Magnetic DIagnostic Assay for neurodegenerative diseases

Livrables

Scaled-up batches (50 mg/type) of selective MNP (at least 3 types)
Achievement of the 10-15 g/ml sensitivity on beta amyloid 42 and/or other selected BM
Full integration of detection unit on prototype platform, detection of 100000 MNP/ml demonstrated
Content management system - CMS
Magneto-microfluidic detection unit assembled
Achievement of the 10-15 g/ml sensitivity on selected commercial protein
Dissemination and training plan
Development and fabrication of the aggregation chamber able to provide the complexation probability above 90% for beta amyloid and selected biofunctionalized MNP
Scaled-up batches (50 mg/type) of peptide aptamers (at least 3 types)
Definition of the best MNP shells for aptamer selectivity
Development of the IC board for selected MR sensor array

Development of the IC board for selected MR sensor array

Model of diffusion coefficient of MNP-biomarker aggregate
Data and samples collection from AD and PD patients
Detection of nanoparticles and measuring their diffusion coefficients for two different diameters: 10 nm and a selected higher diameter

Project website

Open Data Research Pilot

Deliverable in the form of section of project website available and populated with non-commercially sensitive data on results obtained in MADIA.

Publications

Neurons Generated by Mouse ESCs with Hippocampal or Cortical Identity Display Distinct Projection Patterns When Co-transplanted in the Adult Brain

Auteurs: Marco Terrigno, Irene Busti, Claudia Alia, Marta Pietrasanta, Ivan Arisi, Mara D'Onofrio, Matteo Caleo, Federico Cremisi
Publié dans: Stem Cell Reports, Numéro 10/3, 2018, Page(s) 1016-1029, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2018.01.010

Novel synthetic routes of large-pore magnetic mesoporous nanocomposites (SBA-15/Fe 3 O 4 ) as potential multifunctional theranostic nanodevices

Auteurs: Z. Vargas-Osorio, M. A. González-Gómez, Y. Piñeiro, C. Vázquez-Vázquez, C. Rodríguez-Abreu, M. A. López-Quintela, J. Rivas
Publié dans: Journal of Materials Chemistry B, Numéro 5/47, 2017, Page(s) 9395-9404, ISSN 2050-7518
Éditeur: Royal Society of Chemistry
DOI: 10.1039/C7TB01963G

"Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer’s disease and other tauopathies"

Auteurs: Fulvio Florenzano, Corsetti Veronica, Gabriele Ciasca, Maria Teresa Ciotti, Anna Pittaluga, Gunedalina Olivero, Marco Feligioni, Filomena Iannuzzi, Valentina Latina, Michele Francesco Maria Sciacca, Alessandro Sinopoli, Danilo Milardi, Giuseppe Pappalardo, De Spirito Marco, Massimiliano Papi, Anna Atlante, Antonella Bobba, Antonella Borreca, Pietro Calissano, Giuseppina Amadoro
Publié dans: Oncotarget, Numéro 8/39, 2017, ISSN 1949-2553
Éditeur: Impact Journals
DOI: 10.18632/oncotarget.17371

The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology

Auteurs: Nadia Canu, Giuseppina Amadoro, Viviana Triaca, Valentina Latina, Valentina Sposato, Veronica Corsetti, Cinzia Severini, Maria Teresa Ciotti, Pietro Calissano
Publié dans: International Journal of Molecular Sciences, Numéro 18/6, 2017, Page(s) 1319, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18061319

Development of a lab-on-a-chip method for rapid assay of Xylella fastidiosa subsp. pauca strain CoDiRO

Auteurs: Maria Serena Chiriacò, Andrea Luvisi, Elisabetta Primiceri, Erika Sabella, Luigi De Bellis, Giuseppe Maruccio
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-25747-4

Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons

Auteurs: Valentina Latina, Silvia Caioli, Cristina Zona, Maria T. Ciotti, Giuseppina Amadoro, Pietro Calissano
Publié dans: Frontiers in Cellular Neuroscience, Numéro 11, 2017, ISSN 1662-5102
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fncel.2017.00068

ProNGF Drives Localized and Cell Selective Parvalbumin Interneuron and Perineuronal Net Depletion in the Dentate Gyrus of Transgenic Mice

Auteurs: Luisa Fasulo, Rossella Brandi, Ivan Arisi, Federico La Regina, Nicola Berretta, Simona Capsoni, Mara D'Onofrio, Antonino Cattaneo
Publié dans: Frontiers in Molecular Neuroscience, Numéro 10, 2017, ISSN 1662-5099
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnmol.2017.00020

Determination of the Protein Layer Thickness on the Surface of Polydisperse Nanoparticles from the Distribution of Their Concentration Along a Measuring Channel

Auteurs: A. Makhaniok, V. A. Goranov, V. A. Dediu
Publié dans: Journal of Engineering Physics and Thermophysics, Numéro 92/1, 2019, Page(s) 19-28, ISSN 1062-0125
Éditeur: Consultants Bureau
DOI: 10.1007/s10891-019-01903-z

Hybrid Nanostructured Magnetite Nanoparticles: From Bio-Detection and Theragnostics to Regenerative Medicine

Auteurs: Yolanda Piñeiro, Manuel González Gómez, Lisandra de Castro Alves, Angela Arnosa Prieto, Pelayo García Acevedo, Román Seco Gudiña, Julieta Puig, Carmen Teijeiro, Susana Yáñez Vilar, José Rivas
Publié dans: Magnetochemistry, Numéro 6/1, 2020, Page(s) 4, ISSN 2312-7481
Éditeur: MDPI
DOI: 10.3390/magnetochemistry6010004

In vivo ultrasound-activated delivery of recombinant tissue plasminogen activator from the cavity of sub-micrometric capsules

Auteurs: Clara Correa-Paz, María F. Navarro Poupard, Ester Polo, Manuel Rodríguez-Pérez, Pablo Taboada, Ramón Iglesias-Rey, Pablo Hervella, Tomás Sobrino, Denis Vivien, José Castillo, Pablo del Pino, Francisco Campos, Beatriz Pelaz
Publié dans: Journal of Controlled Release, Numéro 308, 2019, Page(s) 162-171, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2019.07.017

NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model

Auteurs: Valentina Latina, Silvia Caioli, Cristina Zona, Maria Teresa Ciotti, Antonella Borreca, Pietro Calissano, Giuseppina Amadoro
Publié dans: Frontiers in Cellular Neuroscience, Numéro 12, 2018, ISSN 1662-5102
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fncel.2018.00487

3D Patterning of cells in Magnetic Scaffolds for Tissue Engineering

Auteurs: V. Goranov, T. Shelyakova, R. De Santis, Y. Haranava, A. Makhaniok, A. Gloria, A. Tampieri, A. Russo, E. Kon, M. Marcacci, L. Ambrosio, V. A. Dediu
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-58738-5

Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer’s disease models

Auteurs: Veronica Corsetti, Antonella Borreca, Valentina Latina, Giacomo Giacovazzo, Annabella Pignataro, Paraskevi Krashia, Francesca Natale, Sara Cocco, Marco Rinaudo, Francesca Malerba, Rita Florio, Roberta Ciarapica, Roberto Coccurello, Marcello D’Amelio, Martine Ammassari-Teule, Claudio Grassi, Pietro Calissano, Giuseppina Amadoro
Publié dans: Brain Communications, Numéro 2/1, 2020, ISSN 2632-1297
Éditeur: Oxford University Press
DOI: 10.1093/braincomms/fcaa039

Shape effect in active targeting of nanoparticles to inflamed cerebral endothelium under static and flow conditions

Auteurs: A. Da Silva-Candal, T. Brown, V. Krishnan, I. Lopez-Loureiro, P. Ávila-Gómez, A. Pusuluri, A. Pérez-Díaz, C. Correa-Paz, P. Hervella, J. Castillo, S. Mitragotri, F. Campos
Publié dans: Journal of Controlled Release, Numéro 309, 2019, Page(s) 94-105, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2019.07.026

Harnessing Selectivity and Sensitivity in Electronic Biosensing: A Novel Lab-on-Chip Multigate Organic Transistor

Auteurs: Vitaliy Parkula, Marcello Berto, Chiara Diacci, Bianca Patrahau, Michele Di Lauro, Alessandro Kovtun, Andrea Liscio, Matteo Sensi, Paolo Samorì, Pierpaolo Greco, Carlo A. Bortolotti, Fabio Biscarini
Publié dans: Analytical Chemistry, 2020, ISSN 0003-2700
Éditeur: American Chemical Society
DOI: 10.1021/acs.analchem.0c01655

Mining clinical and laboratory data of neurodegenerative diseases by Machine Learning: transcriptomic biomarkers

Auteurs: Ivan Arisi, Patrizia Mecocci, Giuseppe Bruno, Marco Canevelli, Magda Tsolaki, Natalia Pelteki, Fabrizio Stocchi, Laura Vacca, Giulia Fiscon, Paola Bertolazzi, Mara D'Onofrio, Rossella Brandi, Michele Sonnessa, Alessandra Campanelli, Rita Florio, Valentina Sposato, Francesca Malerba, Antonino Cattaneo
Publié dans: 2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2018, Page(s) 2735-2737, ISBN 978-1-5386-5488-0
Éditeur: IEEE
DOI: 10.1109/bibm.2018.8621072

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