mitoFOIE GRAS: Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease

Project Information

mtFOIE GRAS

Grant agreement ID: 734719

DOI 10.3030/734719

Project closed

EC signature date 5 December 2016

Start date 1 June 2017

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 454 500,00

EU contribution € 454 500,00

Coordinated by

CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO
Portugal

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Deliverables

Websites, patent fillings, videos etc. (1)

Project Website and social media

Documents, reports (1)

Pinpointed putative novel biomarkers and advanced methodologies.

Publications

Peer reviewed articles (36)

Mechanisms for increased risk of diabetes in chronic liver diseases

Author(s): Gianluca Svegliati-Baroni,Melania Gaggini,Fabrizia Carli,Chiara Barbieri,Monica Cucco,Ramy Younes,Chiara Rosso,Elisabetta Bugianesi,Amalia Gastaldelli
Published in: Liver International, Issue 14783231, 2020, ISSN 1478-3231
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/liv.14556

Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life

Author(s): Jorge Beleza,Jelena Stevanović-Silva,Pedro Coxito,Hugo Rocha,Paulo Santos,António Ascensão,Joan Ramon Torrella and José Magalhães
Published in: International Journal of Molecular Sciences, Issue 23(7), 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073916

Distinct impacts of fat and fructose on the liver, muscle, and adipose tissue metabolome: An integrated view.

Author(s): Pina A, Meneses MJ, Ribeiro RT, Raposo JF, Macedo MP.
Published in: Frontiers in Endocrinology, Issue 16642392, 2022, ISSN 1664-2392
Publisher: Frontiers Media SA
DOI: 10.3389/fendo.2022.898471

PPAR-γ-induced changes in visceral fat and adiponectin levels are associated with improvement of steatohepatitis in patients with NASH

Author(s): Amalia Gastaldelli,Silvia Sabatini,Fabrizia Carli,Melania Gaggini,Fernando Bril,Renata Belfort-DeAguiar,Vincenzo Positano,Diana Barb,Sushma Kadiyala,Stephen Harrison,Kenneth Cusi
Published in: Liver International, Issue 14783231, 2021, ISSN 1478-3231
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/liv.15005

Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases

Author(s): Luís Sousa,Mariana Guarda,Maria João Meneses,M Paula Macedo,Hugo Vicente Miranda
Published in: The Journal of Pathology, Issue 255(4), 2021, ISSN 0022-3417
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/path.5777

Paraoxonase-1 as a Regulator of Glucose and Lipid Homeostasis: Impact on the Onset and Progression of Metabolic Disorders

Author(s): Maria João Meneses,Regina Silvestre,Inês Sousa-Lima and Maria Paula Macedo
Published in: Internation Jounral of Molecular Sciences, Issue 14220067, 2019, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20164049

Gut-Pancreas-Liver Axis as a Target for Treatment of NAFLD/NASH

Author(s): Svegliati-Baroni, G.; Patrício, B.; Lioci, G.; Macedo, M.P.; Gastaldelli, A.
Published in: International Journal of Molecular Sciences, Issue 14220067, 2020, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165820

Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems

Author(s): Ricardo Amorim, Inês C.M. Simões, José Teixeira, Fernando Cagid, Yaiza Potes, Pedro Soares, Adriana Carvalho, Ludgero C. Tavaresa, Sofia Benfeito, Susana P.Pereira, Rui F. Simões, Agnieszka Karkucinska-Wieckowska, Ivan Viegas, Sylwia Szymans, Michał Dąbrowski, Justyna Janikiewicz, Teresa Cunha-Oliveira, Agnieszka Dobrzyń, John G.Jones, Fernanda Borgesb, Mariusz R.Wieckowski, Paulo J. Olivei
Published in: Redox Biology, Issue 22132317, 2022, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2022.102400

Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets

Author(s): Adriana Fontes,João Ramalho-Santos,Hans Zischka,Anabela Marisa Azul
Published in: European Journal of Clinical Investigation, Issue 13652362, 2022, ISSN 1365-2362
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/eci.13667

Physical exercise and liver “fitness”: Role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease

Author(s): Jelena Stevanović, Jorge Beleza, Pedro Coxito, António Ascensão, José Magalhães
Published in: Molecular Metabolism, Issue 22128778, 2019, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.11.015

Interorganellar calcium signaling in the regulation of cell metabolism: A cancer perspective

Author(s): AlessandroRimessia,GaiaPedrialia,BiancaVezzania,AnnaTaroccoa,SaverioMarchic,Mariusz R.Wieckowski,CarlottaGiorgia,PaoloPintonae
Published in: Seminars in Cell & Developmental Biology, Issue 10849521, 2020, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2019.05.015

Mitophagy in Cardiovascular Diseases

Author(s): Giampaolo Morciano,Simone Patergnani,Massimo Bonora,Gaia Pedriali,Anna Tarocco,Esmaa Bouhamida,Saverio Marchi,Gina Ancora,Gabriele Anania,Mariusz R. Wieckowski,Carlotta Giorgi andPaolo Pinton
Published in: Journal of Clinical Medicine, Issue 20770383, 2020, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9030892

Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

Author(s): Massimo Bonora,Simone Patergnani,Daniela Ramaccini,Giampaolo Morciano,Gaia Pedriali,Asrat Endrias Kahsay,Esmaa Bouhamida,Carlotta Giorgi,Mariusz R. Wieckowski, and Paolo Pinton
Published in: Biomolecules, Issue 2218273X, 2020, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom10070998

Building-up fit muscles for the future

Author(s): Jorge Beleza,Jelena Stevanović-Silva,Pedro Coxito,Rui Carlos Costa,António Ascensão,Joan Ramon Torrella,José Magalhães
Published in: European Journal of Clinical Investigation, Issue 13652362, 2021, ISSN 1365-2362
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/eci.13515

Anti-ApoA-1 IgGs predict resistance to waist circumference reduction after Mediterranean diet

Author(s): Federico Carbone,Agostino Di Ciaula,Sabrina Pagano,Silvia Minetti,Anna Maria Ansaldo,Daniele Ferrara,Anna Belfiore,Edoardo Elia,Stefania Pugliese,Vincenzo Ostilio Palmieri,Fabrizio Montecucco,Nicolas Vuilleumier,Piero Portincasa
Published in: European Journal of Clinical Investigation, Issue 13652362, 2021, ISSN 1365-2362
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/eci.13410

Fit mothers for a healthy future

Author(s): Jelena Stevanović-Silva,Jorge Beleza,Pedro Coxito,Rui Carlos Costa,António Ascensão,José Magalhães
Published in: European Journal of Clinical Investigation, Issue 13652362, 2022, ISSN 1365-2362
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/eci.13596

Cytoprotective Mechanisms in Fatty Liver Preservation against Cold Ischemia Injury: A Comparison between IGL-1 and HTK

Author(s): Arnau Panisello-Roselló, Eva Verde, Alexandre Lopez, Marta Flores, Emma Folch-Puy, Anabela Rolo, Carlos Palmeira, Georgina Hotter, Teresa Carbonell, René Adam, Joan Roselló-Catafau
Published in: Internation Journal of Molecular Sciences, Issue 14220067, 2018, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19020348

Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship

Author(s): Agnieszka Karkucinska-Wieckowska,Ines C. M. Simoes,Piotr Kalinowski,Magdalena Lebiedzinska-Arciszewska,Krzysztof Zieniewicz,Piotr Milkiewicz,Magdalena Górska-Ponikowska,Paolo Pinton,Afshan N. Malik,Marcin Krawczyk,Paulo J. Oliveira,Mariusz R. Wieckowski
Published in: European Journal of Clinical Investigation, Issue 13652362, 2022, ISSN 1365-2362
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/eci.13622

Loss of postprandial insulin clearance control by Insulin-Degrading Enzyme drives dysmetabolism traits

Author(s): Diego O. Borges,Rita S. Patarrão,Rogério T. Ribeiro,Rita Machado de Oliveira,Nádia Duarte,Getachew Debas Belew,Madalena Martins,Rita Andrade,João Costa,Isabel Correia,José Manuel Boavida,Rui Duarte,Luís Gardete-Correia,José Luís Medina,João F. Raposo,John G. Jones,Carlos Penha-Gonçalves,M. Paula Macedo
Published in: Metabolism - Clinical and Experimental, Issue 00260495, 2021, ISSN 0026-0495
Publisher: Elsevier BV
DOI: 10.1016/j.metabol.2021.154735

The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production

Author(s): Inês C. M. Simões, Ricardo Amorim, José Teixeira,Agnieszka Karkucinska-Wieckowska,Adriana Carvalho, Susana P. Pereira, Rui F. Simões, Sylwia Szymanska, Michał Dąbrowski, Justyna Janikiewicz, Agnieszka Dobrzyń, Paulo J. Oliveira, Yaiza Potes, and Mariusz R. Wieckowski
Published in: International Journal of Molecular Sciences, Issue 14220067, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22136848

Adipose tissue insulin resistance and lipidome alterations as the characterizing factors of non-alcoholic steatohepatitis

Author(s): Sara Guerra,Gabriele Mocciaro,Amalia Gastaldelli
Published in: European Journal of Clinical Investigation, Issue 52(3), 2022, ISSN 0014-2972
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/eci.13695

The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective

Author(s): Ines C.M. Simoes, Giampaolo Morciano, Magdalena Lebiedzinska-Arciszewska, Gianluca Aguiari, Paolo Pinto, Yaiza Potesa, Mariusz R. Wieckowsk
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Issue 09254439, 2020, ISSN 0925-4439
Publisher: Elsevier BV
DOI: 10.1016/j.bbadis.2020.165834

Mitochondrial Impairment by MitoBloCK-6 Inhibits Liver Cancer Cell Proliferation

Author(s): Yaschar Kabiri, Anna Fuhrmann, Anna Becker, Luisa Jedermann, Carola Eberhagen, Ann-Christine König, Tiago Barros Silva, Fernanda Borges, Stefanie M Hauck, Bernhard Michalke, Percy Knolle, Hans Zischka
Published in: Frontiers in Cell and Developmental Biology, Issue 2296634X, 2021, ISSN 2296-634X
Publisher: Frontiers Media SA
DOI: 10.3389/fcell.2021.725474

Mitochondria in non-alcoholic fatty liver disease

Author(s): Inês C.M. Simões, Adriana Fontes, Paolo Pinton, Hans Zischka, Mariusz R. Wieckowski
Published in: The International Journal of Biochemistry & Cell Biology, Issue 95, 2018, Page(s) 93-99, ISSN 1357-2725
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biocel.2017.12.019

Dipeptidyl Peptidase-4 Is a Pro-Recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells

Author(s): Nádia Duarte, Inês Coelho, Denys Holovanchuk, Joana Inês Almeida, Carlos Penha-Gonçalves, Maria Paula Macedo
Published in: Hepatology Communications, Issue 2/9, 2018, Page(s) 1080-1094, ISSN 2471-254X
Publisher: American Association for the Study of Liver Diseases
DOI: 10.1002/hep4.1225

Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease

Author(s): Ignazio Grattagliano, Liliana P. Montezinho, Paulo J. Oliveira, Gema Frühbeck, Javier Gómez-Ambrosi, Fabrizio Montecucco, Federico Carbone, Mariusz R. Wieckowski, David Q.-H. Wang, Piero Portincasa
Published in: Biochemical Pharmacology, Issue 160, 2019, Page(s) 34-45, ISSN 0006-2952
Publisher: Elsevier BV
DOI: 10.1016/j.bcp.2018.11.020

Self-Paced Free-Running Wheel Mimics High-Intensity Interval Training Impact on Rats’ Functional, Physiological, Biochemical, and Morphological Features

Author(s): Jorge Beleza, João Albuquerque, Estela Santos-Alves, Pedro Fonseca, Garoa Santocildes, Jelena Stevanovic, Sílvia Rocha-Rodrigues, David Rizo-Roca, António Ascensão, Joan Ramon Torrella, José Magalhães
Published in: Frontiers in Physiology, Issue 10, 2019, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00593

A Diet Induced Maladaptive Increase in Hepatic Mitochondrial DNA Precedes OXPHOS Defects and May Contribute to Non-Alcoholic Fatty Liver Disease

Author(s): Malik, Simões, Rosa, Khan, Karkucinska-Wieckowska, Wieckowski
Published in: Cells, Issue 8/10, 2019, Page(s) 1222, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells8101222

Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease

Author(s): Simoes, Janikiewicz, Bauer, Karkucinska-Wieckowska, Kalinowski, Dobrzyń, Wolski, Pronicki, Zieniewicz, Dobrzyń, Krawczyk, Zischka, Wieckowski, Potes
Published in: Nutrients, Issue 11/12, 2019, Page(s) 2871, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu11122871

Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells

Author(s): Ricardo Amorim, Inês C. M. Simões, Caroline Veloso, Adriana Carvalho, Rui F. Simões, Francisco B. Pereira, Theresa Thiel, Andrea Normann, Catarina Morais, Amália S. Jurado, Mariusz R. Wieckowski, José Teixeira and Paulo J. Oliveira
Published in: Nutrients, Issue 20726643, 2021, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13051723

Aortic Valve Stenosis and Mitochondrial Dysfunctions: Clinical and Molecular Perspectives

Author(s): Gaia Pedriali,Giampaolo Morciano,Simone Patergnani,Paolo Cimaglia,Cristina Morelli,Elisa Mikus,Roberto Ferrari,Vincenzo Gasbarro,Carlotta Giorgi,Mariusz R. Wieckowski and Paolo Pinton
Published in: International Journal of Molecular Sciences, Issue 14220067, 2020, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21144899

Measuring and estimating insulin resistance in clinical and research settings

Author(s): Amalia Gastaldelli
Published in: Obesity - A research journal, Issue 19307381, 2022, ISSN 1930-7381
Publisher: Wiley-Blackwell
DOI: 10.1002/oby.23503

Fibrosis nonalcoholic steatohepatitis index validation and applicability considering glycaemic severity and T2D duration.

Author(s): Pina A, Meneses MJ, Ribeiro RT, Raposo JF, Macedo MP.
Published in: Liver International, Issue 14783231, 2022, ISSN 1478-3231
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/liv.15406

Big Data and Machine Learning to tackle Diabetes Managemen.

Author(s): Pina AF, Meneses MJ, Sousa-Lima I, Henriques R, Raposo JF, Macedo MP.
Published in: European Journal of Clinical Investigation, Issue 13652362, 2022, ISSN 1365-2362
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/eci.13890

Physical Activity Modulating Lipid Metabolism in Gallbladder Diseases

Author(s): Shanmugam H, Molina Molina E, Di Palo DM, Faienza M, Di Ciaula A, Garruti G, Wang D, Portincasa P.
Published in: Journal of Gastrointestinal and Liver Diseases, Issue 18418724, 2020, Page(s) 99-110, ISSN 1841-8724
Publisher: Editura Medicala
DOI: 10.15403/jgld-544

Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomarkers of NAFLD

Author(s): Vanda Marques, Marta B. Afonso, Nina Bierig, Filipa Duarte-Ramos, Álvaro Santos-Laso, Raul Jimenez-Agüero, Emma Eizaguirre, Luis Bujanda, Maria J. Pareja, Rita Luís, Adília Costa, Mariana V. Machado, Cristina Alonso, Enara Arretxe, José M. Alustiza, Marcin Krawczyk, Frank Lammert, Dina G. Tiniakos, Bertram Flehmig, Helena Cortez-Pinto, Jesus M. Banales, Rui E. Castro1, Andrea Normann and Cec
Published in: Frontiers in Medicine, 2021, ISSN 2296-858X
Publisher: Frontiers Media SA
DOI: 10.3389/fmed.2021.683250

Other (2)

The heart of FOIE GRAS and mtFOIE GRAS: fundamental and clinical investigation for training and innovation in non-alcoholic fatty liver disease

Author(s): Paulo J. Oliveira
Published in: European Heart Journal, Issue 15229645, 2021, ISSN 1522-9645
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehab399

Bioenergetic remodeling in the pathophysiology and treatment of nonalcoholic fatty liver disease

Author(s): Anabela Marisa Azul,Martin Winter,Daniel Silva,Liljana Georgievska,Paulo J. Oliveira
Published in: European Journal of Clinical Investigation, Issue 52(3), 2022, ISSN 0014-2972
Publisher: John Wiley & Sons
DOI: 10.1111/eci.13749

Monographic books (1)

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Author(s): Carlotta Giorgi, Saverio Marchi, Ines C.M. Simoes, Ziyu Ren, Giampaolo Morciano, Mariasole Perrone, Paulina Patalas-Krawczyk, Sabine Borchard, Paulina Jędrak, Karolina Pierzynowska, Jędrzej Szymański, David Q. Wang, Piero Portincasa, Grzegorz Węgrzyn, Hans Zischka, Pawel Dobrzyn, Massimo Bonora, Jerzy Duszynski, Alessandro Rimessi, Agnieszka Karkucinska-Wieckowska, Agnieszka Dobrzyn, Gyorgy Sz
Published in: Mitochondria and Longevity, 2018, Page(s) 209-344
Publisher: Elsevier
DOI: 10.1016/bs.ircmb.2018.05.006

Intellectual Property Rights

Patent (4)

HYDROXYCINNAMIC DERIVATIVES, METHODS AND USES THEREOF

Application/Publication number: 17 809369
Date: 2017-10-16
Applicant(s): UNIVERSIDADE DO PORTO

HYDROXYBENZOIC ACID DERIVATIVES, METHODS AND USES THEREOF

Application/Publication number: 17 835943
Date: 2017-12-29
Applicant(s): UNIVERSIDADE DO PORTO

HYDROXYCINNAMIC DERIVATIVES, METHODS AND USES THEREOF

Application/Publication number: 17 809369
Date: 2017-10-16
Applicant(s): CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO

HYDROXYBENZOIC ACID DERIVATIVES, METHODS AND USES THEREOF

Application/Publication number: 17 835943
Date: 2017-12-29
Applicant(s): CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO