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Magnetic DIagnostic Assay for neurodegenerative diseases

Objectif

MADIA aims at realizing a versatile and cheap diagnostic device based on magnetoresistive sensors, microfluidic device,
ultra–small Magnetic Nanoparticles (MNPs) and advanced bio-chemical functionalization methods for the early and ultrasensitive.
in vitro detection of biomarkers trustfully associated with 2 incurable neurodegenerative diseases: Alzheimer’s
Disease (AD) and Parkinson Disease (PD). We plan to achieve sensitivities at least three orders of magnitude higher than
best state-of-the-art values flexibility to operate for a wide range of concentrations.
WHY: Neurodegenerative diseases (ND) are debilitating and largely untreatable conditions that are strongly linked with age.
Amongst these disorders, the dementias are responsible for the greatest burden of disease, with Alzheimer’s disease and
related disorders affecting some 7 million people in Europe. The current costs of the order of €130 billion per annum to care
for people with dementia across Europe highlight age-related neurodegenerative disease as one of the largest medical and
societal challenges faced by our society. PD is the second most common neurodegenerative disorder worldwide after AD.
WHAT: The operation principle behind the proposed tool embodies a Magnetic Sensor Assay approach and consists of
recognizing the targeted core and downstream biomarkers obtained from body fluids (such as cerebrospinal fluid - CSF and
blood) through their complexation with nano-magnetic labels (MNPs) followed by a highly sensitive magnetic detection at
micro-scales. The specific recognition of the protein by the magnetic nanoparticles will be achieved and ensured via protein
bonding to functionalizing groups grafted on the surface of the MNP. The complexes MNP-BM will be injected into
microfluidics channels flowing in the close vicinity of magnetic sensors, bringing thus the MNP-BM to distances where the
magnetic field of the MNP will trigger a quantitatively detectable sensor response.

Appel à propositions

H2020-ICT-2016-2017

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Sous appel

H2020-ICT-2016-1

Coordinateur

CONSIGLIO NAZIONALE DELLE RICERCHE
Contribution nette de l'UE
€ 701 412,00
Adresse
Piazzale Aldo Moro 7
00185 Roma
Italie

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Région
Centro (IT) Lazio Roma
Type d’activité
Research Organisations
Contribution hors UE
€ 0,00

Participants (9)

UNIVERSITY OF BRIGHTON
United Kingdom
Contribution nette de l'UE
€ 530 986,25
Adresse
Lewes Road Mithras House
BN2 4AT Brighton

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Région
South East (England) Surrey, East and West Sussex Brighton and Hove
Type d’activité
Higher or Secondary Education Establishments
Contribution hors UE
€ 0,00
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Espagne
Contribution nette de l'UE
€ 358 420,00
Adresse
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela

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Région
Galicia A Coruña
Type d’activité
Higher or Secondary Education Establishments
Contribution hors UE
€ 0,00
UNIVERSITAET BIELEFELD
Allemagne
Contribution nette de l'UE
€ 400 000,00
Adresse
Universitaetsstrasse 25
33615 Bielefeld

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Région
Nordrhein-Westfalen Detmold Bielefeld, Kreisfreie Stadt
Type d’activité
Higher or Secondary Education Establishments
Contribution hors UE
€ 0,00
SERVIZO GALEGO DE SAUDE
Espagne
Contribution nette de l'UE
€ 249 572,50
Adresse
Edificio Administrativo San Lázaro
15703 Santiago De Compostela

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Région
Galicia A Coruña
Type d’activité
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contribution hors UE
€ 0,00
FONDAZIONE EUROPEAN BRAIN RESEARCHINSTITUTE RITA LEVI
Italie
Contribution nette de l'UE
€ 383 250,00
Adresse
Via Regina Elena 295
00161 Roma

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Région
Centro (IT) Lazio Roma
Type d’activité
Research Organisations
Contribution hors UE
€ 0,00
SCRIBA NANOTECNOLOGIE SRL
Italie
Contribution nette de l'UE
€ 390 687,50
Adresse
Via Di Corticella 183/8
40128 Bologna

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PME

L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention.

Oui
Région
Nord-Est Emilia-Romagna Bologna
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contribution hors UE
€ 0,00
ORTHOKEY ITALIA SRL
Italie
Contribution nette de l'UE
€ 332 437,50
Adresse
Piazza Nazioni Unite 15
54033 Carrara Ms

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PME

L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention.

Oui
Région
Centro (IT) Toscana Massa-Carrara
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contribution hors UE
€ 0,00
BIODEVICE SYSTEMS SRO
Tchéquie
Contribution nette de l'UE
€ 292 796,25
Adresse
Bulharska 996 20
10100 Praha

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PME

L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention.

Oui
Région
Praha Hlavní město Praha
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contribution hors UE
€ 0,00
INNOVA SRL
Italie
Contribution nette de l'UE
€ 251 500,00
Adresse
Via Giacomo Peroni 386
00131 Roma

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PME

L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention.

Oui
Région
Centro (IT) Lazio Roma
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contribution hors UE
€ 0,00