Leistungen
Networkbased approaches to modulation of brain plasticity and micrographia in PD using noninvasive brain stimulation In this part of the study we will include patients with PD and agematched healthy controls Results from taskinduced brain activation fMRI studies will be used and regions of betweengroups differences in brain activation changes in neural correlates of micrographia in PD patients will serve as our regions of interest ROIs for targeting an rTMS coil Using rTMS repetitive transcranial magnetic stimulation over two identified ROIs and over a control site ie over vertex we will evaluate whether rTMS may be an effective tool to modulate handwriting impairment in PD
Progress report 1The progress report will summarize the work done in the first year of the project including information on internal reports including report on subject recruitment and report on clinical and MRI data acquisition and analysisThe progress report will also include report on planned dissemination activities and public engamement conducted by the delivery date specifically one MSCA Open Days project website release information on the kickoff meeting information on a popular publication released M12 fMRI workshop organised at the MU and Course on Cognitive impairment and dementia
Standardized protocol for language and acoustic assessment and analysisStandardized protocol for language and acoustic assessment and analysis We will design a short but as comprehensive as possible speech task that could be used in all 3 languages English Czech Hungarian and assess both dysarthria and apraxia of speech Specific acoustic analysis of speech data will be performed in all 3 languages The battery should not exceed 15 min of data acquisition We will test this in older healthy subjects
MRI data acquisition for tasks 3, 4MRI data acquisition for tasks 3 4 we will acquire data in healthy controls and patients with PD as described in the protocol and WP4
Structural MRI identified changes associated with impaired AMWM and abnormal brain activation/connectivity in PDStructural MRI identified changes associated with impaired AMWM and abnormal brain activationconnectivity in PD By structural MRI data analysis brain atrophy brain structural connectivity we will be able to identify structural correlates of deficits in attentional modulation of working memory in PD patients as compared to healthy controls
Progress report IIThe second Progress report will present and summarize three years of the research project including reports on clinical and MRI data acquisition and analysis and on MRI data acquisition for tasks completed within the periodThe progress report will also include information on all dissemination activities to be completed by this report delivery month specifically two project consortium meeting two MSCA Open Days two participantion in European Researchers Night fMRI course and workshop organised at the MU and Neuroimaging Workshop on innovative methods organised at the USZ two runs of Course on Cognitive impairment and dementiaThis progreess report will also include plans for the remaing period of the project in the dissemination and public engagement activities which should include specifically one remianing MSCA Open Days in M41 one more popular magazine publication M48 one more participation in European Researchers Night M46 two International workshop on behavioural neurology organised at the MU and USZ M44 M48 one more fMRI course and workshop at the MU M40 one more Course on Cognitive impairment and dementia M46 and a workshop NIBS in modulation of brain plasticity and speech prosody handwriting in PD patients and healthy controls M40 M44
Standardized protocol for cognitive assessment and composite domain z-score calculationStandardized protocol for cognitive assessment and composite domain zscore calculation We will design a cognitive assessment battery that could be used in all 3 languages English Czech Hungarian Only tests validated in all 3 countries will be used to enable to calculate composite domain zscores in the following domains attention executive function memory visuospatial functions language The battery should not exceed 60 min of testing We will test feasibility of this battery in older healthy subjects
Pilot data for kinematic assessment and analysis releasedPilot data for kinematic assessment and analysis released We will develop a test a protocol for handwriting which would enables us to efficiently assess all aspects of micrographia dysgraphia in patients with Parkinsons disease PD We will use a digitizing tablet and assess both onsurface and inair movements We will use both healthy controls n10 and PD patients n10 for this pilot study Best handwriting parameters will be identified and described
Pilot fMRI data for language and acoustic assessmentPilot fMRI data for language and acoustic assessment We will design and test an fMRI protocol an eventrelated fMRI taskinduced activation design to test reading of emotionally neutral short sentences in the scanner The speech data will be acquired and assessed for noise artefacts while performing the acoustic analysis of the speech data Pilot fMRI study will be performed in healthy controls and we will test and analyse fMRI data from 20 aged healthy subjects
Kinematic abnormalities produced by damage to the cortical vs. subcortical components of the handwriting motor control networkKinematic abnormalities produced by damage to the cortical vs subcortical components of the handwriting motor control network Neural substrates of dysgraphia in patients with different neurological diseases across three different languages Patient groups and agematched healthy controls will be compared with respect to their brain structure changes In this part of the study we will evaluate lesion correlates of dysgraphia as described in the protocol and WP3 Patients with primary progressive aphasiaAlzheimers disease stroke patients and patients with Parkinsons disease will be included In PD patients and healthy controls we will additionally perform an fMRI study to assess functional correlates of impaired handwriting in PD and to identify the best cortical targets for an rTMS repetitive transcranial magnetic stimulation study see also below
Specific behavioural and task-induced fMRI protocols for language and acoustic assessmentSpecific behavioural and taskinduced fMRI protocols for language and acoustic assessment Pilot fMRI protocols will be used to assess and compare neural correlates of speech prosody impairment in patients with Parkinsons disease and in agematched healthy controls
Network-based approaches to modulation of brain plasticity and speech prosody in PD using non-invasive brain stimulationNetworkbased approaches to modulation of brain plasticity and speech prosody in patients with Parkinsons disease PD using noninvasive brain stimulation In this part of the study we will include patients with PD and agematched healthy controls Results from taskinduced brain activation fMRI studies will be used and regions of betweengroups differences in brain activation changes in neural correlates of speech prosody in PD patients will serve as our regions of interest ROIs for targeting an rTMS coil Using rTMS repetitive transcranial magnetic stimulation over two identified ROIs and over a control site ie over vertex we will evaluate whether rTMS may be an effective tool to modulate speech prosody in PD We will identify ROI with the best behavioural stimulation aftereffects and then we will use multiplesession rTMS with an aim to treat speech prosody impairment in PD
Neural substrates of speech prosody impairment in patients with different neurological diseases across three different languagesNeural substrates of speech prosody impairment in patients with different neurological diseases across three different languages Patient groups and agematched healthy controls will be compared with respect to their brain structure changes In this part of the study we will evaluate lesion correlates of dysarthria and apraxia of speech as described in the protocol and WP2 Patients with primary progressive aphasiaAlzheimers disease stroke patients and patients with Parkinsons disease will be included
Identification of alterations in patterns of brain activation and connectivity associated with deficient AMWM in PD using fMRIIdentification of alterations in patterns of brain activation and connectivity associated with deficient AMWM in PD using fMRI By functional MRI data analysis we will be able to identify functional correlates of deficits in attentional modulation of working memory in PD patients as compared to healthy controls We will specifically study deficits in bottomup and topdown control of attentional visual processing
Behavioural deficits in the attentional modulation of working memory (AMWM) in patients with Parkinson's disease (PD)Behavioural deficits in the attentional modulation of working memory AMWM in patients with Parkinsons disease PD Using data from the MRI scanner we will be able to evaluate behavioural deficits in the attentional modulation of working memory AMWM in patients with PD as compared to healthy controls
Pilot MRI dataWe will design and test two fMRI protocols eventrelated fMRI taskinduced activation designs to test attentional modulation of working memory using a visual task as described in the protocol and WP4 Pilot fMRI study will be performed in healthy controls and we will test and analyse fMRI data from 10 young healthy subjects for each of the fMRI task
Publication of novel parametrization software for kinematic analysis Since hundreds of parameters may be analysed by using kinematic analysis of handwriting data and it is very timeconsuming we will develop a novel parametrization software to speed the whole process and we will identify and choose only those kinematic parameters that best reflect micrographia dysgraphia
Novel parametrization software for acoustic analysisNovel parametrization software for acoustic analysis Since hundreds of parameters may be analysed by using acoustic analysis of speech data and it is very timeconsuming we will develop a novel parametrization software to speed the whole process and we will identify and choose only those speech parameters that reflect both dysarthria and apraxia of speech in the most efficient way
A project website will be released presenting the project and its results to general and expert publicIt will present the institutions involved and the ey researchers It will also be a place where there will be presented results of the research and its progress as well as training and other academic activities of the partners
Veröffentlichungen
Autoren:
BRABENEC, L.; KLOBUŠIAKOVÁ, P.; ŠIMKO, P.; KOŠŤÁLOVÁ, M.; MEKYSKA, J.; REKTOROVÁ, I.
Veröffentlicht in:
BRAIN STIMULATION, 2021, ISSN 1935-861X
Herausgeber:
Elsevier BV
DOI:
10.1016/j.brs.2021.03.010
Autoren:
Dániel Veréb, Eszter Tóth, Bence Bozsik, András Király, Nikoletta Szabó, Bálint Kincses, Krisztián Kocsis, Péter Faragó, Vécsei László, Krisztina Bencsik, Péter Klivényi, Zsigmond Tamás Kincses
Veröffentlicht in:
Multiple Sclerosis Journal, 2020, Seite(n) 135245852095836, ISSN 1352-4585
Herausgeber:
SAGE Publications
DOI:
10.1177/1352458520958360
Autoren:
Nikoletta Szabó, Péter Faragó, András Király, Dániel Veréb, Gergő Csete, Eszter Tóth, Krisztián Kocsis, Bálint Kincses, Bernadett Tuka, Árpád Párdutz, Délia Szok, János Tajti, László Vécsei, Zsigmond T. Kincses
Veröffentlicht in:
Frontiers in Neuroanatomy, Ausgabe 11, 2018, ISSN 1662-5129
Herausgeber:
Frontiers Research Foundation
DOI:
10.3389/fnana.2017.00138
Autoren:
Veréb, D., Szabó, N., Tuka, B., Tajti, J., Király, A., Faragó, P., … Kincses, Z. T.
Veröffentlicht in:
PAIN, 2020, ISSN 0304-3959
Herausgeber:
Elsevier BV
DOI:
10.1097/j.pain.0000000000001770
Autoren:
Patricia Klobusiakova, Jiri Mekyska, Lubos Brabenec, Zoltan Galaz, Vojtech Zvoncak, Jan Mucha, Steven Z. Rapcsak, Irena Rektorova
Veröffentlicht in:
Parkinsonism & Related Disorders, Ausgabe 84, 2021, Seite(n) 122-128, ISSN 1353-8020
Herausgeber:
Elsevier BV
DOI:
10.1016/j.parkreldis.2021.02.012
Autoren:
Krisztián Kocsis, Gergő Csete, Zsombor Erdei, András Király, Nikoletta Szabó, László Vécsei, Zsigmond Tamás Kincses
Veröffentlicht in:
PLOS ONE, Ausgabe 14/4, 2019, Seite(n) e0216032, ISSN 1932-6203
Herausgeber:
Public Library of Science
DOI:
10.1371/journal.pone.0216032
Autoren:
Lubos Brabenec, Patricia Klobusiakova, Jiri Mekyska, Irena Rektorova
Veröffentlicht in:
PARKINSONISM & RELATED DISORDERS, 2022, ISSN 1353-8020
Herausgeber:
Elsevier BV
DOI:
10.1016/j.parkreldis.2021.11.037
Autoren:
Alzbeta Sejnoha Minsterova, Patricia Klobusiakova, Adrian Pies, Zoltan Galaz, Jiri Mekyska, Lubomira Novakova, Nela Nemcova Elfmarkova, Irena Rektorova
Veröffentlicht in:
Parkinsonism & Related Disorders, Ausgabe 81, 2020, Seite(n) 96-102, ISSN 1353-8020
Herausgeber:
Elsevier BV
DOI:
10.1016/j.parkreldis.2020.10.032
Autoren:
Lenka Krajcovicova, Patricia Klobusiakova, Irena Rektorova
Veröffentlicht in:
Current Neurology and Neuroscience Reports, Ausgabe 19/11, 2019, ISSN 1528-4042
Herausgeber:
Current Science Inc.
DOI:
10.1007/s11910-019-1006-z
Autoren:
Krisztián Kocsis, Nikoletta Szabó, Eszter Tóth, András Király, Péter Faragó, Bálint Kincses, Dániel Veréb, Bence Bozsik, Katalin Boross, Melinda Katona, Péter Bodnár, Nyúl Gábor László, László Vécsei, Péter Klivényi, Krisztina Bencsik, Zsigmond Tamás Kincses
Veröffentlicht in:
Frontiers in Neurology, Ausgabe 12, 2021, ISSN 1664-2295
Herausgeber:
Frontiers Research Foundation
DOI:
10.3389/fneur.2021.619135
Autoren:
Nela Nemcova Elfmarkova, Martin Gajdos, Irena Rektorova, Radek Marecek, Steven Z. Rapcsak
Veröffentlicht in:
Neuropsychologia, Ausgabe 106, 2017, Seite(n) 236-244, ISSN 0028-3932
Herausgeber:
Pergamon Press Ltd.
DOI:
10.1016/j.neuropsychologia.2017.09.034
Autoren:
Jan Mucha, Jiri Mekyska, Zoltan Galaz, Marcos Faundez-Zanuy, Karmele Lopez-de-Ipina, Vojtech Zvoncak, Tomas Kiska, Zdenek Smekal, Lubos Brabenec, Irena Rektorova
Veröffentlicht in:
Applied Sciences, Ausgabe 8/12, 2018, Seite(n) 2566, ISSN 2076-3417
Herausgeber:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/app8122566
Autoren:
Lubos Brabenec, Patricia Klobusiakova, Marek Barton, Jiri Mekyska, Zoltan Galaz, Vojtech Zvoncak, Tomas Kiska, Jan Mucha, Zdenek Smekal, Milena Kostalova, Irena Rektorova
Veröffentlicht in:
Parkinsonism & Related Disorders, 2018, ISSN 1353-8020
Herausgeber:
Elsevier BV
DOI:
10.1016/j.parkreldis.2018.10.011
Autoren:
Bálint Kincses, Tamás Spisák, Péter Faragó, András Király, Nikoletta Szabó, Dániel Veréb, Krisztián Kocsis, Bence Bozsik, Eszter Tóth, László Vécsei, Zsigmond Tamás Kincses
Veröffentlicht in:
Journal of Neuroimaging, Ausgabe 30/4, 2020, Seite(n) 512-522, ISSN 1051-2284
Herausgeber:
Sage Science Press
DOI:
10.1111/jon.12705
Autoren:
Irena Rektorova
Veröffentlicht in:
Parkinsonism & Related Disorders, Ausgabe 59, 2019, Seite(n) 65-73, ISSN 1353-8020
Herausgeber:
Elsevier BV
DOI:
10.1016/j.parkreldis.2019.02.042
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