Magnetic DIagnostic Assay for neurodegenerative diseases

Project Information

MADIA

Grant agreement ID: 732678

DOI 10.3030/732678

Project closed

EC signature date 25 October 2016

Start date 1 January 2017

End date 31 March 2020

Funded under

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)

Total cost € 3 891 062,00

EU contribution € 3 891 062,00

Coordinated by

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy

Deliverables

Documents, reports (14)

Scaled-up batches (50 mg/type) of selective MNP (at least 3 types)
Achievement of the 10-15 g/ml sensitivity on beta amyloid 42 and/or other selected BM
Full integration of detection unit on prototype platform, detection of 100000 MNP/ml demonstrated
Content management system - CMS
Magneto-microfluidic detection unit assembled
Achievement of the 10-15 g/ml sensitivity on selected commercial protein
Dissemination and training plan
Development and fabrication of the aggregation chamber able to provide the complexation probability above 90% for beta amyloid and selected biofunctionalized MNP
Scaled-up batches (50 mg/type) of peptide aptamers (at least 3 types)
Definition of the best MNP shells for aptamer selectivity
Development of the IC board for selected MR sensor array

Development of the IC board for selected MR sensor array

Model of diffusion coefficient of MNP-biomarker aggregate
Data and samples collection from AD and PD patients
Detection of nanoparticles and measuring their diffusion coefficients for two different diameters: 10 nm and a selected higher diameter

Other (1)

Project website

Open Research Data Pilot (1)

Open Data Research Pilot

Deliverable in the form of section of project website available and populated with non-commercially sensitive data on results obtained in MADIA.

Publications

Peer reviewed articles (15)

Neurons Generated by Mouse ESCs with Hippocampal or Cortical Identity Display Distinct Projection Patterns When Co-transplanted in the Adult Brain

Author(s): Marco Terrigno, Irene Busti, Claudia Alia, Marta Pietrasanta, Ivan Arisi, Mara D'Onofrio, Matteo Caleo, Federico Cremisi
Published in: Stem Cell Reports, Issue 10/3, 2018, Page(s) 1016-1029, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2018.01.010

Novel synthetic routes of large-pore magnetic mesoporous nanocomposites (SBA-15/Fe 3 O 4 ) as potential multifunctional theranostic nanodevices

Author(s): Z. Vargas-Osorio, M. A. González-Gómez, Y. Piñeiro, C. Vázquez-Vázquez, C. Rodríguez-Abreu, M. A. López-Quintela, J. Rivas
Published in: Journal of Materials Chemistry B, Issue 5/47, 2017, Page(s) 9395-9404, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7TB01963G

"Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer’s disease and other tauopathies"

Author(s): Fulvio Florenzano, Corsetti Veronica, Gabriele Ciasca, Maria Teresa Ciotti, Anna Pittaluga, Gunedalina Olivero, Marco Feligioni, Filomena Iannuzzi, Valentina Latina, Michele Francesco Maria Sciacca, Alessandro Sinopoli, Danilo Milardi, Giuseppe Pappalardo, De Spirito Marco, Massimiliano Papi, Anna Atlante, Antonella Bobba, Antonella Borreca, Pietro Calissano, Giuseppina Amadoro
Published in: Oncotarget, Issue 8/39, 2017, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.17371

The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology

Author(s): Nadia Canu, Giuseppina Amadoro, Viviana Triaca, Valentina Latina, Valentina Sposato, Veronica Corsetti, Cinzia Severini, Maria Teresa Ciotti, Pietro Calissano
Published in: International Journal of Molecular Sciences, Issue 18/6, 2017, Page(s) 1319, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18061319

Development of a lab-on-a-chip method for rapid assay of Xylella fastidiosa subsp. pauca strain CoDiRO

Author(s): Maria Serena Chiriacò, Andrea Luvisi, Elisabetta Primiceri, Erika Sabella, Luigi De Bellis, Giuseppe Maruccio
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-25747-4

Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons

Author(s): Valentina Latina, Silvia Caioli, Cristina Zona, Maria T. Ciotti, Giuseppina Amadoro, Pietro Calissano
Published in: Frontiers in Cellular Neuroscience, Issue 11, 2017, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2017.00068

ProNGF Drives Localized and Cell Selective Parvalbumin Interneuron and Perineuronal Net Depletion in the Dentate Gyrus of Transgenic Mice

Author(s): Luisa Fasulo, Rossella Brandi, Ivan Arisi, Federico La Regina, Nicola Berretta, Simona Capsoni, Mara D'Onofrio, Antonino Cattaneo
Published in: Frontiers in Molecular Neuroscience, Issue 10, 2017, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2017.00020

Determination of the Protein Layer Thickness on the Surface of Polydisperse Nanoparticles from the Distribution of Their Concentration Along a Measuring Channel

Author(s): A. Makhaniok, V. A. Goranov, V. A. Dediu
Published in: Journal of Engineering Physics and Thermophysics, Issue 92/1, 2019, Page(s) 19-28, ISSN 1062-0125
Publisher: Consultants Bureau
DOI: 10.1007/s10891-019-01903-z

Hybrid Nanostructured Magnetite Nanoparticles: From Bio-Detection and Theragnostics to Regenerative Medicine

Author(s): Yolanda Piñeiro, Manuel González Gómez, Lisandra de Castro Alves, Angela Arnosa Prieto, Pelayo García Acevedo, Román Seco Gudiña, Julieta Puig, Carmen Teijeiro, Susana Yáñez Vilar, José Rivas
Published in: Magnetochemistry, Issue 6/1, 2020, Page(s) 4, ISSN 2312-7481
Publisher: MDPI
DOI: 10.3390/magnetochemistry6010004

In vivo ultrasound-activated delivery of recombinant tissue plasminogen activator from the cavity of sub-micrometric capsules

Author(s): Clara Correa-Paz, María F. Navarro Poupard, Ester Polo, Manuel Rodríguez-Pérez, Pablo Taboada, Ramón Iglesias-Rey, Pablo Hervella, Tomás Sobrino, Denis Vivien, José Castillo, Pablo del Pino, Francisco Campos, Beatriz Pelaz
Published in: Journal of Controlled Release, Issue 308, 2019, Page(s) 162-171, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2019.07.017

NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model

Author(s): Valentina Latina, Silvia Caioli, Cristina Zona, Maria Teresa Ciotti, Antonella Borreca, Pietro Calissano, Giuseppina Amadoro
Published in: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2018.00487

3D Patterning of cells in Magnetic Scaffolds for Tissue Engineering

Author(s): V. Goranov, T. Shelyakova, R. De Santis, Y. Haranava, A. Makhaniok, A. Gloria, A. Tampieri, A. Russo, E. Kon, M. Marcacci, L. Ambrosio, V. A. Dediu
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-58738-5

Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer’s disease models

Author(s): Veronica Corsetti, Antonella Borreca, Valentina Latina, Giacomo Giacovazzo, Annabella Pignataro, Paraskevi Krashia, Francesca Natale, Sara Cocco, Marco Rinaudo, Francesca Malerba, Rita Florio, Roberta Ciarapica, Roberto Coccurello, Marcello D’Amelio, Martine Ammassari-Teule, Claudio Grassi, Pietro Calissano, Giuseppina Amadoro
Published in: Brain Communications, Issue 2/1, 2020, ISSN 2632-1297
Publisher: Oxford University Press
DOI: 10.1093/braincomms/fcaa039

Shape effect in active targeting of nanoparticles to inflamed cerebral endothelium under static and flow conditions

Author(s): A. Da Silva-Candal, T. Brown, V. Krishnan, I. Lopez-Loureiro, P. Ávila-Gómez, A. Pusuluri, A. Pérez-Díaz, C. Correa-Paz, P. Hervella, J. Castillo, S. Mitragotri, F. Campos
Published in: Journal of Controlled Release, Issue 309, 2019, Page(s) 94-105, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2019.07.026

Harnessing Selectivity and Sensitivity in Electronic Biosensing: A Novel Lab-on-Chip Multigate Organic Transistor

Author(s): Vitaliy Parkula, Marcello Berto, Chiara Diacci, Bianca Patrahau, Michele Di Lauro, Alessandro Kovtun, Andrea Liscio, Matteo Sensi, Paolo Samorì, Pierpaolo Greco, Carlo A. Bortolotti, Fabio Biscarini
Published in: Analytical Chemistry, 2020, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.0c01655

Conference proceedings (1)

Mining clinical and laboratory data of neurodegenerative diseases by Machine Learning: transcriptomic biomarkers

Author(s): Ivan Arisi, Patrizia Mecocci, Giuseppe Bruno, Marco Canevelli, Magda Tsolaki, Natalia Pelteki, Fabrizio Stocchi, Laura Vacca, Giulia Fiscon, Paola Bertolazzi, Mara D'Onofrio, Rossella Brandi, Michele Sonnessa, Alessandra Campanelli, Rita Florio, Valentina Sposato, Francesca Malerba, Antonino Cattaneo
Published in: 2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2018, Page(s) 2735-2737, ISBN 978-1-5386-5488-0
Publisher: IEEE
DOI: 10.1109/bibm.2018.8621072