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Optimizing a deployable high efficacy malaria vaccine

Objective

A highly effective malaria vaccine against Plasmodium falciparum should help prevent half a million deaths from malaria each year. New vaccine technologies and antigen discovery approaches now make accelerated design and development of a highly effective multi-antigen multi-stage subunit vaccine feasible. Leading malariologists, vaccine researchers and product developers will here collaborate in an exciting programme of antigen discovery science linked to rapid clinical development of new vaccine candidates.
Our approach tackles the toughest problems in malaria vaccine design: choice of the best antigens, attaining high immunogenicity, avoiding polymorphic antigens and increasing the durability of vaccine immunogenicity and efficacy.
We take advantage of several recent advances in vaccinology and adopt some very new technologies: sequencing malaria peptides eluted from the HLA molecules, parasites expressing multiple transgenes, multi-antigen virus-like particles constructed with new bonding technologies, delayed release microcapsules, and liver-targeted immunisation with vaccine vectors.
We enhance our chances of success by using a multi-stage multi-antigen approach, by optimising the magnitude and durability of well-characterised immune responses to key antigens, and using stringent infectious challenges and functional assays as established criteria for progression at each stage.
The consortium comprises many of the foremost researchers in this field in Europe with leading groups in the USA, Australia and Africa. We link to EDCTP programmes and harmonise our timeline to fit with the recent roadmaps for malaria vaccine development. We include a major pharma partner and several excellent European biotech companies helping enhance Europe’s leading position in the commercial development of vaccines.
This ambitious and exciting programme should have a high chance of success in tackling the major global health problem posed by malaria.

Call for proposal

H2020-SC1-2016-2017

See other projects for this call

Sub call

H2020-SC1-2016-RTD

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Net EU contribution
€ 12 064 496,39
Address
Wellington Square University Offices
OX1 2JD Oxford
United Kingdom

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (18)

STICHTING RADBOUD UNIVERSITEIT

Participation ended

Netherlands
Net EU contribution
€ 0,00
Address
Houtlaan 4
6525 XZ Nijmegen

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
Net EU contribution
€ 1 179 726,11
Address
Albinusdreef 2
2333 ZA Leiden

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Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SORBONNE UNIVERSITE
France
Net EU contribution
€ 437 500,00
Address
21 Rue De L'ecole De Medecine
75006 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
GENOME RESEARCH LIMITED

Participation ended

United Kingdom
Net EU contribution
€ 250 000,00
Address
The Gibbs Building, Euston Road 215
NW1 2BE London

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Region
London Inner London — West Camden and City of London
Activity type
Research Organisations
Non-EU contribution
€ 0,00
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT
France
Net EU contribution
€ 183 775,00
Address
Boulevard De Dunkerque 44 Cs 90009
13572 Marseille

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Region
Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône
Activity type
Research Organisations
Non-EU contribution
€ 0,00
STATENS SERUM INSTITUT
Denmark
Net EU contribution
€ 1 965 000,00
Address
Artillerivej 5
2300 Kobenhavn S

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Region
Danmark Hovedstaden Byen København
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITE DE LAUSANNE
Switzerland
Net EU contribution
€ 0,00
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 3 000 000,00
NOVAVAX AB
Sweden
Net EU contribution
€ 150 000,00
Address
Kungsgatan 109
753 18 Uppsala

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Region
Östra Sverige Östra Mellansverige Uppsala län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
EXPRES2ION BIOTECHNOLOGIES APS
Denmark
Net EU contribution
€ 445 056,25
Address
Agern Alle 1
2970 Horsholm

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Danmark Hovedstaden Nordsjælland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
IMAXIO SA

Participation ended

France
Net EU contribution
€ 5 158,05
Address
Rue Saint Roch 5/7
75001 Paris

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
JAMES COOK UNIVERSITY
Australia
Net EU contribution
€ 0,00
Address
James Cook University
4811 Townsville

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 650 787,50
PROGRAM FOR APPROPRIATE TECHNOLOGYIN HEALTH
United States
Net EU contribution
€ 25 000,00
Non-EU contribution
€ 0,00
UNITED KINGDOM RESEARCH AND INNOVATION

Participation ended

United Kingdom
Net EU contribution
€ 0,00
Address
Polaris House North Star Avenue
SN2 1FL Swindon

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Region
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Swindon
Activity type
Research Organisations
Non-EU contribution
€ 0,00
JANSSEN VACCINES & PREVENTION BV
Netherlands
Net EU contribution
€ 25 000,00
Address
Archimedesweg 4
2333 CN Leiden

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Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
OSIVAX SAS
France
Net EU contribution
€ 19 841,95
Address
4 Rue De Copenhague
75008 Paris

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands
Net EU contribution
€ 3 274 887,50
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
VACCINE FORMULATION INSTITUTE(CH)LTD
Switzerland
Net EU contribution
€ 0,00
Address
Chemin Des Aulx 14
1228 Plan Les Ouates

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Region
Schweiz/Suisse/Svizzera Région lémanique Genève
Activity type
Other
Non-EU contribution
€ 40 000,00
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
Net EU contribution
€ 25 000,00
Address
Keppel Street
WC1E 7HT London

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00