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mitoFOIE GRAS: Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease

Objective

"Non-Alcoholic Fatty Liver Disease (NAFLD), including its more pathologic consequence, non-alcoholic steatohepatitis (NASH), is believed to be the most common chronic liver disease worldwide, affecting between 6 to 37% of the population. NAFLD is a so called ‘silent killer’, as clinical symptoms only surface at late stages of the disease, when it is no longer treatable: untreated, NAFLD/NASH can lead to cirrhosis and hepatocellular carcinoma, culminating in liver failure. Currently the best method of diagnosing and staging the disease is liver biopsy, a costly, invasive and somewhat risky procedure, not to mention unfit for routine assessment. Besides, no therapeutic consensus exists for NAFLD/NASH treatment.
mtFOIE GRAS (Foie Gras being French for ""fat liver"") proposes to address the pressing need for non-invasive, accurate, rapid assessment of NAFLD/NASH stages, before and after intervention, through the development of biomarkers and innovative tools to follow mitochondrial (mt) dysfunction, a central mediator of fatty liver disease pathogenesis. This promising R&D strategy will also bring new knowledge about the disease mechanisms and improved understanding of the pathogenic process and disease drivers.
To that end, mtFOIE GRAS envisages a training-through-work plan that brings together an intersectoral, multidisciplinary team of researchers and technicians experts in their fields, from basic to translational research, clinical practice, technology commercialization and public advocacy. Together with several PhD students, the team will share expertises and work synergistically along the value creation chain to address the unmet medical need of more informative NAFLD assessment. In the process, mtFOIE GRAS will endow the involved staff with excellent scientific knowledge and transferable skills while building and strengthening intersectoral cooperation among partners, thus contributing to EU RD&I excellence."

Call for proposal

H2020-MSCA-RISE-2016
See other projects for this call

Coordinator

CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO
Address
Universidade De Coimbra Largo Marques De Pombal
3004 517 Coimbra
Portugal
Activity type
Research Organisations
EU contribution
€ 121 500

Participants (12)

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 36 000
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Faculdade de Farmácia da Universidade de Lisboa
Portugal
EU contribution
€ 18 000
Address
Av. Prof. Gama Pinto
1649-003 Lisboa
Activity type
Higher or Secondary Education Establishments
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 31 500
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 0
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italy
EU contribution
€ 45 000
Address
Piazza Umberto I 1
70121 Bari
Activity type
Higher or Secondary Education Establishments
UNIVERSIDADE DO PORTO
Portugal
EU contribution
€ 36 000
Address
Praca Gomes Teixeira
4099 002 Porto
Activity type
Higher or Secondary Education Establishments
INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
Poland
EU contribution
€ 13 500
Address
Ul. Ludwika Pasteura 3
02 093 Warszawa
Activity type
Research Organisations
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 36 000
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
MEDIAGNOST GESELLSCHAFT FUR FORSCHUNG UND HERSTELLUNG VON DIAGNOSTIKA GMBH
Germany
EU contribution
€ 31 500
Address
Aspenhaustrasse 25
72770 Reutlingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASSOCIACAO PROTECTORA DOS DIABETICOS DE PORTUGAL
Portugal
EU contribution
€ 76 500
Address
Rua Salitre 118-120
1250-203 Lisboa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
OROBOROS INSTRUMENTS GmbH
Austria
EU contribution
€ 4 500
Address
Schopfstrasse 18
6020 Innsbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MICRO-BIOLYTICS GMBH
Germany
EU contribution
€ 4 500
Address
Schelztorstrasse 54-56
73728 Esslingen Am Neckar
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)