Objective MADIA aims at realizing a versatile and cheap diagnostic device based on magnetoresistive sensors, microfluidic device,ultra–small Magnetic Nanoparticles (MNPs) and advanced bio-chemical functionalization methods for the early and ultrasensitive.in vitro detection of biomarkers trustfully associated with 2 incurable neurodegenerative diseases: Alzheimer’sDisease (AD) and Parkinson Disease (PD). We plan to achieve sensitivities at least three orders of magnitude higher thanbest state-of-the-art values flexibility to operate for a wide range of concentrations.WHY: Neurodegenerative diseases (ND) are debilitating and largely untreatable conditions that are strongly linked with age.Amongst these disorders, the dementias are responsible for the greatest burden of disease, with Alzheimer’s disease andrelated disorders affecting some 7 million people in Europe. The current costs of the order of €130 billion per annum to carefor people with dementia across Europe highlight age-related neurodegenerative disease as one of the largest medical andsocietal challenges faced by our society. PD is the second most common neurodegenerative disorder worldwide after AD.WHAT: The operation principle behind the proposed tool embodies a Magnetic Sensor Assay approach and consists ofrecognizing the targeted core and downstream biomarkers obtained from body fluids (such as cerebrospinal fluid - CSF andblood) through their complexation with nano-magnetic labels (MNPs) followed by a highly sensitive magnetic detection atmicro-scales. The specific recognition of the protein by the magnetic nanoparticles will be achieved and ensured via proteinbonding to functionalizing groups grafted on the surface of the MNP. The complexes MNP-BM will be injected intomicrofluidics channels flowing in the close vicinity of magnetic sensors, bringing thus the MNP-BM to distances where themagnetic field of the MNP will trigger a quantitatively detectable sensor response. Fields of science natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsmedical and health sciencesbasic medicineneurologydementiaalzheimerengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsengineering and technologymedical engineeringmedical laboratory technologydiagnostic technologiesmedical and health sciencesbasic medicineneurologyparkinson Programme(s) H2020-EU.2.1.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT) Main Programme Topic(s) ICT-03-2016 - SSI - Smart System Integration Call for proposal H2020-ICT-2016-2017 See other projects for this call Sub call H2020-ICT-2016-1 Funding Scheme RIA - Research and Innovation action Coordinator CONSIGLIO NAZIONALE DELLE RICERCHE Net EU contribution € 701 412,00 Address PIAZZALE ALDO MORO 7 00185 Roma Italy See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 701 412,00 Participants (9) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITY OF BRIGHTON United Kingdom Net EU contribution € 530 986,25 Address LEWES ROAD MITHRAS HOUSE BN2 4AT Brighton See on map Region South East (England) Surrey, East and West Sussex Brighton and Hove Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 530 986,25 UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Spain Net EU contribution € 358 420,00 Address COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N 15782 Santiago De Compostela See on map Region Noroeste Galicia A Coruña Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 358 420,00 UNIVERSITAET BIELEFELD Germany Net EU contribution € 400 000,00 Address UNIVERSITAETSSTRASSE 25 33615 Bielefeld See on map Region Nordrhein-Westfalen Detmold Bielefeld, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 400 000,00 SERVIZO GALEGO DE SAUDE Spain Net EU contribution € 249 572,50 Address Edificio Administrativo San Lázaro 15703 Santiago De Compostela See on map Region Noroeste Galicia A Coruña Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 249 572,50 FONDAZIONE EUROPEAN BRAIN RESEARCHINSTITUTE RITA LEVI Italy Net EU contribution € 383 250,00 Address VIA REGINA ELENA 295 00161 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 383 250,00 SCRIBA NANOTECNOLOGIE SRL Italy Net EU contribution € 390 687,50 Address VIA DI CORTICELLA 183/8 40128 Bologna See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nord-Est Emilia-Romagna Bologna Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 390 687,50 ORTHOKEY ITALIA SRL Italy Net EU contribution € 332 437,50 Address PIAZZA NAZIONI UNITE 15 54033 Carrara Ms See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (IT) Toscana Massa-Carrara Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 332 437,50 BIODEVICE SYSTEMS SRO Czechia Net EU contribution € 292 796,25 Address BULHARSKA 996 20 10100 Praha See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Česko Praha Hlavní město Praha Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 292 796,25 INNOVA SRL Italy Net EU contribution € 251 500,00 Address VIA GIACOMO PERONI 386 00131 Roma See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (IT) Lazio Roma Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 251 500,00