trigger nerve action potentials using MFs implanted in the rat spinal cord.

Electrical parameters safe and effective to trigger nerveaction potentials using MFs implanted in the rat spinal cord

2P-microscopy analysis of dynamic axonal regeneration on the MFs, visualised through an implanted glass window.

2Pmicroscopy analysis of dynamic axonal regeneration on the MFs visualised through an implanted glass window

Comparative analysis of the glial cell responses in vivo to MFs and to the different MF functionalisation schemes.

Comparative analysis of the glial cell responses in vivo to MFs and to the different MF functionalisation schemes.

Analytical and numerical models for the mechanical behaviour of the implanted MFs.

Open Research Data Pilot (1)

Data management plan

Websites, patent fillings, videos etc. (1)

Website and logo for NEUROFIBRES

Pubblicazioni

Peer reviewed articles (22)

Neuropathological and Motor Impairments after Incomplete Cervical Spinal Cord Injury in Pigs

Autori: Patricia Del Cerro, Andrés Barriga-Martín, Hugo Vara, Luis M. Romero-Muñoz, Ángel Rodríguez-De-Lope, Jorge E. Collazos-Castro
Pubblicato in: Journal of Neurotrauma, 2021, ISSN 0897-7151
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/neu.2020.7587

The Cortical Motor System in the Domestic Pig: Origin and Termination of the Corticospinal Tract and Cortico-Brainstem Projections

Autori: Patricia del Cerro, Ángel Rodríguez-De-Lope, Jorge E. Collazos-Castro
Pubblicato in: Frontiers in Neuroanatomy, Numero 15, 2021, Pagina/e 87, ISSN 1662-5129
Editore: Frontiers Research Foundation
DOI: 10.3389/fnana.2021.748050

YAP regulates cell mechanics by controlling focal adhesion assembly

Autori: Giorgia Nardone, Jorge Oliver-De La Cruz, Jan Vrbsky, Cecilia Martini, Jan Pribyl, Petr Skládal, Martin Pešl, Guido Caluori, Stefania Pagliari, Fabiana Martino, Zuzana Maceckova, Marian Hajduch, Andres Sanz-Garcia, Nicola Maria Pugno, Gorazd Bernard Stokin, Giancarlo Forte
Pubblicato in: Nature Communications, Numero 8, 2017, Pagina/e 15321, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms15321

Serpentine locomotion through elastic energy release

Autori: F. Dal Corso, D. Misseroni, N. M. Pugno, A. B. Movchan, N. V. Movchan, D. Bigoni
Pubblicato in: Journal of The Royal Society Interface, Numero 14/130, 2017, Pagina/e 20170055, ISSN 1742-5689
Editore: The Royal Society
DOI: 10.1098/rsif.2017.0055

A hybrid deterministic-probabilistic approach to model the mechanical response of helically arranged hierarchical strands

Autori: M. Fraldi, G. Perrella, M. Ciervo, F. Bosia, N.M. Pugno
Pubblicato in: Journal of the Mechanics and Physics of Solids, Numero 106, 2017, Pagina/e 338-352, ISSN 0022-5096
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.jmps.2017.05.013

Hierarchical Spring-Block Model for Multiscale Friction Problems

Autori: Gianluca Costagliola, Federico Bosia, Nicola M. Pugno
Pubblicato in: ACS Biomaterials Science & Engineering, Numero 3/11, 2017, Pagina/e 2845-2852, ISSN 2373-9878
Editore: American Chemical Society
DOI: 10.1021/acsbiomaterials.6b00709

Tuning friction with composite hierarchical surfaces

Autori: Gianluca Costagliola, Federico Bosia, Nicola M. Pugno
Pubblicato in: Tribology International, Numero 115, 2017, Pagina/e 261-267, ISSN 0301-679X
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.triboint.2017.05.012

A 2-D model for friction of complex anisotropic surfaces

Autori: Gianluca Costagliola, Federico Bosia, Nicola M. Pugno
Pubblicato in: Journal of the Mechanics and Physics of Solids, Numero 112, 2018, Pagina/e 50-65, ISSN 0022-5096
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.jmps.2017.11.015

Nanomechanics of individual aerographite tetrapods

Autori: Raimonds Meija, Stefano Signetti, Arnim Schuchardt, Kerstin Meurisch, Daria Smazna, Matthias Mecklenburg, Karl Schulte, Donats Erts, Oleg Lupan, Bodo Fiedler, Yogendra Kumar Mishra, Rainer Adelung, Nicola M. Pugno
Pubblicato in: Nature Communications, Numero 8, 2017, Pagina/e 14982, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms14982

Current technical approaches to brain energy metabolism

Autori: L. Felipe Barros, Juan P. Bolaños, Gilles Bonvento, Anne-Karine Bouzier-Sore, Angus Brown, Johannes Hirrlinger, Sergey Kasparov, Frank Kirchhoff, Anne N. Murphy, Luc Pellerin, Michael B. Robinson, Bruno Weber
Pubblicato in: Glia, 2017, ISSN 0894-1491
Editore: John Wiley & Sons Inc.
DOI: 10.1002/glia.23248

Microfluidization of Graphite and Formulation of Graphene-Based Conductive Inks

Autori: Panagiotis G. Karagiannidis, Stephen A. Hodge, Lucia Lombardi, Flavia Tomarchio, Nicolas Decorde, Silvia Milana, Ilya Goykhman, Yang Su, Steven V. Mesite, Duncan N. Johnstone, Rowan K. Leary, Paul A. Midgley, Nicola M. Pugno, Felice Torrisi, Andrea C. Ferrari
Pubblicato in: ACS Nano, Numero 11/3, 2017, Pagina/e 2742-2755, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.6b07735

The Role of the Oligodendrocyte Lineage in Acute Brain Trauma

Autori: Anja Scheller, Xianshu Bai, Frank Kirchhoff
Pubblicato in: Neurochemical Research, Numero 42/9, 2017, Pagina/e 2479-2489, ISSN 0364-3190
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11064-017-2343-4

Friction and Adhesion of Different Structural Defects of Graphene

Autori: Manoj Tripathi, Firas Awaja, Rafael A. Bizao, Stefano Signetti, Erica Iacob, Guido Paolicelli, Sergio Valeri, Alan Dalton, Nicola Maria Pugno
Pubblicato in: ACS Applied Materials & Interfaces, Numero 10/51, 2018, Pagina/e 44614-44623, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.8b10294

Grafting carbon nanotubes onto carbon fibres doubles their effective strength and the toughness of the composite

Autori: Luca Lavagna, Daniele Massella, Maria F. Pantano, Federico Bosia, Nicola M. Pugno, Matteo Pavese
Pubblicato in: Composites Science and Technology, Numero 166, 2018, Pagina/e 140-149, ISSN 0266-3538
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.compscitech.2018.03.015

Nitrile butadiene rubber composites reinforced with reduced graphene oxide and carbon nanotubes show superior mechanical, electrical and icephobic properties

Autori: L. Valentini, S. Bittolo Bon, M. Hernández, M.A. Lopez-Manchado, N.M. Pugno
Pubblicato in: Composites Science and Technology, Numero 166, 2018, Pagina/e 109-114, ISSN 0266-3538
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.compscitech.2018.01.050

Bionicomposites

Autori: Nicola M. Pugno, Luca Valentini
Pubblicato in: Nanoscale, Numero 11/7, 2019, Pagina/e 3102-3111, ISSN 2040-3364
Editore: Royal Society of Chemistry
DOI: 10.1039/c8nr08569b

Laser-Based Texturing of Graphene to Locally Tune Electrical Potential and Surface Chemistry

Autori: Manoj Tripathi, Alice King, Giuseppe Fratta, Manuela Meloni, Matthew Large, Jonathan P. Salvage, Nicola Maria Pugno, Alan B. Dalton
Pubblicato in: ACS Omega, Numero 3/12, 2018, Pagina/e 17000-17009, ISSN 2470-1343
Editore: American
DOI: 10.1021/acsomega.8b02815

Folding Large Graphene-on-Polymer Films Yields Laminated Composites with Enhanced Mechanical Performance

Autori: Bin Wang, Zhancheng Li, Chunhui Wang, Stefano Signetti, Benjamin V. Cunning, Xiaozhong Wu, Yuan Huang, Yi Jiang, Haofei Shi, Seunghwa Ryu, Nicola M. Pugno, Rodney S. Ruoff
Pubblicato in: Advanced Materials, Numero 30/35, 2018, Pagina/e 1707449, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201707449

The influence of substrate roughness, patterning, curvature, and compliance in peeling problems

Autori: Lucas Brely, Federico Bosia, Nicola M Pugno
Pubblicato in: Bioinspiration & Biomimetics, Numero 13/2, 2018, Pagina/e 026004, ISSN 1748-3190
Editore: British
DOI: 10.1088/1748-3190/aaa0e5

Silkworm silk fibers vs PEEK reinforced rubber luminescent strain gauge and stretchable composites

Autori: Luca Valentini, Silvia Bittolo Bon, Lorenzo Mussolin, Nicola M. Pugno
Pubblicato in: Composites Science and Technology, Numero 156, 2018, Pagina/e 254-261, ISSN 0266-3538
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.compscitech.2017.12.031

Enhanced spinal cord microstimulation using conducting polymer-coated carbon microfibers

Autori: Hugo Vara, Jorge E. Collazos-Castro
Pubblicato in: Acta Biomaterialia, Numero 90, 2019, Pagina/e 71-86, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2019.03.037

Intravital Assessment of Cells Responses to Conducting Polymer-Coated Carbon Microfibres for Bridging Spinal Cord Injury

Autori: Bilal El Waly, Vincent Escarrat, Jimena Perez-Sanchez, Jaspreet Kaur, Florence Pelletier, Jorge Eduardo Collazos-Castro, Franck Debarbieux
Pubblicato in: Cells, Numero 10/1, 2021, Pagina/e 73, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10010073

Diritti di proprietà intellettuale

Patent (1)

ROLLED HETERO-STRUCTURES AND METHOD OF MANUFACTURING ROLLED HETERO-STRUCTURES

Numero candidatura/pubblicazione: 20 20061906
Data: 2020-04-29