Livrables Documents, reports (14) Scaled-up batches (50 mg/type) of selective MNP (at least 3 types) Scaled-up batches (50 mg/type) of selective MNP (at least 3 types) Achievement of the 10-15 g/ml sensitivity on beta amyloid 42 and/or other selected BM Achievement of the 10-15 g/ml sensitivity on beta amyloid 42 and/or other selected BM Full integration of detection unit on prototype platform, detection of 100000 MNP/ml demonstrated Full integration of detection unit on prototype platform, detection of 100000 MNP/ml demonstrated Content management system - CMS Content management system - CMS Magneto-microfluidic detection unit assembled Magneto-microfluidic detection unit assembled Achievement of the 10-15 g/ml sensitivity on selected commercial protein Achievement of the 10-15 g/ml sensitivity on selected commercial protein Dissemination and training plan Dissemination and training plan Development and fabrication of the aggregation chamber able to provide the complexation probability above 90% for beta amyloid and selected biofunctionalized MNP Development and fabrication of the aggregation chamber able to provide the complexation probability above 90% for beta amyloid and selected biofunctionalized MNP Scaled-up batches (50 mg/type) of peptide aptamers (at least 3 types) Scaled-up batches (50 mg/type) of peptide aptamers (at least 3 types) Definition of the best MNP shells for aptamer selectivity Definition of the best MNP shells for aptamer selectivity Development of the IC board for selected MR sensor array Development of the IC board for selected MR sensor array Model of diffusion coefficient of MNP-biomarker aggregate Model of diffusion coefficient of MNP-biomarker aggregate Data and samples collection from AD and PD patients Data and samples collection from AD and PD patients Detection of nanoparticles and measuring their diffusion coefficients for two different diameters: 10 nm and a selected higher diameter Detection of nanoparticles and measuring their diffusion coefficients for two different diameters: 10 nm and a selected higher diameter Other (1) Project website Project website Open Research Data Pilot (1) Open Data Research Pilot Deliverable in the form of section of project website available and populated with non-commercially sensitive data on results obtained in MADIA. Publications Peer reviewed articles (15) Neurons Generated by Mouse ESCs with Hippocampal or Cortical Identity Display Distinct Projection Patterns When Co-transplanted in the Adult Brain Auteurs: Marco Terrigno, Irene Busti, Claudia Alia, Marta Pietrasanta, Ivan Arisi, Mara D'Onofrio, Matteo Caleo, Federico Cremisi Publié dans: Stem Cell Reports, Issue 10/3, 2018, Page(s) 1016-1029, ISSN 2213-6711 Éditeur: Cell Press DOI: 10.1016/j.stemcr.2018.01.010 Novel synthetic routes of large-pore magnetic mesoporous nanocomposites (SBA-15/Fe 3 O 4 ) as potential multifunctional theranostic nanodevices Auteurs: Z. Vargas-Osorio, M. A. González-Gómez, Y. Piñeiro, C. Vázquez-Vázquez, C. Rodríguez-Abreu, M. A. López-Quintela, J. Rivas Publié dans: Journal of Materials Chemistry B, Issue 5/47, 2017, Page(s) 9395-9404, ISSN 2050-7518 Éditeur: Royal Society of Chemistry DOI: 10.1039/C7TB01963G "Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer’s disease and other tauopathies" Auteurs: Fulvio Florenzano, Corsetti Veronica, Gabriele Ciasca, Maria Teresa Ciotti, Anna Pittaluga, Gunedalina Olivero, Marco Feligioni, Filomena Iannuzzi, Valentina Latina, Michele Francesco Maria Sciacca, Alessandro Sinopoli, Danilo Milardi, Giuseppe Pappalardo, De Spirito Marco, Massimiliano Papi, Anna Atlante, Antonella Bobba, Antonella Borreca, Pietro Calissano, Giuseppina Amadoro Publié dans: Oncotarget, Issue 8/39, 2017, ISSN 1949-2553 Éditeur: Impact Journals DOI: 10.18632/oncotarget.17371 The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology Auteurs: Nadia Canu, Giuseppina Amadoro, Viviana Triaca, Valentina Latina, Valentina Sposato, Veronica Corsetti, Cinzia Severini, Maria Teresa Ciotti, Pietro Calissano Publié dans: International Journal of Molecular Sciences, Issue 18/6, 2017, Page(s) 1319, ISSN 1422-0067 Éditeur: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms18061319 Development of a lab-on-a-chip method for rapid assay of Xylella fastidiosa subsp. pauca strain CoDiRO Auteurs: Maria Serena Chiriacò, Andrea Luvisi, Elisabetta Primiceri, Erika Sabella, Luigi De Bellis, Giuseppe Maruccio Publié dans: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322 Éditeur: Nature Publishing Group DOI: 10.1038/s41598-018-25747-4 Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons Auteurs: Valentina Latina, Silvia Caioli, Cristina Zona, Maria T. Ciotti, Giuseppina Amadoro, Pietro Calissano Publié dans: Frontiers in Cellular Neuroscience, Issue 11, 2017, ISSN 1662-5102 Éditeur: Frontiers Research Foundation DOI: 10.3389/fncel.2017.00068 ProNGF Drives Localized and Cell Selective Parvalbumin Interneuron and Perineuronal Net Depletion in the Dentate Gyrus of Transgenic Mice Auteurs: Luisa Fasulo, Rossella Brandi, Ivan Arisi, Federico La Regina, Nicola Berretta, Simona Capsoni, Mara D'Onofrio, Antonino Cattaneo Publié dans: Frontiers in Molecular Neuroscience, Issue 10, 2017, ISSN 1662-5099 Éditeur: Frontiers Research Foundation DOI: 10.3389/fnmol.2017.00020 Determination of the Protein Layer Thickness on the Surface of Polydisperse Nanoparticles from the Distribution of Their Concentration Along a Measuring Channel Auteurs: A. Makhaniok, V. A. Goranov, V. A. Dediu Publié dans: Journal of Engineering Physics and Thermophysics, Issue 92/1, 2019, Page(s) 19-28, ISSN 1062-0125 Éditeur: Consultants Bureau DOI: 10.1007/s10891-019-01903-z Hybrid Nanostructured Magnetite Nanoparticles: From Bio-Detection and Theragnostics to Regenerative Medicine Auteurs: Yolanda Piñeiro, Manuel González Gómez, Lisandra de Castro Alves, Angela Arnosa Prieto, Pelayo García Acevedo, Román Seco Gudiña, Julieta Puig, Carmen Teijeiro, Susana Yáñez Vilar, José Rivas Publié dans: Magnetochemistry, Issue 6/1, 2020, Page(s) 4, ISSN 2312-7481 Éditeur: MDPI DOI: 10.3390/magnetochemistry6010004 In vivo ultrasound-activated delivery of recombinant tissue plasminogen activator from the cavity of sub-micrometric capsules Auteurs: Clara Correa-Paz, María F. Navarro Poupard, Ester Polo, Manuel Rodríguez-Pérez, Pablo Taboada, Ramón Iglesias-Rey, Pablo Hervella, Tomás Sobrino, Denis Vivien, José Castillo, Pablo del Pino, Francisco Campos, Beatriz Pelaz Publié dans: Journal of Controlled Release, Issue 308, 2019, Page(s) 162-171, ISSN 0168-3659 Éditeur: Elsevier BV DOI: 10.1016/j.jconrel.2019.07.017 NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model Auteurs: Valentina Latina, Silvia Caioli, Cristina Zona, Maria Teresa Ciotti, Antonella Borreca, Pietro Calissano, Giuseppina Amadoro Publié dans: Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102 Éditeur: Frontiers Research Foundation DOI: 10.3389/fncel.2018.00487 3D Patterning of cells in Magnetic Scaffolds for Tissue Engineering Auteurs: V. Goranov, T. Shelyakova, R. De Santis, Y. Haranava, A. Makhaniok, A. Gloria, A. Tampieri, A. Russo, E. Kon, M. Marcacci, L. Ambrosio, V. A. Dediu Publié dans: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322 Éditeur: Nature Publishing Group DOI: 10.1038/s41598-020-58738-5 Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer’s disease models Auteurs: Veronica Corsetti, Antonella Borreca, Valentina Latina, Giacomo Giacovazzo, Annabella Pignataro, Paraskevi Krashia, Francesca Natale, Sara Cocco, Marco Rinaudo, Francesca Malerba, Rita Florio, Roberta Ciarapica, Roberto Coccurello, Marcello D’Amelio, Martine Ammassari-Teule, Claudio Grassi, Pietro Calissano, Giuseppina Amadoro Publié dans: Brain Communications, Issue 2/1, 2020, ISSN 2632-1297 Éditeur: Oxford University Press DOI: 10.1093/braincomms/fcaa039 Shape effect in active targeting of nanoparticles to inflamed cerebral endothelium under static and flow conditions Auteurs: A. Da Silva-Candal, T. Brown, V. Krishnan, I. Lopez-Loureiro, P. Ávila-Gómez, A. Pusuluri, A. Pérez-Díaz, C. Correa-Paz, P. Hervella, J. Castillo, S. Mitragotri, F. Campos Publié dans: Journal of Controlled Release, Issue 309, 2019, Page(s) 94-105, ISSN 0168-3659 Éditeur: Elsevier BV DOI: 10.1016/j.jconrel.2019.07.026 Harnessing Selectivity and Sensitivity in Electronic Biosensing: A Novel Lab-on-Chip Multigate Organic Transistor Auteurs: Vitaliy Parkula, Marcello Berto, Chiara Diacci, Bianca Patrahau, Michele Di Lauro, Alessandro Kovtun, Andrea Liscio, Matteo Sensi, Paolo Samorì, Pierpaolo Greco, Carlo A. Bortolotti, Fabio Biscarini Publié dans: Analytical Chemistry, 2020, ISSN 0003-2700 Éditeur: American Chemical Society DOI: 10.1021/acs.analchem.0c01655 Conference proceedings (1) Mining clinical and laboratory data of neurodegenerative diseases by Machine Learning: transcriptomic biomarkers Auteurs: Ivan Arisi, Patrizia Mecocci, Giuseppe Bruno, Marco Canevelli, Magda Tsolaki, Natalia Pelteki, Fabrizio Stocchi, Laura Vacca, Giulia Fiscon, Paola Bertolazzi, Mara D'Onofrio, Rossella Brandi, Michele Sonnessa, Alessandra Campanelli, Rita Florio, Valentina Sposato, Francesca Malerba, Antonino Cattaneo Publié dans: 2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2018, Page(s) 2735-2737, ISBN 978-1-5386-5488-0 Éditeur: IEEE DOI: 10.1109/bibm.2018.8621072 Recherche de données OpenAIRE... Une erreur s’est produite lors de la recherche de données OpenAIRE Aucun résultat disponible
